Machine Motion is the joint support formula which marks the beginning of the Dr. Stu Series by MTS Nutrition. It contains a few well-established ingredients at clinical doses…
Glucosamine is commonly found in two forms: Glucosamine Sulfate and Glucosamine HCl. Most of the positive results noted throughout various studies have resulted from Glucosamine Sulfate, so that is the form we generally like to see in joint-support formulas.
We discuss Glucosamine’s mechanism of action in this article, but to make a long story short: Glucosamine Sulfate (not HCL) can be moderately effective when it comes to joint preservation, but may not do much in the way of reversing damage that has already occurred.
For this reason, Glucosamine Sulfate supplementation makes sense for athletes/bodybuilders whose joints may be under a lot of stress on a pretty regular basis. Machine Motion contains 2g per serving, well within the effective range of 1.5-3g/daily.
Methylsulfonylmethane (MSM) is similar to Glucosamine Sulfate in terms of its influence on joint-health. It is hypothesized that the real benefit of MSM lies in the fact that it contains sulfur, which is a component of collagen, and thus necessary for functional, healthy joints. This might also explain why Glucosamine Sulfate (which contains Sulfur) is more effective than Glucosamine HCL (which does not contain sulfur).
In the context of Machine Motion, MSM serves roughly the same purpose as Glucosamine (joint preservation).
Cissus Quadrangularis is a plant indigenous to Africa and parts of Asia, but has recently gained popularity as a joint/bone support supplement. We discuss Cissus in-depth in this article, but (to make a long story short) preliminary research indicates Cissus can be effective for reducing joint-pain and encouraging connective tissue health.
Machine Motion contains 1000mg of Cissus per serving, standardized to 10% Ketosterones (primary bioactives).
Chondroitin is a major component of Cartilage and is commonly paired with Glucosamine in joint-support supplements (such as Machine Motion) because of an alleged synergy. In vitro, chondroitin and glucosamine have been demonstrated to synergistically induce collagen synthesis. However, in vivo studies comparing and contrasting the effects of chondroitin relative to glucosamine fail to find such synergy between the two.
Studies that have compared the two have found that much of the benefit obtained with the combination of Glucosamine and Chondroitin can be obtained from Glucosamine alone, meaning Chondroitin might not be so important after all.
That said, the addition of Chondroitin to Machine Motion certainly can’t hurt the formula.
Bromelain, also known as Pineapple Extract, contains protein-digesting enzymes called proteases, which possess moderately potent anti-inflammatory properties. For this reason, Bromelain has been investigated for the treatment of osteoarthritis (OA), but with mixed results.
A 2002 study, published in Phytomedicine, reported that Bromelain supplementation modestly improved symptoms in subjects with knee pain. However, it should be noted this study was un-blinded and not placebo controlled. For that reason, the researchers concluded that double-blind, placebo controlled studies were needed before drawing accurate conclusions about Bromelain’s potential for joint health.
A 2006 placebo controlled study investigating the effects of Bromelain supplementation on symptoms of osteoarthritis found no significant differences between a group of subjects receiving 800mg Bromelain daily and the placebo group. A possible reason for the discrepancy (assuming first study was not flawed) might be that Bromelain is only effective for mild OA and not moderate to severe OA.
Machine Motion contains 400mg of Bromelain per serving.
Hyaluronic Acid is a major constituent of synovial fluid, the body’s natural joint lubricant. It has been studied primarily as a potential treatment for joint pain, and while a significant analgesic (painkiller) effect has been noted in rats following injections with hyaluronic acid, similar treatment has only been mildly effective in humans suffering from osteoarthritis of the knee.
While most studies have used injection, a 2012 study published in “The Scientific World Journal” found that oral supplementation with 200mg hyaluronic acid daily over a 12 month period improved symptoms in subjects suffering from Osteoarthritis of the knee.
Machine Motion contains the same 200mg dose used in the above-mentioned study.
Piper nigrum, also known as Black Pepper, contains Piperine. Several studies have found that black pepper extract, when combined with other supplements, has increased the absorption of those supplements (as measured by plasma levels). Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).
THE BOTTOM LINE:
Machine Motion contains clinically validated doses of most key ingredients and therefore has what it takes to protect and preserve joints, especially in athletes who are at risk of joint issues.
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