Alpha T1 is marketed by Advantage Nutraceuticals as a Testosterone-Booster. The ingredient profile is similar to other test-boosters we’ve reviewed, some of which are effective, but we have our concerns about dosing…
D-Aspartic Acid has become extremely popular as a Test-booster in recent years, with research suggesting it is indeed effective, at least in the short term, though we have our concerns about the dose present in Alpha T1
A 2012 study from “Advances in Sexual Medicine”, the subjects of which were infertile men (initially low Testosterone) found that 2.66g of D-Aspartic Acid was able to significantly increase Testosterone levels when measured after 90 days of supplementation. These results were in-line with those of an earlier study from 2009 in which D-Aspartic Acid supplementation raised Testosterone by 42% after 12 days in healthy men (initially normal Testosterone).
However, a 2013 study published in “Nutrition Research” found that athletes who supplemented with D-Aspartic Acid for 28 days showed no difference in testosterone levels.
The researchers in the failed study noted abnormally high levels of D-Aspartate Oxidase, the enzyme which degrades D-Aspartic Acid, indicating that prolonged supplementation in individuals with healthy Testosterone levels may cause “negative feedback”.
Alpha T1 contains an undisclosed amount of D-Aspartic Acid but, based on the weight of the proprietary blend as a whole, a clinical dose is impossible.
Tribulus has a well-documented history of use as an aphrodisiac and libido enhancer and this is commonly alleged to be the result of increased Testosterone. That, however, is a misconception.
A 2005 study, published in the “Journal of Ethnopharamcology” found that 200mg daily (60% saponin content) had no effect on Testosterone in healthy men.
These results were replicated in a 2007 study in which 450mg of Tribulus extract daily failed to influence Testosterone levels in male athletes.
Even a 2012 study, this time testing the effects of 6g of Tribulus extract on infertile men, found a less than significant trend towards increased Testosterone.
Tribulus may fuel the libido enhancement properties of Alpha T1, but will not boost Testosterone.
Calcium Fructate is a combination of Calcium, Fructose, and Boron, which is touted to be a superior delivery form of Boron.
Boron has somewhat of a questionable track record regarding its use as a test-booster. In the early days of bodybuilding, Boron became popular, but then lost popularity (one would think because it doesn’t work).
Recently, however, Boron is making a come-back with the same claims attached to it. A 2011 study, published in the “Journal of Trace Minerals in Medicine and Biology”, found that boron supplementation (11.6 mg daily) over a one week period was found to increase Testosterone to a statistically significant degree (28%).
An earlier study (1993), found that daily supplementation with 2.5 mg of boron over a 7 week period failed to increase testosterone levels.
The obvious reason for the discrepancy is that the 2011 study used 4-5 times as much boron as the earlier study. So, assuming Alpha T1 provides at least 11.6mg of Boron, it may encourage higher Testosterone levels, Unfortunately, because the entire Alpha T1 formula is one proprietary blend, we don’t know the exact dose of Boron.
Coleus Forskohlii is generally standardized for the active component, Forskolin (sometimes spelled Forskohlin), which has implications for both weight-loss and increasing Testosterone. Forskohlin works by increasing Cyclic Adenosine Monophosphat (cAMP), a signaling molecule which, when elevated, can induce a wide variety of physiological changes including increased Tesetosterone, increased lean body mass, and decreased fat mass.
A 2005 study, published in “Obesity Research”, found that Forskohlin (25mg/day for 12 weeks) increased Testosterone (total test increased 16%, free test increased 3.4%) and favorably influenced body composition in obese men.
Though the effects of Forskohlin on Testosterone levels in humans have not been studied extensively, Forskohlin is quite reliable at increasing cAMP, and cAMP is quite reliable at increasing Testosterone. So ultimately, Forskohlin possesses a sound mechanism by which it can positively influence Testosterone levels in humans.
Unfortunately, we can’t be certain that Alpha T1 contains an effective dose of Forskolin.
HORNY GOAT WEED:
Horny Goat Weed is generally used as an aphrodisiac and libido enhancer, but does possess mechanisms by which it may boost Testosterone. These effects are primarily attributed to the active compound, Icariin.
A 2006 study, published in the “Asian Journal of Andrology”, found that Icariin (80mg/kg) was able to increase Testosterone roughly three times as much as the control group in chemically castrated mice.
However, the dose used in this particular study would be roughly equivalent to a 200lb human consuming 1150mg pure Icariin daily. That being said, Icariin has demonstrated varying degrees of efficacy at varying doses, so it is possible that there is a slight influence at the dose present in Isa-Test DA3. At the very least, Icariin supplementation is generally associated with enhanced libido and sexual well-being (providing the illusion of increased Testosterone without the strength gains).
Alpha T1 contains an undisclosed dose of Icariin but, based on the weight of the proprietary blend as a whole, we can be certain that it contains nowhere near what has been used in studies.
