Hordenine is a pretty popular supplement.
But there’s one issue with Hordenine…
It hasn’t actually been studied in humans.
So, are the alleged benefits real? Or is this just another sketchy, unproven ingredient that we’re better off without?
Well, that’s what we’re going to discuss in this article!
By the end of it, you’ll know everything there is to know about Hordenine. More importantly, you’ll be fully equipped to determine whether this is something you should work into your daily supplement regimen.
So let’s just dive right in…
What Is Hordenine?
Hordenine, also known as N,N-dimethyltyramine, is an naturally occurring molecule found in various plant species, including Barley and Bitter Orange.
It was first discovered in the blood of Horses who were fed Barley and subsequent studies showed that Hordenine had moderately potent adrenergic effects.
Hordenine is typically used or the purposes of fat-burning and weight loss, increasing energy levels, and improving mood.
While it hasn’t been studied in humans too extensively (or at all really), the effects of Hordenine have been studied in animals enough for us to know how it works.
How Does Hordenine Work?
Research indicates that Hordenine functions as a Noradrenaline reuptake inhibitor.
Noradrenaline is a neurotransmitter/hormone which is heavily involved in the fight-or-flight response.
Increased Noradrenaline levels are typically associated with things like:
- more energy and alertness
- enhanced focus and attention
- increased lipolysis (fat breakdown)
So Hordenine is believed to provide benefits in these areas.
What Are The Benefits Of Hordenine?
Before we dive into the benefits that Hordenine MAY provide, I’d like to make one thing clear…
Hordenine has NEVER actually been studied in humans, so none of the alleged benefits have actually been proven. That said, Hordenine is a Monoamine Oxidase Inhibitor, so there are a few ways in which it may be useful.
Just know that these benefits are all based on what we know about how Hordenine works, not any direct evidence.
Hordenine May Help You Lose Weight
One of the primary reasons people use Hordenine supplements is because they believed it will help them lose weight.
While there are no studies directly investigating the impact of Hordenine on body weight or fat mass, it does have a sound mechanism of action by which it may burn fat and encourage weight-loss.
Research shows that Hordenine blocks the reuptake of Noradrenaline, effectively increasing Noradrenaline levels.
Noradrenaline is a potent inducer of lipolysis, or fat-breakdown.
By blocking the reuptake of Noradrenaline, Hordenine can potentially increase lipolysis and research indicates that more lipolysis typically results in more fat oxidation.
One study found that a weight-loss supplement containing Hordenine, among other things, increased energy expenditure, but obviously these results can’t be attributed to Hordenine alone.
Again, Hordenine has never actually been shown to burn fat or encourage weight-loss, even in animals, but it does have the potential to do so.
Hordenine May Enhance Focus And Energy
Aside from fat-burners, you’ll also find Hordenine in many pre-workouts and energy supplements, where it is believed to increase focus and energy levels.
No studies have actually proven that Hordenine can do this, but again, the mechanism is there.
Since Hordenine acts as a Noradrenaline reuptake inhibitor, effectively increasing levels of Noradrenaline, it stands to reason that it may enhance perceived energy and focus.
As a neurotransmitter, Noradrenaline is heavily involved with cognitive functions such as:
By increasing levels of Noradrenaline, it stands to reason that Hordenine may provide enhancements in these areas.
Hordenine is commonly combined with Caffeine and these two substances may be somewhat synergistic.
Caffeine triggers the release of Noradrenaline and Hordenine blocks the re-uptake of Noradrenaline.
Hordenine May Improve Mood
Pharmaceutical Monoamine Oxidase Inhibitors (MAOIs) are commonly prescribed for the purposes of treating depression and improving mood.
Monoamines–a group of chemicals which includes Dopamine, Noradrenaline, and Serotonin–play a role in regulating mood and happiness and depression can be caused by an imbalance in these chemicals.
So, although Hordenine hasn’t actually been studied in this area, it makes sense that it could provide some mood-boosting benefits due to it being a moderately potent MAOI.
Anecdotal reports indicate that Hordenine can help extend the mood-enhancing effects of other supplements like Phenylethylamine (PEA), which are ordinarily short-lived.
If you’re clinically depressed, you should probably talk to your doctor before taking some kind of supplement as a treatment.
Since there are no human studies assessing things like efficacy or safety with Hordenine, we really don’t know what the optimal dosage is.
Anecdotally speaking, 30-50mg seems to be the preferred range, but I’ve seen pre-workouts and fat-burners with as much as 100mg of Hordenine, in addition to other stimulants.
Formula 56, for example, contains 50mg of Hordenine per serving, in addition to 300mg of Caffeine.
Hordenine Side Effects
Since Hordenine has the potential to act as a stimulant, there are some side effects to be wary of prior to use.
- Increased Blood Pressure
- Rapid Heart Beat
- Sweating More Than Usual
You know, all the usual stimulant-induced side effects.
Hordenine isn’t particularly powerful on it’s own, but combined with other stimulants, the likelihood of side effects may be increased.
People with high blood pressure should probably just stay away from Hordenine.
