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Everything You Need To Know About Noopept

noopept increasing the activity in the brain

If you’re reading this, it’s probably because you’re looking for a supplement to give you a mental edge, and you heard Noopept may be the brain-booster you’re looking for.

This once obscure molecule has quickly become one of the most popular nootropic (cognitive enhancement) supplements out there.

Companies that sell it promise the world, claiming Noopept is some kind of revolutionary brain-booster that’ll make you smarter, sharper, and just better at life in general!

But is this all just another over-hyped supplement or is there something more here?  Well, that’s exactly what we’re going to get to the bottom of in this article.

Well cover everything you need to know about this unique, potentially useful cognitive enhancement supplement so you can make an informed decision as to whether it’s for you or not.

This is everything you need to know about Noopept…

What Is Noopept?

Noopept is a brand name for N-phenylacetyl-L-prolylglycine ethyl ester, a synthetic nootropic (brain-boosting) compound which was originally developed by Russian scientists in 1996.

Noopept Molecule

Because of the fact that Noopept is primarily aimed at enhancing cognitive function, it is often described as similar to Piracetam, another popular brain-boosting supplement.

These two molecules aren’t actually related though.  Noopept is not considered part of the racetam family.

Furthermore, research indicates that Noopept may be 1000 times potent, therefore requiring a much lower dose than Piracetam.

Noopept may be similar to Piracetam in the sense that they’re both supposed to enhance cognitive abilities, but it appears to be far more powerful at doing so.

What Are The Effects Of Noopept?

Noopept has hardly been studied in humans, but preliminary and anecdotal evidence indicates it can enhance cognitive function

That means things like:

  • Sharper thinking
  • Better memory
  • Quicker reaction time
  • Improved concentration ability
  • Mild stimulation

But again, research is scarce.

Actually, most of the claims made about Noopept in general are based on rodent studies to begin with, but we do know enough about it to know more or less how it works.

How Does Noopept Work?

Before we get into the research behind Noopept, there are two things we need to make abundantly clear:

  1. There isn’t much in the way of HUMAN research
  2. The human research that does exist is limited to people with cognitive impairments

A lot of the claims you see regarding Noopept are stated as fact–mostly by the companies that sell Noopept–when in reality, a lot of it is just pure speculation.

I just wanted to make that clear before we start talking about “How Noopept Works”.  There’s a big different between how something works and how MUCH it works.

Without more research, it’s hard to say to what degree Noopept improves cognitive function, and in who, but we do know how it works.

Noopept appears to work in two ways:

  1. Increasing the brains sensitivity to Acetylcholine
  2. Inducing the production of Neurotrophins

Let’s break each of those mechanisms down in a bit more detail…

Increasing Acetylcholine Sensitivity

Acetylcholine is a neurotransmitter which is involved in various aspects of cognitive function, particularly memory and learning processes.

It is the target of most nootropic supplements.  Some nootropics increase Acetylcholine production.  Others reduce the breakdown of Acetylcholine, indirectly boosting concentrations in the brain.

Noopept, however, appears to work by making the brain more sensitive to Acetylcholine, effectively making the same amount of Acetylcholine do more.

Triggering Neurotrophin Production

Neurotrophins are a kind of protein that exist within the brain where they’re tasked with keeping neurons (nerve cells) alive and functional.

Research has shown that Neurotrophin levels are increased in the brains of mice given Noopept and increases in  Neurotrophin levels is associated with better long-term memory.

This would explain why Noopept has been shown to improve long-term memory with chronic (ongoing) use in both mice and humans.

What Does The Research Say About Noopept?

Like I said earlier, most of the research on Noopept has been conducted in mice, not humans.

This makes it difficult to say how Noopept might impact a normal, healthy individuals but at least we know that it’s orally active at feasible doses.

Noopept has been shown to restore memory in rats with cognitive impairments, but has failed to do so in healthy rats.

In humans, Noopept has been shown to enhance certain aspects of cognitive function, outperforming Piracetam.  The subjects in this study, however, were initially suffering from some sort of cognitive deficit.

So, Noopept has never actually been shown to enhance cognitive abilities in healthy people.  It has only been shown to help restore cognitive function when it’s sub-par to begin with.

Does this mean it won’t improve YOUR cognitive function.  Not necessarily.  It just means that it’s there’s no guarantee.

Noopept Dosage

There’s a couple problems with interpreting the ideal dosage for Noopept based on the current body of research.

  1. A lot of the rodent studies used injection
  2. There’s only been one human study

With those limitations in mind, Noopept appears to exert it’s effects at doses of 10-30mg/day.

It’s unknown how much timing really matters, but it’s probably best to take Noopept in the morning due to the fact that it is slightly stimulatory.

Does Noopept Have Any Side Effects?

The lone human study that exists found Noopept to be well-tolerated by all subjects.  While more research is certainly warranted in the area of safety, Noopept does appear to be pretty safe at standard doses.

Any stimulatory effects are very slight, so it’s not likely that Noopept would cause the same kinds of side effects as stimulants such as Caffeine.

That said, it may be possible to over-do it, so it’s probably not a good idea to exceed the established 10-30mg/day range.

Is Noopept A Stimulant?

Noopept is alleged to have mild stimulant properties, but we’re talking VERY mild.

If you’re used to using stimulants like Caffeine, you probably won’t notice much of a stimulant feeling.

If you’re used to taking hardcore stimulants like Focalin, for example, you may not notice any sort of stimulation at all while using Noopept.

