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Everything You Need To Know About Fasoracetam

man researching fasoracetam on his laptop

It seems like every week, there’s some new nootropic (brain-booster) that’s supposedly more powerful than all its predecessors.

This week, it’s Fasoracetam.

According to ‘the internet’, Fasoracetam is like…

If Aniracetam and Noopept had sex on a pile of Lion’s Mane and had a kid.

Seriously though, if you read reviews and testimonials, people are saying some pretty incredible things about this stuff…

  • Better Memory
  • Enhanced Focus
  • More Creativity
  • Mood Imrovement
  • Less Anxiety

These are just a few of the many claims made about Fasoracetam, but you get the idea.  It’s supposedly the ultimate brain-booster, but is there any research to back that up?

I mean, talk is cheap and on the internet, it’s free.

The term ‘nootropic’ has basically become synonymous with ‘over-hyped nonsense’.  The companies that sell nootropics often promise the world and then deliver very little.

Is Fasoracetam one of those nootropics?  Or is it different?

Well, that’s exactly what we’re going to get to the bottom of in this article.

Let’s begin…

What Is Fasoracetam?

Fasoracetam belongs to the racetam family of nootropics.

fasoracetam chemical molecule

It was originally developed by researchers at the Japanese pharmaceutical company, Nippon Shinyaku as a treatment for vascular dementia.

Fasoracetam initially appeared promising for treating this condition, making it all the way to Phase III clinical trials before ultimately being abandoned due to lack of efficacy.

Apparently it didn’t work as well as they thought.

But that didn’t stop a US company, neuroFix Therapeutics, from acquiring the data collected on Fasoracetam from Nippon Shinyaku and attempting to re-purpose the drug as a treatment or ADHD.

ADHD drugs like Adderall and Focalin tend to come with harsh side effects and plenty of people have questioned whether it’s really a good idea to give children amphetamine salts (that’s what Adderall is), so the demand for safer alternatives is definitely there.

Clinical trials are under way but Fasoracetam has already made it’s way into the nootropic community and has created quite a stir.

Many people consider it to be ‘the best racetam’.

Why Do People Use Fasoracetam?

Fasoracetam is generally used by people who want to:

  • improve memory
  • enhance focus/attention
  • learn better
  • be more creative
  • react quicker

This is the same list of benefits associated with all the racetams, though, and it’s not quite clear how much more effective Fasoracetam really is than the others.

Anecdotal reports indicate it’s awesome!  But those are just anecdotal reports.

The truth is, racetams in general have very little evidence for their efficacy in healthy people (without some sort of cognitive impairment) and Fasoracetam has even less evidence than pretty much every other racetam.

But at least we know how it’s supposed to work…

How Does Fasoracetam Work?

Since Fasoracetam is part of the racetam family, we know it behaves similary to the others, but there isn’t much actual research out there on Fasoracetam in particular.

We do have a few clues about how it might work though…

In one rodent study, Fasoracetam (NS-105) was shown to interact with a certain subset of Glutamate receptors.

In another study (also in mice), Fasoracetam reversed memory disruption caused by Baclofen, a potent GABA agonist, by enhancing Acetylcholine signaling.

Fasoracetam also appears to act on the B subset of GABA receptors, which may have anti-depressant effects, but without influencing monoamines like Dopamine and Serotonin.

This is what separates the potential anti-depressant effects of Fasoracetam from the more traditional anti-depressants, such as MAOIs and SSRis, both of which impact monoamine function.

While the research is still in it’s infancy, it would appear that, like most nootropics, Fasoracetam interacts with a handful of key neurotransmitters to elicit it’s cognitive effects.

  • Glutamate
  • Acetylcholine
  • GABA (B)

Unfortunately, while we have a few studies demonstrating how Fasoracetam works, there aren’t that many studies indicating how well it works in human subjects.

Fasoracetam is still in clinical trials (under the names LAM 105 and AEVI-001) for treatment of ADHD, so more studies will surface eventually.

So far, we’ve seen that it can improve cognitive abilities in people with ADHD but we have no idea how well it works in healthy human subjects.

The results of these clinical trials have been encouraging so far and Fasoracetam may very well turn out to be an effective drug for improving attention and certain aspects of cognitive function.

But when nootropic vendors are pitching Fasoracetam, claiming all kinds of benefits, just keep in mind these benefits have never actually been observed in healthy, human subjects.

At least not yet…

What Kind Of Results Can I Expect With Fasoracetam?

Here’s the thing…

All the benefits Fasoracetam is said to provide are based on a combination of what little research has been conducted in rodents and the subjective experiences of nootropic users which you’ll find all over the internet.

I’ve read everything from “It changed my life” to “I didn’t feel a thing”.

