STW is a pump-inducing pre-workout by Run Everything Labs, makers of DTE, which combines some well-established pump enhancers like Citrulline and Agmatine with some lesser known ingredients such as NMDA and Epicatechin…FIND IT HERE
Citrulline Malate 2:1
Citrulline Malate is one of the more research-backed, reliable performance enhancing supplements out there. It has been shown to enhance muscular endurance at doses of 6-8g.
Unfortunately, STW contains just 2.5g of Citrulline Malate per serving, far less than what has been studied clinically at this time.
It’s possible that some marginal benefit could be achieved at this dose, but nothing is certain.
Agmatine, though not necessarily as research-backed as something like Citrulline, has a fair amount of preliminary evidence in favor of it’s as a Nitric Oxide booster. It has been shown (in vitro) to increase the activation of Endothelial Nitric Oxide Synthase (eNOS), an enzyme which catalyzes the production of Nitric Oxide.
There is also preliminary evidence suggesting that Agmatine can enhance glucose uptake in muscle tissues, offering a secondary mechanism of action by which it may enhance performance.
STW contains 1000mg of Agmatine Sulfate, a pretty standard dose which, according to anecdotal evidence, is pretty effective.
Norvaline is an analogue of the amino acid Valine which appears to be an Arginase inhibitor (in vitro), meaning it blocks the enzyme responsible for the degradation of Arginine. The result: more Arginine is available for Nitric Oxide synthesis
To be clear, Norvaline has never been studied in humans and these alleged benefits are based on strictly preliminary evidence.
STW contains 100mg of Norvaline.
N-Methyl D-Aspartic Acid
N-Methyl D-Aspartic Acid is an alternate form of D-Aspartic Acid which is alleged to be biologically active at much lower concentrations.
At this time there is really no reason to suspect that NMDA is especially helpful for increasing pumps. STW contains 30mg, a standard dose.
Epicatechin is a flavonol alleged to inhibit Myostatin, a type of myokine (signaling protein released by muscle fibers) which suppresses muscle growth. The opposite of Myostatin is Follistatin, a signaling protein which induces muscle growth by blocking Myostatin.
A 2014 study, published in “The Journal of Nutritional Biochemistry”, found that 7 days of Epicatechin supplementation (150mg daily) was able to favorably influence the Follistatin/Myostatin ratio and subjects showed a 7% in hand grip strength.
These results certainly appear to lend credibility to the notion that Epicatechin can enhance strength, but they should still be viewed as strictly preliminary right now. We need more studies before drawing that conclusion!
The Bottom Line
STW contains a couple effective pump ingredients, although with regards to dosing it may leave something to be desired. At two servings, the pumps would be pretty powerful, but that would get become quite costly. Ultimately, there are far more effective (clinically-dosed) pump pre-workouts out there worth considering.
Still not sure which non-stimulant pre-workout is right for you? Check out our Best Non-Stimulant Pre-Workout Supplements List!