Dialene is a stimulant-based fat-burner made by Scivation. In terms of ingredient profile, it is similar to other fat-burners on the market and contains nothing that can’t be found elsewhere.
GREEN TEA EXTRACT:
Multiple studies have confirmed Green Tea Extract appears to be able to induce fat-loss. Although this effect was originally thought to be related to caffeine content, more recent research has pointed to a green tea catechin known as Epigallocatechin gallate as the compound primarily responsible for these effects.
Epigallocatechin gallate (EGCG) is an antioxidant found in green tea, and is a member of the group of antioxidants known as catechins. In addition to these antioxidant properties, EGCG has demonstrated the ability to induce fat–loss when combined with caffeine, more than just caffeine alone. EGCG works synergistically with caffeine in regards to its effect on noradrenaline. Caffeine boosts noradrenaline while EGCG inhibits catechol-o-methyl transferase (COMT), the enzyme responsible for the degredation of noradrenaline.
So, caffeine increases noradrenaline, while EGCG prevents its breakdown, the net effect of which is increased levels of noradrenaline (which induces the breakdown of fat). Although caffeine is generally used along-side EGCG to induce catecholamine release, EGCG should be theoretically synergistic with endogenously produced catcholamines (from exercise) as well as other fat burning compounds that release catecholamines. With regards to fat-burning, scientifically validated doses of EGCG range from 400-500mg daily.
Given that the Green Tea Extract is standardized to 60% EGCG and it shares a 693mg blend with Caffeine and Yohimbine, it isn’t likely that the dose is within that range, but could be could be close.
Caffeine is the most widely consumed psychoactive substance in the world, and is a well-established ergogenic aid. Caffeine consumption causes an increase in Catecholamines (Adrenaline, Noradrenaline, and Dopamine), which tend to increase focus, concentration, and perceived energy while simultaneously promoting lipolysis. However, the weight loss effects of caffeine tend to fade with prolonged use, so it does not appear as though caffeine is a long-term effective fat burner. While caffeine’s weight loss potential is negligible, it increases focus and perceived energy in most people, which generally leads to more intense workouts (thus burning more fat), and may potentiate the action of other stimulants like yohimbine. While we don’t know the exact amount of caffeine present in the formula, we estimate it is slightly upwards of 200mg (based on the blend as a whole).
Yohimbine, which acts as an alpha-2 receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis (fat burning). By blocking the action of this receptor Yohimbine essentially “leaves the gates open” for lipolysis to occur. A 2006 study showed that while there were no increases in strength, supplementation induced fat loss in athletes (soccer players). As previously stated, Yohimbine directly acts on alpha-2 receptors, but its fat loss capabilities may also be magnified by its ability to increase the catecholamine neurotransmitters adrenaline and noradrenaline which in turn induce lipolysis. As mentioned above, an increase in these neurotransmitters may result in increased focus and workout intensity. However, this secondary effect tends to fade with prolonged use, leaving the alpha-antagonist effect (which does not appear to fade).
Raspberry Ketone, a molecular constituent of Raspberries, has become a popular weight-loss additive in dietary supplements. However, the evidence for Raspberry Ketone as a fat-burning ingredient is extremely limited and there is actually no direct evidence the ingredient is effective in oral, supplemental doses. In vitro studies using very high concentrations have shown positive results, but human studies are non-existent. The only human study that exists grouped Raspberry Ketone in with several other popular weight loss ingredients so the effects cannot be attributed to raspberry ketone. Even in rat studies, Raspberry Ketone has failed to show any significant fat-burning effects. The overall consensus of the scientific community is that Raspberry Ketone are nothing more than industry hype.
GREEN COFFEE EXTRACT:
A 2010 study from “Food and Chemical Toxicology” found noted multiple anti-obesity effects of Chlorogenic Acid administered to mice including increase beta-oxidations. However, Chlorogenic Acid may also have an alternative mechanism of action via inhibition of carbohydrate absorption.
A 2007 study, published in the “Journal of International Medical Research”, found that 12 weeks of Green Coffee (yielding 450-500mg Clorogenic Acid) supplementation resulted in a reduction (6.9%) in glucose absorption in healthy volunteers. Researchers also noted average weight loss of 5.4 kg (almost 12 lbs) over the duration of the study in the group receiving the Green Coffee Extract.
