MusclePharm OxySport Black: An Evidence-Based Review

OxySport Black is MusclePharm’s Black Series fat-burner which consists of some pretty well-known ingredients as well as some that are new/under-utilized…

OxySport Black


L-Carnitine L-Tartrate

Carnitine is an amino acid that is heavily involved with the metabolism of fat for energy. It is required for the proper transport of fatty acids in the mitochondria, where they are oxidized (burned) for energy through the process known as “beta-oxidation”.

Carnitine deficiency has been shown to hinder fat-burning capacity, but studies investigating whether excess Carnitine intake (i.e. supplementation) can burn-fat haven’t been very encouraging thus far.

Although Carnitine supplementation (1g/day) has been shown to increase fatty acid oxidation rates in humans without Carnitine deficiency, it has failed to induce weight-loss in rats, as well as moderately obese women.

Carnitine supplementation is unlikely to burn fat in non-deficient individuals, so it’s unclear how effective it really is in the context of OxySport Black.

Sinetrol XPUR

Sinetrol XPUR is a patented combination of citrus polyphenols, some of which can be found in grapefruit, orange, etc. Certain compounds found in Citrus fruits have long been alleged (and, in certain cases, proven) to exert weight-loss effects, but only recently has Sinetrol XPUR been put to the test.

A recent (2014) study, published in “Phytotherapy Research”, found that daily Sinetrol XPUR supplementation was able to reduce abdominal fat and favorably influence body composition over a period of 12 weeks in overweight human subjects.

While more research would be ideal, the preliminary findings of this study indicate that Sinetrol XPUR may certainly be effective as a weight-loss solution in humans. OxySport Black contains 450mg of Sinetrol XPUR.


Lipase is a naturally occurring bodily enzyme, the main function of which is to help digest and break down fat which can then be used for energy. Though no claims are made directly as to Lipase’s role in the OxySport Black formula, it seems MusclePharm is implying that supplementing with additional Lipase can help break down more fat from the diet.

Unfortunately, there is no evidence that supplemental Lipase can be an effective weight-loss solution. In fact, there is only evidence to the contrary. Lipase deficiencies are quite rare, meaning most people already have plenty.

Furthermore, Lipase is not acid-resistant, meaning it may breakdown and cease to be effective upon reaching the stomach.

Ultimately, Lipase does not take away from the efficacy of the OxySport Black formula, but it doesn’t appear to be of much value either.


PurEnergy is a patented combination of Caffeine and Pterostilbene which, according to the manufacturer, is superior in terms of absorption and duration of effects.

The only study was conducted by Chromadex, the company that manufactures PurEnergy.

OxySport Black contains 250mg of PurEnergy, enough to make the average individual feel more alert and focused as well as encourage fat-burning.

Choline Chloride

Choline, once inside the body, is converted into the neurotransmitter Acetylcholine which is associated with many functions including (but not limited to) memory, attention, and muscle control.

Choline (Bitartrate) supplementation has been shown to reduce bodyweight while preserving strength in female Judo athletes.

In the context of OxySport Black, it’s not really clear how effective Choline is as it pertains to weight-loss.


Theacrine is an alkaloid found almost exclusively in Camellia Assamica, also known as Kucha tea. In terms of its chemical structure, Theacrine (1,3,7,9-tetramethyluric acid) is very similar to Caffeine (1,3,7-trimethylxanthine), so its physiological effects are alleged to be similar as well.

We discuss the research behind Theacrine in this article but, to make a long story short, it appears to increase perceived energy levels in humans.

Theacrine definitely helps to enhance the energy aspect of OxySport Black and may enhance the fat-burning effects of such compounds as Caffeine (though further research is needed).

Cinnamon Extract

Though referring to Cinnamon Extract as an “insulin mimetic” may be an exaggeration, it has demonstrated the ability to lower blood glucose in several human studies, and has potentiated the effects of insulin in vitro.

It is unlikely that Cinnamon Extract would significantly contribute to weight-loss in the average human, but for those with high insulin resistance, it may help keep blood-glucose in check.

MusclePharm has placed Cinnamon Extract in the Appetite Control Matrix part of the OxySport Black formula.


Cayenne contains the compounds, Capsaicin, which has been shown to increase in fat oxidation(relative to placebo) during low intensity exercise in healthy adult males.

Capsimax is listed under the Appetite Control Matrix section of the OxySport Black formula, although we’re not really sure why. It may effective enhance metabolic rate, but there is no evidence to suggest this would curb appetite.

The Bottom Line

OxySport Black contains a few effective fat-burning/weight-loss ingredients as well as some that are pretty questionable (like Lipase and Carnitine). If taken on a consistent basis for several weeks, the formula may induce some moderate weight-loss, but there is nothing about it that is particularly superior in any way to other fat-burners.

Still not sure which fat-burner is right for you? Check out our Top 10 Fat-Burners List!

[expand title=”REFERENCES” tag=”h5″]

  1. Wutzke, Klaus D., and Henrik Lorenz. “The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects.”Metabolism 53.8 (2004): 1002-1006
  2. Seim, H., W. Kiess, and T. Richter. “Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults.” Metabolism 51.11 (2002): 1389-1391
  3. Melton, S. A., et al. “L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise.” International journal for vitamin and nutrition research 75.2 (2005): 156-160.
  4. Villani, Rudolph G., et al. “L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.”International journal of sport nutrition and exercise metabolism 10.2 (2000): 199-207.
  5. Karanth, Jyothsna, and K. Jeevaratnam. “Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity.” (2010).
  6. Dallas, Constantin, et al. “Clinical Study to Assess the Efficacy and Safety of a Citrus Polyphenolic Extract of Red Orange, Grapefruit, and Orange (Sinetrol‐XPur) on Weight Management and Metabolic Parameters in Healthy Overweight Individuals.” Phytotherapy Research 28.2 (2014): 212-218.
  7. Layer, Peter, and Jutta Keller. “Lipase supplementation therapy: standards, alternatives, and perspectives.” Pancreas 26.1 (2003): 1-7.
  8. Elsawy, Gehan, Osama Abdelrahman, and Amr Hamza. “Effect of choline supplementation on rapid weight loss and biochemical variables among female Taekwondo and Judo athletes.” Journal of human kinetics 40.1 (2014): 77-82
  9. Wang, Yuanyuan, et al. “Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.” Fitoterapia 81.6 (2010): 627-631.
  10. Feduccia, Allison A., et al. “Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors.” Pharmacology Biochemistry and Behavior 102.2 (2012): 241-248
  11. Habowski, S. M., et al. “The effects of TeacrineTM, a nature-identical purine alkaloid, on subjective measures of cognitive function, psychometric and hemodynamic indices in healthy humans: a randomized, double-blinded crossover pilot trial.” Journal of the International Society of Sports Nutrition11.Suppl 1 (2014): P49.
  12. Kirkham, S., et al. “The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance.” Diabetes, obesity and metabolism 11.12 (2009): 1100-1113
  13. Pham, Antony Q., Helen Kourlas, and David Q. Pham. “Cinnamon supplementation in patients with type 2 diabetes mellitus.” Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 27.4 (2007): 595-599.
  14. Mang, B., et al. “Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2.” European journal of clinical investigation 36.5 (2006): 340-344.

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