Reviews

Performax Labs OxyMax XT: An Evidence-Based Review

OxyMax XT is a fat-burner and mood-enhancement supplement by Performax Labs, the brand behind HyperMax, which makes some pretty hardcore formulas…

OxyMax XT

Claims

Performax Labs claims OxyMax XT will:

  • Burn Fat
  • Enhance Mood
  • Suppress Appetite

Judging by the long list of stimulant-ingredients, it looks like OxyMax XT definitely has what it takes to deliver on each one of these claims, but let’s take a closer look (just to be sure)…

OxyMax XT Ingredients

As alluded to above, most of the ingredients in OxyMax XT are stimulants.  In fact, only four ingredients are non-stims, one of which is Black Pepper Extract—an absorption ehancer, not an active weight-loss ingredient—so if you’re sensitive to stimulants you should probably just turn back now…

Eria Jarensis

Eria Jarensis is a type of Orchid which, unlike so many other types of Orchid, is alleged to actually contain Phenylethylamine (PEA) and PEA derivatives.  Unfortunately, like so many other herbal ingredients alleged to contain powerful stimulants, there isn’t actually any solid evidence to support the use of Eria Jarensis.

Still, we’ve seen it pop up here and there lately in supplements like Olympus Labs BloodShr3d and RedCon1 Total War.

So, it’s probably a super-effective stimulant, but we won’t comment on it for now…because we like  to see studies first.

Beta-PHENYLETHYLAMINE

Beta-Phenylethylamine (B-PEA) can induce a short, but powerful release of Catecholamines (Dopamine, Adrenaline, Noradrenaline), thereby enhancing mood and overall well-being.

Although the weight-loss potentially of B-PEA has not been looked at directly in a clinical setting, it stands to reason that it can induce lipolysis because Noradrenaline itself is a powerful inducer of lipolysis.

AMENTOFLAVONE

Amentoflavone has recently gained recognition for its alleged performance benefits, but it may also have some potential for fat loss.

Amentoflavone inhibits phosphodiesterase (PDE), an enzyme that is ultimately involved in the degradation of cAMP.  Theoretically, by inhibiting PDE, cAMP is increased and fat-loss should occur.

However, while the mechanism of action exists by which Amentoflavone supplementation may encourage fat-loss, it has not be studied in humans at this time, making the magnitude of such an effect difficult to determine.

In the context of OxyMax XT, Amentoflavone offers a unique mechanism of action by which it may influence fat-loss.  This helps further separate OxyMax XT from many other fat-burners that are solely stimulant-powered.

HORDENINE

Hordenine is included in many fat-burners because of its ability to amplify the effects of Caffeine. Preliminary studies indicate that its primary mechanism of action is via Momoamine Oxidase inhibition, with oral doses being shown to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself.

So, rather than acting as a stand-alone stimulant, Hordenine can amplify/extend the effects of other stimulants by blocking the reuptake of Noradrenaline (and other Monoamines).

In the context of OxyMax XT, Hordenine will contribute to longer-lasting mood enhancement as well as potentially enhancing/extending the lipolytic effects of the stimulants.

COLEUS FORSKOHLII

Coleus Forskohlii contains the active compound, Forskolin, which has been demonstrated to increaseCyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.

We discuss the weight-loss implications of Forskolin in this article.  In the context of OxyMax XT, Forskolin helps round out the non-stimulant weight-loss dimension.

CAFFEINE ANHYDROUS

Caffeine is a well-established ergogenic aid, oral consumption of which triggers the release of Catcholamines such as Noradrenaline, a powerful inducer of lipolysis.  OxyMax XT contains an undisclosed amount of Caffeine but, given that it is listed first in a 275mg proprietary blend, we’d estimate anywhere from 150-250mg per serving.

HIGENAMINE HCL

Higenamine is a Beta(2) Adrenergic Agonist (same mechanism as Ephedra), meaning it stimulates the Beta(2) Adrenergic Receptors which initiate the fat-burning process.

Though Performax doesn’t list the exact dose of Higenamine present in OxyMax XT, it doesn’t take much to elicit fairly noticeable effects.  10-20mg will get the job done.

RAUWOLSCINE

Rauwolscine, also known as Alpha-yohimbine, is a close chemical relative of Yohimbine. In the context of OxyMax XT it has essentially the same function.
Rauwolscine is an Alpha Receptor Antagonist, meaning it blocks the receptors responsible for blocking lipolysis. By blocking these receptors, Rauwolscine is able to potentiate the effects of other stimulant fat-burners and allow more fat-burning than would normally occur from exercise alone.

