Etizolam: Everything You Need To Know


When it comes to research chemicals, nothing rings bells like Etizolam.

It’s been around for decades, but has gained massive popularity in recent years as a recreational drug, similar to Xanax.

In this article, we’ll discuss everything you need to know about Etizolam, including:

  • What It Is
  • The Effects
  • How It Works
  • Dosage
  • Side EffectsA
  • Addictive Potential
  • Legality
  • Drug Testing
  • Where To Buy

And, of course, I’ll share my personal experience as well (I’ve got plenty).

You can think of this article as what’s missing when you google “Etizolam”.

The scientific evidence AND the anecdotal.

So, if you’re ready to learn just about everything there is to learn about Etizolam, read on…

What Is Etizolam?

Etizolam tablets

Etizolam is a pharmaceutical drug which belongs to a class of chemicals known as Thienodiazepines.


Thienodiazepines are closely related to the more commonly known, Benzodiazepines, a family of chemicals which includes drugs like:

  • Alprozolam (Xanax)
  • Clonazepam (Klonopin)
  • Lorozepam (Ativan)
  • Temazepam (Norkotral)
  • Diazepam (Valium)

Etizolam works similarly to these drugs by acting on the same set of receptors and producing the same kinds of psychoactive effects.

In terms of onset, effects, and dosage, it falls somewhere between Clonazepam and Alprazolam.

Etizolam was originally developed in Japan in the early 1980’s as a treatment for anxiety and insomnia.  Currently, it’s a prescription drug in Japan, India, and Italy.

In the US, however, it remains unscheduled at the federal level.

This has led to an explosion in recreational use, as there is no federal law banning its sale, distribution, or use.

We’ll get more into the legal status of Etizolam a little further down (in the Legality section), but first, let’s talk about what it does and how it works.

What Are The Effects Of Etizolam?

Etizolam Effects

Like similar drugs (benzodiazepines), Etizolam has been shown to:

Research also indicates that Etizolam produces an anti-depressant effect that is greater than that of Alprozolam (Xanax) or Bromazepam (another benzo that isn’t very popular anymore).

Thienodiazepines, in general, are also used for their muscle relaxant effects, making Etizolam a popular choice among people who suffer from muscle stiffness, pain, or spasms.

At higher doses, Etizolam produces a high that is similar to that of Xanax (and other benzos).

The direct effects include things like:

  • relaxation
  • mild euphoria
  • feeling less inhibited
  • sedation/drowsiness
  • not caring about stuff

If you’ve taken any kind of benzodiazepine drug before–like Xanax, Valium, or Klonopin–then you can imagine what the Etizolam high feels like.

For all intents and purposes, it’s pretty much a benzo.

How Does Etizolam Work?

How Etizolam Affects The Brain

Etizolam, like all benzodiazepines, works primarily by influencing the action GABA receptors.

GABA is the chief inhibitory neurotransmitter in the brain.  It’s job is simply to inhbit the firing of neurons (communications between brain cells) which reduces overall brain activity.

You see, on a fundamental level, anxiety is the result of too much brain activity.

That translates to over-thinking, stressing, and freaking out about things that probably aren’t worth freaking out about. You know…

All the usual symptoms of anxiety.

Any substance that increases the activity of GABA in the brain is most likely going to have some kind of anxiolytic (anxiety-reducing) effect.

It just so happens that Etizolam is particularly potent in this regard.

In terms of dosage, it’s roughly as potent as Xanax and has extremely similar effects.

Etizolam is rapidly absorbed, with peak concentrations being reached in the 30 minute to 2 hour range.  It has a biological half-life of about 3.5 hours, meaning the effects may last for several hours.

People who use Etizolam to go to sleep, sleep better, or stay sleep longer may experience some grogginess the next day.

When taken during the day, drowsiness is not uncommon, as is the case with pretty much anything that acts on GABA receptors, like Phenibut for example.

Etizolam Dosage

Etizolam is similar to Xanax in terms of dosage, requiring no more than 1 or 2mg to exert its effects.

It typically comes in 0.5 or 1mg tablets and if you’re actually just trying to reduce anxiety, you don’t need much more than that.

People who are using Etizolam to get high obviously take higher doses, but even 2mg for a first-time user can be heavy enough to put you to sleep.

Everyone’s tolerance is different and there’s no easy way to predict it, so it’s probably not a good idea to take more than 1mg your first time around.

Once you see how you respond to 1mg, you can decide whether or not to increase the dose.

