Reviews

Testogenix Review

Testogenix is Cellusyn’s testosterone-booster which features a variety of alleged test-boosting ingredients, most of which can be found in many other test-boosters out there. Unfortunately, as with many other test-boosters, the doses of some of the key ingredients may be less than effective…

Testogenix

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D-ASPARTIC ACID

D-Aspartic Acid has become extremely popular as a test-booster in recent years as a few studies now have indicated that it can boost Testosterone at least in the short-term.

A 2012 study from “Advances in Sexual Medicine”, the subjects of which were infertile men (initially low Testosterone) found that 2.66g of D-Aspartic Acid was able to significantly increase Testosterone levels when measured after 90 days of supplementation.

These results were in-line with those of an earlier study from 2009 in which D-Aspartic Acid supplementation raised Testosterone by 42% after 12 days in healthy men (initially normal Testosterone).

However, a 2013 study published in “Nutrition Research” found that athletes who supplemented with D-Aspartic Acid for 28 days showed no difference in testosterone levels.

The researchers in the failed study noted abnormally high levels of D-Aspartate Oxidase, the enzyme which degrades D-Aspartic Acid, indicating that prolonged supplementation in individuals with healthy Testosterone levels may cause “negative feedback”.

Unfortunately, the 500mg dose of DAA present in Testogenix is significantly less than what has been shown to influence Testosterone in a clinical setting.

CISSUS QUADRANGULARIS

Cissus has received a fair amount of attention in the supplement community for its role in joint-health, but there is (very) preliminary evidence to suggest it may be androgenic. This is because Cissus contains compounds which can act as Glucocorticoid antagonists, ultimately reducing catabolic effects and possibly being androgenic.

However, this area requires much further elucidation, as no human studies have been conducted at this time. In the context of Testogenix, we’d definitely consider Cissus a speculative ingredient.

CALCIUM FRUCTATE

Calcium Fructate is a combination of Calcium, Fructose, and Boron, which is touted to be a superior delivery form of Boron.

Boron has somewhat of a questionable track record regarding its use as a test-booster. In the early days of bodybuilding, Boron became popular, but then lost popularity (one would think because it doesn’t work).

Recently, however, Boron is making a come-back with the same claims attached to it. A 2011 study, published in the “Journal of Trace Minerals in Medicine and Biology”, found that boron supplementation (11.6 mg daily) over a one week period was found to increase Testosterone to a statistically significant degree (28%).

An earlier study (1993), found that daily supplementation with 2.5 mg of boron over a 7 week period failed to increase testosterone levels.

The obvious reason for the discrepancy is that the 2011 study used 4-5 times as much boron as the earlier study.

Testogenix contains 250mg of Calcium Fructate, precisely in-line with what has been used clinically to boost Testosterone levels.

MACA

Maca is a pretty versatile herbal ingredient commonly found in test-boosters, libido enhancers, and even pre-workout supplements. With regards to boosting-testosterone it has actually been studied pretty extensively.

A 2002 study, published in “Andrologia”, found that Maca supplementation increased sexual desires, but that this effect was independent of Testosterone, which stayed the same. These findings were replicated in a 2003 study, published in the “Journal of Endrocrinology”, in which supplementation with 1.5 and 3 grams of Maca extract for 12 weeks had no influence on Testosterone levels in healthy men.

In several human studies, Maca has demonstrated a clear aphrodisiac effect when at least 1.5 grams is consumed. A 2009 study using 2400mg of Maca showed “a small but significant effect of Maca supplementation on subjective perception of general and sexual well-being in adult patients with mild ED.” A separate 2009 pilot study, this time investigating a potential effect on physical performance, found that Maca supplementation effectively improved physical performance (cycling) in trained male cyclists, while simultaneously increasing sexual desires.

Maca is ineffective for boosting Testosterone but can be used to reliable enhance libido and improve performance. However, Testogenix contains just 118mg, far less than what has been used clinically.

EURYCOMA LONGIFOLIA

Eurycoma Longifolia, also known as Tongkat Ali has been shown, in various studies, to increase Testosterone in male rats, but the only human studies that exist have tested the effects of Tongkat Ali in infertile men, not healthy men.

A 2010 study published in the “Asian Journal of Andrology” found that supplementation with 200mg of an extract of Eurycoma Longifolia significantly improved various indications of male fertility (in humans), though the mechanism of action was unknown.

A 2012 study published in “Andrologia: Volume 44” (the same researchers from the above mentioned human study) found that men suffering from Hypogonadism (diminishing functionality of the gonads) who were treated with a 200 mg daily dose of Eurycoma longifolia extract reached normal Testosterone levels after a 30 day period. To be fair, at the start of the study about 35% of the men were showing normal Testosterone levels, and at the end about 90% showed normal levels. Still, 35% to 90% is clearly statistically significant.

With 100mg per serving, users will need roughly two servings of Testogenix to yield a “clinical dose” of Eurycoma Longifolia, though it is possible that 100mg can be beneficial.

AVENA SATIVA

Avena Sativa, also known as the common oat, is claimed by supplement companies to boost free testosterone levels via blocking the action of sex hormone binding globulin (SHBG). Unfortunately, while claims by supplements companies that Avena Sativa effectively blocks Sex Hormone Binding Globulin (SHBG) levels are pervasive, the research is completely non-existent.

Testogenix contains 100mg of Avena Sativa but, given the lack of research, this dose is difficult to interpret.

HORNY GOAT WEED

Horny Goat Weed contains Icariin, the compound primarily responsible for the sexual-enhancement effects.

