Evogen Carnigen Review

Carnigen is a combination of multiple forms of Carnitine which Evogen positions as an “Energy and Recovery” supplement…

Evogen Carnigen


Carnitine and Weight Loss

Evogen’s claim that Carnitine “converts fat to energy” is technically true but a little misleading. On a cellular level, Carnitine is required for the transport of fatty acids into the mitochondria, where they are oxidized (burned) for energy. However, supplementing with Carnitine will not simply convert all your fat into energy. Unfortunately, it’s a little more complicated than that.

A 2002 study, published in “Metabolism”, found that Carnitine supplementation (1g/day) increased fatty acid oxidation rates in humans without Carnitine deficiency.

A 2004 study from the same journal found that L-Carnitine supplementation (3g/day) increased fatty acid oxidation in overweight subjects.

However, these two studies did not measure bodyweights before or after the supplementation period. While Carnitine supplementation does appear to increase fatty acid oxidation, this does not necessarily translate into weight-loss.

A 2005 study, published in the “International Journal for Vitamin and Nutrition Research”, found that Carnitine supplementation failed to influence weight-loss in rats.

In a 2000 study, L-Carnitine supplementation (4g/day) failed to influence fat mass, body mass, or resting lipid utilization in moderately obese women.

Carnitine does possess the mechanisms by which it “should” burn fat, but has yet to demonstrate actual weight-loss potential in a clinical setting. That being said, Carnitine supplementation can be an effective way of encouraging optimal fat-burning, even it doesn’t directly induce it. Carnigen provides roughly 1g total Carnitine per serving, so two or three servings a day provides more than enough to achieve a favorable fat-burning environment.

Carnitine and Recovery

When it comes to preventing muscle damage and aiding in recovery, Carnitine is actually quite effective.

A 2002 study, published in the “American Journal of Physiology-Endocrinology and Metabolism”, found that 2 grams of L-Carnitine L-Tartrate significantly reduced markers of exercise induced stress following squats in healthy adult males.

A 2007 study, published in the “Journal of Strength & Conditioning Research”, found that 1 and 2 grams of supplemental L-Carnitine L-Tartrate effectively reduced markers of muscular damage following exercise in healthy humans.

While the previously mentioned studies were unable to identify an exact mechanism of action, researchers in a 2008 study from the “Journal of Strength & Conditioning Research” noted signs of increased muscle oxygenation and concluded that this was likely the mechanism through which Carnitine prevented muscle damage.

Carnitine Orotate

A 2014 study, published in the “Journal of Gastroenterology and Hepatology”, found that a combination of Carnitine-Orotate and Metformin favorably impacted blood sugar levels in subjects with type 2 diabetes, moreso than Metformin by itself.

To be clear, these results tell us nothing about the efficacy of Carnitine-Orotate by itself, so whether it really makes a difference in the Carnigen formula is unclear.

The Bottom Line

As a weight-loss formula, Carnigen is iffy. While Carnitine has the mechanisms by which it could theoretically induce weight-loss, human studies have failed to note any actual weight-loss. Carnitine can certainly encourage proper fat-burning, but users are not likely to experience actual fat-loss. As a recovery formula, Carnigen should be quite effective, given that the research in that area is unanimous.

Still don’t know which weight loss supplement is right for you?  Check out our Top 10 Fat-Burners List!


  1. Hong, Eun Shil, et al. “Effect of carnitine‐orotate complex on glucose metabolism and fatty liver: a double‐blind, placebo‐controlled study.” Journal of gastroenterology and hepatology (2014).
  2. Spiering, Barry A., et al. “Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate.” The Journal of Strength & Conditioning Research 21.1 (2007): 259-264.
  3. Volek, Jeff S., et al. “L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress.” American Journal of Physiology-Endocrinology and Metabolism 282.2 (2002): E474-E482.
  4. Spiering, Barry A., et al. “Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise.” The Journal of Strength & Conditioning Research 22.4 (2008): 1130-1135.
  5. Wutzke, Klaus D., and Henrik Lorenz. “The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects.”Metabolism 53.8 (2004): 1002-1006
  6. Seim, H., W. Kiess, and T. Richter. “Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults.” Metabolism 51.11 (2002): 1389-1391.
  7. Melton, S. A., et al. “L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise.” International journal for vitamin and nutrition research 75.2 (2005): 156-160.
  8. Villani, Rudolph G., et al. “L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.”International journal of sport nutrition and exercise metabolism 10.2 (2000): 199-207.
  9. Karanth, Jyothsna, and K. Jeevaratnam. “Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity.” (2010). exists to educate the supplement community and seperate the science from the hype.

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