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HPN T5 Test Booster Review

T5 is a test-booster by HPN which contains a relatively simply, but potentially pretty effective blend of ingredients, most of which are relatively well-researched…

HPN T(5)

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FENUGREEK SEED EXTRACT (50% SAPONINS)

While Fenugreek (as Testofen) has demonstrated the ability to increase Testosterone in one study, it has failed to do so elsewhere under similar conditions. We discuss Fenugreek and its effects on Testosterone in depth in this article.

At this time, the reason for the discrepancy is unknown. So, as a Test-booster, the reliability of Fenugreek should be questioned. Fenugreek is an effective libido enhancer and may provide the illusion of increased Testosterone regardless of whether an actual increase occurs.

T5 contains a clinical 600mg dose of Fenugreek. Those who respond to Fenugreek will definitely respond to this dose.

TRIBULUS ALATUS

In mice, extract of Tribulus Alatus have been shown to increase Testosterone levels. Unfortunately, there are no human studies testing the effects of Tribulus Alatus on testosterone, and Tribulus Terrestris has failed in multiple studies to do so.

In the context of T5 it’s not clear how effective Tribulus Alatus is, but it’s certainly more promising than other forms of Tribulus and may provide some libido enhancement at the very least.

EURYCOMA LONGIFOLIA

Eurycoma Longifolia, also known as Tongkat Ali has been shown, in various studies, to increase Testosterone in male rats, but the only human studies that exist have tested the effects of Tongkat Ali in infertile men, not healthy men.

A 2010 study published in the “Asian Journal of Andrology” found that supplementation with 200mg of an extract of Eurycoma Longifolia significantly improved various indications of male fertility (in humans), though the mechanism of action was unknown.

A 2012 study published in “Andrologia: Volume 44” (the same researchers from the above mentioned human study) found that men suffering from Hypogonadism (diminishing functionality of the gonads) who were treated with a 200 mg daily dose of Eurycoma longifolia extract reached normal Testosterone levels after a 30 day period. To be fair, at the start of the study about 35% of the men were showing normal Testosterone levels, and at the end about 90% showed normal levels. Still, 35% to 90% is clearly statistically significant.

Although HPN does not disclose the exact dose of Eurycoma Longifolia present in T5, but given that a clinical dose would be 200mg or so, there aren’t any obvious red flags regarding dosage.

SAW PALMETTO

Saw Palmetto is a widely used supplement for treating BPH (discussed above) as well as overall prostate health. One cause of BPH is thought to be excess dihydrotestosterone (DHT), which is a byproduct of Testosterone itself. Testosterone is converted into dihydrotestosterone by the enzyme known as 5-alpha-reductase. While Saw Palmetto does appear to act as a 5-alpha-reductase inhibitor in animal models, human studies directly testing its effects on Testosterone are non-existent. The mechanism of action here is perfectly plausible but there just isn’t enough evidence to determine how effective Saw Palmetto really is at reducing Testosterone-DHT conversion.

In the context of T5 we’d consider Saw Palmetto a speculative, but potentially effective ingredient.

BIOPERINE

Piper nigrum, also known as Black Pepper, contains Piperine. Several studies have found that black pepper extract, when combined with other supplements, has increased the absorption of those supplements (as measured by plasma levels). Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).

Bioperine has no influence on Testosterone. It just serves as a means of enhancing the absorption of the other ingredients in T5.

THE BOTTOM LINE

As far as ‘natural’ test-boosters go, T5 is actually pretty effective. Of course, those with initially low testosterone levels will experience the most notable (relative) increase, but in individuals with healthy Testosterone levels, T5 may serve as a means of maintaining. The only issue may be the price.

Still not sure which Testosterone Booster is right for you? Check out our Best Testosterone Boosters List!

Supplement Facts

  1. Bushey, Brandon, et al. “Fenugreek Extract Supplementation Has No effect on the Hormonal Profile of Resitance-Trained Males.” International Journal of Exercise Science: Conference Proceedings. Vol. 2. No. 1. 2009.
  2. Steels, Elizabeth, Amanda Rao, and Luis Vitetta. “Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum‐graecum Extract and Mineral Formulation.” Phytotherapy Research 25.9 (2011): 1294-1300
  3. El-Tantawy, Walid H., Abeer Temraz, and Omayma D. El-Gindi. “Free serum testosterone level in male rats treated with Tribulus alatus extracts.” International braz j urol 33.4 (2007): 554-559.
  4. Tambi, M. I. B. M., M. K. Imran, and R. R. Henkel. “Standardised water‐soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late‐onset hypogonadism?.” Andrologia 44.s1 (2012): 226-230.
  5. Ang, H. H., S. Ikeda, and E. K. Gan. “Evaluation of the potency activity of aphrodisiac in Eurycoma longifolia Jack.” Phytotherapy Research 15.5 (2001): 435-436.
  6. Zanoli, P., et al. “Influence of< i> Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats.” Journal of ethnopharmacology 126.2 (2009): 308-313.
  7. Ang, H. H., S. Ikeda, and E. K. Gan. “Evaluation of the potency activity of aphrodisiac in Eurycoma longifolia Jack.” Phytotherapy Research 15.5 (2001): 435-436.
  8. Tambi, Mohd Ismail Bin Mohd, and M. Kamarul Imran. “Eurycoma longifolia Jack in managing idiopathic male infertility.” Asian journal of andrology 12.3 (2010): 376-380.
  9. Bhat, Rajeev, and A. A. Karim. “Tongkat Ali (< i> Eurycoma longifolia Jack): A review on its ethnobotany and pharmacological importance.”Fitoterapia 81.7 (2010): 669-679.
  10. Rogerson, Shane, et al. “The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players.” The Journal of Strength & Conditioning Research 21.2 (2007): 348-353.
  11. Sellandi, Thirunavukkarasu M., Anup B. Thakar, and Madhav Singh Baghel. “Clinical study of Tribulus terrestris Linn. in Oligozoospermia: A double blind study.” Ayu 33.3 (2012): 356.
  12. Gauthaman, Kalamegam, and Adaikan P. Ganesan. “The hormonal effects of< i> Tribulus terrestris and its role in the management of male erectile dysfunction–an evaluation using primates, rabbit and rat.” Phytomedicine 15.1 (2008): 44-54.
  13. Gauthaman, K., P. G. Adaikan, and R. N. V. Prasad. “Aphrodisiac properties of< i> Tribulus Terrestris extract (Protodioscin) in normal and castrated rats.” Life Sciences 71.12 (2002): 1385-1396.
  14. Martino-Andrade, Anderson J., et al. “Effects of< i> Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats.” Journal of ethnopharmacology 127.1 (2010): 165-170.
  15. Neychev, Vladimir Kostadinov, and Vanyo Ivano Mitev. “The aphrodisiac herb< i> Tribulus terrestris does not influence the androgen production in young men.” Journal of Ethnopharmacology 101.1 (2005): 319-323.
  16. YAMADA, Shizuo. “Isolation and pharmacological characterization of fatty acids from saw palmetto extract.” Analytical Sciences 25.553 (2009).
  17. Suzuki, Mayumi, et al. “Pharmacological effects of saw palmetto extract in the lower urinary tract.” Acta Pharmacologica Sinica 30.3 (2009): 271-281.
  18. Badmaev, Vladimir, Muhammed Majeed, and Lakshmi Prakash. “Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation.” The Journal of Nutritional Biochemistry 11.2 (2000): 109-113.
  19. Majeed, Muhammed, and Lakshmi Prakash. “Targeting Optimal Nutrient Absorption with Phytonutrients.” (2007)

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