Prime Nutrition Partition MD Review

Partition MD

Partition MD is Prime Nutrition’s recently released “Nutrient Partitioning Catalyst”, which is just a scientific/fancy way of saying: It’s a supplement designed to encourage optimal nutrient uptake into muscle cells and not fat-cells…


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Partition MD is Prime Nutrition’s recently released “Nutrient Partitioning Catalyst”, which is just a scientific/fancy way of saying: It’s a supplement designed to encourage optimal nutrient uptake into muscle cells and not fat-cells…



Though referring to Cinnamon Extract as an “insulin mimetic” may be an exaggeration, it has demonstrated the ability to lower blood glucose in several human studies, and has potentiated the effects of insulin in vitro.

In the context of Partition MD, Cinnulin may encourage glucose uptake in muscle cells, although the degree of efficacy would logically depend on the individual’s initial insulin sensitivity.  Those will low insulin sensitivity (insulin resistant) are more likely to benefit.


Aurora Blue, as Prime Nutrition explains on their site, is an ultra-premium blend of Blueberry/Bilberry which is apparently higher in various bio-actives, specifically Anthocyanins.  So ultimately, the benefits of Aurora Blue are equivalent to high doses of these berries.

Blueberry, in the form of both special preparations and blueberry enriched diets, have been shown to decrease blood pressure and relax blood vessels in rats, although with no precise mechanism of action identified.


Paradoxine is a standardized form of 6-Paradol, the active component of Grains of Paradise.

Grains of Paradise has been to shown to increase metabolic rate in response to a physiological stressor (in this case cold exposure) via activation of Brown Adipose Tissue. Its potential for weight-loss is discussed in this article, but any nutrient partitioning properties of the herb would be via the same pathways.


Berberine is a compound found in (and extracted from) many species of plant, which has been studied with regards to controlling blood sugar.

Indeed, Berberine has been shown to reduce blood glucose in diabetics (individuals abnormally high blood glucose) via stimulation of AMPK, an enzyme which induces various physiological changes including increased glucose uptake into muscle cells and increased fat oxidation.

Berberine hasn’t been studied extensively in healthy human subjects so it is unclear what the effects may be in individuals with initially high insulin sensitivity, but overall it would stand to reason that Berberine can encourage healthy blood-glucose levels.


Alpha Lipoic Acid (ALA) is a potent anti-oxidant with wide variety of health implications, including blood glucose regulation and weight loss.

In the context of Partition MD, R-ALA (the bioavailable form of ALA) may encourage muscle-glucose uptake.


Momordica Charantia, more commonly known as Bitter Melon, has been used traditionally as an alternative to (or in conjuction with) insulin treatment in individuals with high/uncontrollable blood sugar (as in diabetes).

Pre-clinical trials have noted clear anti-diabetic (blood glucose-lowering) properties, but controlled, structurally sound human studies are virtually non-existent.

At this time, we would consider Bitter Melon a speculative ingredient in the Partition MD formula, although one that could potentially be quite effective.


Piper nigrum, also known as Black Pepper, contains Piperine. Several studies have found that black pepper extract, when combined with other supplements, has increased the absorption of those supplements (as measured by plasma levels). Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).


Chromium is an essential mineral which plays an integral role in the regulation of blood glucose and insulin sensitivity.

Several meta-analyses have been conducted to determine the potential of Chromium supplementation for weight-loss, but the results are less than encouraging.

A 2012 meta-analysis concluded that Chromium supplementation had no reliable influence on body weight in diabetic subjects, despite helping to lower blood glucose.

A later (2013) meta-analysis, published in the “Journal of Pharmacy & Pharmaceutical Sciences”, ultimately concluded that Chromium supplementation can potentially reduce body weight in obese/overweight humans, but the results were lackluster at best, with no more than a couple pounds being lost.

In the context of Partition MD, we’d consider Chromium more of a “support” ingredient, with the magnitude of benefit depending mostly on individual insulin sensitivity/chromium status.


Partition MD contains several ingredients which have demonstrated varying degrees of efficacy with regards to lowering blood-glucose, increasing muscular glucose uptake, improving cardio-vascular health, and encouraging fat-loss.  As a nutrient partitioning agent, it may be effective but many of the ingredients have not been studied strictly as “partitioning agents” so it’s tough for us to draw conclusions.  Partition MD is most likely to favorably affect people with poor insulin sensitivity.


[expand title=”REFERENCES” tag=”h5″]

  1. Kirkham, S., et al. “The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance.” Diabetes, obesity and metabolism 11.12 (2009): 1100-1113
  2. Pham, Antony Q., Helen Kourlas, and David Q. Pham. “Cinnamon supplementation in patients with type 2 diabetes mellitus.” Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 27.4 (2007): 595-599.
  3. Mang, B., et al. “Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2.” European journal of clinical investigation 36.5 (2006): 340-344.
  4. Del Bo′, Cristian, et al. “A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers.” Nutrition research 33.3 (2013): 220-227.
  5. Norton, Cynthia, et al. “Wild blueberry-rich diets affect the contractile machinery of the vascular smooth muscle in the Sprague-Dawley rat.” Journal of medicinal food 8.1 (2005): 8-13.
  6. Elks, Carrie M., et al. “A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress.” PloS one 6.9 (2011): e24028.
  7. Xu, Jie, et al. “Intake of Blueberry Fermented by Lactobacillus plantarum Affects the Gut Microbiota of L-NAME Treated Rats.” Evidence-Based Complementary and Alternative Medicine 2013 (2013).
  8. Fernández-Galilea, Marta, et al. “Effects of lipoic acid on apelin in 3T3-L1 adipocytes and in high-fat fed rats.” Journal of physiology and biochemistry 67.3 (2011): 479-486.
  9. Prieto-Hontoria, P. L., et al. “Lipoic acid prevents body weight gain induced by a high fat diet in rats: effects on intestinal sugar transport.” Journal of physiology and biochemistry 65.1 (2009): 43-50.
  10. Butler, Judy A., Tory M. Hagen, and Régis Moreau. “Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion.” Archives of biochemistry and biophysics 485.1 (2009): 63-71.
  11. Koh, Eun Hee, et al. “Effects of alpha-lipoic acid on body weight in obese subjects.” The American journal of medicine 124.1 (2011): 85-e1.
  12. Liu, Li-Zhong, et al. “Berberine modulates insulin signaling transduction in insulin-resistant cells.” Molecular and cellular endocrinology 317.1 (2010): 148-153.
  13. Kong, Wei-Jia, et al. “Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression.” Metabolism58.1 (2009): 109-119.
  14. Liu, Li-Zhong, et al. “The pivotal role of protein kinase C zeta (PKCzeta) in insulin-and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells.” Cellular signalling 22.10 (2010): 1513-1522.
  15. Joseph, Baby, and D. Jini. “Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency.” Asian Pacific Journal of Tropical Disease3.2 (2013): 93-102.
  16. Basch, Ethan, Steven Gabardi, and Catherine Ulbricht. “Bitter melon (Momordica charantia): a review of efficacy and safety.” American Journal of Health System Pharmacy 60.4 (2003): 356-359.

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