Some of the most commonly reported benefits of Fasoracetam are:

  • better memory
  • faster reaction time
  • more creativity
  • increased motivation
  • mild stimulation
  • less social anxiety
  • attention/learning enhancements

Whether you’ll experience any of these benefits, all of  them, or none of them likely depends on a bunch of variables including your individual brain chemistry.

I’m not going to promise you the world of Fasoracetam. There are plenty of bloggers and forum contributors doing that already.

I’ll just leave it at this…

Fasoracetam MIGHT improve your cognitive abilities to a noticeable extent.  It’s not guaranteed though.

Keep in mind that these kinds of nootropics take time for the benefits to become noticeable.

It’s possible that you take Fasoracetam and immediately feel something, but it’s really meant to improve cognitive function over time (at least several weeks).

 

What Is An Effective Dosage Of Fasoracetam

In the one human study I referenced above, subjects took 100mg of Fasoracetam per day.

There were no reported side effects at this dose, but since this study didn’t actually measure cognitive function, it’s not clear how effective that dose is.

If you read reviews and testimonials of Fasoracetam users, some of them report benefits in the 10-50mg range, while others take much higher doses.

So, it would appear as though Facoracetam is safe up to at least 100mg/day but potentially effective at lower doses anyway, making the need to super-dose it non-existent.

Just stick with somewhere between 50 and 100mg to start and see how it goes.  There’s no need to take massive 500mg doses of Fasoracetam.

Does Fasoracetam Have Any Side Effects?

Due to a lack of research, it’s difficult to draw solid conclusions about the kinds of side effects users of Fasoracetam are likely to experience.

If you care to speculate based on other racetams, though, side effects would include:

  • headache
  • vertigo
  • mild nausea (maybe)

Overall, there’s no reason to suspect that Fasoracetam will cause any sort of notable side effects at normal doses, but it’s possible.

The one human study in which subjects were given 100mg of Fasoracetam, reported no adverse effects.

Of course, individual brain chemistry would probably be the deciding factor here.

Some people may experience side effects while others experience nothing at all.  This is true of all psychoactive substances.

If you’ve taken Fasoracetam and have experienced any sorts of side effects, I’d love to here about those too (comment below)!

Is Fasoracetam Legal?

In the US, Fasoracetam is technically considered an unapproved drug, meaning it can’t be sold for the purposes of human consumption.

That doesn’t mean you can’t buy it.  It just means that companies who sell it as a dietary supplement may get in some trouble down the road.

You see, in the United States, we have a massive legal gray area for research chemicals.  When a drug is unapproved but isn’t a scheduled substance, it can be sold as a research chemical.

Although a lot of nootropics are considered research chemicals, and therefore cannot be sold for human consumption, a lot of companies label them as supplements anyway.

Ultimately, as the consumer, you’re not going to be on the hook for anything.  The company that sold it to you is.  So who really cares?

Just make sure you’re getting your Fasoracetam from a trusted source.  That’s really what matters.  Not whether or not it says ‘dietary supplment’ in tiny font at the bottom.

Where To Buy Fasoracetam

Fasoracetam can be purchased from a number of online vendors.  As with any research chemical though, source REALLY matters.

Some vendors are going to rip you off.  Others are going to give you a high quality, reliable product.

Do your research on forums like reddit and make sure your vendor accepts credit cards.  That way, if there’s an issue you can file a dispute and you won’t be on the hook.

In fact, accepting credit cards is a positive signal.

Most vendors who accept credit cards don’t want to deal with charge-backs, so they’re more likely to provide a quality product and good customer service.

I’ve never purchased Fasoracetam, but I’ve purchased other nootropics (which were legit) from the following vendors:

Of course, there are others.  These are just a couple that I know and trust.

If you’ve purchased Fasoracetam from a vendor and can vouch for them, feel free to comment below!

Some Other Nootropics To Consider

I’m not hating on Fasoracetam, but the reality is it’s still very under-researched.

We really don’t know exactly what it’s capable of at this time.

There’s no reason NOT to give Fasoracetam a shot, I guess, but if you really want to optimize your cognitive abilities, you should start with the basics.

By that I mean developing a stack of a few core supplements that have actually been PROVEN to work and trying that for a while.

I recommend the following supplements:

  • Alpha GPC
  • Phosphatidylserine
  • Bacopa Monnieri

In fact, this is a pretty effective nootropic stack on it’s own.

At the very least, though, it provides a solid foundation upon which you can experiment with other more speculative nootropics, like Fasoracetam.

Let’s talk about each of these ingredients in a little more detail, so you understand what you’re taking (and why).

Alpha GPC

Alpha GPC is a natural choline-containing phospholipid.

All phospholipids play a role in maintaining the structural integrity of cell membranes, but Alpha GPC is special because it also contributes Choline for the production of Acetylcholine.

