OxyTherm Pro is a fat-burner now under the PNI brand name and has been reformulated to include AMP Citrate…[Skip to the Bottom Line]
4-amino-2-methylpentane citrate, also known as 1,3 dimethylbutylamine, bares striking chemical similarities to 1,3 dimethylamylamine (DMAA), the compound that became wildly popular among pre-workouts and fat-burners before being banned by the FDA. Like DMAA, very little is known about 1,3 dimethylbutylamine, other than that it has a very similar chemical structure so it should have similar effects. Anecdotal reports of 1,3 dimethylbutylamine indicate the effects are similar, though perhaps not as overwhelmingly potent, and many are calling it “the next DMAA”. Unfortunately, until more studies are published, we really won’t know too much about this compound, the benefits or the pitfalls.
Though Nutrex isn’t the first to use AMP Citrate, the ingredient is still a relatively new entrant in the supplement industry, so even anecdotal evidence is hard to come by. Because AMP Citrate is chemically similar to DMAA, it is possible that it may have similar potential for weight-loss (albeit less potent), making it a potentially effective, but still highly speculative, addition to the Adipodex formula.
Bauhinia Purpurea is a flowering plant, found primarily in Southern China, which has a wide variety of potential health implications. In the context of OxyTherm Pro, PNI seems mostly concerned with preliminary evidence indicating that Bauhinia Purpurea can upregulate Thyroid Hormones, T3 and T4.
A 1999 study, published in the “Journal of Ethnopharmacology”, found that Bauhinia Purpurea extract, at 2.5mg/kg, was able to increase circulating T3 and T4 concentrations in female mice. Other than this one study, the effects of Bauhinia Purpurea have not been investigated with regards to Thyroid function, so we still view this ingredient as highly speculative in the context of OxyTherm Pro.
BACOPA MONNIERI (AS 50% BACOSIDES):
Bacopa Monnieri is an herb which has traditionally been used as a nootropic and anxiolytic. However, in the context of Lipo PM, Applied Nutraceuticals claims that Bacopa Monnieri is able to influence Thyroid Hormones, thus positively impacting body weight. A 2002 study from “Ethnopharmacology” found that 200mg/kg daily of Bacopa Extract was able to raise T4 (a Thryoid Hormone) by about 42% in male mice. Currently, the effects of Bacopa on Thyroid hormones have not been studied in human subjects, and it is unknown how beneficial it can be for weight loss. Logically, the most likely individuals to benefit from Bacopa supplementation would be those with Thyroid issues and abnormally low levels of T4.
Given that Lipo PM cannot possibly contain the same relative dose (200mg/kg) of Bacopa used in the above mentioned study, it is unlike that any comparable effects would occur. Still, it’s possible that there is some benefit to be obtained here.
ASHWAGANDHA (WITHANIA SOMNIFERA):
Ashwagandha is an Ayurvedic herb with a well-documented history of use and a variety of implications including: cognitive enhancement, combating anxiety, enhancing vitality, and supporting bone health. However, in the context of OxyTherm Pro, PNI is most likely concerned with preliminary research regarding Ashwagandha as a potential fat-loss agent.
The same 1999 study, published in the “Journal of Ethnopharmacology”, involving Bauhinia Purpurea and Thyroid Hormones also found that Ashwagandha increased T3 levels.
A 2008 in vitro study from “Biofactors” noted that Withaferin A (an isolated compound found in Ashwagandha) was able to kill fat-cells. Unfortunately, the dose used in this study was so high that the same effect could not realistically be achieved with oral supplementation of Ashwagandha.
So, Ashwagandha does possess some mechanisms by which it may favorably influence weight-loss, but we wouldn’t consider it a key ingredient, given strictly preliminary support for these claims.
A 2009 study from the “International Journal of Biological Sciences” found that Cirsium Oligophyllum extract administration was able to significant reduce fat mass in rats, with the mechanism of action being related to beta-adrenergic receptors. Although no human studies currently exist, further research is certainly warranted, given these preliminary findings.
OxyTherm Pro contains an undisclosed amount of Cirsium OIigophyllum, but even if we did know the dose, it would be hard to gauge the efficacy (because of the lack of human research).
Rauvolfia Canescens is generally standardized for Rauwolscine (also known as alpha-yohimbine) which is chemically related to Yohimbine and has the same function when it comes to fat-burning.
Like Yohimbine, Rauwolscine is an Alpha Receptor Antagonist, meaning it blocks the receptors responsible for blocking lipolysis. By blocking these receptors, Rauwolscine is able to potentiate the effects of other stimulant fat-burners and allow more fat-burning than would normally occur from exercise alone. However, since Rauwolscine generally appears alongside Yohimbine, it hasn’t been studied much in isolation, and an optimal (effective) dose has not yet been established. Combined with AMP Citrate, Caffeine, and Cirsium Oligophyllum, Rauwolscine may contribute rather considerably to the overall fat-burning effects of OxyTherm Pro.
Caffeine triggers the release of Catecholamines (i.e. Noradrenaline, Adrenaline, Dopamine) which, in addition to enhancing focus and alertness, are inherently pro-lipolytic. Although this mechanism can certainly burn fat in the short-term, prolonged Caffeine consumption (by itself) generally results in tolerance build-up so the effects become less potent over time. This was demonstrated in a 1992 study in which 24 weeks of Caffeine intake (200mg/day) failed to induce weight-loss in humans.
However, Caffeine’s effect on fat-loss can be amplified or extended by beta-agonists/alpha-antagonists such as Cirsium Oligophyllum and Rauwolscine (both found in OxyTherm Pro).
THE BOTTOM LINE:
OxyTherm Pro is a combination of some proven fat-burning compounds as well as some that are not so proven, with strictly preliminary support. At two servings per day, users are likely to experience some fat-loss, mostly due to the stimulants and beta-adrenergic receptor agonists in the formula. At about 65 cents per dose, taking two servings may actually be a viable option, and while we can’t say OxyTherm Pro is the absolute best fat-burner we’ve seen, it may be worth a shot for fans of PNI looking for a moderately effective stimulant fat-burner.
[expand title=”REFERENCES” tag=”h5″]
- Mori, Shinobu, et al. “Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract.” International journal of biological sciences 5.4 (2009): 311.
- Panda, S., and A. Kar. “< i> Withania somnifera and< i> Bauhinia< i> purpurea in the regulation of circulating thyroid hormone concentrations in female mice.” Journal of Ethnopharmacology 67.2 (1999): 233-239.
- Kar, A., S. Panda, and S. Bharti. “Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice.”Journal of ethnopharmacology 81.2 (2002): 281-285.
- Acheson, K. J., et al. “Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals.” The American journal of clinical nutrition 33.5 (1980): 989-997.
- Astrup, Arne, et al. “The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial.” International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity 16.4 (1992): 269-277.
- Timmermans, Pieter BMWM, et al. “Characterization of α-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine.” European journal of pharmacology70.1 (1981): 7-15.