Is Laxogenin Really An Effective Muscle Builder?

laxogenin supplement

Every once in a while, a new supplement comes along that promises to be the best all-natural muscle building supplement since Creatine.

And time after time, the results fall far short of our exptectations.

One of most popular all-natural muscle-building supplements, as of late, is none other than Laxogenin.

It’s been hailed as “having an anabolic profile similar to that of Anavar” (one of the most versatile oral steroids) and there are scattered anecdotal reports of people actually making gains with Laxogenin.

Which begs the question…

Is this just another over-hyped ‘all-natural muscle-builder’ that’s actually just a load of BS, or is there actually something to Laxogenin?

Well, that’s exactly what we’re going to get to the bottom of in this article.

By the end, you’ll be completely up to speed on what Laxogenin is, how it works, and what it’s realistically capable of doing.

If that sounds good, then let’s get into it…

What Is Laxogenin?

Laxogenin, otherwise known as 5a-hydroxy Laxogenin (the ‘a’ stands for ‘alpha’, in case you’re wondering) belongs to a class of plant-based molecules known as Brassinosteroids.

5a-hydroxy laxogenin molecule

Brassinosteroids is term which refers to steroid hormones in plants which are growth promoting.

The idea here is that certain plant steroids like Laxogenin, which we know promotes anabolic activity in plants, can also promote anabolic activity in humans.

We’ve see similar claims made about other plant steroids, like Ecdysterone.  While in vitro research indicates there might be something to it, research in humans indicates otherwise.

Ecdysterone has failed to influence androgenic activity in humans and this has been attributed to a weak binding affinity for androgen receptors.

You can think of androgen receptors as key holes that require certain keys (androgens) for activation.  You can think of these various plant-based steroids as potential keys, but in reality, most of the keys don’t fit.

Even if a key appears to fit in vitro, when it comes to living organisms, there are a lot more variables at play.

I mean, should we really expect plant or insect steroids to function the same way in humans?  Are we that similar?  The same molecule that makes a plant grow will make my muscles bigger?

What Are The (Alleged) Benefits Of Laxogenin?

Laxogenin is mostly promoted as a muscle builder, but supplement companies that sell Laxogenin aren’t just stopping there.

Legend has it that Laxogenin:

  • increases strength and muscle mass
  • speeds up recovery time
  • increases muscular endurance
  • promotes fat-loss
  • reduces Cortisol levels

That all sounds great and everything, but is any of that true?

By true I mean…

Is any of it backed up by science?

To answer that question, we need to take a minute to understand how Laxogenin supposedly works in the first place.

How Does Laxogenin (Allegedly) Work?

In vitro, Laxogenin has demonstrated similar anabolic properties to the oral steroid, Anavar, so it’s often referred to as the all-natural alternative to prohormones.

But let’s just be crystal clear about this…

There’s no chance in hell that Laxogenin will cause the sort of muscle increases, fat-loss, and over-all body-composition changes that Anavar does.

It’s not a prohormone, so don’t expect prohormone-like results.

What Does Research Tell Us About Laxogenin?

Well, here’s the funny thing about that…

There’s not much research on Laxogenin specifically.

Most of what we know (or think we know) about it comes from comparisons to other Ecdysteroids (insect molting hormones) and Brassinosteroids (plant steroid hormones), like 28-Homobrassinolide.

In mice, 28-Homobrassinolide has been shown to improve physical performance and trigger ‘selective anabolic responses’ without altering androgenic activity.

Ecdysterone has been shown to increase strength and muscular endurance in mice, but has failed to do so in humans.

Now, like I said, supplement companies love to use the in vitro findings that Laxogenin exhibits similar anabolic/androgenic ratio to Anavar as proof that Laxogenin is the real deal.

After all, Anavar is DEFINITELY capable of:

  • increasing strength and muscle mass
  • decreasing fat mass
  • increasing muscular endurance
  • enhancing exercise recovery

But again, it’ a massive stretch to say that Laxogenin is anywhere near as powerful or effective as an oral steroid like Anavar.

What Kind Of Results Can You Expect With Laxogenin?

It’s important to set realistic expectations here.

First off, there is absolutely no chance that Laxogenin will result in the same degree of strength gains, muscle mass increases, or fat-loss as any kind of SARMsprohormones, or steroids.

In fact, there isn’t any evidence that it’s even any better than the reigning champ of natural muscle-builders, Creatine.

That said, anecdotal reports indicate Laxogenin is capable of increasing muscular endurance, strength, and recovery, and perhaps producing low-single digit gains in muscle mass.  Take it with a grain of salt, though…

The placebo effect cannot be ruled out here.

In other words, people think they’re supposed to be gaining muscle so they push themselves extra hard in the gym and end up a gaining a few extra pounds of muscle, then attribute it to the supplement when it was really the hard work that actually made the difference.

