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Nutrex Lipo 6 Rx Review

Lipo 6 Rx is a 100% Transparent fat-burner from Nutrex which derives most of it’s fat-burning potential from a few stimulants, including Caffeine, Rauwolscine, and Theacrine…

Lipo 6 Rx

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DMAE

Dimethylaminoethanol, or DMAE for short, is a cholinergic compound which is generally used for cognitive enhancement or, perhaps more reliably, to prevent cognitive decline.  It has been shown to improve certain aspects of cognitive function in older subjects with mild cognitive impairment, but has not been studied much in healthy individuals, let alone athletes.

So, in the context of Lipo 6 Rx, DMAE may function as a cognitive support agent, but the degree of benefit remains unclear.  We wouldn’t necessarily consider it a “key” ingredient compared to the others in Lipo 6 Rx.

Theacrine

Theacrine is an alkaloid found almost exclusively in Camellia Assamica, also known as Kucha tea. In terms of its chemical structure, Theacrine (1,3,7,9-tetramethyluric acid) is very similar to Caffeine (1,3,7-trimethylxanthine), so its physiological effects are alleged to be similar as well.

We discuss Theacrine more in this article.  So far, its fat-burning potential has not been explored but it does appear to be effective for increasing perceived energy (similar to Caffeine) and may be less prone to tolerance build-up (compared to Caffeine).

In the context of Lipo 6 Rx, Theacrine may help even out the energy blend by providing more of a sustained boost.

N-Acetyl-L-Tyrosine

Tyrosine is a non-essential amino acid (the body can produce it from Phenylalanine) which serves a precursor to Dopamine (by first being converted into L-Dopa) and Noradrenaline.

Because of this relationship, Tyrosine is alleged to increase levels of these neurotransmitters, which would theoretically lead to performance enhancement. However, research has demonstrated thatTyrosine cannot outright raise Dopamine or Noradrenaline levels upon ingestion, though it can help maintain optimal levels when depletion might otherwise occur.

Upon ingestion, Tyrosine forms substrate pool, which can then be drawn from when an acute stressor (exercise, cold exposure, etc.) causes a temporary depletion of Dopamine/Noradrenaline. For this reason, Tyrosine can be useful for maintaining cognitive function during stressful activity.

So, in the context of Lipo 6 Rx, N-Acetyl-L-Tyrosine functions more as a cognitive support ingredient.  It has no direct weight-loss implications.

DiCaffeine Malate

Dicaffeine Malate is simply a combination of Caffeine and Malic Acid which is alleged to have longer-lasting effects and a smoother overall transition (no crash).  These claims haven’t exactly been substantiated by unbiased scientific research, but at the very least DiCaffeine Malate serves as an alternate source of Caffeine in Lipo 6 Rx.

Caffeine Anhydrous

Caffeine releases neurotransmitters such as Noradrenaline which induce lipolysis (fat-breakdown) so it does have direct fat-loss implications.  Combined with the other stimulants in the Lipo 6 Rx formula, Caffeine may also increase perceived energy and focus.

Hordenine

Hordenine is included in many fat-burners because of its ability to amplify the effects of Caffeine. Preliminary studies indicate that its primary mechanism of action is via Momoamine Oxidase inhibition, with oral doses being shown to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself.

So, rather than acting as a stand-alone stimulant, Hordenine can amplify/extend the effects of other stimulants by blocking the reuptake of Noradrenaline (and other Monoamines).

Lipo 6 Rx contains a standard 50mg dose of Hordenine, enough to amplify the effects of the other stimulants in the formula and ultimately encourage excess fat-burning.

Ginger

Ginger is a very common household digestive aid, commonly prescribed by loving mothers for stomach problems.

However, a 2012 pilot study from “Metabolism” found that 2 grams of Ginger consumed with a mea lincreased caloric expenditure for several hours following the meal in overweight men.

Ginger has also been shown to increase Insulin secretion via acting as a serotonin receptor antagonist (serotonin normally suppresses insulin to some degree) in mice, though a human study using 1 gram of Ginger failed to replicate this results.

Lipo 6 Rx contains 20mg of Ginger Extract.

Rauwolscine

Rauwolscine, also known as Alpha-yohimbine, is a close chemical relative of Yohimbine. In the context of Lipo 6 Rx it has essentially the same function.

Rauwolscine is an Alpha Receptor Antagonist, meaning it blocks the receptors responsible for blocking lipolysis. By blocking these receptors, Rauwolscine is able to potentiate the effects of other stimulant fat-burners and allow more fat-burning than would normally occur from exercise alone.

Lipo 6 Rx contains .75mg of Rauwolscine, not an overly-intense dose but still enough to enhance the fat-burning and energy aspect of the formula as a whole.

The Bottom Line

Lipo 6 Rx is mostly stimulant fueled with ingredients like Ginger and Tyrosine complementing the fat-burning properties of the stims.  In addition to being a moderately effective fat-burner, Lipo 6 Rx will also increase perceived energy/focus/mood in the average individual (assuming Caffeine tolerance isn’t through the roof).

Still don’t know which fat-burner is right for you? Check out our Top 10 Fat-Burners List!

REFERENCES
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  3. Yeghiayan, Sylva K., et al. “Tyrosine improves behavioral and neurochemical deficits caused by cold exposure.” Physiology & behavior 72.3 (2001): 311-316
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  5. Shurtleff, David, et al. “Tyrosine reverses a cold-induced working memory deficit in humans.” Pharmacology Biochemistry and Behavior 47.4 (1994): 935-941.
  6. Wang, Yuanyuan, et al. “Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.” Fitoterapia 81.6 (2010): 627-631.
  7. Feduccia, Allison A., et al. “Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors.” Pharmacology Biochemistry and Behavior 102.2 (2012): 241-248
  8. Desideri, Giovambattista, et al. “Benefits in Cognitive Function, Blood Pressure, and Insulin Resistance Through Cocoa Flavanol Consumption in Elderly Subjects With Mild Cognitive Impairment The Cocoa, Cognition, and Aging (CoCoA) Study.” Hypertension 60.3 (2012): 794-801.
  9. Graham, T. E., and L. L. Spriet. “Metabolic, catecholamine, and exercise performance responses to various doses of caffeine.” Journal of Applied Physiology 78.3 (1995): 867-874
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  11. Ebashi, S., and Mi Endo. “Calcium and muscle contraction.” Progress in biophysics and molecular biology 18 (1968): 123-183
  12. Poisner, Alan M. “Caffeine–Induced Catecholamine Secretion: Similarity to Caffeine–Induced Muscle Contraction.” Experimental Biology and Medicine142.1 (1973): 103-10
  13. Perry, Bruce D., and David C. U’Prichard. “[3 H] rauwolscine (α-yohimbine): A specific antagonist radioligand for brain α 2-adrenergic receptors.” European journal of pharmacology 76.4 (1981): 461-464.

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