Tim Muriello’s Spazmatic: An Evidence-Based Review

Spazmatic is a pre-workout supplemet by Tim Muriello who you may know from doing a ton of reviews on YouTube for IllPumpYouUp.  Well, it now appears as though Tim is branching out.  This is the first official release of a Tim Muriello branded product and we have to say…we love the name!

Tim Muriello's Spazmatic


Spazmatic Claims

Tim Muriello claims that Spazmatic will:

  • Increased Energy
  • Enhanced Focus
  • Better Pumps/Endurance/Performance

Of course, these are the same claims attached to most pre-workout supplements so the only way to be sure if Tim Muriello’s Spazmatic will live up to the claims is to analyze the ingredients and dosing of those ingredients, one by one…

Spazmatic Ingredients

Spazmatic is not overly complicated, but does contain a wide variety of ingredients, each with a specific way of contributing to the formula as a whole.  You may recognize some or all of the ingredients from various other pre-workout supplements, but let’s brush up a little, shall we?


Taurine is a unique amino acid with anti-oxidant properties which underlie it’s performance and recovery enhancing properties.  Taurine supplementation has been shown, in multiple studies, to reduce oxidative damage in muscle tissue.  Less damage to muscle tissue means a speedier recovery.

Taurine has also been shown to improve exercise performance, but since it has failed to do so in at least one other study, it can’t be considered a highly reliable performance enhancer like, say, Creatine.

Similarly to Creatine, Taurine is an Osmolyte.  This is simply a scientific way of saying that it can increase the amount of fluid within a cell.  Although it has yet to be studied directly, it stands to reason that Taurine can increase the size of your muscles and induce some nice pumps the same way other Osmolytes such as Creatine and Betaine do.

Spazmatic contains 2 grams of Taurine, about double what you’ll find in the average pre-workout supplement (assuming it contains Taurine as well).


Caffeine is the most widely used psychoactive substance in the world…

Consumption generally triggers the release of Catecholamines, a group of chemicals including Dopamine and Noradrenaline which increase feelings of mental energy and focus.  Caffeine also has additonal mechanisms by which it can enhance exercise performance, so if having the best workout you possibly can is your goal, then Caffeine should be in your pre-workout arsenal.

Depending on your individual tolerance to Caffeine (how often you consume it), you’re going to find your ideal dose somewhere between 100 and 400 mg.

Spazmatic contains a whopping 400 mg of Caffeine, 100 mg of which is from Green Tea.  This is enough to get pretty much anyone feeling noticeably more alert and focused.


2-Aminoisoheptane, also known as DMHA, has quickly become the go-to replacement for DMAA.  Unfortunately, there’s no doubt about it…it’s NOT DMAA.  DMAA is a much more powerful stimulant, hence why no pre-workout with DMHA has ever reached the status of such pre-workouts as the original Jack3d and Dust Extreme.

Still, DMHA may do something for you if stimulants are you thing.  Give it a shot, jus don’t expect a DMAA-like experience.

Furthermore, there aren’t any studies pertaining to safety OR efficacy yet, so DMHA should still be considered a speculative ingredient in the eyes of science.  That said, tons of people have used it so there is a good amount of anecdotal evidence floating around the internet.

If you’re interested in reading more, PricePlow published an excellent article on 2-Aminoisoheptane which is packed with more information than you’ll probably be able to take in at once.  Check it out here.


Higenamine is a powerful beta-receptor agonist (same mechanism as Ephedrine and Synephrine) which may increase feelings of mental energy and focus as well, especially in combination with other stimulants such as Caffeine.

We break down everything you need to know about Higenamine in this article but the bottom line is that it’s pretty awesome!  In fact, we’d go as far as to say that no high-stim pre-workout is truly complete without a solid dose of Higenamine.

Spazmatic contains 30 mg of this wonderful substance, more than what you’ll find in the average Higenamine-containing pre-workout.


Hordenine is unique molecule found in Barley which has been shown to function as a Monoamine Oxidase Inhibitor (MAOI).  Monoamine Oxidase is an enzyme (really a group of related enzymes) which breaks down Monoamines including Dopamine and Noradrenaline.  These two neurotransmitters, being heavily involved in the fight or flight response, play a crucial role in producing feelings of focus and alertness.

By blocking the enzyme that breaks these neurotransmitters down, Hordenine allows them to remain active within the brain longer and prehaps more intensely.

