T-X3 is a test-booster from Lecheek Nutrition which contains just three ingredients: DAA, Fenugreek, and Arimastane…FIND IT HERE
Out of the three human studies done specifically to test the effect of D-Aspartic Acid on testosterone, two have shown a significant increase in testosterone levels.
A 2012 study from “Advances in Sexual Medicine”, the subjects of which were infertile men (initially low Testosterone) found that 2.66g of D-Aspartic Acid was able to significantly increase Testosterone levels when measured after 90 days of supplementation. These results were in-line with those of an earlier (2009) study in which D-Aspartic Acid supplementation raised Testosterone by 42% after 12 days in healthy men (initially normal Testosterone).
However, a 2013 study published in “Nutrition Research” found that athletes who supplemented with D-Aspartic Acid for 28 days showed no difference in testosterone levels.
The researchers in the failed study noted abnormally high levels of D-aspartate oxidase, the enzyme which degrades D-Aspartic Acid, indicating that prolonged supplementation in individuals with healthy Testosterone levels may cause “negative feedback” which reduces the effects.
Ultimately, D-Aspartic acid is an effective short-term Test-booster for healthy individuals with initially normal Testosterone levels, but the effects may fade after a few weeks of supplementation. Those individuals with abnormally low Testosterone levels may benefit from longer term supplementation however.
T-X3 contains a clinically validated 3200mg dose of D-Aspartic Acid per serving, meaning a short-term Testosterone increase can be expected. However, long that increase lasts is subject to change from person to person.
FENUGREEK SEED EXTRACT
Trigonella Foenum Greacum (also known as Fenugreek) has gained serious traction in the supplement industry as a libido enhancer and alleged Testosterone-booster. However, a 2009 study, published in the “International Journal of Exercise Science”, found that Fenugreek supplementation had no influence on Testosterone (or any other hormone). A similar failure was noted in a 2011 double-blind, placebo controlled study in which 6 weeks of supplementation with a Fenugreek derived extract (Testofen) led to scoring 25% higher on a libido test (sexual arousal and orgasm in particular) than the placebo group, but with no increase in Testosterone levels, meaning that the mechanism of action was not an increase in Testosterone.
While two studies have failed to show any Testosterone-boosting effect of Fenugreek supplementation, one 2010 study, published in “The International Journal of Sports Nutrition”, found that supplementation with 500 mg of Fenugreek extract (Testofen again) resulted in a significant increase in free-Testosterone levels.
So why the mixed results? At this time, the discrepancy remains a mystery and while most supplement companies prefer to brush the two failed studies under the rug, we prefer to look at the bulk of the research as a whole to draw our conclusions. Fenugreek is an unreliable Testosterone booster, but it tends to be pretty reliable as a libido enhancer and Testosterone optimizer (keeping Test levels healthy).
T-X3 contains 300mg of Fenugreek per serving, enough to induce some noticeable libido enhancement and encourage healthy Testosterone levels.
Does Fenugreek Boost Testosterone?
Fenugreek is alleged to indirectly boost Testosterone via inhibiting 5-alpha-reductase, the enzyme responsible for the conversion of excess Testosterone into its more potent metabolite, dihydrotestosterone (DHT)…[Continue Reading]
3-desoxy, 7-keto-DHEA is a metabolite of the more well-known 7-Keto DHEA which appears to possess some distinct anti-aromatase properties.
A 1994 study from the “Journal of Medicinal Chemistry” found that 3-desoxy, 7-keto-DHEA acted as a potent aromatase inhibitor in vitro. Although this particular metabolite has not been tested in humans for the purpose of aromatase inhibition, the potency noted in the in vitro study indicates that oral consumption may be effective.
T-X3 contains 50mg of 3-desoxy, 7-keto-DHEA as Arimistane (trademark), which is in-line with what anecdotal reports indicate is an effective dose. Further research is needed to gauge the true potential of 3-desoxy, 7-keto-DHEA as an aromatase inhibitor, but what little evidence exists is promising.
THE BOTTOM LINE
Due to the inclusion of a highly effective 3200mg dose of D-Aspartic Acid, an increase in Testosterone can be expected from T-X3. Fenugreek and Arimistane remain speculative at this point, but may at the very least encourage a favorable hormonal environment for gaining lean muscle and decreasing fat. At about $1 per serving, T-X3 is priced more or less appropriately, relative to products with similar profiles.
- Bushey, Brandon, et al. “Fenugreek Extract Supplementation Has No effect on the Hormonal Profile of Resitance-Trained Males.” International Journal of Exercise Science: Conference Proceedings. Vol. 2. No. 1. 2009.
- Steels E, Rao A, Vitetta L. Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum-graecum Extract and Mineral Formulation. Phytother Res.
- Numazawa, Mitsuteru, et al. “Synthesis of androst-5-en-7-ones and androsta-3, 5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase.” Journal of medicinal chemistry 37.14 (1994): 2198-2205.
- D’Aniello, Autimo, Anna Di Cosmo, Carlo Di Cristo, Lucio Annunziato, Leonard Petrucelli, and George Fisher. “Involvement of D-Aspartic Acid in the Synthesis of Testosterone in Rat Testes.” Life Sciences 59.2 (1996): 97-104.
- Willoughby, Darryn S., and Brian Leutholtz. “d-Aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men.” Nutrition Research 33.10 (2013): 803-810.
- Topo, Enza, et al. “The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats.” Reprod Biol Endocrinol 7 (2009): 120.