MuscleTech NaNOX9 Next Gen: An Evidence-Based Review

NaNOX9 is a non-stimualnt pump-enhancer by MuscleTech…

MuscleTech NanoX9 Next Gen



Nitrosigine is a patented combination of Arginine and Silcon (as Inositol Salicate) which is more readily absorbed than ordinary L-Arginine, atleast according to research conducted by the company that owns the patent.  Assuming this research is indeed without flaws, Nitrosigine makes for an effective addition to any formula seeking to enhance the pump, but dosing is the more important thing.

Most formulas with Nitrosigine don’t use a full clinical dose, mostly due to the high cost of this ingredient.  We’re happy to see that MuscleTech isn’t under-dosing it in the NanoX9 Next Gen formula though, which contains 1500mg per serving.


Beta-Alanine is precursor to the dipeptide Carnosine which accumulates in muscle tissue and is associated with better muscular endurance.  Beta-Alanine supplementation is a reliable way of increasing muscular Carnosine concentrations and has been shown to increase muscular endurance in humans.

We’re curious as to why MuscleTech elected to use Beta-Alanine in the NanoX9 Next Gen formula because it has absolutely no influence on Nitric Oxide levels, but then again, it’s an effective performance enhancer so why not?

Choline Bitartrate

Choline Bitartrate is the least bioavailable form of Choline, but extremely high doses may still be able to increase circulating Choline levels and possible Acetylcholine production.  However, the 100mg present in NanoX9 Next Gen is nowhere near what would really be needed.  Common doses of Choline Bitartrate are around 1-2g, not 100mg.

It seems MuscleTech is doing a little pixi-dusting with this one, as there is no research anywhere to suggeste that 100mg of Choline Bitartrate is effective for anything, let alone inducing pumps or better muscle contractions, as some other forms of Choline have been shown to do.

Rhodiola + Eleuthero

Both Rhodiola Rosea and Eleuthero (also known as Siberian Ginseng) have well-established adaptogenic properties.  That is, they can help the body adapt to stress (i.e. better mental/physical functioning during stressful conditions).  Yes, exercise would be considered a “stressful condition” because the body is being subjected to stress and must adapt.  Both Rhodiola and Eleuthero have some exercise performance enhancement implications, but the doses used in NanoX9 Next Gen  are far below what has been used clinically

For that reason, they’re probably not particularly useful in this case.  Sorry…

Is NanoX9 NextGen Safe?

NanoX9 Next Gen is certainly safe.  There are no stimulants in the formula and nothing that hasn’t been studied enough to know if it’s safe or not.

The Bottom Line

NanoX9 Next Gen may induce some noticeable pumps during your workout, but probably isn’t worth the premium that MuscleTech is charging for it.  Most of the ingredients are at least somewhat under-dosed, and the same results could likely be obtained through just supplementing withe Nitrosigine and Beta-Alanine, which would cost a lot less.  If you must give NanoX9 Next Gen a shot, feel free, but you would be better off with one of the pump pre-workouts from our Best Non-Stimulant Pre-Workout Supplements List. exists to educate the supplement community and seperate the science from the hype.

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