So, is this simply a comeback attempt by the once iconic brand? Or is Gaspari actually onto something with this knew formula? Let’s check it out and see for ourselves…
Novedex (Not Nolvadex)
The first thing you absolutely MUST understand before even thinking about using Novedex XT it is NOT the same thing as Nolvadex, also called Tamoxifen Citrate.
Tamoxifen Citrate is a Selective Estrogen Receptor Modulator (SERM) which potently suppresses Estrogen and is prescribed usually for Breast Cancer patients to prevent the growth of tumors but has another “off label” purpose as well.
It has been used for many years for Post Cycle Therapy to suppress Estrogen in men who are coming off (or just came off) cycles of prohormones, steroids, or other anabolic compounds that influence your hormones.
Gaspari intentionally named the product Novedex because it’s quite close to Nolvadex (Tamoxifen) when spoken outloud so, needless to say, some people have probably been tricked into buying it thinking it’s “the real deal” when in fact it’s nothing like real Nolvadex.
Okay, now that we’ve got that straightened out, let’s talk about Nolvadex XT by Gaspari…
Novedex XT 2017 Claims
Gaspari is keeping things pretty simple in the claim department, probably because the brand has been under the scope by the FDA since the early 2000s. Regardless of the reason, Novedex XT is designed to do 2 things:
- Suppress Estrogen
- Restore Testosterone
When you think about it, this is really all a Post Cycle Therapy supplement should do anyway. If you’ve recently run a cycle and you have elevated Testosterone levels, you’re body will generally do 2 things:
- Stop producing Testosterone naturally
- Increase Estrogen production to keep the balance
So, a proper Post Cycle Therapy protocol should restore your natural Testosterone levels as well as keep Estrogen levels on the low. Well, needless to say, a lot of PCT Supplements make similar claims and very few of them are actaully any good.
Is Gaspari’s 2017 version of Nolvedex XT just another over-the-counter PCT supplement that doesn’t work? Or is there something that sets it apart from the competition?
Well, the only way to figure that out, other than risking your hard earned money and trying it yourself, is to take a step back and look at the scientific evidence behind each ingredient…which is exactly what we do here at SuppWithThat.com, so let’s get started…
Novedex XT 2017 Ingredients
Perhaps the most interesting thing to note about the ingredients Gaspari has elected to use for Novedex XT is the fact that two out of three are virtually non-existent. In other words, there are no studies to go by, but we can make some assumptions (Gaspari is just making assumptions too) about how they might impact your hormones.
But first, we need to go over some chemistry. If all those strange chemical prefixes, suffixes, and seemingly random numbers are confusing, don’t worry…You’re not alone.
The most important thing to keep in mind is that anyone can make up some chemical nomenclature and print it on a label. That doens’t mean they know what it is, what it does, or how well it works. Unfortunately, that leaves us to do a whole lot of guess work!
Understanding Chemical Nomenclature
The term “Nomenclature” simply refers to a system or set of rules for naming things. In Chemistry, this is especially important because it creates a universal language that can be freely shared and understood, translated, and expanded upon.
In fact, if you take the time to do a little research on the ingredients in the supplements you take (real research, not Bodybuilding.com research), what you’ll find is that most supplement ingredients go by a few names, but they all have chemical nomenclature by which their chemical structure can be identified.
Caffeine. We all know what it is. Many of us use it for the purposes of increasing energy and focus, but did you know that Caffeine has another name?
1,3,7-Trimethylxanthine. Not as friendly sounding as Caffeine right? But it’s the same thing. Pick any other compound/ingredient/substance that you consume regularly, Google it, and you’ll almost certainly find that it has some strange, complicated chemical name with a bunch of numbers, commas, dashes, sciency suffixes, etc.
So don’t be scared of chemical nomenclature. Everything has a scary name that follows the same basic set of rules, but once you understand the rules and a little bit of Chemistry lingo, these seemingly drawn out, confusing chemical names become much easier to understand.
In Organic Chemistry, numbers (in this case 3, 4,6, and 17) are simply used to describe the position and type of the functional group(s).
Functional Groups are simply the atoms (or collection of atoms) responsible for giving a chemical it’s properties. If you examine any somewhat complex chemical compounds, you’ll find that it has a Carbon backbone, meaning a chain of Carbon atoms that connect different atoms and form bonds.
Carbon is a unique element in that a Carbon atom can bond with up to four different atoms. This allows Carbon to serve as the “chemical skeleton” (for lack of a better term) for much more complex chemicals such as amino acids (the buildig blocks of life).
