Super HD Xtreme is the most recent release from Cellucor which is essentially a high-stim-powered version of the brand’s fat-burner, Super HD…FIND IT HERE
Caffeine triggers the release of Noradrenaline, a potent activator of lipolysis (fat-breakdown). This is primarily why Caffeine is a major ingredient in fat-burners such as Super HD Xtreme.
Cellucor does not disclose the amount of Caffeine Anhydrous present in Super HD Xtreme but based on a 435mg proprietary blend we would estimate somewhere between 150-250mg per serving.
Theacrine is an alkaloid found almost exclusively in Camellia Assamica, also known as Kucha tea. In terms of its chemical structure, Theacrine (1,3,7,9-tetramethyluric acid) is very similar to Caffeine (1,3,7-trimethylxanthine), so its physiological effects are alleged to be similar as well.
We discuss the research behind Theacrine in this article but, to make a long story short, it appears to increase perceived energy levels in humans.
Theacrine definitely helps to enhance the energy aspect of Super HD Xtreme and may enhance the fat-burning effects of such compounds as Caffeine (though further research is needed).
Capsimax is a standardized form of Red Pepper Extract which contains the compound, Capsaicin. Capsaicin has been shown to increase in fat oxidation(relative to placebo) during low intensity exercise in healthy adult males.
In the context of Super HD Xtreme, Capsaicin helps round out the non-stimulant component of the formula.
The combination of Caffeine and Pterostilbene is alleged to have a less rapid onset and offset, effectively smoothing out the transition of perceived energy. Theoretically, this should help the Super HD Xtreme formula in terms of fat-burning as well as duration of perceived energy.
Sceletium tortuosum, also known as Kanna, is an herb mostly indigenous to South Africa which has a long history of use as a mood elevator/anxiolytic. Kanna contains two types of alkaloids, mesembrine tortuosamine, which are alleged to convey the psychoactive effects.
A 2011 study published in the “Journal of Ethnopharmacology” found that Sceletium tortuosum extract had limited anxiolytic effects in rats subjected to psychological stress (in the form of restraint).
While no mechanism of action has been established, the results of the study indicated that the herb does not act as a serotonin reuptake inhibitor (SSRI).
In the context of Super HD Xtreme, Sceletium may help improve mood and cognition.
Ruawolfia Vomitoria is standardized for Rauwolscine (alpha-Yohimbine) which is a close chemical relative of Yohimbine. In the context of Thermo Rev, its function is basically the same, although the psychoactive effects (perceived energy, improved mood, focus, etc.) may be more potent than Yohimbine.
Cellucor doesn’t disclose the exact amount of Rauwolscine present in Super HD Xtreme but given that very small quantities (1mg) are effective, we aren’t worried about any under-dosing.
The Bottom Line
Super HD Xtreme may be moderately effective as a fat-burner. Since most of the weight-loss potential is derived from stimulants, we wouldn’t recommend it to those who are particularly sensitive to stimulants, have anxiety, or are looking for a non-stimulant weight-loss solution.
Still not sure which fat-burner is right for you? Check out our Top 10 Fat-Burners List!
[expand title=”REFERENCES” tag=”h5″]
- Wang, Yuanyuan, et al. “Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.” Fitoterapia 81.6 (2010): 627-631.
- Feduccia, Allison A., et al. “Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors.” Pharmacology Biochemistry and Behavior 102.2 (2012): 241-248
- Habowski, S. M., et al. “The effects of TeacrineTM, a nature-identical purine alkaloid, on subjective measures of cognitive function, psychometric and hemodynamic indices in healthy humans: a randomized, double-blinded crossover pilot trial.” Journal of the International Society of Sports Nutrition11.Suppl 1 (2014): P49.
- Graham, T. E., and L. L. Spriet. “Metabolic, catecholamine, and exercise performance responses to various doses of caffeine.” Journal of Applied Physiology 78.3 (1995): 867-874
- Graham, Terry E. “Caffeine and exercise.” Sports medicine 31.11 (2001): 785-807.
- Ebashi, S., and Mi Endo. “Calcium and muscle contraction.” Progress in biophysics and molecular biology 18 (1968): 123-183
- Poisner, Alan M. “Caffeine–Induced Catecholamine Secretion: Similarity to Caffeine–Induced Muscle Contraction.” Experimental Biology and Medicine142.1 (1973): 103-10
- Kim, Kyung-Mi, et al. “Increase in swimming endurance capacity of mice by capsaicin-induced adrenal catecholamine secretion.” Bioscience, biotechnology, and biochemistry 61.10 (1997): 1718
- Costill, D. L., Gl P. Dalsky, and W. J. Fink. “Effects of caffeine ingestion on metabolism and exercise performance.” Medicine and science in sports 10.3 (1977): 155-158.
- Ohnuki, Koichiro, et al. “Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice.” Bioscience, biotechnology, and biochemistry 65.12 (2001): 2735-2740.
- Smith, C. “The effects of< i> Sceletium tortuosum in an< i> in vivo model of psychological stress.” Journal of ethnopharmacology 133.1 (2011): 31-36.
- Smith, Michael T., et al. “Psychoactive constituents of the genus< i> Sceletium NE Br. and other Mesembryanthemaceae: a review.” Journal of ethnopharmacology 50.3 (1996): 119-130
- WATANABE, TATSUO, et al. “Adrenal sympathetic efferent nerve and catechol secretion excitation caused by capsaicin in rats.” (1988).
- Perry, Bruce D., and David C. U’Prichard. “[3 H] rauwolscine (α-yohimbine): A specific antagonist radioligand for brain α 2-adrenergic receptors.” European journal of pharmacology 76.4 (1981): 461-464.