AdrenaLEAN LDS is a stimulant-based fat-burner made by BioRhythm. As a whole, the formula may be moderately effective, although we question the use of Hoodia (discussed below)…[Skip to the Bottom Line]
Caffeine consumption causes an increase in catecholamines (adrenaline, noradrenaline, and dopamine), which induce lipolysis (breakdown of fats). However, the weight loss effects of caffeine tend to fade with prolonged use, so caffeine is not very effective as a fat-burner in the long term. While caffeine’s weight loss potential is negligible, it increases focus and perceived energy in most people, which generally leads to more intense workouts (thus burning more fat), and may act as a mild appetite suppressant in some. AdrenaLean LDS contains 200mg of Caffeine, which is enough to provide the average individual with a noticeable, but not overwhelming, increase in perceived energy. Caffeine may also work somewhat synergistically with Synephrine.
Hoodia gordonii is a small shrub, the extract of which has been alleged to reduce appetite and result in weight-loss when supplemented. A 2004 study from “Brain Research” found that injections of the active component found in Hoodia (P57) increased ATP in the brains of rats, a mechanism that is known to suppress appetite. These findings were replicated in 2007 with oral supplementation in rats, as opposed to injections. However, a 2011 study, published in “The American Journal of Clinical Nutrition”, found that 15 days of Hoodia extract supplementation (1110mg/day) failed to reduce appetite and thus had no influence on weight, in humans. Furthermore, this study noted adverse side effects, indicating that Hoodia may be slightly toxic. While AdrenaLean LDS contains a low enough to dose of Hoodia to avoid this toxicity, it is unlikely that this dose is effective in any way for suppressing appetite.
CITRUS AURIANTUM (YIELDING 20 MG SYNEPHRINE):
Citrus Auriantum, also known as Bitter Orange Extract, is generally standardized for Synephrine. Syneprhine became popular after the FDA banned Ephedra as a dietary supplement for weight loss, because they share a similar mechanism of action. While Synephrine has been touted as a replacement for Ephedra, it is important to understand that it is significantly less potent (which is why it is not banned). However, that’s not to say it is completely useless. A 2011 study, published in the “International Journal of Medicinal Sciences”, found that supplementation of 50mg Syneprhine increased the metabolic rate in human subjects without affecting blood pressure or heart rate. Similarly to Ephedrine, Synephrine is a beta-receptor agonist and an alpha-receptor antagonist, the net effect of which is an increase in lipolysis.
YOHIMBE EXTRACT (STANDARDIZED FOR YOHIMBINE):
The primary active component of Yohimbe (Pausinystalia Yohimbe) is Yohimbine, which acts as an alpha-2 receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis. By blocking the action of this receptor Yohimbine allows for more lipolysis to occur. A 2006 study showed that while there were no increases in strength, supplementation induced fat loss in athletes (soccer players). As previously stated, Yohimbine directly acts on alpha-2 receptor, but its fat loss capabilities may also be magnified by its ability to increase the catecholamine neurotransmitters adrenaline and noradrenaline which in turn induce lipolysis. However, its ability to increase catcholamines may degrade fairly quickly (a few weeks), so for Yohimbine to be truly effective as a weight-loss agent, it must be combined with something that activates the beta-adrenergic receptors in the first place (i.e. caffeine and other stimulants or exercise). AdrenaLean LDS contains 3mg of Yohimbine which is an average dose which, if taken multiple times a day, may certainly induce fat-loss to some degree.
THE BOTTOM LINE:
AdrenaLean LDS is nothing spectacular, and the inclusion of Hoodia contributes no additional efficacy to the otherwise entirely stimulant-based formula. That being said, the combination of Caffeine, Syneprhine, and Yohimbine will generally result in slight-to-moderate weight-loss in the average individual when paired with a regular exercise regimen. The doses of those three ingredients are just about where they should be, although a little more Yohimbine would be ideal. The price is where AdrenaLean LDS falls short. At 50 cents a dose, AdrenaLean LDS costs about 5 times more than the cost of simply combining the three main ingredients at their stated doses. So, those looking for a fat-burner that is both physically effective AND cost effective should pass on AdrenaLean LDS.
[expand title=”REFERENCES” tag=”h5″]
- Blom, Wendy AM, et al. “Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial.” The American journal of clinical nutrition 94.5 (2011): 1171-1181.
- MacLean, David B., and Lu-Guang Luo. “Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside.” Brain research 1020.1 (2004): 1-11.
- van Heerden, Fanie R., et al. “An appetite suppressant from< i> Hoodia species.” Phytochemistry 68.20 (2007): 2545-2553.
- Arciero, PAUL J., et al. “Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men.” American Journal of Physiology-Endocrinology And Metabolism 268.6 (1995): E1192-E1198.
- Astrup, A., et al. “Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers.” The American journal of clinical nutrition 51.5 (1990): 759-767.
- Haaz, S., et al. “Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update.” Obesity reviews 7.1 (2006): 79-88
- Stohs, Sidney J., Harry G. Preuss, and Mohd Shara. “The Safety of Citrus aurantium (Bitter Orange) and its Primary Protoalkaloid p‐Synephrine.”Phytotherapy Research 25.10 (2011): 1421-1428.
- Seifert, John G., et al. “Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans.” International journal of medical sciences 8.3 (2011): 192.
- Ostojic, Sergej M. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Research in Sports Medicine 14.4 (2006): 289-299.
- Dhir, Ashish, and S. K. Kulkarni. “Effect of addition of yohimbine (alpha-2-receptor antagonist) to the antidepressant activity of fluoxetine or venlafaxine in the mouse forced swim test.” Pharmacology 80.4 (2007): 239-243.