If you take a look at the ingredients in the new Novedex XT formula, you’ll notice the functional groups are represented by the terms Hydroxy and Androsta, with the remaining numbers, prefixes, simply serving as indications of the number and position of bonds attached to the Carbon chain that serves as the chemical backbone.
In Organic Chemistry, the alpha Carbon is the Carbon that directly attaches to the functional group and the beta Carbon is simply the carbon next to the alpha carbon. It’s not particularly important. It’s just nice to know where the b (beta) comes from. It’s simply the carbon attached to whichever functional group it’s referring to.
Okay, hopefully that wasn’t too complicated, but feel free to reference this section if you need to while we attempt to understand these ingredients…
If you google beta-hydroxy-androsta-1,4,6,triene-17-one (at least at the time this review was written), you’ll find absolutely nothing. In fact, even massive chemical suppliers like Sigma Aldrich don’t have this compound cataloged. That means Gaspari Nutrition either invented it or are just using incorrect nomenclature (possibly on purpose).
Still, using our knowledge of basic chemistry, we can pick it apart.
The Hydroxy-Androsta group would be the functional group and the “one” at the end indicates a Ketone (another functional group). Everything else is mereley an indication of where the bonds are and how they’re positioned.
The term “beta” simply refers to the Carbon atom adjacent to the alpha Carbon (the Carbon atom which is attached directly to a functional group). So, you can think of the “beta-Carbon” as the second in line, so to speak…
The numbers 1,4,6, and 17 indicate which Carbon atoms attach to the functional groups and the term “triene” means that there are two sets of double hydrogen-oxygen bonds (the Hydroxy group).
The term “one” (sounds like “own”) signifies a Ketone, a category of organic molecules which many of the new wave of so-called “muscle-builders” fall into.
So, when we slap it all together we have a substance that should function something like Androsta (also called Arimistane which we’ll discuss in a minute) but with slightly different properties which potentially make it function differently.
Unfortunatley, as stated earlier, there are no studies do go by here, nor can we speculate as to the value of adding a Hydroxy group to Arimistane and changing the position of some bonds.
In other words, beta-hydroxy-androsta-1,4,6,triene-17-one is a complete gamble. There’s no evidence that it does anything.
Like beta-hydroxy-androsta-1,4,6,triene-17-one, not much information is known about this particular compound. Or, perhaps Gaspari Nutrition is just using uncommon nomenclature, making it difficult to figure out exactly what 3b-hydroxy-androsta-4,6-diene-17-one is even supposed to do.
Since there are absolutely no studies which have used a compound called 3b-hydroxy-androsta-4,6-diene-17-one, we’ll have to resort to some basic chemistry yet again in order to understand what this compound even is, let alone what it may be capable of (or not).
The nomenclature chosen by Gaspari to represent this particular compound may as well be written in Mandarin as far as the average user of prohormones in concerned (assuming you don’t speak Mandarin that is).
And, since Gaspari doesn’t seem to be in any hurry to explain the science behind any of the ingredients in Novedex XT or, at the very least, the reasoning for them, we have some guess work to do.
Luckily, we atleast have the chemical structure here which gives us some further clues…
Since carbon chains can potentially be endless, it is possible to have multiple beta carbons, as is the case with 3b-hydroxy-androsta-4,6-diene-17-one (indicated by 3b).
For example, the suffix “diene” simply means there are two double bonds. The numbers before it indicate which Carbon atoms those double bonds attach to. So, “4-6,diene” means there are two double bonds between atoms 4-5 and 6-7.
The suffix “one” spelling out (not the number 1), typically indicates that a particular molecule is a Ketone. In organic Chemistry, Ketones are molecules which contains a Carbonyl group–another way of saying carbon-oxygen double bond. Yes, those would be the double bonds denoted by 4 and 6. See? Not so complicated, right?!
Still, based on the nomenclature used, it would appear that this compound is meant to boost Testosterone and/or suppress Estrogen, the reason being that 3b-hydroxy-androsta-4,6-diene-17-one is pretty close to Androsta 3,5-dien-7,17-dione (Arimistane), just with a beta-hydroxy group tacked on and the position/location of the bonds changed around.
Again, no studies, but it should function similar to Arimistane.
androsta 3,5-dien-7,17-dione (Arimistane)
Androsta 3,5-dien-7,17-dione, referred to more commonly as Arimistane, is a fairly potent suicidal Aromtase Inhibitor, meaning it suppresses the enzyme (Aromatase) responsible for converting excess Testosterone into Estrogen.
The chemical structure of Arimistane is represented below and we discuss it in detail here.
Keeping Aromatase as low as possible is the goal for any bodybuilder/athlete/lifter who wants to keep the gains they made on cycle and not suffer any Estrogen related side effects.
