EHP Labs OxyRem: An Evidence-Based Review

OxyRem is a night-time fat-burner by EHP Labs.  The night-time fat-burner category is one that hasn’t really popped, perhaps because most supplements claiming to burn fat while you sleep don’t work.  But is there anything special about OxyRem?  Let’s take a look…

EHP Labs OxyRem


EHP Labs claims that OxyRem:

  • Promotes Restful Sleep
  • Helps Curb Your Appetite
  • Enhances Fat-Burning While You Sleep

Like we said earlier, night-time fat-burners are tough to pull off, the main reason being that most effective fat-burning ingredients are stimulants and stimulants will keep you awake at night.  Still, there are some ingredients that can effectively facilitate fat-loss through non-stimulant mechanisms, right?  So why can’t a night-time fat-burner be effective?

That may be true, but for some reason  every night-time fat-burner we’ve ever seen was weak at best and usually just completely ineffective.  So does OxyRem have what it takes to surprise us (positively)?  Let’s take a look…

OxyRem Ingredients

OxyRem contains several active ingredients, some of which are intended to help you sleep deeper and some of which are intended to facilitate fat-loss in a few different ways.  Unfortunately, EHP is still using proprietary blends, so it’s tough to tell how much of each ingredient is in there…


GABA is the chief inhibitory neurotransmitter in the brain.  In other words, it’s a naturally produced chemical messenger that helps your brain settle down when its excited.  GABA receptors are the target of various anti-anxiety and sleep medications, so GABA itself has been investigated as a supplement for anxiety and sleep.

If you google “GABA Supplements”, you’ll probably find a bunch of nonsense about GABA not being able to cross the blood brain barrier and therefore being an ineffective oral supplement.  Although there was some initial skepticism about the bioavailability of GABA supplements, high enough doses are still effective.

We discuss GABA in much more depth in our article 3 Effective Sleep Aids To Consider, for anyone interested in learning more.

Raspberry Ketone

Raspberry Ketone is a natural component of Raspberries, responsible for their tart taste.  It’s popularity as a weight-loss supplement has grown in recent years, mostly due to Dr. Oz making a big deal about it, but research indicates it isn’t nearly as effective as initial reports suggested.

In fact, it has never actaully been shown to induce weight-loss in human subjects and the concentrations used in vitro (cells in a test tube) is so high that it isn’t realistic via supplementation.


Theanine is a non-dietary amino acid found almost exclusively in Green Tea.  It has long been believed to be the reason that Green Tea, despite containing Caffeine, is relaxing in nature and doesn’t seem to cause the same types of side effect as other Caffeine sources.

Research indicates Theanine can enhance the benefits of Caffeine while reducing the negatives, but it has also been studied in isolation (without Caffeine) and has been shown to induce calmness and relaxation (without drowsiness).

This makes it useful in any supplement that is intended to bring about a state of relaxation, such as OxyRem.


Gymnema Slyvestre

Banaba Leaf

Cinnamon Bark

Trace Mineral Foundation Blend


OxyRem Ingredient Takeaway

OxyRem definitely has what it takes to help you acheive deeper, more restful sleep, but it leaves something to be desired in the area of fat-loss.  There are a few ingredients that may help control blood glucose (which could encourage weight-loss in the long-term), but you’ll almost certainly be disappointed if you’re expecting any kind of profound weight-loss.  If fat-loss fast is your goal, check out our Top 10 Fat-Burners list.

Is OxyRem Safe?

OxyRem is perfectly safe.  There is nothing in it that is habit-forming or dangerous.

The Bottom Line.

When it comes to night-time fat-burners, many have tried and few have succeeded.  Actaully, as far as we know, none have succeeded.  Unfortunately, OxyRem is no exception.  If you’re looking for a fat-burner, you’d be better off just going with something that contains stimulants and actually works.  Such products can be found on our Top 10 Fat-Burners list.  If you’re looking for a sleep-aid, OxyRem may get the job done, but so do 1000 other supplements that contain GABA and Melatonin, for a lot cheaper. exists to educate the supplement community and seperate the science from the hype.

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