HyperTest XTR Review

HyperTest XTR is a test-booster by Axis Labs which features several pretty well-known alleged test-boosting ingredients…

HyperTest XTR



Zinc is required for Testosterone production, so it is commonly included in test-boosters such as HyperTest XTR. We discuss the relationship between Zinc and Testosterone a bit more in-depth in this article, but to sum it up: Zinc supplementation is useful for encouraging optimal Testosterone levels, but will not boost Testosterone beyond the normal range.

HyperTest XTR contains 30mg of Zinc per serving (200% RDI), more than enough to ensure adequate zinc for Test-production.


D-Aspartic Acid has become extremely popular as a Test-booster in recent years, with research suggesting it is indeed effective, at least in the short term.

A 2012 study from “Advances in Sexual Medicine”, the subjects of which were infertile men (initially low Testosterone) found that 2.66g of D-Aspartic Acid was able to significantly increase Testosterone levels when measured after 90 days of supplementation. These results were in-line with those of an earlier study from 2009 in which D-Aspartic Acid supplementation raised Testosterone by 42% after 12 days in healthy men (initially normal Testosterone).

However, a 2013 study published in “Nutrition Research” found that athletes who supplemented with D-Aspartic Acid for 28 days showed no difference in testosterone levels.

The researchers in the failed study noted abnormally high levels of D-Aspartate Oxidase, the enzyme which degrades D-Aspartic Acid, indicating that prolonged supplementation in individuals with healthy Testosterone levels may cause “negative feedback”.

HyperTest XTR contains 3120mg of D-Aspartic Acid, exactly in-line with the doses that have been used in a clinical setting to boost testosterone.


Eurycoma Longifolia, also known as Tongkat Ali has been shown, in various studies, to increase Testosterone in male rats, but the only human studies that exist have tested the effects of Tongkat Ali in infertile men, not healthy men.

A 2010 study published in the “Asian Journal of Andrology” found that supplementation with 200mg of an extract of Eurycoma Longifolia significantly improved various indications of male fertility (in humans), though the mechanism of action was unknown.

A 2012 study published in “Andrologia: Volume 44” (the same researchers from the above mentioned human study) found that men suffering from Hypogonadism (diminishing functionality of the gonads) who were treated with a 200 mg daily dose of Eurycoma longifolia extract reached normal Testosterone levels after a 30 day period. To be fair, at the start of the study about 35% of the men were showing normal Testosterone levels, and at the end about 90% showed normal levels. Still, 35% to 90% is clearly statistically significant.

Axis Labs lists the amount of Eurycoma Longifolia at 200mg, another precise clinical dose which may enhance libido and help optimize Testosterone levels.


Urtica dioica (Stinging Nettle) is alleged (mostly by supplement companies) to boost Testosterone by blocking Sex Hormone Binding Globulin (SHBG) and inhibiting 5-alpha reductase. SHBG is a protein that binds to the sex hormones (androgen/estrogen), thus rendering them biologically inactive. 5-alpha reductase is the enzyme which converts free Testosterone into DHT. Theoretically, blocking either SHBG or 5-alpha-reductase would indirectly raise free Testosterone levels.

A 2012 study, published in “Andrologia”, found that Nettle Extract increased serum Testosterone in rats via 5-alpha-reductase inhibition.

However, these results sort of conflict with an earlier 2005 study from the “Journal of Herbal Pharmacology” which found no influence on Testosterone, in human subjects.

While the mechanism of action exists by which Stinging Nettle could theoretically increase Testosterone, human studies are lacking and the only one we have to go by was a failure.

Ultimately, we wouldn’t consider Urtica Dioica a crucial ingredient in the HyperTest XTR formula, but it may not be completely useless.


Ashwagandha is a popular Ayurvedic herb with a relatively wide variety of health implications, ranging from cognitive support to anti-cancer effects. However, in the context of HyperTest XTR, the focus is on Ashwagandha’s influence on Testosterone.

A 2010 study, published in Fertility and Sterility”, found that Ashwagandha (5g basic root powder) was able to restore Testosterone levels in infertile men, though subjects did not experience spikes beyond the normal range.

These findings were replicated in a 2011 study in which it was also noted that the effects were more apparent in stressed men (Ashwagandha is a known adaptogen).

There is certainly no reliable evidence to suggest that Ashwagandha can outright increase Testosterone in non-deficient individuals, but research indicates it can help to stabilize/optimize Testosterone.

HyperTest XTR contains 300mg of Ashwagandha Root, but Axis Labs makes no mention of the standardization. If we are to assume that this is just 300mg of root powder, than it is far below what has been shown to restore Testosterone levels in the above-mentioned study.


HyperTest XTR features several alleged testosterone-boosting ingredients, a few of which may be moderately effective, at least for encouraging optimal Testosterone. DAA is the only ingredient which has been shown to boost Testosterone beyond the normal range, but this effect may be short lived in healthy individuals. At about $1.50 per serving, HyperTest is priced about average compared to other test-boosters with similar profiles.

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