Machine Motion is the joint support formula which marks the beginning of the Dr. Stu Series by MTS Nutrition. It contains a few well-established ingredients at clinical doses…
Glucosamine is commonly found in two forms: Glucosamine Sulfate and Glucosamine HCl. Most of the positive results noted throughout various studies have resulted from Glucosamine Sulfate, so that is the form we generally like to see in joint-support formulas.
We discuss Glucosamine’s mechanism of action in this article, but to make a long story short: Glucosamine Sulfate (not HCL) can be moderately effective when it comes to joint preservation, but may not do much in the way of reversing damage that has already occurred.
For this reason, Glucosamine Sulfate supplementation makes sense for athletes/bodybuilders whose joints may be under a lot of stress on a pretty regular basis. Machine Motion contains 2g per serving, well within the effective range of 1.5-3g/daily.
Methylsulfonylmethane (MSM) is similar to Glucosamine Sulfate in terms of its influence on joint-health. It is hypothesized that the real benefit of MSM lies in the fact that it contains sulfur, which is a component of collagen, and thus necessary for functional, healthy joints. This might also explain why Glucosamine Sulfate (which contains Sulfur) is more effective than Glucosamine HCL (which does not contain sulfur).
In the context of Machine Motion, MSM serves roughly the same purpose as Glucosamine (joint preservation).
Cissus Quadrangularis is a plant indigenous to Africa and parts of Asia, but has recently gained popularity as a joint/bone support supplement. We discuss Cissus in-depth in this article, but (to make a long story short) preliminary research indicates Cissus can be effective for reducing joint-pain and encouraging connective tissue health.
Machine Motion contains 1000mg of Cissus per serving, standardized to 10% Ketosterones (primary bioactives).
Chondroitin is a major component of Cartilage and is commonly paired with Glucosamine in joint-support supplements (such as Machine Motion) because of an alleged synergy. In vitro, chondroitin and glucosamine have been demonstrated to synergistically induce collagen synthesis. However, in vivo studies comparing and contrasting the effects of chondroitin relative to glucosamine fail to find such synergy between the two.
Studies that have compared the two have found that much of the benefit obtained with the combination of Glucosamine and Chondroitin can be obtained from Glucosamine alone, meaning Chondroitin might not be so important after all.
That said, the addition of Chondroitin to Machine Motion certainly can’t hurt the formula.
Bromelain, also known as Pineapple Extract, contains protein-digesting enzymes called proteases, which possess moderately potent anti-inflammatory properties. For this reason, Bromelain has been investigated for the treatment of osteoarthritis (OA), but with mixed results.
A 2002 study, published in Phytomedicine, reported that Bromelain supplementation modestly improved symptoms in subjects with knee pain. However, it should be noted this study was un-blinded and not placebo controlled. For that reason, the researchers concluded that double-blind, placebo controlled studies were needed before drawing accurate conclusions about Bromelain’s potential for joint health.
A 2006 placebo controlled study investigating the effects of Bromelain supplementation on symptoms of osteoarthritis found no significant differences between a group of subjects receiving 800mg Bromelain daily and the placebo group. A possible reason for the discrepancy (assuming first study was not flawed) might be that Bromelain is only effective for mild OA and not moderate to severe OA.
Machine Motion contains 400mg of Bromelain per serving.
Hyaluronic Acid is a major constituent of synovial fluid, the body’s natural joint lubricant. It has been studied primarily as a potential treatment for joint pain, and while a significant analgesic (painkiller) effect has been noted in rats following injections with hyaluronic acid, similar treatment has only been mildly effective in humans suffering from osteoarthritis of the knee.
While most studies have used injection, a 2012 study published in “The Scientific World Journal” found that oral supplementation with 200mg hyaluronic acid daily over a 12 month period improved symptoms in subjects suffering from Osteoarthritis of the knee.
Machine Motion contains the same 200mg dose used in the above-mentioned study.
Piper nigrum, also known as Black Pepper, contains Piperine. Several studies have found that black pepper extract, when combined with other supplements, has increased the absorption of those supplements (as measured by plasma levels). Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).
THE BOTTOM LINE:
Machine Motion contains clinically validated doses of most key ingredients and therefore has what it takes to protect and preserve joints, especially in athletes who are at risk of joint issues.
- Biggee, Beth Anne, et al. “Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness.” Annals of the rheumatic diseases 65.2 (2006): 222-226.
- Noyszewski, Elizabeth A., et al. “Preferential incorporation of glucosamine into the galactosamine moieties of chondroitin sulfates in articular cartilage explants.” Arthritis & Rheumatism 44.5 (2001): 1089-1095.
- Momomura, Rei, et al. “Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers.” Molecular medicine reports 7.3 (2013): 742-746.
- Henrotin, Yves, et al. “Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities.” BMC research notes 6.1 (2013): 115.
- Yoshimura, Masafumi, et al. “Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players.” International journal of molecular medicine 24.4 (2009): 487.
- Sawitzke, Allen D., et al. “Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT.” Annals of the rheumatic diseases 69.8 (2010): 1459-1464.
- Deal, Chad L., and Roland W. Moskowitz. “Nutraceuticals as therapeutic agents in osteoarthritis: the role of glucosamine, chondroitin sulfate, and collagen hydrolysate.” Rheumatic Disease Clinics of North America 25.2 (1999): 379-395.
- Bruyere, Olivier, and Jean-Yves Reginster. “Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis.” Drugs & aging24.7 (2007): 573-5
- Black, Corrinda, et al. “The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation.” (2009).80.
- Walker, A. F., et al. “Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults.” Phytomedicine 9.8 (2002): 681-686.
- Brien, S., et al. “Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.” QJM99.12 (2006): 841-850.
- Hale, Laura P., et al. “Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL‐10‐deficient mice with colitis.” Inflammatory bowel diseases 16.12 (2010): 2012-2021.
- Brien, Sarah, et al. “Bromelain as a treatment for osteoarthritis: a review of clinical studies.” Evidence-based complementary and alternative medicine 1.3 (2004): 251-257.
- Gotoh, Sachiko, et al. “Effects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats.” Annals of the rheumatic diseases 52.11 (1993): 817-822.
- Lo, Grace H., et al. “Intra-articular hyaluronic acid in treatment of knee osteoarthritis.” JAMA: the journal of the American Medical Association 290.23 (2003): 3115-3121.
- Neo, Hisashi, et al. “The effect of hyaluronic acid on experimental temporomandibular joint osteoarthrosis in the sheep.” Journal of oral and maxillofacial surgery 55.10 (1997): 1114-1119.
- Aggarwal, Anita, and Ian P. Sempowski. “Hyaluronic acid injections for knee osteoarthritis. Systematic review of the literature.” Canadian family physician50.2 (2004): 249-256.
- Tashiro, Toshiyuki, et al. “Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period.” The Scientific World Journal 2012 (2012)
- Chidambara Murthy, K. N., et al. “Antioxidant and antimicrobial activity of Cissus quadrangularis L.” Journal of medicinal food 6.2 (2003): 99-105.
- Shirwaikar, Annie, Saleemulla Khan, and S. Malini. “Antiosteoporotic effect of ethanol extract of< i> Cissus quadrangularis Linn. on ovariectomized rat.”Journal of ethnopharmacology 89.2 (2003): 245-250.
- Bloomer, R. J., et al. “Cissus quadrangularis reduces joint pain in exercise-trained men: A pilot study.” The Physician and sportsmedicine 41.3 (2013): 29-35.