Run Everything Labs EWP Review

EWP is a pre-workout by Run Everything Labs which contains both non-stimulant performance enhancing ingredients as well as a focus and energy complex which features the contraversial ingredient Arecoline Hydrobromide…

Run Everything Labs EWP

Beta-Alanine Oratate

Beta-Alanine is a precursor to the dipeptide Carnosine, which functions as a lactic acid buffer in muscle tissue, thereby preventing muscular fatigue during workouts.

At doses of 1.6g/day and up, the benefits of Beta-Alanine supplementation have been demonstrated in multiple human studies.  It is extremely reliable, but takes time to accumulate in muscle tissue (1-2 weeks, depending on dose).

EWP contains 2.5g of Beta-Alanine Oratate.


Creatinol-O-Phosphate (COP) is somewhat similar to Beta-Alanine in terms of the (alleged) benefit, but it has been studied much less extensively and should therefore still be considered speculative.

EWP contains 500mg of COP, a pretty standard dose as far as most pre-workouts go.

Agmatine Sulfate

Agmatine Sulfate has become pretty pervasive in pre-workout supplements as a pump-enhancer.  Indeed, preliminary research indicates that it can activate Endothelial Nitric Oxide Synthase, thus increasing NO production, but it has not been studied in humans much at this time.

That said, anecdotal evidence suggests it is indeed effective and although the research isn’t quite there yet, we actually like Agmatine a lot.

EWP contains 1g of Agmatine per serving.


Taurine has been shown to reduce exercise-induced oxidative damage in muscle tissue, making it an effective ingredient for enhancing recovery.  It is has also been shown to enhance exercise performance, but has failed elsewhere to do so, so it is not 100% reliable as a performance enhancer.

Still, with 1g per serving, EWP contains enough Taurine to enhance recovery from exercise.

Betaine Anhydrous

Betaine, also known as Trimethylglycine, has quickly become a popular ingredient in pre-workout supplements based several human studies which found ergogenic benefits.  We discuss these benefits in-depth here.

Unfortunately, most studies have used 2.5g/day and EWP only contains 1g per serving.  At this dose, it’s not clear if the ergogenic benefits of Betaine are noticeable.

Beta Vulgaris

Beta Vulgaris is simply another term of Beet Root.  It is often included in pre-workout supplements because Beets are naturally high in Nitrates.  While it is true that Nitrate supplementation, in the range of 300-600mg daily, can enhance exercise performance, Beet Root Extract simply does not contain effective enough quantities.

Most Beet Extracts are standardized for 1% Nitrate or less, meaning you would need 30,000mg or so to yield an effective dose.

Run Everything Labs doesn’t disclose the Nitrate standardization of the Beta Vulgaris used, so we can only assume the worst.  Most likely this is a completely useless ingredient in EWP.

Caffeine Anhydrous

Caffeine triggers the release of Catecholamines such as Noradrenaline which induce a state of alertness and focus and providing the base for the energy blend in EWP.

With 300mg of Caffeine per serving, EWP is up there in terms of stimulant-level.  Definitely not for the stimulant sensitive individual.


Theobromine is a chemical relative of Caffeine (in the Xanthine family) but it is not psychoactive like Caffeine is.  Instead, Theobromine has been shown to act as a cardiac stimulant.


Synephrine is similar to Ephedrine in terms of mechanism of action.  In the context of EWP, it may enhance the perceived energy boost in conjunction with Caffeine.

Arecoline Hydrobromide

Arecoline Hydrobromide is a chemical relative to Nicotine and is potential quite dangerous.  We would highly suggest all our readers take a look at this blog post on Price Plow, which details the use of Arecoline Hydrobromide in supplements, before making any purchases of Arecoline Hydrobromide containing supplements such as EWP.

The Bottom Line

EWP is nothing impressive in terms of the performance enhancement benefits or the energy/focus blend.  Beyond that, it contains an ingredient (Arecoline Hydrobromide) which may actually be quite harmful.  For that reason, we’re giving this one a pass…

Not sure which pre-workout is right for you?  Take a look at our Top 10 Pre-Workout Supplements List! exists to educate the supplement community and seperate the science from the hype.

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