Personally, I use no more than 2mg of Etizolam at a time because I tend to just fall asleep at higher doses, but I’ve taken up to 10mg at a time for the sake of experimentation.

To be honest, I think high doses are just kind of a waste, but it really depends what your goal is I guess.

What Are The Side Effects Of Etizolam?

The Side Effects Of Etizolam

Etizolam has been shown to be remarkably well-tolerated (safe) when used at normal doses.

While there is some evidence which suggests the side effects are less severe than say, Xanax, there are still plenty of side effects to be wary of.

  • Drowsiness
  • Dizziness
  • Disorientation
  • Dependence (addiction)
  • Headaches
  • Impaired Motor Abilities
  • Lack Of Motivation

Of course, this is basically the same list of side effects associated with most anti-anxiety drugs.  Etizolam is no more likely to cause negative side effects than similar substances.

In fact, there is evidence to suggest that it’s less addictive than benzodiazepines.

This may actually explain why it’s not pushed on us by pharmaceutical companies the same way Xanax is.

Think about it like this…

If you sold drugs, would you rather sell an addictive substance, or a HIGHLY ADDICTIVE substance?

Assuming you had absolutely no moral compass (like a pharmaceutical company), you’d obviously want to push the highly addictive substance.

From this perspective, it’s easy to see why Etizolam has been side lined by big pharma.  They’d just rather have you on Xanax because it’s slightly more addictive!

It’s really that simple.

Is Etizolam Addictive?

Is Etizolam Addictive?

Yes, if taken too frequently, Etizolam can become an addiction.

Research indicates  it may be less addictive than what’s currently prescribed for anxiety in the US (Xanax, Klonopin, etc.) but taking it everyday and then stopping can result in severe withdrawal symptoms.

Etizolam withdrawal symptoms are similar to benzo withdrawal symptoms.

  • agitation
  • trouble sleeping
  • loss of appetite
  • anxiety/panic attacks
  • muscle spasms

So, it’s really no joke.

Don’t think that just because it’s unscheduled (in the US) that addiction isn’t an issue.

If you take Etizolam every day (or every night), you may very well find yourself addicted.  Once you’re phsyically addicted, stopping immediately can lead to sudden and possibly severe withdrawal.

Etizolam Legality (It’s Complicated)

Is Etizolam Legal?

This is the interesting part…

In the US, Etizolam is not a controlled substance, meaning it isn’t classified as anything.

At the federal level, it’s considered an unscheduled drug which means it’s entirely legal to possess, buy, or distribute, just not for the purposes of human consumption.

However, some states have taken the liberty to schedule Etizolam (most likely due to lobbying from pharma companies who see it as competition for the Xanax their pushing on people), so it is illegal to buy, sell, and possess in certain states.

The states which have officially banned the use of Etizolam (meaning they have laws on the books) include:

Some of these states have made Etizolam a Schedule I drug (highest level of abuse potential) while others have made it a schedule IV drug (relatively low abuse potential).

The fact that it remains unscheduled at the federal level, however, has opened up a massive gray area where anyone can order it on the internet legally under the assumption that they’re using it for research purposes only.

Of course, most people buying Etizolam aren’t giving it to rats and studying the effects; they’re just taking it themselves.

But that’s the good old US government for you!

Until  it becomes a big enough issue for congress to actually talk about, it’s up to each individual state as to whether it’s legal or illegal and let’s face it…

Most state legislators have bigger fish to fry, but when they’re done ‘tackling the opiod epidemic’ (good luck), they’ll be on the lookout for their next target, no doubt about it.

So far, Etizolam remains legal in most states.

Will Etizolam Show Up On Drug Tests?

There’s some debate as to whether Etizolam will trigger a false positive for benzodiazepines on drug tests.

Technically, Etizolam is not a benzodiazepine.  It’s a thienodiazepine.

It’s unlikely that Etizolam would trigger a false positive for benzodiazepines on a store-bought urine test, but it’s entirely possible that GC/MS testing has evolved to the point where they test for Etizolam at certain labs.

There are some reports of people failing drug tests for Etizolam specifically.

Again, it depends on the type of test.  If you’re in rehab and your urine gets sent to a lab, I wouldn’t mess around with Etizolam.

Even if they don’t currently test for it, it won’t take too long for them to figure out that all the benzo-addicts have switched to Etizolam to circumvent their drug tests.

If you’re concerned about a drug test for a job, on the other hand, there’s probably nothing to worry about.

This may sound cliche but…

The best way to pass a drug test is to refrain from using drugs. 

