When it comes to Post Cycle Therapy, no compound, drug, or supplement receives more attention than Nolvadex.
It’s become known as the “gold standard” of estrogen blockers and is used by everyone from cancer patients to bodybuilders.
In this article, we’ll discuss everything you need to know about it, including:
- What It Is
- How It Works
- Why People Use It
- Where To Buy It
And a whole lot more. So, if you’re ready to learn all there is to learn about Nolvadex, let’s dive right in…
What Is Nolvadex?
Nolvadex is a brand name for Tamoxifen Citrate, a powerful Selective Estrogen Receptor Modulator (SERM) originally developed way back in the 1960’s by ICI (now known as AstraZeneca).
The invention of Nolvadex was actually kind of an accident. You see, ICI chemical researchers were actually trying to develop a contraceptive, but Tamoxifen ended up falling short when they tested it in humans.
However, a few of the researchers recognized the powerful estrogen suppression effects of the drug and realized it could potentially treat Breast Cancer. And…
They were right!
Tamoxifen was put to the test and was found to be quite effective at reducing the spread of Breast Cancer cells due to potent suppression of Estrogen (known to accelerate the spread of cancer cells).
Thus, the drug was re-positioned and introduced as Nolvadex which soon became the one of the leading treatments for Breast Cancer and still is today.
How Does Nolvadex Work?
As mentioned before, Nolvadex is a powerful Selective Estrogen Receptor Modulator (SERM).
This means its chemical structure is close enough to Estrogen that it can bind to Estrogen Receptors, thereby blocking actual Estrogen from binding to those receptors and carrying out it’s function.
Less Estrogenic activity which has numerous physiological effects in the body, including reducing the spread of cancer cells.
The following diagram illustrates how Tamoxifen (Nolvadex) binds to the Estrogen receptor, blocking Estrogen from doing so.
SERMs are considered a first-line treatment for Breast Cancer or any other condition that requires potent Estrogen suppression.
Directly binding the Estrogen Receptors (so Estrogen cannot) is perhaps the most direct route for blocking Estrogen in general.
This is in contrast to Aromatase Inhibitors (AIs) such as androsta 3 5 diene 7 17 dione which block Estrogen by preventing the enzyme Aromatase from converting Testosterone into Estrogen.
Both SERMs and AIs block Estrogen, but in different ways. A powerful SERM like Nolvadex will reduce Estrogen to a greater degree than most AIs.
Nolvadex also has another mechanism that makes it of use for Post Cycle Therapy. Research has shown that Tamoxifen (Nolvadex) can stimulate the release of Luteinizing Hormone (LH) which in turn helps restore natural Testosterone production.
This is why many people rely on Nolvadex alone for their PCT needs, although using both a SERM and an AI would be ideal in most cases.
Why Do People Use Nolvadex?
As we’ve already established, Estrogen progresses the spread of Breast Cancer, Nolvadex makes for an effective treatment option. However, because it possesses such potent Estrogen-blocking properties, it has another off-label use and an entirely separate market.
That’s right, bodybuilders and athletes who take steroids rely on Nolvadex to combat the Estrogen-rebound that generally accompanies any kind of steroid cycle.
You see, when you artificially boost your Testosterone far beyond the normal range–where Nitrogen retention is increased and muscle protein synthesis is accelerated–your body will typically attempt to compensate by producing more and more Estrogen.
Your body normally keeps a specific balance (or ratio) of Testosterone and Estrogen, so when it all the sudden realizes there’s way more Testosterone floating around, it naturally produces more Estrogen.
Unfortunately, higher than normal Estrogen levels can lead to some unwanted side effects, some of which are quite severe.
- Erectile Dysfunction
- Loss Of Sex-Drive
- Gynecomastia (Bitch Tits)
So, if you’re running any kind of steroid cycle (or any compound that actually boosts your Testosterone levels beyond the normal range, blocking Estrogen becomes extremely important.
Otherwise, there may be serious consequences.
That’s why Nolvadex serves as a major component of the experienced steroid user’s Post Cycle Therapy regimen.
What Are The Benefits Of Nolvadex? Why Is Nolvadex So Important For PCT?
Nolvadex blocks Estrogen. For cancer patients, this lowers the likelihood that the cancer will spread.
For bodybuilders, this massively reduces the likelihood of developing the Estrogen-related side effects we discussed above while their natural Testosterone levels return to normal.
As a potent Estrogen suppressor, Nolvadex may:
- reduce water weight (dries you out)
- prevent hair loss
- make you leaner and more defined
- keep your mood constant
- prevent gynecomastia
Maintaining low Estrogen levels has some additional benefits as well but these are the things are all primary concerns for steroid users, especially gyno.
There is no SERM stronger than Nolvadex, so it’s become known as the ‘gold standard’ for Post Cycle Therapy.
What Kind Of Results Can I Expect With Nolvadex?
If you’re on steroids, and you’re using Nolvadex as a PCT solution, you can expect to avoid the bulk of the Estrogen-induced side effects we discussed above
That means NO:
- mood swings
More importantly, Nolvadex suppresses Estrogen long enough for your natural Testosterone levels to have a chance to be restored.
If you’ve ever taken steroids and come off without a PCT, you were taking a gamble. While you may not have developed gynecomastia (worst case scenario), you probably felt terrible.
Now you know why…
Too much Estrogen!
What Are The Side Effects Of Nolvadex?
