Thermo is a True GRIT’s upcoming fat-burner which contains both stimulant and non-stimulant ingredient designed to attack fat and reduce bodyweight through multiple diferent mechanisms…FIND IT HERE
Although Caffeine possesses pro-fat-loss properties, the effects tend to fade with prolonged use, rendering it ineffective as a long-term weight loss solution on its own. However, when paired with other fat-burning stimulants, Caffeine can kick-start the fat-burning process, so it’s a useful addition to the True GRIT Thermo formula.
True GRIT Thermo contains 270mg of Caffeine per serving, a sizeable dose for the average non-habitual Caffeine user.
GARCINIA CAMBOGIA EXTRACT (HYDROXYCITRIC ACID)
Garcinia Cambogia contains Hydroxycitric Acid (HCA), which is alleged to reduce body weight via inhibition of ATP Citrate Lysase, an enzyme required for the synthesis of fatty acids from carbohydrates (de novo lipogenisis).
Theoretically speaking, blocking this enzyme would essentially stop excess carbs from being stored as fat. While this has resulted in weight-loss in rodents, the implications for humans are less promising, because de novo lipogenesis occurs less in humans than rodents.
We discuss Garcinia Cambogia in-depth in this article, but to summarize:
2 out of 3 human studies have failed to show any influence on weight-loss using doses that are much higher than the 200mgs present in True GRIT Thermo.
GREEN COFFEE EXTRACT
Green Coffee Bean Extract is generally standardized for Chlorogenic Acid content, as is the case in True GRIT Thermo. We discuss the influence of Green Coffee Extract in-depth in this article, but to summarize:
Green Coffee Extract can be effective for blocking the absorption of carbs, ultimately simulating a reduced-carb diet, but efficacy is dependent upon enough Chlorogenic Acid being present.
True GRIT Thermo contains 200mg of Green Coffee Extract yielding 90mg of Chlorogenic Acid per serving. At this dose, users may need two servings to receive any noticeable benefit.
Coleus Forskohlii is an Ayurvedic herb which has been studied (though not extensively) for its potential as a non-stimulant weight-loss agent and natural testosterone booster. The active component, Forskolin, has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.
A 2005 study, published in the “Journal of the International Society of Sports Nutrition”, found that 25mg Forskolin twice a day for 12 weeks was able to prevent weight gain compared to the control group in overweight women.
Another 2005 study, the subjects of which were overweight men, found that the same dose (25mg) was able to favorably influence body composition (i.e. less fat, more lean mass), which corresponded with an increase in testosterone over 12 weeks.
A more recent 2011 study noted a roughly 2.5% decrease in BMI after 2 months of supplementation. Ultimately, Forskolin may certainly result in weight-loss or at the very least, prevent weight gain. These effects may be more apparent in men, as an increase in cAMP also increases testosterone, which inherently burns fat and increases lean muscle mass.
True GRIT Thermo contains 100mg of Coleus Forskohlin yielding 10mg of Forskolin per serving. Two servings is needed to yield a truly effective (20mg) dose.
Green Tea Extract is actually one of the most extensively-researched non-stimulant weight-loss supplements currently available, and demonstrated consistently favorable results.
A 2009 study, published in “The Journal of Nutrition”, found that subjects consuming 625mg Green Tea Catechins (EGCG) alongside 40mg Caffeine paired with exercise lost an average of 2.2kg (4.8lbs)compared to the subjects in the control group (consuming just Caffeine), who lost an average of 1kg (2.2lbs).
These findings were corroborated by a 2009 meta-analysis, published in the “International Journal of Obesity”, which concluded that Green Tea extract tended to cause about 1.2kg (2.6lbs) reduction in bodyweight, and that effects could be amplified with Caffeine in non-caffeine tolerant individuals.
Further research has revealed that EGCG can effectively block Catechol-o-Methyl Transferase (COMT), the enzyme responsible for the degradation of Catcholamines such as Noradrenaline. The result is an indirect increase in Noradrenaline which induces lipolysis.
So, while EGCG is not likely to induce noticeable weight-loss alone, when combined with Caffeine or other Noradrenaline-releasing stimulants, it can be quite synergistic.
Unfortunately, True GRIT does not disclose the concentration of EGCG present in the Green Tea Extract used in Thermo, making it tough to gauge the actual efficacy.
Ophiopogon japonicas has been used, mostly in Traditional Chinese Medicine, as a cardiovascular health-agent, but preliminary evidence suggests it may be useful for controlling blood glucose. At this time, the only studies have been conducting in mice, with absolutely no research in humans to date.
In the context of True Grit Thermo, Ophiopogon japonicas may play something of a “support” role but we wouldn’t consider it a particularly important addition to the formula.
Yohimbe Bark is standardized for Yohimbine, which is an alpha(2) receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis (breakdown of fat). By blocking the action of this receptor Yohimbine allows for more lipolysis than would otherwise be possible from exercise.
