Rauwolscine: The Most Powerful Natural Fat-Burner

Rauwolscine Burns Fat

Rauwolscine, also known as Alpha-Yohimbine, is a naturally occurring molecule found in a variety of species of plants in the Raufolvia and Pausinystalia genera.

It has several potential benefits, but Rauwolscine just so happens to function as a pretty powerful fat-burner when used in supplement form.

But first, let’s just get one thing out of the way…

The unfortunate truth about fat-burning supplements is that:

Most of them don’t work!

Sorry, but it’s true.  If you’ve ever been suckered into buying a BS weight-loss supplement, they probably made claims like:

  • “Torches Stubborn Fat!”
  • “Burns Calories Around The Clock!”
  • “Stops Your Body From Storing Fat!”

To be crystal clear, most of the supplements that tend to have these claims attached are COMPLETE garbage.  Studies have proven that some of the most popular weight-loss supplements over the years are nothing but hype.  Among the most popular are:

And the list goes on…

Unfortuantely, despite the fact that studies have debunked the efficacy of these supplements and scientifically proven that they DON’T WORK, they’re still widely used in supplements that are marketed for fat-loss.

That’s really quite a shame, but luckily, there are some supplements which actually can burn fat at a substantial rate, and make no mistake…

Rauwolscine can be VERY effective for fat-loss when used correctly!

And since we here at SuppWithThat don’t condone the use of ANY supplement without first gaining a proper understanding of what that particular supplements is, where it comes from, how it works, etc…

Let’s just start from the top, shall we?

Rauwolscine Has Been Identified In Several Kinds Of Plants

Some of the most common species used for Rauwolscine extraction to make supplements are:

  • Pausinystalia Yohimbe
  • Rauwolfia Vomitoria
  • Rauwolfia Canescens
  • Rauwolfia Serpentina

There are many other species that have been shown to contain Rauwolscine and even more that probably contain some trace amounts, but when it comes to supplements, these four tend to be the favorites.

Rauwolfia Vomitoria is particularly popular because it naturally contains higher levels than the other genuses mentioned, making the isolation and extraction process a bit easier.

We’ll discuss the issue with using plant-based extracts later.  But first, let’s talk chemistry…

Chemical Structure

Rauwolscine is a steroisomer of Yohimbine, meaning they have exactly the same molecular formula and sequence of atoms, but some of the atoms are arranged differently in space.  Such a slight difference can only be seen in a three dimensional model, such as the one below.

Yohimbine Vs Rauwolscine

You don’t need to sit there and disect this model, peice by piece, to try to understand what it means.  All you need to observe is that these two moecules are almost completely identical in terms of chemical structure, but there are slight differences which make them behave differently when used as supplements.


Rauwolscine functions as an alpha-adrenergic receptors antagonist, as does Yohimbine, meaning it blocks the receptors (alpha receptors) that ordinarily put a stop to lipolysis, a the process depicted below by which Triglyercides (stored fats) are broken down into their individual components–fatty acids and glycerol–which are then released into the blood stream.


If there’s a need for energy (like exercise), those fatty acids are then free to be oxidized (burned) for energy.  Certain neurotransmitters (which also function as hormones) like Norepinephrine and Epinephrine trigger a series of cellular processes that ultimately result in the liberation of fatty acids and glycerol from triglycerides (stored fat).

By blocking the receptors (alpha receptors) that normally regulate (turn off) Lipolysis, Rauwolscine allows you to burn more fat during exercise than you would otherwise be able to.

It does not directly initiate fat-breakdown, but instead allows it to continue.  This can lead to noticeable fat-loss and body recompositioning in as little as two weeks when paired with regular exercise.

Mood Enhancement

Both Yohimbine and Rauwolscine are considered Serotogenic, meaning they can elevate Serotonin levels.  They do this by agonizing (activating) 5-HT1a/b receptors.  Rauwolscine is capable of saturating more receptors than Yohimbine, so it is more effective in this regard.

That is why pre-workouts and fat-burners that contain it tend to provide mood elevation.  By antagonizing alpha-receptors, Rauwolscine triggers the release of Noradrenaline, a potent fat-burning neurotransmitter that is also responsible for euphoria and mood elevation that some users report.

This effects may be further potentiated by Caffeine or other stimulants.

Pro-Erectile Effects

Although it hasn’t been studied directly in this area, Rauwolscine shares the same mechanism as Yohimbine that gives it its pro-erectile properties.  Yohimbine has been shown to improve symptoms of erectile dysfunction and is actually perscribed clinically in some countries.

So, it stands to reason that Rauwolscine would have more or the less the same impact on erectile function as Yohimbine, but given that it’s less likely to cause side effects, it makes sense to give it a shot (if you think you may benefit from it in that area).