Nolvadex may sound like a miracle drug, but it does come with its fair share of potential side effects, including:
- Extreme thirst (it dries you out)
- Headache (perhaps due to water loss)
- Hot Flashes
- General Fatigue
- Joint Pain/Dry Joints
Of course, these are just some of the more common, less severe side effects.
It’s unlikely, but Nolvadex can also result in:
- Weight Gain (Not Necessarily A Bad Thing)
- Sexual Dysfunction (So Does Low Test Though)
- Skin Rash
But we’re talking about a pretty low likelihood here, especially when only used for a short period of time for PCT purposes.
The most common complaint with Nolvadex is that it makes you extremely thirsty may cause stiff or dry joints.
This most likely has to do with the fact that Estrogen increases water retention and lowering it reduces water retention, resulting in the physiological sensation of thirst.
This extreme thirst is pretty normal and can be easily remedied/handled by carrying a water bottle and staying hydrated.
How much Nolvadex you should be taking during your Post Cycle Therapy depends entirely on the severity of the cycle you’re running.
For lighter cycles of not-so-harsh compounds, an appropriate dosing schedule would be something like:
- Week 1 – 20mg
- Week 2 – 20mg
- Week 3 – 10mg
- Week 4 – 10mg
For more serious, harsher compounds, an appropriate dosing schedule would look something like:
- Week 1 – 40mg
- Week 2 – 30mg
- Week 3 – 30mg
- Week 4 – 10mg
It’s not wise to run Nolvadex for much longer than 4 weeks or so, nor is it necessary.
You see, Estrogen isn’t just some annoying hormone that makes you pack on water weight and act like a girl. It has legitimate physiological roles for which it is required.
Suppressing it for to long can interfere with things like:
To put it simply, you need Estrogen if you’re a man…Just not too much of it.
When Should I Start Taking Nolvadex?
Most people begin their PCT regimen immediately after they finish their cycle. There’s some debate as to whether it’s a good idea to start taking your PCT while still on cycle but, ultimately, it depends on what kind of cycle you’re running.
If the compound you’re on Aromatizes (freely converts into Estrogen), you may need some Estrogen-blockage while still on cycle. If it doesn’t, as is the case with most not-so-harsh compounds, you can simply begin taking your Nolvadex the day you stop taking whatever it is you’re taking.
Everyone’s different and every reacts to steroids/pro-hormones differently. It’s important to pay attention to your body and make sure you have your Nolva before you begin your cycle.
That way, if you notice any kind of Estrogen-related side effects (i.e. puffy, sore nipples) you can immediately hit it with the Nolva. Even if you’re already experiencing symptoms of gynecomastia, Nolvadex can help treat it.
Is Nolvadex Safe?
While all drugs have potential side effects that may occur, research indicates Nolvadex is pretty safe when used correctly.
If you’re using it for PCT purposes, you don’t have much to worry about. Cancer patients literally take it for years at a time, so 1 month won’t do you any harm, even if you experience some minor side effects.
That is, assuming you get legitimate Nolvadex.
Unfortunately, due to it being the most powerful SERM on the market, but remaining unscheduled in the United States (no obvious abuse potential), there’s a ton of fake Tamoxifen Citrate (Nolvadex) being sold on the internet.
Is Nolvadex Legal?
Nolvadex is a prescription only drug, but it remains unscheduled in the US. Scheduled drugs are drugs that have some sort of misuse or abuse potential. Schedule I drugs are seen as having a high misuse/abuse potential while Schedule V drugs are seen as less likely to be misused/abused.
Tamoxifen (Nolvadex) is not scheduled at all, meaning it has no real misuse/abuse potential.
It’s certainly not addictive and doesn’t cause any sort of high, so in the US, it’s not seen as much of an issue.
This means it can legally be used, bought, and sold for “research purposes”.
Given the fact that there are more problematic drugs such as Heroin and Meth with high abuse potential for the government to be concerned with, it’s unlikely that Tamoxifen will ever be scheduled.
So, at least for the time being, you can easily find it online and it’s not illegal for you to buy it.
This is the same “research purposes only” loophole that’s used by people selling all other research chemicals, such as Etizolam.
Where To Buy Legit Nolvadex
If you Google “buy Nolvadex” or “buy Tamoxifen Citrate”, you’ll find tons of Nolvadex for sale…
You’ll find tons of sites claiming to have real Nolvadex or sale.
Usually, it’s sold in the form of powder suspended in a liquid solution.
Somehow, the people who sell it are under the impression that this makes it more legal…
But it doesn’t.
Tamoxifen is Tamoxifen whether it’s liquid, powder, or tablets.
The more important thing to worry about is whether you can trust your source. Some research chemical websites with solid reputations include:
There are others out there, but why risk it? Go with a supplies that has been around for a while, visit forums, and read reviews (carefully).
It’s also a good idea to go with a supplier that accepts credit cards. That way, if there’s an issue, you can always file a dispute and you’ll most likely get your money back while simultaneously causing trouble for the fraudster that tried to rip you off.
The Bottom Line
If you want the absolute strongest Estrogen-blocker known to man, you want Nolvadex. There are other SERMs out there, but Nolva really is the gold standard when it comes to Post Cycle Therapy.
Not taking your Post Cycle Therapy seriously can have serious consequences and, while there are PCT supplements that can handle less harsh compounds, a real steroid cycle requires a real PCT (like Nolvadex).
The main issue you’re going to run into is a matter of trust. Plenty of people claim to have legit Nolvadex, but only a small handful actually do.
Do your research and choose carefully!