However, blocking Aromatase is just one side of the equation when it comes to perfecting your Post Cycle Therapy protocol. Yes, it’s true that Arimistane can bind with the Aromatase enzyme, rendering it inactive, but what about the Aromatase that gets past it? It’s free to grab up all the Testosterone it can and convert it into Estrogen.
This doesn’t mean Arimistane isn’t worth taking. It is DEFINITELY worth taking. It’s just that you also need something to block the Estrogen Receptors themselves (like a SERM).
Furthermore, we have no idea how much Arimistane is present in the Novedex XT 2017 formula. Given that it’s listed last out of three ingredients in a 75mg proprietary blend, we know it’s no more than 25mg (not a particularly effective dose) on it’s own.
Novedex XT 2017 Ingredient Takeaway
Once you get over the headache the nomenclature presents, it’s pretty clear that Novedex XT is essentailly two different Arimistane-like compounds and Arimistane itself. In other words, it’ll help lower your Estrogen and restore natural Testosterone levels, but HOW MUCH remains unclear.
The truth is nobody really knows what these compound do. The only way to find out is to either wait for a study (may never happen) or take it yourself.
Arimistane itself is an effective AI, so it makes sense that the other two–beta-hydroxy-androsta-1,4,6,triene-17-one and 3b-hydroxy-androsta-4,6-diene-17-one would have similar effects, but that’s purely speculation based on the molecular structure of those compounds combined with the information we do have on Arimistane.
Should You Stack Novedex XT With Halodrol (2016)?
If you’re interested in buying Novedex XT, you may be wondering if it’s an adequate PCT supplement for the most recent (2016) version of Halodrol.
To be honest, the new Halodrol does not appear to be very effective. It’s certainly no where near as effective as the original Halodrol, that’s for sure. So, you probably don’t need a PCT at all for it, but of course it’s an extra product for Gaspari to sell and when you use the word “prohormone” to describe a product (even if itof doesn’t do anything), people automatically assume they need a PCT.
The reality is there are much better PCT Supplements available that will actually save you from the Estrogen-induced and low-Testosterone side effects of running a real cycle.
Is Novedex XT 2017 Legal?
We’re not even sure if the word “legal” applies to the supplement industry anymore. It seems more like the Wild West where anything flies until it doesn’t anymore and then the next “break-through supplement” is released and the same thing happens again.
According to the FDA, a supplement is considered adulterated if it contains ingredients that aren’t naturally occurring and/or haven’t been used in dietary supplement prior to 1994 (for some reason). Yes, this makes no sense…but it’s basically the FDA’s current stance.
Who knows if that will change. Who knows if the FDA will even be around in a few years (it’s at the bottom of Trumps list of most important agencies, so it may get restructured or dissolved altogether. That would literally mean anything goes in the world of supplements.
Guess we’ll see how it all pans out…
Is Novedex XT 2017 Safe?
Probably, but not definitely. The thing about synthetic compounds that nobody’s ever heard of or even documented yet is that you don’t REALLY know what it’ll do to your body until you take it. Even if you take it, it’s nearly impossible to determine whether it’s safe until it’s been given to a large population and there haven’t been instances of adverse effects or hospitalizations.
It’s probbaly about as safe as Arimistane which, at this point, seems pretty safe.
Is Liposomal Delivery Technology Real?
Liposomal delivery has been around for a while, mostly used in the pharmaceutical space. Now, however, it’s starting to pop up in supplements. You can think of a Liposome as a little bubble with atleast one protective lipid (fat) layer which can be used to deliver drugs or supplements into the body.
Does it make a difference? Well, it probably depends on the compound more than anything. Compounds that are subject to premature or immediate breakdown may benefit from the protection of Liposomes.
Unfortunately, as much as we want to believe in this seemingly amazing technology, we have our doubts. Liposomal delivery or not, these compounds aren’t particularly strong and there’s no evidence that coating them with lipids makes them absorb so much better that they mimick the effects of more powerful, known pharmaceutical Estrogen suppression drugs (like Tamoxifen).
It’s your money though, so you decide
The Bottom Line
The problem with over-the-counter (OTC) Post Cycle Therapy supplements is that most of them promise the world and then don’t deliver. Given theat Novedex XT 2017 contains Arimistane, it should be somewhat helpful with regards to coming off cycle, but it’s not quite as all-encompassing as Gaspari makes it sound.
The reality is it’s just a bunch of altered forms of the same basic compound (Arimistane) which, as you know if you read our Complete Guide To Post Cycle Therapy Supplements, isn’t EVERYTHING you need for a perfect PCT regimen.
If you’re looking for the best PCT Supplement money can buy, you’ll want to take a look at our Best PCT Supplements list instead.