Since we original published this article, we’ve received a fair amount of emails from readers claiming that Rauwolscine did the trick in this department.  Anecdotal evidence isn’t the same as scientific evidence, of course.  But it’s still worth mentioning.

Source: The Most Important Factor To Consider

As mentioned above, Rauwolscine can be found in a variety of plants and so it’s common for it to turn up in supplements in the form of a plant extract.  Usually, you’ll see something like:

Extracts Of Rauvolfia Canescens And Vomitoria

What that means is that a supplement contains Rauwolfia Vomitoria Root Extract that allegedly contains atleast 90% Rauwolscine.  What that doesn’t tell us is whether the extraction method used would also yield other bioactive compounds that we may no want to be consuming.  If it’s only 90%, what’s the other 10%?


Unfortunately, resarch has confirmed that the actual chemical content of Yohimbe Extract supplements are often way off of what it says on the label.  Some contain far less and others contain way more.

Either way, one thing is crystal clear…

You can’t trust extracts just because the manufacturer claims it’s standardized for a certain amount of the active component.  It could very well contain less, more, none at all, or even a completely different compound altogether.

In fact, given that literally all plant species contain hundreds if not thousands of different chemical compounds, some of which may be physiologically active, any Rauwolscine supplement that isn’t completely pure most likely contains additional chemical compounds that aren’t listed on the label.

Most people would consider that a bad thing…That’s where pure Rauwolscine comes in…

Rauwolscine HCL

If you value purity, certainty, and safety, you want to take Rauwolscine HCL.  That is, Rauwolscine bonded with Hydrochloric Acid (Hcl).  It is the only form that is entirely (98-99%) pure and guaranteed free of any additional unwanted chemicals.


In chemistry, when we refer to a compound as “pure”, what we really mean is that the compound is at least 98-99%.  It’s important to understand that nothing can actually be 100% pure.  99.9999 maybe, but 100% is absolute.  Nothing is absolute!

So, if you’re looking to take advantage of the fat-loss benefits Rauwolscine has to offer, it would be wise to go with a pure form like Rauwolscine HCL.

You’re just gambling when you take an extract.  The studies are pretty clear…

Statisticaly speaking, you’re either:

  1. Not getting what you’re paying for
  2. Getting way more than you think you’re getting (dangerous?)

So don’t be stupid…You should always go with pure forms of any single ingredient supplement when possible.

Sure, some extracts are worth taking such as Ashwagandha, Maca, or Fucoxanthin, but why would you roll the dice on an extract with unpredictibe levels of active ingredients that may cause isssues when you can obtain the pure form of whatever supplement it is you want to use.

Unfortunately, most the supplements out there which supposedly contain Rauwolscine contain extracts which may or may not contain the stated ingredients.  You just don’t know for sure so often times it comes down to how much you trust a pariticular brand.

Take it from us…

Most supplement companies are NOT trustworthy.

Products That Contain Rauwolscine

Though not as widespread as many other supplements you can find it in a variety of places, in extract form and/or pure hcl form.

Single Ingredient Rauwolscine Supplements

Fat-Burners Which Contain Rauwolscine

Pre-Workouts Which Contain Rauwolscine

It should be noted that most, if not all, of these multi-ingredient supplements contain some sort of extract.  This means that, even though they promise a certain standardization, you have no idea what other compounds are present or if that standardization is accurate.

So, although you can find it in many different forms, it’s best to just go with HCL.

How To Use Rauwolscine For Maximum Fat-Loss

Rauwolscine is significantly more potent than Yohimbine, milligram for milligram, so small doses such as 1-3mg are effective and tend to be well-tolerated.

Beacuse it blocks the receptors that normally put a stop to Lipolysis, it will allow your body to burn fat more fat during exercise than it would under normal conditions.  For this reason, it’s best taken just prior to exercise and the higher the intensity, the better.

If you’re using Rauwolscine for weight-loss, it’s extremely important that you grasp that point…

You MUST exercise!

There is no magic fat-burner where you just pop and few pills and fat just melts right off.  Any company claiming to have such a pill is lying to you.  Rauwolscine, on the other hand, is QUITE an effective fat-loss supplement when COMBINED WITH EXERCISE.

A good way to think about it is this:

Rauwolscine leaves the furnace on, it’s up to you how much fat you burn.  Combined with regular high intensity exercise, fat-loss can be acheived in as little as two weeks.

Potential Side Effects

Since Rauwolscine and Yohimbine are extremely similar, they also share similar potential side effects.  Rauwolscine is less likely to cause them, but it’s possible if you take too much.  Some common side effects from taking too much include:

  • Jitters
  • Anxiety
  • Dizziness
  • Rapid Heart Beat
  • Irritability

The best way to avoid these types of side effeects would be to use a low dose (1-3mg max).