A clinical dose or range for Hordenine has yet to be established, but you’ll usually find it dosed between 20 and 50  mg.  Like Higenamine, Spazmatic contains 30 mg of Hordenine.


Tyrosine is an amino acid (found in various sources of protein) which, in addition to building muscle, is also used by the brain to produce Dopamine and Noradrenaline.  As mentioned above, these two neurotransmitters tend to increase feelings of mental energy and focus, so optimizing their production is important any time you’re going hard in the gym for hours.

Tyrosine supplementation won’t directly increase levels of Dopamine or Noradrenaline, but instead serves as substrate to maintain optimal levels.  In other words, when the brain is low on Dopamine and Noradrenaline, as would be the case following an intense, highly-focused workout, Tyrosine can be used to make more.

This makes it worth using in your pre-workout supplement, especially when it also contains several stimulants which cause the brain to secrete Dopamine and Noradrenaline.

Spazmatic contains 1000 mg of L-Tyrosine.

Huperzine A

Huperzine A is a unique molecule found in various plant species.  Most notably, Huperzia Serrata.

Huperzine has been shown to function as a powerful Acetylcholinesterase Inhibitor, meaning it blocks the enzyme (Acetylcholinesterase) which breaks down the neurotransmitter Acetylcholine.  Acetylcholine is involved with several mental processes, ranging from memory formation and learning to muscle contraction and dreaming.

By blocking the enzyme that normally breaks Acetycholine down, Huperzine indirectly increases levels of this important neurotransmitter in the brain.

Theoretically, this should lead to better muscle contractions and cognitive function, but studies haven’t really investigated the impact of Huperzine on exercise performance at this time, so we’re speculating a little here…

Huperzine is so powerful that it must be dosed in micrograms (mcg) as opposed to milligrams (mg).  Spazmatic contains 200 mcg of Huperzine A, far more than most other pre-workout supplements containing the same ingredient.


L-Citrulline is an amino acid which has two important roles in the body which underlie its performance enhancement capabilities:

  1. It’s the precursor to Arginine which in turn is a precursor to Nitric Oxide
  2. It’s invoved in the Urea Cycle (the cycle by which Ammonia is reduced to Uric Acid in the body)

Although it is a pre-pre-cursor to Nitric Oxide, Citrulline supplementation is actually more effective than Arginine supplementation for the purposes of increasing Nitric Oxide levels.  This makes Citrulline–not Arginine–ideal for acheiving the benefits associated with Nitric Oxide (i.e. PUMPS!)…

As an integral component of the Urea Cycle, Citrulline has been shown to reduce Ammonia build-up in working muscle, effectively delaying muscular fatigue later on on in the workout when it would normally be a contributing factor to muscle failure.

Citrulline is hands down one of the best performance enhancing supplements there is.  It has been proven in multiple studies to increase muscular endurance and should offer some awesome pumps as well.

Spazmatic contains 4,500 mg of L-Citrulline per serving, a super solid dose!  Tim Muriello…THANK YOU for including an ADEQUATE dose of L-Citrulline.  You’re one of the few!


Norvaline is an analogue of Valine which has been shown, in vitro (not in humans) to function as an Arginase inhibitor.  Arginase is the enzyme which breaks down Arginine before it gets a chance to be converted into Nitric Oxide.

Theoretically, by reducing Arginase activity and increasing Arginine, Norvaline should increase Nitric Oxide levels.  That said, it remains a bit speculative as a supplement for pumps because of the whole not being studied in humans thing.

Spazmatic contains 200 mg of L-Norvaline.

Spazmatic Ingredient Takeaway

Spazmatic definitely contains the right ingredients, at the right doses, to bring about some serious:

  • Energy
  • Focus
  • Pumps
  • Performance Enhancement

So…good job Tim Muriello!

Is Spazmatic Safe?

We wouldn’t recommend Spazmatic to anyone who is particuarly sensitive to stimulants and prone to anxiety, jitters, etc., but when used correctly, there is nothing inherently “dangerous” about Spazmatic.  It’s safe…Just don’t over-do it of course.

Where To Buy

Right now, Spazmatic is only available at Tim Muriello’s website, but we’d expect more retailers to come soon.  IllPumpYouUp maybe?

The Bottom Line

If you’re looking for the next pre-workout supplement to support every aspect of your workout, especially the focus/energy part, you’ll want to give Spazmatic a shot.  It contains no BS ingredients.  Everything is research-backed and clinically dosed.  Once again…Good job Tim! exists to educate the supplement community and seperate the science from the hype.

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