On Point is Haleo’s fat-burner which contains a combination of some effective non-stimulant weight-loss ingredients as well as a 200mg of Caffeine (per serving). Although the formula is by no means dependent on any one ingredient for overall efficacy, Haleo places emphasis on Irithin…[Skip to the Bottom Line]
GREEN COFFEE EXTRACT:
Green Coffee Bean Extract is generally standardized for Chlorogenic Acid content, and in the case of On Point, it has been standardized to 50%. Chlorogenic Acid is the bioactive compound primarily responsible for the moderate weight-loss effects of Green Coffee observed in multiple studies.
A 2007 study, published in the “Journal of International Medical Research”, found that 12 weeks of Green Coffee (450-500mg Clorogenic Acid) supplementation resulted in a reduction (6.9%) in glucose absorption in healthy volunteers. Researchers also noted average weight loss of 5.4 kg (almost 12 lbs) over the duration of the study in the group receiving the Green Coffee Extract.
A 2006 study, this time using a smaller dose of Green Coffee Extract (yielding 140mg Chlorogenic Acid), found no such weight-loss benefit over a 12 week period. The obvious difference between these two studies is that the dose of the first (positive) study was about 3 times the dose used in the second (negative) study.
A 2012 study found that adults who consumed GCE (containing about 315mg Chlorogenic Acid) daily lost an average of 8kg with the average reduction in body fat being about 4%.
Though Green Coffee Extract has shown mixed results when looking at all of the research as a whole, higher doses have consistently resulted in weight loss. Around 300mg of Chlorogenic Acid daily is considered an effective dose. Haleo discloses that there is 175mg of Chlorogenic Acid in one serving of On Point, so two servings (Haleo’s recommend dosing protocol) spread out across the day yields an effective 350mg.
GREEN TEA EXTRACT:
Like Green Coffee, Green Tea Extract has demonstrated the capacity for weight-loss in multiple studies, although through a very different mechanism of action. The primary compound present in Green Tea Extract, responsible for the weight-loss benefits, is Epigallocatechin gallate (EGCG).
A 2009 study, published in “The Journal of Nutrition”, found that subjects consuming 625mg Green Tea Catechins (EGCG) alongside 40mg Caffeine paired with exercise lost an average of 2.2kg (4.8lbs) compared to the subjects in the control group (consuming just Caffeine), who lost an average of 1kg (2.2lbs). These findings were corroborated by a 2009 meta-analysis, published in the “International Journal of Obesity”, which concluded that Green Tea extract tended to cause about 1.2kg (2.6lbs) reduction in bodyweight, and that effects could be amplified with Caffeine in non-caffeine tolerant individuals.
Further research has revealed that EGCG can effectively block Catechol-o-Methyl Transferase (COMT), the enzyme responsible for the degradation of Catcholamines such as Noradrenaline. The result is an indirect increase in Noradrenaline which induces lipolysis. So, while EGCG is not likely to induce noticeable weight-loss alone, when combined with Caffeine or other Noradrenaline-releasing stimulants, it can be quite synergistic. Most of the efficacy has been demonstrated using doses of 400-500mg EGCG daily, and the less caffeine-tolerant the individual, the better.
On Point contains 250mg of Green Tea Extract, containing 150mg of EGCG, per serving. So, the recommended protocol (two servings daily) would yield 300mg EGCG, slightly less than the recommended 400-500mg range, but still potentially somewhat effective.
Caffeine triggers the release of Catecholamines (i.e. Noradrenaline, Adrenaline, Dopamine) which, in addition to enhancing focus and alertness, are inherently pro-lipolytic. Unfortunately, habitual Caffeine consumption tends to lead to tolerance, making it less and less effective as time goes on. That being said, Caffeine tends to by quite synergistic with EGCG. In fact, research indicates that it may be downright necessary to truly derive the full benefit, so it is actually quite an important addition to the On Point formula. Haleo has included 200mg per serving, a reasonable, but not extremely overwhelming dose.
Capsimax is a brand name for capsicum extract, a group of plants that include the pepper family. Though commonly standardized for Capsaicin content, Capsicum also contains other compounds, collectively referred to as Capsaicinoids, which include Dihydrocapsaicin and Nordihydrocapsaicin.
A 2007 study noted an increase in fat oxidation (relative to placebo) during low intensity exercise in healthy adult males who consumed 150mg of capsaicin one hour before exercise.
A 2001 found subjects who consumed CH-19 Sweet (containing Capsinoids) had significantly higher core body temperatures and increased oxygen consumption (indicative of energy production) compared to the placebo group.
A later (2010) study, published in “The American Journal of Clinical Nutrition”, found that Dihydrocapsiate supplementation (3-9mg/day) caused a small but noticeable increase in the resting metabolic rate of healthy human subjects.
On Point contains 100mg of Capsimax, standardized to 2% Capsaicinoids, although the levels of each individual compound are undisclosed.
Irithin is patented form of Pyrroloquinoline Quinone which is alleged to increase levels of Irisin, a hormone that is secreted during exercise that has been shown to induce weight loss in mice.
A 2014 study from “Diabetes” found that Irisin was able to induce weight-loss in mice via upregulation of uncoupling proteins (which regulate the fat-burning capacity of brown adipose tissue) and improved glucose utilization. However, an earlier (2012) study which sought to determine the relevance of Irisin for human health (as opposed to rats) found that exercise tended to increase Irisin only in elderly subjects, indicating that it may not be as heavily involved in fat-burning in humans as it is in mice. These findings were reiterated in a later (2013) study which concluded that it is unlikely that the effects of Irisin in mice can be translated to humans.
Overall, while Irisin is certainly an exciting and potentially important weight-loss hormone, the evidence thus far suggests that the efficacy demonstrated in rats may not manifest itself in humans the same way. That being said, Haleo has been fairly straightforward about the fact that Irithin is a speculative ingredient in the On Point formula, and the efficacy of the other ingredients is certainly concrete enough to offset the possibility that Irithin is not so effective in humans.
THE BOTTOM LINE:
On Point is a concise, but comprehensive blend of some pretty effective weight-loss ingredients, the only stimulant of which is Caffeine. Although we’re not quite sold on IriThin, it makes for an interesting speculative addition to the formula and ultimately helps to separate On Point from other fat-burners with otherwise similar profiles. Two servings daily provide, for the most part, effective doses of each ingredient, and may certainly induce/contribute to weight-loss (assuming steady diet and exercise).
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