A 2006 study, published in “Research in Sports Medicine”, found that Yohimbine supplementation (20mg/day) induced relatively significant fat loss in athletes (soccer players), but had no influence on measures of exercise performance.
True GRIT lists the amount of Yohimbe in Thermo at 12.5mg but doesn’t disclose the concentration of Yohimbine. For this reason, it’s tough to say how much it really contributes to the True GRIT Thermo formula.
Bioperine is patented form of Black Pepper extract, standardized for Piperine, which has been shown to enhance the absorption of other nutrients when co-ingested. This is due to Piperine’s ability to slow intestinal transit as well as inhibit certain enzymes that would normally break down nutrients too quickly.
It has no weight-loss implications on its own, but it may enhance the effectiveness of the True GRIT Thermo formula as a whole.
THE BOTTOM LINE
True Grit Thermo contains several effective ingredients, both stimulant and non-stimuant, the combination of which may certainly induce weight-loss. Like some of the other True Grit formulas, the Thermo formula is clearly intended for two servings daily and that’s the dose we’d recommend for maximum benefit. However, some of the non-stimulant ingredients may still be under-dosed.
Still not sure which fat-burner is right for you? Check out our Top 10 Fat-Burners List!
- Costill, D. L., Gl P. Dalsky, and W. J. Fink. “Effects of caffeine ingestion on metabolism and exercise performance.” Medicine and science in sports 10.3 (1977): 155-158.
- Arciero, PAUL J., et al. “Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men.” American Journal of Physiology-Endocrinology And Metabolism 268.6 (1995): E1192-E1198.
- Astrup, A., et al. “Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers.” The American journal of clinical nutrition 51.5 (1990): 759-767
- Graham, Terry E., Jorn W. Helge, David A. MacLean, Bente Kiens, and Erik A. Richter. “Caffeine Ingestion Does Not Alter Carbohydrate or Fat Metabolism in Human Skeletal Muscle during Exercise.” The Journal of Physiology 529.3 (2000): 837-47
- Chen, Xiaoming, et al. “Protective effect of the polysaccharide from< i> Ophiopogon japonicus on streptozotocin-induced diabetic rats.”Carbohydrate polymers 94.1 (2013): 378-385.
- Wang, Hong. “Preventive effects of ophiopogon-polysaccharide on apiponectin in gestational diabetes mellitus rat.” Asian Pacific journal of tropical medicine6.4 (2013): 296-299.
- Chen, Xiaoming, et al. “Extraction, purification, characterization and hypoglycemic activity of a polysaccharide isolated from the root of< i> Ophiopogon japonicus.” Carbohydrate Polymers 83.2 (2011): 749-754.
- Heymsfield, Steven B., et al. “Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial.” Jama 280.18 (1998): 1596-1600.
- Kim, Ji-Eun, et al. “Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial.” Nutrition journal 10.1 (2011): 94.
- Watson, John A., and John M. Lowenstein. “Citrate and the Conversion of Carbohydrate into Fat FATTY ACID SYNTHESIS BY A COMBINATION OF CYTOPLASM AND MITOCHONDRIA.” Journal of Biological Chemistry 245.22 (1970): 5993-6002.
- Mattes, Richard D., and Leslie Bormann. “Effects of (−)-hydroxycitric acid on appetitive variables.” Physiology & behavior 71.1 (2000): 87-94.
- Watanabe, Takuya, et al. “The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.”Clinical and experimental hypertension 28.5 (2006): 439-449.
- Vinson, Joe A., Bryan R. Burnham, and Mysore V. Nagendran. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.”Diabetes, metabolic syndrome and obesity: targets and therapy 5 (2012): 21.
- Thom, E. “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.” Journal of International Medical Research 35.6 (2007): 900-908.
- Henderson, Shonteh, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr 2.2 (2005): 54-62.
- Godard, Michael P., Brad A. Johnson, and Scott R. Richmond. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obesity Research 13.8 (2005): 1335-1343.
- Jagtap, Madhavi, H. M. Chandola, and B. Ravishankar. “Clinical efficacy of Coleus forskohlii (Willd.) Briq.(Makandi) in hypertension of geriatric population.”Ayu 32.1 (2011): 59.
- Thielecke, Frank, et al. “Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study.” European journal of clinical nutrition 64.7 (2010): 704-713.
- Lu, Hong, Xiaofeng Meng, and Chung S. Yang. “Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (−)-epigallocatechin gallate.” Drug metabolism and disposition 31.5 (2003): 572-579.
- Keränen, Tapani, et al. “Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone.” European journal of clinical pharmacology 46.2 (1994): 151-157.
- Brown, A. L., et al. “Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial.” British Journal of Nutrition106.12 (2011): 1880-1889.
- Ostojic, Sergej M. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Research in Sports Medicine 14.4 (2006): 289-299.