Acetylcholine is an important neurotransmitter which is involved in various aspects of cognitive function such as learning and memory.

Higher Acetylcholine levels are seen as inherently beneficial for cognitive function and Alpha GPC is considered one of the most effective supplements for increasing Acetylcholine levels.

Studies show it can help preserve cognitive function in people with cognitive impairments, but there is some evidence to suggest it works in young, mentally healthy people as well.

There’s more than enough evidence to conclude that Alpha GPC supports optimal brain health and better cognitive function.

A clinical dose of Alpha GPC is anywhere from 600-1200mg/day.

Unfortunately, because it’s an expensive ingredient, most companies under-dose it.

You’ll typically find anywhere from 300mg all the way down to 50mg of Alpha GPC in most multi-ingredient nootropic supplements.  So, if you truly want to reap the benefits Alpha GPC has to offer, it’s a better idea to just purchase it separately and dose it correctly.

After years of researching supplements, experimenting with different ones, and eventually launching my own supplement company, I arrived at the unfortunate realization that you really can’t trust most supplements.

You may think all single-ingredient supplements are the same, but independent studies have confirmed that many supplements contain lower levels of the ingredients than what is listed on the label.

Sometimes it’s intentional.  Sometimes it’s just a matter of manufacturers sourcing poor quality ingredients and not getting them tested.

Upon realizing and accepting this unfortunate reality, I did the only think I could think of…

I made my own Alpha GPC supplement!

Singular Sport Alpha GPC With AlphaSize

LEARN MORE

Singular Sport Alpha GPC uses AlphaSize®, a patented form of Alpha GPC which is produced with quality in mind and subject to identity, purity, and contaminant testing.

In other words, it’s the only Alpha GPC you can really trust.

You take a chance with some off-brand Alpha GPC supplement, but with Singular Sport Alpha GPC, you can be absolutely sure that you’re getting what you pay for.

Phosphatidylserine

Phosphatidylserine is also a phospholipid, but it does not directly supply the body with Choline like Alpha GPC.

Studies show that Phosphatidylserine can improve cognitive function, not just in people with memory impairments, but in perfectly healthy individuals as well.

It’s not 100% how Phosphatidylserine elicits its impact on cognitive function, though.

Research indicates it may work by:

Research has revealed that it has some stress-reducing properties as well which may further optimize performance.

A clinical dose of Phosphatidylserine is anywhere from 200-800mg/day.

Unfortunately, as is the case with Alpha GPC, Phosphatidylserine tends to be under-dosed for cost-cutting purposes.

So, again, it’s a better idea to just buy it separately and dose it correctly.

Phosphatidylserine is a lot like Alpha GPC in the sense that it’s difficult to manufacture and most suppliers aren’t keeping quality in mind.

That’s why I decided to throw my hat in the ring…

Singular Sport Phosphatidylserine uses 100% SerinAid®, a patented form of Phosphatidylserine made by the same company (Chemi Nutra) that makes AlphaSize®.

bottle of Singular Sport Phosphatidylserine with SerinAid

LEARN MORE

You can roll the dice with some off-brand form of Phosphatidylserine that’s a tiny bit cheaper, but if you want to be absolutely sure that you’re Phosphatidylserine is of the highest quality, and contains exactly the dose listed on the label, you want Singular Sport Phosphatidylserine.

Quality and transparency.  That’s what I’m about.  That’s what Singular Sport is about.

Citicoline

Citicoline, also known as CDP-Choline is a molecule which, upon ingestion, contributes both Choline for the production of Acetylcholine and Cytidine for the production of Uridine.

Higher levels of Acetylcholine and Uridine are associated with improved cognitive function.

Research shows that Citicoline can improve aspects of cognitive function such as memory and attention.

In terms of Acetylcholine-boosting abilities, Citicoline is right up there with Alpha GPC, but since it increases Uridine levels as well, there appear to be additional benefits, beyond what Alpha GPC can provide alone.

For that reason, it makes sense to supplement with both of them.

A clinical dose of Citicoline is 250mg which is exactly how much I included in my clinically-dosed fat-burner, Formula 56.

The Bottom Line On Fasoracetam

Fasoracetam is a promising nootropic which seems to be stronger than Aniracetam and comparable to Noopept in terms of potency.

Unfortunately, the research on Fasoracetam is limited to a few rodent studies and one or two human studies, which didn’t test the effects of the drugs in normal, healthy people.

That said, the preliminary research indicates there might be something to it and, if you spend enough time reading forums and reviews, people have some pretty positive things to say about Fasoracetam.

Personally, I like to stick with nootropics that have actually been proven to work (and be safe), but if you want to roll the dice on Fasoracetam, go ahead.

The risks appear minimal and the upside looks good.

Have Any Experience With Fasoracetam?  Anything To Add?  Comment Below…

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