As someone who spent the majority of his teen years in and out of various drug programs, trying to figure out ways to trick the tests before ultimately realizing the best way to not get caught is to actually not do drugs, that’s the best advice I can give you.

Take it or leave it.

My Personal Experience With Etizolam

My Personal Experience With Etizolam

To be honest,  I don’t like drugs that slow me down.

As I explained pretty thoroughly in my articles on Focalin and Modafinil, though, I’m no stranger to drugs that help you get stuff done.

So why then, you might ask, would I want anything to do with Etizolam?


Because life is stressful sometimes and there’s nothing like a Lam or two to relieve the tension.

I don’t have any kind of anxiety disorder, but I’ve had prescriptions for Xanax and Klonopin (both benzos which are similar to Etizolam in terms of potency and effects), but to tell you the truth I really wasn’t a big fan.

Sure, they eliminate anxiety and can be potentially useful during stressful situations, but they also turned me into a dysfunctional zombie.

I first tried Etizolam after reading about it as a legal alternative to the more commonly prescribed benzos for anxiety and stress.

Perhaps the most intriguing aspect of Etizolam was the fact that it is a prescription medication in countries like Japan, India, and Italy.  This adds an element of legitimacy that other research chemicals (like Clonazolam) lack entirely.

Most of these chemicals are cooked up in underground labs by who knows using methods that aren’t exactly ‘textbook chemistry’.

Etizolam, on the other hand, is produced by pharmaceutical companies and sold in first world countries where it is subject to testing for things like identity, purity, potency, and harmful additives.

Since it’s entirely legal to buy and possess where I live, I decided to give the it a shot.

How Etizolam Affects Me

Etizolam is perhaps the only anxiety drug that doesn’t knock me out.  I can actually take it during the day (long, stressful days) and still get things done.

It just eases the tension, removes any anxiety I may be feeling, and when it’s time to go to sleep, it’s lights out!

I’ll be honest though…

I have pushed it to the limit in terms of both dosage and frequency and I can tell you first-hand that the more you take. and the more frequently you take it, the more likely you are to become physically addicted.

Withdrawal is a bitch.  You don’t want to go through it.  Trust me!

When I first starting taking Etizolam, I got carried away and ended up using it every night to fall asleep.  When I tried to stop taking it, i went through the worst withdrawal I ever could have imagined.

I couldn’t eat, sleep, or get anything done.  Not to mention, the rebound anxiety was HORRIBLE!

It took a couple weeks for me to feel normal again.

Trust me, you don’t want to end up there.  And if you do end up there, you want to taper yourself off, just like a doctor would with any other addictive medication.

No well-trained medical professional will ever recommend going ‘cold turkey’, especially with anything that’s benzo-related.

These days, I keep a supply of Etizolam on deck for emergencies, but I don’t use it often.  It’s pretty much just something I use to fall asleep on planes or chill out after I’ve had way too much Coffee or Adderall.

If I had to describe it, I’d say Etizolam is basically a cross between Alprazolam (Xanax) and Clonazepam (Klonopin), except better.

I don’t use it often, but when I do, it always does the trick.  No anxiety.  No stress.  Just a calm, functional state of relaxation.

Where To Buy Etizolam

Where To Buy Etizolam

You can buy Etizolam from a wide range of research chemical vendors, both domestic and abroad.

Of course, as with any gray area research chemical, there are a ton of scams out there, so source matters.


You can check out this article where I discuss 5 legit Etizolam vendors.

Definitely worth the read.

If you know of any other reliable vendors, feel free to comment below!

The Bottom Line On Etizolam

The Bottom Line On Etizolam

Unless you live in one of the few states in which it’s banned, Etizolam is like legal Xanax.  There’s really not much of a difference in terms of mechanisms, effects, or dosage.

The high you get with Etizolam is virtually indistinguishable from that of Xanax.

Research shows that they’re basically the same thing and, based on my experience, I’m inclined to agree.

The only real difference is one requires a prescription (Xanax) and one can easily (and legally) be ordered on the internet (Etizolam).

Make no mistake though…

Etizolam is some powerful stuff!

If you take it every day, you will almost certainly find yourself addicted.

If you’re going to give it a shot, make sure you use a reliable vendor and DO NOT take it every day.  Seriously.

Have Anything To Share About Etizolam?  Comment Below…

I’m Matt Theis, founder of SuppWithThat, Momentum Nutrition, and Singular Sport. I created SWT to separate the science from the hype and publish accurate, research-based information on supplements. If you like what I have to say here, feel free to check out my supplements at and

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