Eurycoma Longifolia, also known as Tongkat Ali has been shown, in various studies, to increase Testosterone in male rats, but the only human studies that exist have tested the effects on infertile men.
A 2010 study published in the “Asian Journal of Andrology” found that supplementation with 200mg of an extract of Eurycoma Longifolia significantly improved various indications of male fertility (in humans), though the mechanism of action was unknown.
A 2012 study published in “Andrologia: Volume 44” (the same researchers from the above mentioned human study) found that men suffering from Hypogonadism (diminishing functionality of the gonads) who were treated with a 200 mg daily dose of Eurycoma longifolia extract reached normal Testosterone levels after a 30 day period. To be fair, at the start of the study about 35% of the men were showing normal Testosterone levels, and at the end about 90% showed normal levels. Still, 35% to 90% is clearly statistically significant.
Alpha T1 contains an unknown amount of Eurycoma Longifolia.
A 2003 study from the “Archives of Sexual Behavior” found that 12 weeks of Deer Velvet supplementation (1g/day) had no influence on Testosterone levels in male subjects.
A similar failure occurred in another 2003 study, this time from the “International Journal of Sports Nutrition and Exercise Metabolism”, using 1.5g for 11 weeks.
Advantage Nutraceuticals included Deer Velvet in the Alpha T1 formula because it contains IGF-1 which is a “key component in the production of lean muscle mass”. However, the second study mentioned above measured IGF-1 levels as well and found no influence at all using a higher dose than what could possibly be present in the Alpha T1 formula.
To put it simply: Deer Velvet in no way enhances the efficacy of the Alpha T1 formula. It’s just a “buzz” ingredient.
7-Keto DHEA is a metabolite of DHEA which has been investigated as a potential testosterone-booster.
A 2000 study, published in “Current Therapeutic Research”, found that 200mg of 7-Keto DHEA daily for 8 weeks had no influence on circulating Testosterone in adult males.
A 2005 study from “The Journal of Steroid Biochemistry and Molecular Biology” found that several DHEA metabolites, including 7-Keto DHEA, exhibited minimal influence on Androgen receptors.
Advantage Nutraceuticals does not disclose the amount of 7-Keto DHEA in Alpha T1, but it doesn’t really matter, since it isn’t an effective test-booster anyway.
A 1992 study from “Hormone and Metabolic Research” treated subjects with a combination of Alpha GPC and Growth Hormone Releasing Hormone (GHRH), the hormone that releases GH, or just GHRH. The researchers found that, while both groups experienced increases in GH, the combination of Alpha GPC and GHRH significantly increased GH response.
A 2008 study, published in the “Journal of the International Society of Sports Nutrition”, found that an acute dose of 600mg of Alpha GPC 90 minutes prior to exercise resulted in a significantly larger exercise-induced Growth Hormone spike compared to the placebo group, which normalized about 60 minutes post-exercise.
A 2012 study, published in “Hormone and Metabolic Research”, found that a single dose of Alpha-GPC increased plasma Choline levels and spiked circulating Growth Hormone levels when measured at 60 minutes post-ingestion. However, when measured at 120 minutes, Growth Hormone levels had returned more or less to baseline.
So, the claims made by Advantage Nutraceuticals about Alpha GPC boosting GH levels are correct but since levels return to normal very quickly, this probably isn’t practically relevant. Furthermore, there is no way Alpha T1 contains anywhere near the doses shown to do this.
Astragin is a patented combination of Panax Ginseng and Astragalus. Although each of these components have their own set of potential benefits, Atragin is marketed as an absorption enhancer. So, in the context of Alpha T1, it simply serves to enhance the absorption of the actual “key” ingredients. Astragin has been shown to enhance the absorption of Citrulline in vitro, but not in a living system at this time.
Piper nigrum, also known as Black Pepper, contains Piperine. Several studies have found that black pepper extract, when combined with other supplements, has increased the absorption of those supplements (as measured by plasma levels). Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).
Bioperine has no influence on Testosterone. It just serves as a means of enhancing the absorption of the other ingredients in Alpha T1.
THE BOTTOM LINE:
The main issue with Alpha T1 is one pertaining to the dosing of key ingredients. Pretty much every ingredient is under-dosed which negatively impacts the efficacy of the entire formula. Users may experience some libido enhancement, but any increases in Testosterone are unlikely in healthy individuals.
[expand title=”REFERENCES” tag=”h5″]
- D’Aniello, Gemma, et al. “d-Aspartate, a key element for the improvement of sperm quality.” Advances in Sexual Medicine 2 (2012): 45.
- Topo, Enza, et al. “The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats.” Reprod Biol Endocrinol 7.120 (2009): 6.
- Willoughby, Darryn S., and Brian Leutholtz. “d-Aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men.” Nutrition Research 33.10 (2013): 803-810.
