Fuel:One Phospha Build Review

Phospha Build is a muscle-builder by Fuel:One, a MuscleTech brand, which contains just two ingredients: Phosphatidic Acid and Tart Cherry. Fuel:One touts Phospha Build as superior to other Phosphatidic Acid supplements out there, most of which are MUCH less expensive, because it contains a standardized form of Phosphatidic Acid known as Mediator®…

Fuel:One Phospha Build



Fuel:One (an Iovate Health Sciences Brand) claims that Phospha Build can induce muscle growth to a moderate extent.  Nothing unbelievable, but nothing too amazing either…

Phospha Build Ingredients

The formuls contains just two active ingredients.  The exact same two active ingredients found in MuscleTech Phospha Muscle


Phosphatidic Acid is a phospholipid component of cell-membranes which has been shown, in vitro, to stimulate mTOR, a signaling molecule which initiates muscle protein synthesis.

Fuel:One references one particular study from the “Nutrition & Metabolism” which found that Phosphatidic Acid enhanced mTOR signaling (measured in vitro) and ultimately increased muscle hypertrophy and strength in resistance trained males over an 8 week period.

The following graph was pulled directly from this study:

Phosphatidic Acid
Interestingly, this study compared the mTOR stimulating abilities of various Phosphatic Acid precursors from different sources and found that Soy-derived Phosphatic Acid was significantly more effective than egg-derived Phosphatidic Acid.

An earlier (2012) pilot study, published in the “Journal of the International Society of Sports Nutrition”, found that Phosphatidic Acid supplementation (750mg daily) increased squat strength and Lean Body Mass (LBM) slightly more than the placebo group in response to 8 weeks of resistance training.

Although the results of this pilot study were not as encouraging as the most recent (2014) study, they both indicate that Phosphatic Acid can enhance strength and muscle growth, at least to some degree. Furthermore, the 2014 study, the study emphasized by Fuel:One, had a better design which may account for the differences.


Tart Cherry is becoming popular as recovery-aid, and we assume that’s why Fuel:One added it to the Phospha Build formula.

A 2010 study, published in the “Scandinavian Journal of Medicine & Science in Sports”, found that Tart Cherry juice reduced various markers of muscular damage in human subjects following exercise.

Tart Cherry may enhance the recovery aspect of the formula, though its clearly not the main attraction in Phospha Build.


Phospha Build comes with a significantly higher price tag than other Phosphatidic Acid supplements we’ve seen. This is because, as Fuel:One explains on their website, Phospha Build contains a standardized form of Phosphatidic Acid which has been tested for purity. This doesn’t mean that every other Phosphatidic Acid supplement does not meet label claims, but it may appeal to those who want to be absolutely sure. So, is the massive premium worth peace of mind? That’s for the customer to decide.


Given that Phospha Build contains the same exact dose of Phosphatidic Acid used in both of the above-mentioned studies, and given that neither of those studies reported any sort of side effects or potential health detriments, Phospha Build appears perfectly safe. Phosphatidic Acid, as mentioned above, is a component of Soy so it is already present in many Soy-based products. Of course, individuals with Soy allergies should probably steer clear.


Phospha Build is essentially just Phosphatic Acid, which may be moderately effective for increasing strength and muscle hypertrophy when combined with a proper training program. We would like to stress however that, given the differences between the studies discussed above, individual results may vary.

Phosphatidic Acid may help build a little muscle, but if you want something that will seriously pack on pounds of lean muscle in 4-6 weeks, check out our Best Muscle Building Supplement List.


  1. Joy, Jordan M., et al. “Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy.” Nutrition & metabolism 11.1 (2014): 29.
  2. Hoffman, Jay R., et al. “Efficacy of phosphatidic acid ingestion on lean body mass, muscle thickness and strength gains in resistance-trained men.” J Int Soc Sports Nutr 9 (2012): 47-53.
  3. Winter, Jeremiah N., et al. “Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway.” American Journal of Physiology-Cell Physiology 299.2 (2010): C335-C344. exists to educate the supplement community and seperate the science from the hype.

Click to comment
To Top