PR-XT is a multi-mechanism hardening agent which combines some relatively unknown (or at least under-utilized) ingredients which, combined, may be moderately effective…FIND IT HERE
Anacylus Pyrethrym is yet another Ayurvedic herb that is alleged to enhance male virility. Evidence regarding it’s potential for boosting Testosterone up to this point is strictly preliminary limited to non-human studies, but the results are relatively promising.
A 2013 study from “Phytotherapy Research” demonstrated that Anacylus Pyrethrym (50-150mg/kg daily for 28 days) was able to approximately double Testosterone levels in otherwise normal male rats, compared to baseline. This substantial increase in Testosterone would likely explain the equally substantial libido boost seen in an earlier 2009 study involving male rats and using roughly the same dose. While the evidence is still in the preliminary stage, these findings do certainly warrant further research in humans to find out if these effects carry over, and to what degree.
PR-XT contains a pretty hefty 3200mg dose of Anacylus Pyrethrym which is more or less in-line with the concentration used in the above-mentioned study. However, without human research, it’s difficult to determine just how effective such a dose really is.
Brassaiopsis glomerulata is a South Asian tree which, despite having anti-estrogenic implications, remains very under-researched. A 2009 study from “Phytochemistry Letters” found that certain compounds found in Brassaiopsis glomerulata showed aromatase inhibiting properties, in vitro. Since then, no studies have been conducted to further investigate these findings. MAN lists Brassaiopsis glomerulata at 100mg per serving, but given absolutely no human research, this dose is difficult to interpret.
N-COUMAROYLDOPAMINE AND N-CAFFEOYLDOPAMINE
N-Coumaroyldopamine and N-Caffeoyldopamine are both found in several species of plant, but most commonly extracted from Cocao. A 2005 study, published in “The FASEB Journal”, found that both compounds were able to increase cAMP via beta-adrenoceptor agonsim in vitro, with N-Coumaroyldopamine being slightly more potent. Although these findings should be viewed as strictly preliminary, they do suggest that N-Coumaroyldopamine and N-Caffeoyldopamine have the potential to be used as a fat-burner in humans, sharing the same mechanism as many stimulant fat-burners. PR-XT contains a combined 50mg of N-coumaroyldopamine and N-Caffeoyldopamine which is towards the higher end of the range we generally see in fat-burners.
Studies investigating the relationship of Vitamin D to Testosterone have found a strong correlation between adequate levels of Vitamin D and normal Testosterone levels, indicating that Vitamin D plays a role in normalizing Testosterone. However, when looking at the research as a whole, nowhere is there an indication that excess Vitamin D supplementation may result in above normal Testosterone levels. Individuals who receive the proper amount of Vitamin D, either from direct sunlight or through supplementation, will not experience increases in Testosterone as a result of excess Vitamin D consumption.
Zinc is required for the conversion of cholesterol (and other lipids) into sex hormones, as well as the existence of androgen receptors, as evidenced in a 1996 study, in which rats fed a zinc deficient diet experienced a decrease in androgen receptor sites and an increase in estrogen receptor sites. So while Zinc deficiency can certainly result in low testosterone, there is no evidence indicating that supplemental Zinc can increase Testosterone above normal. In fact, there is ample evidence to the contrary.
A 2009 study, published in the “European Journal of Clinical Nutrition”, concluded that zinc (ZMA) supplementation had no influence on serum testosterone levels in non-zinc deficient men. A similar failure to influence testosterone via zinc supplementation was seen in a 2011 study, the subjects of which were trained cyclists who consumed sufficient dietary zinc.
However, a 2005 study, the subjects of which were wrestlers, demonstrated that zinc supplementation was able to attenuate exercise-induced declines in testosterone levels.
So, while Zinc may help to encourage/preserve optimal Testosterone levels, it will not increase levels beyond normal, and will have no noticeable anabolic effect in individuals with already healthy Testosterone levels.
THE BOTTOM LINE
PR-XT is essentially a bulking and hardening agent, meant to encourage lean mass gain while cutting fat. For both purposes, the formula is pretty speculative, with none of the ingredient actually having been studied in humans, let alone extensively. However, for the purpose of cutting fat, PR-XT may be moderately effective, with N-Coumaroyldopamine and N-Caffeoyldopamine being entirely responsible. At close to $2 per serving, PR-XT is over-priced at best and we feel there are better (more economical and effective) formulas out there for promoting lean mass gain while reducing fat.
- Sharma, Vikas, et al. “Evaluation of the Anabolic, Aphrodisiac and Reproductive Activity of Anacyclus Pyrethrum DC in Male Rats.” Scientia pharmaceutica77.1 (2009).
- Sharma, Vikas, et al. “Androgenic and Spermatogenic Activity of Alkylamide‐Rich Ethanol Solution Extract of Anacyclus pyrethrum DC.” Phytotherapy Research 27.1 (2013): 99-106.
- Balunas, Marcy J., et al. “Isolation and characterization of aromatase inhibitors from< i> Brassaiopsis glomerulata(Araliaceae).” Phytochemistry letters 2.1 (2009): 29-33.
- Koehler, K., et al. “Serum testosterone and urinary excretion of steroid hormone metabolites after administration of a high-dose zinc supplement.” European journal of clinical nutrition 63.1 (2009): 65-70.
- Neek, Leila Shafiei, Abas Ali Gaeini, and Siroos Choobineh. “Effect of zinc and selenium supplementation on serum testosterone and plasma lactate in cyclist after an exhaustive exercise bout.” Biological trace element research 144.1-3 (2011): 454-462.
- Kilic, Mehmet, et al. “The effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zinc.” Neuro endocrinology letters 27.1-2 (2005): 247-252.
- Om AS, Chung KW. Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver. J Nutr. (1996)