These findings conflict with an earlier 2006 study in which Green Coffee Extract (yielding 140mg Chlorogenic Acid) supplementation did not result in weight loss over the same 12 week period. The obvious difference between these two studies is that the dose of the first (positive) study was about 3 times the dose used in the second (negative) study. A 2012 study found that adults who consumed GCE (containing about 315mg Chlorogenic Acid) daily lost an average of 8kg with the average reduction in body fat being about 4%. Though GCE has shown mixed results in various studies, efficacy has been demonstrated using higher doses. However, one serving of Dialene does not contain such a dose, given that it shares a 355mg proprietary blend with several other ingredients and is standardized to 45% Chlorogenic Acid.
Hordenine (chemical name N, N-dimethyltyramine) is chemically related to the above mentioned Tyramine, and likewise, is used in dietary supplements as a fat-burner as well as for increased energy. Hordenine has been shown in animals to augment adrenaline induced muscle contraction while not directly inducing contractions itself, which indicates it works as a catecholamine (Adrenaline) reuptake inhibitor (similar to Tyramine). However, we’d like to be very clear that there is very little research published on the use of Hordenine in humans, especially as it relates to physical performance and exercise.
Perewinkle is generally standardized for the alkaloid Vincamine, which is then used to synthesize Vinpocetine. Vinpocetine is an effective vasodilator which has been demonstrated to increase cerebral blood flow (and thus slightly more oxygenation). Scivation claims that be acting as a vasodilator, Vinpocetine aids in the transport of fatty acids to the tissues for more efficient fat burning. Theoretically, this may seem plausible but currently there are no studies regarding Vinpocetine as a fat-burner. Although not commonly mentioned by supplement companies, Vinpocetine can fulfill a secondary role when it comes to stimulant-based fat-burners. Stimulants tend to be vasoconstrictors by nature, which may result in a feeling of pressure in the heads of individuals who are not used to these compounds. By acting as a vasodilator, Vinpocetine may help avoid potential stimulant headaches. Ultimately, we’d recommend taking stimulants with some sort of vasodilator to prevent this potential issue from occurring.
THE BOTTOM LINE:
Aside from Raspberry Ketone, the Dialene blend has substantial fat-burning potential, mostly fueled by the stimulants present in the formula. However, the doses of several of the ingredients are less than the scientifically validated doses used in the studies that have demonstrated efficacy. Therefore, two servings would likely have to be consumed to convey the full fat-burning benefits. At around 55 cents per serving, this may or may not be an ideal strategy, though one serving is certainly at the lower end of the range for fat-burners with similar ingredient profiles.
[expand title=”REFERENCES” tag=”h5″]
- Thielecke, Frank, et al. “Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study.” European journal of clinical nutrition 64.7 (2010): 704-713.
- Lu, Hong, Xiaofeng Meng, and Chung S. Yang. “Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (−)-epigallocatechin gallate.” Drug metabolism and disposition 31.5 (2003): 572-579.
- Keränen, Tapani, et al. “Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone.” European journal of clinical pharmacology 46.2 (1994): 151-157.
- Brown, A. L., et al. “Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial.” British Journal of Nutrition106.12 (2011): 1880-1889.
- Watanabe, Takuya, et al. “The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.”Clinical and experimental hypertension 28.5 (2006): 439-449.
- Thom, E. “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.” Journal of International Medical Research 35.6 (2007): 900-908.
- Vinson, Joe A., Bryan R. Burnham, and Mysore V. Nagendran. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.”Diabetes, metabolic syndrome and obesity: targets and therapy 5 (2012): 21.
- Wang, Lili, Xianjun Meng, and Fengqing Zhang. “Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.” Journal of medicinal food 15.5 (2012): 495-503.
- Park, Kyoung Sik. “Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes.” Planta medica 76.15 (2010): 1654.
- Morimoto, Chie, et al. “Anti-obese action of raspberry ketone.” Life sciences77.2 (2005): 194-204. 1
- Charney, Dennis S., George R. Heninger, and D. Eugene Redmond Jr. “Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine.” Life sciences 33.1 (1983): 19-29
- Sax, L. “Yohimbine does not affect fat distribution in men.” International journal of obesity 15.9 (1991): 561-565.
- Gurguis, George NM, Bernard J. Vitton, and Thomas W. Uhde. “Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls.” Psychiatry research 71.1 (1997): 27-39.
- Drew, Geoffrey M. “Effects of α-adrenoceptor agonists and antagonists on pre-and postsynaptically located α-adrenoceptors.” European journal of pharmacology 36.2 (1976): 313-320.
- Lim, C. C., P. J. Cook, and I. M. James. “The effect of an acute infusion of vincamine and ethyl apovincaminate on cerebral blood flow in healthy volunteers.” British journal of clinical pharmacology 9.1 (1980): 100-101.