If you’re on any kind of psychoactive medication–especially one that impacts Noradrenaline levels, like an Monoamine Oxidase Inhibitor (MAOI)–you may want to check with a doctor prior to use.
My Personal Experience With Hordenine
I have experimented with Hordenine on and off for quite some time and have elected to use it in two supplement formulations, Catalyst (my pre-workout) and Formula 56 (my fat-burner).
Normally, I don’t bother with supplements that haven’t been proven to do anything, but Hordenine is the exception.
Hordenine has a sound mechanism of action (Noradrenaline reuptake inhibition) by which it may do things like burns fat, increase energy, and improve mood, and in my experience, it works.
I have found that Hordenine amplifies the effects of other stimulants, such as Caffeine, so it makes sense to take Hordenine anytime you’re trying to maximize the effects of your Caffeine intake.
Sometimes I take a little Hordenine with my morning coffee when I feel like a need an extra boost, but usually, I just take it in the form of Formula 56, which contains 50mg per serrving.
The effects are subtle, but noticeable.
If you drink Caffeine every day, and you add some Hordenine, you’ll notice a slight enhancement.
Where To Buy Hordenine
You can find Hordenine is a ton of pre-workout supplements and fat-burners, but it’s also available in single-ingredient form, as Hordenine Hcl.
Here are some single-ingredient Hordenine supplements I trust:
If you know of any other single-ingredient Hordenine supplements, feel free to comment below.
If you’re buying Hordenine powder, you’re going to need a milligram scale.
Remember, an effective dose of Hordenine is anywhere from 30-50mg, so an accurate scale is essential if you’re dealing with powder.
How To Maximize The Effects Hordenine
Whether you’re using it to lose weight or increase energy, Hordenine by itself ins’t going to do much. However, the effects can be amplified by combining Hordenine with the right complimentary supplements.
That’s why my fat-burner Formula 56 contains 50mg of Hordenine along with several other ingredients which have each been proven to help burn fat and facilitate weight-loss.
Caffeine triggers the release of Noradrenaline, among other Catecholamines, and Hordenine blocks the reuptake of Noradrenaline. Theoretically, this makes them sort of synergistic.
Hordenine can enhance the energy and focus effects of Caffeine, but it also may enhance Caffeine’s ability to burn fat.
By itself, Caffeine has been shown to increase fat oxidation and boost the metabolic rate and these effects are partially the result of increased Noradrenaline levels.
By blocking the reuptake of Noradrenaline, it stands to reason that Hordenine can enhance the fat-burning effects of Caffeine.
Synephrine is a mild stimulant which is naturally found alongside Hordenine in Bitter Orange.
Research has shown that Synephrine can directly stimulate fat oxidation (burning) and increase the metabolic rate.
It works by activating beta-receptors, a kind of receptors found in fat tissue which regulate the process of lipolysis (fat breakdown).
Given their natural coexistence, it makes sense to combine Hordenine with Synephrine for the purposes of enhancing fat-loss.
Naringin And Hesperidin
Naringin and Hesperidin are naturally occurring molecules in citrus fruit. Research indicates that each of them may have some inherent fat-loss properties, but that’s not why I included them in Formula 56.
This combination has been shown to enhance the metabolic rate boost seen with Synephrine, indicating that these three ingredients are synergistic with one another.
Forskolin is a the active component in the herb Coleus Forskohlii which has an extensive history of use throughout systems of traditional medicine.
It is one of the few non-stimulant weight-loss supplements that has actually been proven to work.
By increasing cellular levels of cAMP–a kind of signaling molecule which triggers lipolysis–Forskolin can help facilitate fat-loss and may enhance the fat-burning effects of other substances, like Caffeine and Synephrine.
Citicoline is a highly bioavailable form of Choline.
Choline is used in the production of Acetylcholine, a neurotransmitter heavily associated with cognitive functions such as memory, learning, and attention.
Research shows that Citicoline can improve cognitive function which makes it ideal for dieting, since cutting your calories can take a toll on your mental abilities.
Formula 56 essentially works in three ways:
- Increasing your metabolic rate (the amount of calories you burn at rest)
- Curbing your appetite (helping you maintain caloric deficit more easily)
- Enhancing energy and focus (so you burn more calories and feel better while dieting)
What separates Formula 56 from all the other so-called fat-burners out there is the clinically effective doses of ingredients which have actually been proven to burn fat and help you lose weight.
If you’re looking for a safe, effective fat-burner that will actually make a difference, you want to try Formula 56.
The Bottom Line On Hordenine
Hordenine may useful for burning fat, losing weight, enhancing energy and focus, and improving mood, but it’s never actually been proven to do any of these things in humans.
Any supplement company that claims Hordenine has been proven to do anything is lying, since it has hardly even been studied in animals.
The benefits of Hordenine are inferred based on preliminary research which indicates it functions as a Noradrenaline reuptake inhibitor.
Personally, I believe in the power of Hordenine and have used it in a few of my formulas, but I’m not convinced that it’s very effective on it’s own.
It makes more sense to stack Hordenine with other stimulants, such as Caffeine, Synephrine, Rauwolscine, or Higenamine, all of which have adrenergic (stimulant) properties on their own which may be enhanced by Hordenine.