A 2006 study, published in the “Asian Journal of Andrology”, found that Icariin (80mg/kg) was able to increase Testosterone roughly three times as much as the control group in chemically castrated mice. However, the dose used in this particular study would be roughly equivalent to a 200lb human consuming 1150mg pure Icariin daily.

At the very least, Icariin supplementation is generally associated with enhanced libido and sexual well-being (providing the illusion of increased Testosterone without the strength gains).

Testogenix contains 100mg of Horny Goat Weed yielding 10mg of Icariin.

LAGERSTROEMIA SPECIOSA

Banaba is generally standardized for the active component, Corosolic Acid, which is alleged to have blood glucose lowering capabilities.

A 2006 study, published in “Diabetes Research and Clinical Practice”, found that 10mg Corosolic Acid prior to a Glucose Tolerance Test (75g Glucose) caused significant reductions in blood Glucose levels which were still present at the 90 minute mark. Several other studies, both animal and human, have confirmed similar effects, although some studies are confounded with the use of other substances.

Testogenix provides 1mg of Corsolic Acid (from 100mg of Banaba) which is about 1/10th the dose shown to influence blood-glucose.

ACETYL-L-CARNITINE

Carnitine comes in a variety of different forms, with Acetyl-L-Carnitine (ALCAR) being one of the more bioavailable. Although Carnitine has many general implications, the makers of Testogenix are clearly concerned with its influence on Androgen receptors.

A 2006 study, this time using mice as the subjects, found that Acetyl-L-Carnitine did not outright increase Testosterone but was effective at preventing Testosterone decline resulting from stress, indicating that Carnitine, similar to Zinc, may help to optimize Testosterone.

Another 2006 study, published in “Medicine and Science in Sports and Exercise”, found that 2g/day L-Carnitine (as L-Carnitine L-Tartrate) for 21 days increased the density of androgen receptors in muscle cells, which would not directly increase Testosterone but may enhance its effects. These findings suggest the same as those of the study involving mice, which is the Carnitine can be effective for maintaining optimized Testosterone levels, but does not outright increase Testosterone.

Unfortunately, the 100mg dose of ALCAR present in Testogenix is probably not enough to significantly influence Androgen-receptor density.

MUCUNA PRURIENS

A 2008 study found that “Treatment with Mucuna Pruriens regulates steroidogenesis and improves semen quality in infertile men.” In addition to increased levels of Dopamine, Adrenaline, and Noradrenaline, the subjects who recieved Mucuna Pruriens also experienced elevated Testosterone levels.

Unfortuantely, there is no evidence to suggest that Mucuna Pruriens can increase Testosterone in healthy individuals with normal Testosterone levels, so it’s not clear how influential the it is in the context of Testogenix.

RESVERATROL

Resveratrol is an anti-oxidant compound found in Red Wine (among other things), which is primarily used as an anti-aging supplement. In the context of Testogenix, however, Resveratrol’s function pertains to controlling Estrogen levels.

A 2006 in vitro study in which Resveratrol reduced the conversion of Testosterone to Estrogen in breast cancer cells (where Estrogen is high). However, no human studies have been conducted to replicate these findings so at this time there is simply not enough to evidence to conclude Resveratrol is an effective Aromatase inhibitor in humans.

BIOPERINE

Piper nigrum, also known as Black Pepper, contains Piperine. Several studies have found that black pepper extract, when combined with other supplements, has increased the absorption of those supplements (as measured by plasma levels). Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).

Bioperine has no influence on Testosterone. It just serves as a means of enhancing the absorption of the other ingredients in Testogenix

THE BOTTOM LINE

From an ingredient standpoint, Testogenix certainly has what it takes to encourage a favorable hormonal environment and keep Testosterone towards the high end of the normal, healthy range. However, several of the ingredients may be under-dosed, in some cases quite significantly. At just over $1 per serving, Testogenix is more or less priced competitively, but there may be better (more effective dosed) options within that price range.

Still not sure which Testosterone Booster is right for you? Check out our Best Testosterone Boosters List!

References

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  2. Topo, Enza, et al. “The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats.” Reprod Biol Endocrinol 7.120 (2009): 6.
  3. D’Aniello, Gemma, et al. “d-Aspartate, a key element for the improvement of sperm quality.” Advances in Sexual Medicine 2 (2012): 45.
  4. Willoughby, Darryn S., and Brian Leutholtz. “d-Aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men.” Nutrition Research 33.10 (2013): 803-810.
  5. Chopra, S. S., M. R. Patel, and R. P. Awadhiya. “Studies of Cissus quadrangularis in experimental fracture repair: a histopathological study.” The Indian journal of medical research 64.9 (1976): 1365.
  6. Tambi, M. I. B. M., M. K. Imran, and R. R. Henkel. “Standardised water‐soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late‐onset hypogonadism?.” Andrologia 44.s1 (2012): 226-230.
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  16. Chopra, S. S., et al. “Studies on Cissus quadrangularis in experimental fracture repair: effect on chemical parameters in blood.” The Indian journal of medical research 63.6 (1975): 824-828.
  17. Zhang, Zhen‐Bao, and Qing‐Tao Yang. “The testosterone mimetic properties of icariin.” Asian journal of andrology 8.5 (2006): 601-605.
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  23. Kraemer, William J., et al. “Androgenic responses to resistance exercise: effects of feeding and L-carnitine.” Medicine and science in sports and exercise 38.7 (2006): 1288.
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  25. Nielsen, Forrest H., et al. “Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.” The FASEB journal 1.5 (1987): 394-397.

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