Unfortunately, until we have some hard data on Laxogenin in human subjects, predicting results is more or less impossible.

Currently, it’s kind of a “try and see” type supplement, not one which carries any sort of scientific merit or guaranteed efficacy.

Laxogenin Dosage

Since there are absolutely no human studies regarding the muscle-building benefits of Laxogenin, an optimal (clinical) dosage has not yet been established.

According to the internet (forums, logs, reviews, etc.), average doses range from 100-300mg/day.

If you’re going to give Laxogenin a shot, that’s probably a good place to start.

Keep in mind that the biological half-life of Laxogenin is roughly 6-8 hours, so it’s wise to spread the dosage out over the course of the day so that it consistently stays in your system.

Decide on your starting dose, split it into 3 doses, and take one dose with breakfast, lunch and dinner.

Laxogenin Side Effects

Although Laxogenin has yet to be studied extensively-especially in terms of safety–no adverse side effects have been reported and millions of dosages have been consumed at this point.

Like most plant-based steroids that may or may not work, Laxogenin has absolutely no impact on sex hormones (Testosterone/Estrogen), so you don’t need to worry about Testosterone-suppression or Estrogen-rebound, as is the case with prohormones and oral steroids.

There’s no doubt about it…

Laxogenin is a much safer–albeit, less effective–alternative to oral steroids and prohormones.

Does Laxogenin Require A PCT?

No, Laxogenin has virtually no impact on your sex hormone.  No testosterone-suppression.  No estrogen-rebound.

In fact, it makes more sense to incorporate Laxogenin itself into your PCT after running a real cycle (SARMs, prohormones, steroids) just as means of maintaining muscle.

That is, assuming it actaully works…

Plant Roids: Are They Really A Thing?

I’ll just be honest here…

I really don’t believe in this whole plant steroid thing.

Sure, it’s true that some phyto-chemicals (chemicals found in plants) can have a profound impact on the way our minds and body’s work (think magic mushrooms), but the notion that the same hormones that plants use to grow will also work in humans just seems to me to be a bit of a stretch.

I’m not saying it definitely doesn’t work.  I’m just saying I need to see some actual studies on Laxogenin before I go out buy some.

If you’re not like me though, and you just want to give it a shot, just make sure you select a quality Laxogenin supplement.

The Best Laxogenin Supplement

If you’re a regular reader of my stuff, you know I don’t trust about 99.9999999% of supplement companies.

In fact, that’s why I started my own.  Unfortunately, we only sell products that definitely work, so Laxogenin isn’t in our catalog.

But that doesn’t mean I can’t steer you in the direction of a quality Laxogenin supplement.

When selecting the best Laxogenin supplement, you want to make sure it contains Laxosterone®–a particular brand of 5a-hydroxy Laxogenin, produced by Bestcom BioTech.

It’s the highest purity Laxogenin supplement on the market, at over 96% purity.

On their site, Bestcom BioTech claims they have tested various other off-brand Laxogenin supplements and have found an average of 25-55% purity.

This is pretty consistent with what I’ve come to realize about dietary supplements.  Unless they’re third party tested, you really can’t be sure of the quality.

I recommend Laxosterone® simply because it’s the only raw material Laxogenin that comes with proof of purity.

Where To Buy Laxogenin Supplements

Since Bestcom BioTech is a wholesale ingredient supplier, you can’t by Laxosterone® from them directly.  You can, however, find it in a variety of products:

If you know of any other brands that use Laxosterone® in their Laxogenin formula, feel free to drop a comment.

The Bottom Line On Laxogenin

Laxogenin is certainly one of the most intriguing and perhaps one of the most promising of the whole plant-steroid wave of supplements.

Unfortunately, with absolutely no human research on Laxogenin specifically, everything we think we know about it comes from similar compounds or the comparison to Anavar.

Somewhere along the line, in vitro research which showed Laxogenin MIGHT have a similar anabolic/androgenic ratio as Anavar turned into “Laxogenin is a natural alternative to Anavar!”

That’s simply not true.

If you’re taking Laxogenin because you heard it was ‘the natural version of Anavar’, that’s a load of BS.

This isn’t one of those situations where you get to have your cake and eat too.  If you want to make serious gains in a short amount of time, no natural substance is going to rival the potency of any anabolic steroid.

That’s just the way it is.

If you’re a natural athlete/bodybuilder looking for a slight edge (and don’t mind the lack of research), then by all means, give Laxogenin a shot.

Just don’t expect steroid like gains from it.  You’ll surely be disappointed in the end.

Have anything to add about Laxogenin?  Feel free to comment below!

I’m Matt Theis, founder of SuppWithThat, Momentum Nutrition, and Singular Sport. I created SWT to separate the science from the hype and publish accurate, research-based information on supplements. If you like what I have to say here, feel free to check out my supplements at and

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