Nutrex T-UP Review

T-UP is a test-booster by Nutrex, the primary active ingredient of which is D-Aspartic Acid…

Nutrex T-UP



Zinc is an integral component in the production of Testosterone, so it is commonly included in test-boosters (like T-UP). We discuss the relationship between Zinc and Testosterone a bit more in-depth in this article, but to sum it up: Zinc supplementation is useful for encouraging optimal Testosterone levels, but will not boost Testosterone beyond the normal range.

T-UP provides 15mg of elemental Zinc which is about 100% of the RDI for Zinc.


D-Aspartic Acid has become extremely popular as a test-booster in recent years.

A 2012 study from “Advances in Sexual Medicine”, the subjects of which were infertile men (initially low Testosterone) found that 2.66g of D-Aspartic Acid was able to significantly increase Testosterone levels when measured after 90 days of supplementation.

These results were in-line with those of an earlier study from 2009 in which D-Aspartic Acid supplementation raised Testosterone by 42% after 12 days in healthy men (initially normal Testosterone).

However, a 2013 study published in “Nutrition Research” found that athletes who supplemented with D-Aspartic Acid for 28 days showed no difference in testosterone levels.

The researchers in the failed study noted abnormally high levels of D-Aspartate Oxidase, the enzyme which degrades D-Aspartic Acid, indicating that prolonged supplementation in individuals with healthy Testosterone levels may cause “negative feedback”.

T-UP contains 3000mg of D-Aspartic Acid per serving, a clinical dose that may boost testosterone in the short-term.


The test-boosting effects of T-UP are dependent entirely on D-Aspartic Acid, the primary ingredient. While it may boost testosterone in the short term, D-Aspartic Acid can be easily purchased separately for much cheaper.


  1. D’Aniello, Autimo, Anna Di Cosmo, Carlo Di Cristo, Lucio Annunziato, Leonard Petrucelli, and George Fisher. “Involvement of D-Aspartic Acid in the Synthesis of Testosterone in Rat Testes.” Life Sciences 59.2 (1996): 97-104.
  2. Topo, Enza, et al. “The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats.” Reprod Biol Endocrinol 7.120 (2009): 6.
  3. D’Aniello, Gemma, et al. “d-Aspartate, a key element for the improvement of sperm quality.” Advances in Sexual Medicine 2 (2012): 45.
  4. Willoughby, Darryn S., and Brian Leutholtz. “d-Aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men.” Nutrition Research 33.10 (2013): 803-810. exists to educate the supplement community and seperate the science from the hype.

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