The largest trend in the supplement industry over the past few years has been the massive rise in the use of SARMs. One compound that often gets grouped in with SARMs, but actually isn’t one, is MK 677.
In this article, we’ll discuss everything there is to discuss about MK 677, including:
- What Is MK 677?
- How Does It Work?
- What Are The Benefits?
- What Type Of Results Can You Achieve?
- Is It Safe?
In other words, after you read this article, you’ll know everything you need to know about MK 677. I don’t preach to people about which substances they should or shouldn’t put in their bodies.
My goal is simply to educate you before you do it, so you can make an informed decision for yourself. So, with that said, let’s get to it!
What Is MK 677?
MK 677, also known as Ibutamoren, is a synthetic Growth Hormone secretagogue.
The term secretagogue refers to any substance that triggers secretion.
In this case, the substance being secreted is Growth Hormone (GH).
GH is a peptide hormone which is released by the Pituitary Gland. It’s primary function is right in the name: Growth.
It stimulates the growth of pretty much all tissues, including muscle and bone. Mostly, this is due to GH triggering the release of Insulin-like Growth Factor 1 (IGF-1).
Your body secretes a small amount of Growth Hormone normally but this tends to decline with age. Many bodybuilders use Growth Hormone to stimulate muscle growth and burn fat, but it also has legitimate medical uses as well.
Treatment with Growth Hormone can:
- Increase Muscle Growth
- Decrease Body Fat
- Improve Cognitive Function
- Slow Aging
- Speed Up Healing Processes
And those are just some of the benefits. Scientists are still learning about all the ways Growth Hormone impacts our health, but one thing is for sure…
So naturally, anything that supposedly increases Growth Hormone is of interest to a wide range of people. Needless to say, a lot of supplements have been marketed as GH-boosters but turned out to be useless. So, is MK 677 any different?
Yes. It actually works…
How Does MK 677 Work?
MK 677 works by mimicking a naturally occurring Growth Hormone Secretagogue called Ghrelin and activating Growth Hormone Secretagogue Receptors (GHSR)–also known as Ghrelin Receptors–in the brain.
Ghrelin, sometimes referred to as ‘the hunger hormone’ is responsible for regulating energy balance in a ‘yin yang’ type of balance with another hormone called Leptin (the satiety hormone).
One of the things Ghrelin does is stimulate the release of Growth Hormone.
Since MK 677 mimicks Ghrelin to the point that it actually binds to the Ghrelin Receptors, it too stimulates the release of Growth Hormone to a pretty significant degree.
Interestingly, it does this without influencing other hormones very much at all.
What Are The Benefits Of MK 677?
The benefits of MK 677 are simply the benefits of increased Growth Hormone. There’s a lot of them and, like I said earlier, the research is ongoing.
But here are a few of the most notable…
MK 677 Increases Muscle Mass
The most common use for MK 677 is to gain muscle. That’s why it’s made such a big splash in the bodybuilding industry, despite not originally being intended for that at all.
The research on Growth Hormone is pretty clear: It increases muscle mass. Bodybuilders have been using GH for years to stimulate muscle growth and tons of supplements have been sold as GH-boosters.
Unlike most other so-called GH-boosters, MK 677 actually has some research behind it (albeit not that much).
In one study, researchers found that 8 weeks on MK 677 (at 25mg/day) resulted in a significant increase in fat-free mass (also known as lean body mass).
These findings were replicated in a more recent (2008) study as well.
Although not many human studies have looked at how MK 677 influences muscle mass, the ones that have show an increase.
MK 677 Preserves Muscle During Calorie Restriction
As I said earlier, MK 677 wasn’t originally developed to help people build muscle. That’s not something that drugs get approved for because it’s viewed as purely cosmetic.
Muscle wasting–the breakdown and loss of muscle tissue–is another story. There are a ton of diseases which are characterized by muscular wasting, either because of a direct effect of the disease or inability to eat in people who have the disease.
Growth Hormone treatment has been shown to preserve muscle in instances of dietary restriction, so naturally, MK 677 has been investigated for this as well.
Not much research has been conducted in this area, but the research that has been conducted is promising.
MK 677 has been shown to preserve muscle mass during severe caloric restriction.
MK 677 Improves Quality Of Sleep
Growth Hormone is known to play a role in regulating sleep.
GH itself has been shown to improve various aspects of sleep. So, it makes sense that some of the research on MK 677 looked specifically at how it impacted sleep.
MK 677 has been shown to improve sleep quality and increase the time spent in REM sleep.
Sure, you could argue that it’s only been shown to do so in one study, but we already know that GH is highly correlated with sleep quality, so it’s not a stretch to say that MK 677 improves sleep quality.
If you take a look around the internet, you’ll find a lot of anecdotal reports that support this notion.
MK 677 Encourages Healthy Bones
Given the obvious role of GH in bone health, it makes sense that some of the research on MK 677 would look specifically at how it impacts bone health.
Out of all the benefits MK 677 has to offer, improving bone health actually appears to have the most research behind it. If you have osteoporosis or any other kind of bone-debilitating condition, you stand to benefit from MK 677.
What Can I Expect When Taking MK 677?
If you’re considering using MK 677, it’s important to set realistic expectations. If you think you’re going to suddenly blow up and be super jacked, you may be disappointed.
Don’t get me wrong. You’ll definitely gain some weight on MK 677, but how much muscle you end up building will largely depend on how much you train and eat.
Here’s what you can expect with MK 677:
- Increased Appetite
- Increased Muscle Mass
- Better Sleep
What Are The Side Effects? Is It Safe?
MK 677 has been remarkably well-tolerated throughout most of the studies. One thing that’s worth point out though, is that it may reduce insulin sensitivity and increase blood sugar.
The impact isn’t likely to be massive, but if you have issues with insulin sensitivity or a pre-existing condition like Diabetes, you may want to stay away.
Other than that, there haven’t really been any reports of adverse health effects with MK 677.
In one study, some elderly subjects (over 80 years old) experienced heart failure, but these subjects had a pre-existing condition (and they were really old).
In healthy individuals, there’s no evidence that MK 677 is particularly harmful.
Is MK 677 Legal?
If you’ve been doing your research on MK 677, you’ve probably read that it’s “perfectly legal” and “available over the counter” in the US.
While it’s true that it’s perfectly legal to buy, sell, and possess MK 677, it can’t be sold as a dietary supplement. Technically, it’s an unscheduled drug.
That means any company that sells an MK 677 product that’s intended for human consumption is breaking the law.
So, you can’t buy it? Not so fast…
This is America, remember? There’s always a loophole. This particular loophole is used for a ton of different drugs and, given the way our laws work here in the US, it doesn’t look like it’ll close up any time soon.
What am I talking about? Research Chemical sites!
These are websites that sell unapproved drugs and various chemical substances which are allegedly for “research purposes only” and “not for human consumption“.
Obviously, this is a bunch of nonsense. But if you want to try MK 677, it’s great news! It means you can buy it online without having to worry about breaking the law. You just have to find a reliable research-chem site.
The Bottom Line On MK 677
MK 677 is an effective Growth Hormone secretagogue which can increase GH and IGF-1 levels to the point that it actually has some beneficial effects. A ton of substances are marketed as GH-boosters, but MK 677 is one that is actually deserving of that title.
If you’re looking to gain muscle mass, it may be just what you’re looking for. Just make sure you understand what you’re doing and do your research on suppliers!
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