Rauwolscine is much stronger than Yohimbine and should NOT be dosed like Yohimbine, especially when you’re just starting out.  I

t’s also a good idea to drink plenty of water as it does tend to make you sweat more during workouts.  Combining it with Theanine may further reduce like liklihood of negative side effects.


Rauwolscine is much safer than it’s counterpart, Yohimbine.  Mostly this has to do with the fact that Yohimbine often comes from questionable extracts with unreliable doses.  So yes, it’s fair to say that Rauwolscine HCL is much safer than the average Yohimbine supplement, but there are many people who can tolerate both Yohimbine and Rauwolscine just fine.

It’s usually just a matter of individual stimulant tolerance, but Rauwolscine tends to be milder on the side effects (jitters, anxiety, etc.).  At least that is what anecdotal reports seem to suggest.

The reality is, no studies have pitted Yohimbine and Rauwolscine against each other in terms of side effects, but the fact that you can benefit from a much smaller dose of Rauwolscine than Yohimbine makes it attractive.


In the United States of America, Rauwolscine is entirely legal.  This is because, for the most part, the FDA allows things to be considerede dietary suppements if they can easily be found and extracted from common plants.  Since it is found in literally hundreds of similar but distinct species of plants, it qualifies as a dietary supplement.

In some other countries, however, Rauwolscine (Alpha-Yohimbine) may not be legal to sell.  If you’re in another country besides the U.S. you should consult your countries supplement laws before trying to order it from the U.S.

Singular Sport: A Brand You Can Trust

Most Rauwolscine supplements we’ve encountered contain some sort of extract which is allegedly standardized for some Rauwolscine.

However, as plenty of studies have shown us, these types of extracts tend to vary widely in terms of their chemical composition.

That means, while there may be some Rauwolscine in there, it’s probably either way less or way more than the stated dose, as was the case in this study on Yohimbe extract supplements.

For that reason, we would advice going with a pure Rauwolscine supplement such as Rauwolscine HCL.  The only brand we’re aware of offering such a supplement is Singular Sport.



Singular Sport was created by SuppWithThat Founder, Matt Theis, with the mission of bringing absolute transparency to the single-ingredient supplement industry by subjecting each finished batch of each supplement to random Third Party Testing.

If you’re not familiar with the term “Third Party Testing”, take a look at Matt’s post on Why You Can’t Trust Most Supplements which exposes some shocking truths about the shady nature of the supplement industry.

If you read that post, you’ll surely agree that most supplements can’t be trusted because the companies that make them don’t subject their products to Third Party Testing, the last and final level of transparency.

Given that this is a brand who has really made a name for itself when it comes to transparency by utilizing Third Party Testing to guarantee that what’s stated on the label is actually in the product, we recommend Singular Sport Rauwolscine above all else.

Why gamble on an extract that may or may not contain what it’s supposed to (and might contain things it’s not supposed to) when you could just go with Singular Sport Rauwolscine and be absolutely sure?  Trick question…You wouldn’t!

Combining Rauwolscine With Other Stimulants

It’s very common to come across Rauwolscine in multiple-ingredient fat-burners and pre-workout supplements.  It generally provides the mood-enhancement and fat-burning edge that users of these supplements tend to enjoy and so far no reports of adverse effects have surfaced regarding, even when combined with other stimulants.

As with any stimulant compound, you should always be careful combining it with other stimulants.

That said, as long as your not prone to high blood pressure and aren’t particularly sensitive to stimulants, it makes sense to combine Rauwolscine with things like Synephrine or Higeamine.



Higenamine is a beta-receptor agonist which means it’s essentially the inverse of Rauwolscine.  Put simply, Higenamine activates the beta-receptors that signal fat breakdown and Rauwolscine keeps the process going.  Combined, the two are quite synergistic.

Summing It Up

Rauwolscine is without a doubt the most powerful fat-burning ingredient that’s still legal.  What makes it so unique, is that it doesn’t directly induce fat-loss.  It merely allows more fat-loss to occur during exercise than would otherwise be possible.

The more frequent and intense your exercise sessions, the more fat you’ll burn.  If you’re looking to get rid of stubborn belly fat, and are willing to put in some work (exercise), Rauwolscine can help you acheive your fat-loss goals quickly.


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  3. Arthur, John M., Shirley J. Casańas, and John R. Raymond. “Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors.” Biochemical pharmacology 45.11 (1993): 2337-2341.
  4. Ostojic, Sergej M. “Yohimbine: the effects on body composition and exercise performance in soccer players.Research in Sports Medicine 14.4 (2006): 289-299.
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  7. Cohen, Pieter A., et al. “Pharmaceutical quantities of yohimbine found in dietary supplements in the USA.” Drug testing and analysis (2015).


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