Those who take Noopept in the hopes of getting some sort of stimulant-like buzz from it will almost surely be disappointed.

The effects are subtle and the way Noopept works suggests that they may not be particularly noticeable at first but become more and more pronounced over time.

In terms of stimulation, it kind of feels like Adrafinil.  Not particularly overwhelming at all.

My Personal Experience With Noopept

I first came across Noopept while doing a lot of research on nootropics in general.  At the time, I was in college and was in a perfect position to put nootropics to the test.

So that’s exactly what I did.

I ordered some Noopept and proceeded to take about 30-50mg every morning, sometimes with coffee, sometimes by itself.

When I take Noopept by itself,  I don’t notice much in the way of mental stimulation.

In combination with Caffeine, however, it becomes more noticeable.

I’ve taken Noopept on and off for periods of several months at a time and haven’t really noticed anything in the way of side effects.

I find that after about 2-3 weeks on Noopept, my thoughts are more clear and I have an easier time remembering things that I might not otherwise remember (because they’re not important).

It has never made a drastic difference in my level of productivity or ability to sold problems, but maybe that’s because I don’t have issues in those areas in the first place.

Noopept isn’t something that I consider to be an essential part of my daily nootropic regimen, but I do believe it’s effective.  The effects are subtle, though, so if you’re expecting some miracle brain-booster, you’re going to be disappointed.

If you’re going to take Noopept, I would first suggest developing a basic stack of natural, safe nootropics that have actually been proven to work.

Is Noopept Legal?

Noopept is legal pretty much everywhere, but in the US, it occupies a bit of a legal gray area.

It’s not considered a dietary supplement by law.  Technically, it’s an unapproved drug.  Since it’s not a scheduled/controlled substance either, though, it’s legal to buy, sell, or possess.

Sellers aren’t supposed to market Noopept for human consumption though, so if you see it labeled as a dietary supplement or with instructions on how to take it, that seller could potentially get in some trouble.

Fortunately, as the consumer, you’re not going to get in any trouble for buying or possessing Noopept or any other similar nootropics, like Centrophenoxine or Adrafinil.

 Where To Buy Noopept

You probably won’t find Noopept for sale at your local supplement shop, but it’s definitely easy to order online.

It’s available from several reputable online nootropics vendors but, personally, I like:

That’s where I ordered my Noopept from when I conducted my personal experiments and I have always found them to be a reliable nootropics vendor in general.

Never had any problems, nor did I suspect that any of the products I purchased from them were of inferior quality.

Of course, there are other vendors who sell Noopept.  If you know of any, or are one, feel free to comment below.

Other Nootropics You Should Stack With Noopept

Noopept may provide cognitive benefits, but it has never been shown to enhance cognitive function in healthy people.

For that reason, it’s best to start with a basic stack of proven nootropics.

Research has confirmed that there are supplements which can enhance things like:

  • Memory
  • Ability To Pay Attention
  • Reaction Time

In other words, there are a few supplements that can give you a slight mental edge.  It’s not going to be like the pill from Limitless with Bradley Cooper, but the effects are still noticeable.

Alpha GPC

Alpha GPC is a choline-containing phospholipid which is 40% Choline.  It is considered a better Choline source than any other cholinergic compound.

Choline is one of the necessary components of Acetylcholine, a neurotransmitter that is directly involved in cognitive functions such as learning and memory.

By providing a direct Choline source, Alpha GPC can increase Acetylcholine levels in the brain.

It has been shown to improve aspects of cognitive function in healthy, human subjects.  Interestingly, studies show Alpha GPC can also enhance exercise performance.

It definitely makes for an effective addition to any nootropic/performance stack.

600-1200mg/day is ideal, but doses as low as 200-400mg may be effective.

Bacopa Monierri

Bacopa Monierri is an Ayurvedic herb which has been used for centuries the purposes of enhancing cognitive function.

It is one of the few herbal nootropics which has been shown to enhance cognitive abilities in normal, healthy-functioning individuals.

Most nootropics only work in people will some sort of cognitive deficit or decline.  Bacopa appears to benefit everyone.

A clinically effective dose of Bacopa is anywhere from 150-500mg, depending on the quality of the extract.

Phosphatidylserine

Phosphatidylserine is a major constituent of cell membranes and plays an important role in general brain health.

It has been shown to improve cognitive function in both instances of cognitive deficit as well as in normal, healthy people.

PS has some unique stress-reducing properties as well, making it of interest to an even wider range of people.

By itself, Phosphatidylserine isn’t going to be overwhelmingly effective as a cognitive enhancer if you’ve already got a healthy-functioning brain, but research indicates it can give you a bit of an edge.

Studies have used a range of different doses, but 600-800mg/day seems to be ideal.

The Bottom Line On Noopept

Noopept is definitely an intriguing molecule.  It appears to work in a much different way than most nootropics, and at low doses too.

However, the research is severely lacking.

Many of the claims made about Noopept are anecdotal and should be taken with a grain of salt.  It’s nothing like Focalin or Adderall.  So if that’s what you’re expecting, you’ll almost certainly be disappointed.

If you’re suffering from some sort of cognitive impairment, Noopept may actually be quite useful, though.

What’s Your Take On Noopept?  Comment Below…

I’m Matt Theis, founder of SuppWithThat, Momentum Nutrition, and Singular Sport. I created SWT to separate the science from the hype and publish accurate, research-based information on supplements. If you like what I have to say here, feel free to check out my supplements at Momentum-Nutrition.com and SingularSport.com.

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