5% Nutrition 5150 Review

5150 is a stimulant-powered pre-workout supplement by 5% Nutrition (Rich Piana) which contains a whopping 400mg of Caffeine per serving, as well as several other potent stimulants…

Rich Piana 5150



L-Citrulline is an amino acid that serves as a precursor to Arginine which, in turn, is a precursor to Nitric Oxide.  Citrulline supplementation, however, is a much more effective means of increasing Nitric Oxide production than Arginine supplementation.  This is due to Arginine being rapidly degraded by the enzyme Arginase upon ingestion, whereas Citrulline is not susceptible to breakdown by Arginase.

Multiple studies have confirmed that Citrulline is an effective performance enhancement supplement.  It has been shown to increase muscular endurance as well as reduce muscle soreness resulting from exercise.

Most pre-workout/amino supplements contain nowhere near an effective dose, but Rich Piana seems to have done some homework with this one by including an effective 4g dose of L-Citrulline per serving.  While we’d ideally like to see 6g of Citrulline Malate (the preferred form in studies) yielding 4g L-Citrulline,4g of L-Citrulline per serving will do the trick.


Taurine is often included in pre-workout supplements and has been shown to ever so slightly enhance performance in atleast one human study.  However, it has also failed to do so elsewhere so it isn’t entirely reliable when it comes to actual performance enhancement.

It is quite effective, however, when it comes to promoting optimal recovery from exercise, having been shown in multiple human studies to reduce oxidative damage resulting from exercise.


Tyrosine is a pre-precursor to the neurotransmitters Dopamine and Noradrenaline, both of which are involved in alertness, focus, and mood.  While research indicates that supplemental Tyrosine does not appear to outright raise Dopamine and Noradrenaline levels (it is not a stimulant), supplementation appears to be an effective means of helping to ensure optimal production of these two neurotransmitters.

In other words, Tyrosine can help maintain cognitive function during times when it would otherwise be compromised.  This is probably only practical during extended duration exercise (like 2 hours or more).

Choline Bitartrate

Choline, once ingested, is used to synthesize Acetylcholine, the neurotransmitter most closely associated with the mind-muscle-connection as well as certain aspects of cognitive function.

Better Acetylcholine signaling is associated with greater muscle contractibility and power output, but Choline Bitartrate is actually the least bioavailable form generally found in supplements.  For that reason, it’s not clear whether the 500mg found in 5150 really does much.


Higenamine, though not having been extensively studied in humans, has demonstrated beta-adrenergic receptor agonist properties in vitro which indicate it may be a useful fat-loss agent.

At this time, no human studies have been conducted to test the benefits of Higenamine on weight-loss or performance enhancement in humans, but it does appear to function as a stimulant and is included in many high-stim pre-workout supplements for that reason.


Hordenine is a weak monoamine oxidase inhibitor, meaning it inhibits the enzymes responsible for the degradation of neurotransmitters like Noradrenaline.  Although Hordenine isn’t particularly useful on its own, it can amplify the effects of Noradrenaline-relasing stimulants such as Caffeine.


Halostachine is a naturally occurring alkaloid found in the Asian shrub halostachys capsica. In terms of its structure and chemical properties, it is similar to Synephrine and Ephedrine. Halostachine is a beta-adrenergic receptor agonist, meaning it can increase cAMP and promote lipolysis.

Unfortunately, Halostachine remains significantly under-researched compared to Synephrine, so it’s tough to determine its relative degree of efficacy as a fat-burner or mental stimulant.


Synephrine, like Higenamine, is a beta-adrenergic receptor agonist, giving it clear weight-loss implications.  Unlike Higenamine, Synephrine has been researched fairly extensively in humans and has been shown to increase metabolic rate and induce lipolysis.

We discuss Synephrine a bit more in-depth in this article, but you can think of it as a weaker, safer version of Ephedrine.

In the context of 5150, it is a stimulant and will add to the “energy”.

Caffeine (from various sources)

5150 contains Caffeine from about five different sources, but at the end of the day, Caffeine is Caffeine.  It triggers the release of Noradrenaline and has both fat-burning and performance enhancing implications.

5% Nutrition lists the total Caffeine content in 5150 at a whopping 400mg per serving, clearly placing 5150 in “high-stim” territory.

The Bottom Line

If you’re looking for a seriously high-stim pre-workout that will not only provide some serious energy and focus but also help with muscular endurance and pumps, you should give 5150 a shot.  Although not marketed as such by 5% Nutrition, 5150 also has the type of stim profile you might find in a fat-burner and will definitely encourage more fat-burning than would otherwise normally occur.

Still not sure which pre-workout supplement is right for you?  Check out our Top 10 Pre-Workout Supplements List or our Best Pre-Workouts For Stimulant Lovers List! exists to educate the supplement community and seperate the science from the hype.

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