Genomyx Speed Xtreme: An Evidence-Based Review

Speed Extreme is a stimulant-powered pre-workout by Genomyx, a brand which appears to be closely tied to Lecheek Nutrition since Lecheek was the original brand behind Speed X3 and other such pre-workouts…

Genomyx Speed Xtreme


The claims attached to Speed Xtreme are simple.  Genomyx claims that Speed Xtreme will provide:

  • Energy
  • Focus 
  • Speed

But is this formula any different from the thousands of other high-stimulant pre-workouts out there?  Let’s take a look…

Genomyx Speed Xtreme Ingredients

Speed Xtreme contains the same basic blend of ingredients you might expect to find in the average pre-workout supplement today.  Our more avid readers may want to just glance at the ingredients and skip this section over.  There’s nothing new here…


Beta-Alanine is a precursor to the dipeptide Carnosine, higher muscular concentrations of which are associated with greater muscular endurance.  This has been shown in athetes and non-athletes, in study after study after study.  It’s a fact.

Beta-Alanine, though not the only amino acid needed for Carnosine synthesis (the other is Histidine), is the rate limiting factor.  Several studies have shown that Beta-Alanine supplementation alone is an effective means of increasing muscular Carnosine concentrations and increasing muscular endurance.

3-6g/day is considered the clinical range, though most pre-workout supplements contain far less.  Genomyx doesn’t disclose the precise amount of Beta-Alanine in Speed Xtreme, but based a 4.4g proprietary blend of which there are five other ingredients, it appears under-dosed.

Creatine Monohydrate

Creatine is hands down the most extensively researched, safe, effective muscle-building supplement there is.  Hundreds of studies have been conducted over the years which have concluded unanimously that Creatine

  • builds muscle
  • increases strength and power
  • enhances muscular endurance

But the issue always comes down to a matter of dosing.  Creatine needs to be dosed at around 5g/day (3 at the lowest), but Speed Xtreme no doubt contains far less than that.  Based on a 4.4g proprietary blend, there’s no doubt about it…Genomyx has under-dosed Creatine in the Speed Xtreme formula (not a big surprise).

Agmatine Sulfate

Agmatine is a metabolite of the amino acid Arginine which is directly involved in Nitric Oxide synthesis.  Bodybuilders and athletes alike have long been intruiged by anything that allegedly inreases Nitric Oxide for the simple fact that Nitric Oxide increases blood flow, and more blood flow to the muscles means:

  • Better pumps
  • More muscle growth
  • Faster recovery

Unfortunately, research on Arginine indicates it isn’t too effective as an oral supplement (Citrulline is though), so Agmatine has become popular as a replacement.  It has been shown to increase the activity of Endothelial Nitric Oxide Synthase, the enzyme which catalyzes the production of Nitric Oxide in Endothelial cells.

However, no real research has been conducted in human subjects regarding Arginine and exercise performance so all we have to go on is a mechanism of action that sounds goood…but that doesn’t make Agmatine effective.

We’d estimate Speed Xtreme contains about 500mg of Agmatine Sulfate, a fairly standard dose as far as most pre-workouts are concerned.


Caffeine triggers the release of a group of neurotransmitters known as Catecholamines.  This includes Dopamine and Noradrenaline which are responsible for that state of focus and mental acuity that Caffeine generally induces.

This is why Caffeine often forms the basis for stimulant-powered pre-workout supplements (such as Speed Xtreme).  Speed Xtreme contains three types of Caffeine:

  • Caffeine Anhydrous (regular ol’ Caffeine)
  • Caffeine Citrate (Caffeine + Citric Acid)
  • Dicaffeine Malate (Caffeine + Malic Acid)

While each of these forms may be absorbed at a different speed, they’re all Caffeine at the end of the day.  So far, we haven’t seen any studies that indicate Caffeine Citrate or Dicaffeine Malate is provides a better/more sustained release of energy, so we’d caution you not to read too far into it.

Caffeine is awesome.  It wakes you up and gets you going.  Designer forms of Caffeine are still just Caffeine…

Olive Leaf

Olive Leaf Extract is generally standardized for Oleuropein, a unique molecule which appears to cause Noradrenaline release and therefore may be useful for inducing a state of alertness and focus.  Unfortunately, not many studies have been conducted at this point (in humans), so we’re pretty much just drawing from rodent studies and giving it the benefit of the doubt.

There does appear to be something to it as a stimulant, but we just don’t know much about it yet.

Green Tea Extract

Green Tea Extract is generally standardized for EGCG, a unique compound which acts as a Catechol-O-Methyltransferase inhibitor, effectively delaying the degradation of Catecholamines (remember, those energizing chemicals released by Caffeine).

For this reason, Green Tea Extract is an excellent addition to any Caffeine-containing supplement.

Speed Xtreme Ingredient Takeaway

Speed Xtreme contains a pretty standard array of pre-workout ingredients, most of which are under-dosed.  If you’re looking for muscular endurance or strength increases, Speed Xtreme will disappoint you.  However, if it’s high amounts of energy and focus you crave, Speed Xtreme may do just the trick.

Is Speed Xtreme Safe?

If taken correctly, Speed Xtreme is safe.  It contains high levels of Caffeine and some other stimulant (or stimulant-like) ingredients, but nothing overwhelming or dangerous.

The Bottom Line

Genomyx appears to have taken the torch from Lecheek (a releated brand) with Speed Xtreme, but the formula isn’t as powerful as it has been in the past.  If you’re looking for energy and focus, Speed Xtreme can definitely provide that, but there are tons of other high-stim pre-workout supplements out there which are better. exists to educate the supplement community and seperate the science from the hype.

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