- D’Aniello, Autimo, Anna Di Cosmo, Carlo Di Cristo, Lucio Annunziato, Leonard Petrucelli, and George Fisher. “Involvement of D-Aspartic Acid in the Synthesis of Testosterone in Rat Testes.” Life Sciences 59.2 (1996): 97-104.
- Rogerson, Shane, et al. “The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players.” The Journal of Strength & Conditioning Research 21.2 (2007): 348-353.
- Sellandi, Thirunavukkarasu M., Anup B. Thakar, and Madhav Singh Baghel. “Clinical study of Tribulus terrestris Linn. in Oligozoospermia: A double blind study.” Ayu 33.3 (2012): 356.
- Gauthaman, Kalamegam, and Adaikan P. Ganesan. “The hormonal effects of< i> Tribulus terrestris and its role in the management of male erectile dysfunction–an evaluation using primates, rabbit and rat.” Phytomedicine 15.1 (2008): 44-54.
- Gauthaman, K., P. G. Adaikan, and R. N. V. Prasad. “Aphrodisiac properties of< i> Tribulus Terrestris extract (Protodioscin) in normal and castrated rats.” Life Sciences 71.12 (2002): 1385-1396.
- Martino-Andrade, Anderson J., et al. “Effects of< i> Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats.” Journal of ethnopharmacology 127.1 (2010): 165-170.
- Neychev, Vladimir Kostadinov, and Vanyo Ivano Mitev. “The aphrodisiac herb< i> Tribulus terrestris does not influence the androgen production in young men.” Journal of Ethnopharmacology 101.1 (2005): 319-323.
- Ferrando, A. A., and N. R. Green. “The effect of boron supplementation on lean body mass, plasma testosterone levels, and strength in male bodybuilders.”International journal of sport nutrition 3.2 (1993): 140.
- Nielsen, Forrest H., et al. “Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.” The FASEB journal 1.5 (1987): 394-397.
- Henderson, Shonteh, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr 2.2 (2005): 54-62.
- Godard, Michael P., Brad A. Johnson, and Scott R. Richmond. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obesity Research 13.8 (2005): 1335-1343.
- Jagtap, Madhavi, H. M. Chandola, and B. Ravishankar. “Clinical efficacy of Coleus forskohlii (Willd.) Briq.(Makandi) in hypertension of geriatric population.”Ayu 32.1 (2011): 59.
- Zhang, Zhen‐Bao, and Qing‐Tao Yang. “The testosterone mimetic properties of icariin.” Asian journal of andrology 8.5 (2006): 601-605.
- Conaglen, Helen M., James M. Suttie, and John V. Conaglen. “Effect of deer velvet on sexual function in men and their partners: a double-blind, placebo-controlled study.” Archives of sexual behavior 32.3 (2003): 271-278.
- Sleivert, Gordon, et al. “The effects of deer antler velvet extract or powder supplementation on aerobic power, erythropoiesis, and muscular strength and endurance characteristics.” International journal of sport nutrition and exercise metabolism 13 (2003): 251-265.
- Tambi, M. I. B. M., M. K. Imran, and R. R. Henkel. “Standardised water‐soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late‐onset hypogonadism?.” Andrologia 44.s1 (2012): 226-230
- Ang, H. H., S. Ikeda, and E. K. Gan. “Evaluation of the potency activity of aphrodisiac in Eurycoma longifolia Jack.” Phytotherapy Research 15.5 (2001): 435-436.
- Zanoli, P., et al. “Influence of< i> Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats.” Journal of ethnopharmacology 126.2 (2009): 308-313.
- Ang, H. H., S. Ikeda, and E. K. Gan. “Evaluation of the potency activity of aphrodisiac in Eurycoma longifolia Jack.” Phytotherapy Research 15.5 (2001): 435-436.
- Tambi, Mohd Ismail Bin Mohd, and M. Kamarul Imran. “Eurycoma longifolia Jack in managing idiopathic male infertility.” Asian journal of andrology 12.3 (2010): 376-380.
- Bhat, Rajeev, and A. A. Karim. “Tongkat Ali (< i> Eurycoma longifolia Jack): A review on its ethnobotany and pharmacological importance.”Fitoterapia 81.7 (2010): 669-679.
- Kaiman, Douglas S., et al. “A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults.”Current therapeutic research 61.7 (2000): 435-442.
- Mo, Qianxing, Shi-fang Lu, and Neal G. Simon. “Dehydroepiandrosterone and its metabolites: differential effects on androgen receptor trafficking and transcriptional activity.” The Journal of steroid biochemistry and molecular biology 99.1 (2006): 50-58.
- Ziegenfuss, T. et al., “Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise,” Journal of the International Society of Sports Nutrition, 5(Suppl 1):P15, 2008.
- Kawamura, Takashi, et al. “Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults.” Nutrition 28.11 (2012): 1122-1126.
- Ceda, G. P., et al. “Alpha-glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects.” Hormone and metabolic research 24.03 (1992): 119-121.