Performax doesn’t list the exact dose of Rauwolscine, but it literally only takes 1-2mg to take effect, so there is no danger of under-dosing here.

CAPSICUM

Though commonly standardized for Capsaicin content alone, Capsicum also contains other compounds, collectively referred to as Capsaicinoids which have thermogenic properties and pretty clear weight-loss implications.

A 2007 study noted an increase in fat oxidation (relative to placebo) during low intensity exercise in healthy adult males who consumed 150mg of capsaicin one hour before exercise.

BIOPERINE

Piper nigrum, also known as Black Pepper, contains Piperine. Several studies have found that black pepper extract, when combined with other supplements, has increased the absorption of those supplements (as measured by plasma levels).

Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).

In the context of OxyMax XT, Black Pepper Extract functions as an absorption enhancer.

Is OxyMax XT Safe?

If used correctly, probably…but as with most speculative stimulant-containing supplements, there hasn’t been much research to establish a safety profile for some of these ingredients.  But, if you can handle your stims, you can handle OxyMax XT…just take it easy is all!

Performax: Effective Formulas, Fast Results

Performax has cultivated a reputation for itself as a hardcore, no-nonsense supplement company which puts out cutting-edge supplements that actaully work.  OxyMax XT is no exception.  If you’re looking for a fat-burner that doesn’t work…check BodyBuilding.com’s list of the most highly rated fat-burners (haha).  Otherwise, give Performax a shot…you won’t be disappointed.

THE BOTTOM LINE

OxyMax XT is undoubtedly an effective fat-burner.  It derives much of its potentially from several powerful stimulants which may also enhance mood and focus, but thanks to such ingredients as Forskolin, Amentoflavone, and Capsaicin, it is actually quite well-rounded.  When used in combination with regular exercise, users can expect some noticeable fat-loss to occur but this isn’t one for individuals that are overly stimulant-sensitive.

If you’re still not sure which fat-burner is right for you, check out our Best Fat-Burners list for some recommendations.

Supplement Facts

  1. Henderson, Shonteh, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr 2.2 (2005): 54-62.
  2. Godard, Michael P., Brad A. Johnson, and Scott R. Richmond. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obesity Research 13.8 (2005): 1335-1343.
  3. Jagtap, Madhavi, H. M. Chandola, and B. Ravishankar. “Clinical efficacy of Coleus forskohlii (Willd.) Briq.(Makandi) in hypertension of geriatric population.”Ayu 32.1 (2011): 59.
  4. Graham, Terry E., Danielle S. Battram, Flemming Dela, Ahmed El-Sohemy, and Farah S.L. Thong. “Does Caffeine Alter Muscle Carbohydrate and Fat Metabolism during Exercise?” Applied Physiology, Nutrition, and Metabolism 33.6 (2008): 1311-31
  5. Graham, T. E., and L. L. Spriet. “Metabolic, catecholamine, and exercise performance responses to various doses of caffeine.” Journal of Applied Physiology 78.3 (1995): 867-874
  6. Graham, Terry E. “Caffeine and exercise.” Sports medicine 31.11 (2001): 785-807.
  7. Ebashi, S., and Mi Endo. “Calcium and muscle contraction.” Progress in biophysics and molecular biology 18 (1968): 123-183
  8. Poisner, Alan M. “Caffeine–Induced Catecholamine Secretion: Similarity to Caffeine–Induced Muscle Contraction.” Experimental Biology and Medicine142.1 (1973): 103-10
  9. Nojima, Hiroshi, Mari Okazaki, and Ikuko Kimura. “Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice.” Journal of Asian natural products research 2.3 (2000): 195-203.
  10. Bai, Gang, et al. “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2‐adrenergic receptor agonist1.” Acta Pharmacologica Sinica 29.10 (2008): 1187-1194.
  11. Shin, Ki Ok, and Toshio Moritani. “Alterations of Autonomic Nervous Activity and Energy Metabolism by Capsaicin Ingestion during Aerobic Exercise in Healthy Men.” Journal of Nutritional Science and Vitaminology 53.2 (2007): 124-32
  12. Ohnuki, Koichiro, et al. “Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice.” Bioscience, biotechnology, and biochemistry 65.12 (2001): 2735.
  13. WATANABE, TATSUO, et al. “Adrenal sympathetic efferent nerve and catechol secretion excitation caused by capsaicin in rats.” (1988).

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