MAN Sports Lean Ph.D Review

Lean Ph.D

Lean Ph.D is MAN Sports most recent thermogenic fat-burner which is essentially part weight-loss supplement and part nootropic. The nootropic component consists of a few of the same ingredients as MAN’s recent pre-workout, NOOPump…

[gard group=’1′]

Lean Ph.D is MAN Sports most recent thermogenic fat-burner which is essentially part weight-loss supplement and part nootropic. The nootropic component consists of a few of the same ingredients as MAN’s recent pre-workout, NOOPump



Carnitine is an amino acid that is heavily involved with the metabolism of fat for energy. It is required for the proper transport of fatty acids in the mitochondria, where they are oxidized (burned) for energy through the process known as “beta-oxidation”.

Carnitine deficiency has been shown to hinder fat-burning capacity, but studies investigating whether excess Carnitine intake (i.e. supplementation) can burn-fat haven’t been very encouraging thus far.
Although Carnitine supplementation (1g/day) has been shown to increase fatty acid oxidation rates in humans without Carnitine deficiency, it has failed to induce weight-loss in rats, as well as moderately obese women.

Carnitine does have mechanisms by which it may stabilize the fat-burning process in individuals who are Carnitine deficient (unlikely if you eat enough protein), but is unlikely to actually burn excess fat. MAN Sports does not disclose the amount of Carnitine present in Lean P.hD but with the entire proprietary blend amounting to just 690mg we assume no more than 200-300mg or so.


Tyrosine is a non-essential amino acid (the body can produce it from Phenylalanine) which serves aprecursor to Dopamine (by first being converted into L-Dopa) and Noradrenaline.

Because of this relationship, Tyrosine is alleged to increase levels of these neurotransmitters, which would theoretically lead to performance enhancement. However, research has demonstrated thatTyrosine cannot outright raise Dopamine or Noradrenaline levels upon ingestion, though it can help maintain optimal levels when depletion might otherwise occur.

Upon ingestion, Tyrosine forms substrate pool, which can then be drawn from when an acute stressor (exercise, cold exposure, etc.) causes a temporary depletion of Dopamine/Noradrenaline. For this reason, Tyrosine can be useful for maintaining cognitive function during stressful activity.

MAN Sports does not list the exact dose of NALT in Lean Ph.D but, based on a 690mg proprietary blend, we’d estimate anywhere from 150-250mg.


Green Tea has been shown to inhibit Catechol-O-Methyl Transferase (COMT), thereby extending/amplifying the effects of stimulants such as Caffeine. We discuss the fat-burning implications of Green Tea Extract more in this article.

Here’s where it gets confusing: MAN lists the amount of EGCG in Lean Ph.D at 150mg per serving and states that the Green Tea Extract is standardized to 60%, meaning there is 250mg total. However, since Green Tea Extract is the third ingredient, for there to be 250mg per serving, the entire proprietary blend would have to be at least 750mg, and that’s assuming no other ingredients.

We’re not saying Lean Ph.D doesn’t contain 150mg of EGCG per serving, just that something appears a little off here.


Nelumbo Nucifera (NN), sometimes referred to as Indian Lotus, is a flowering plant which has been shown to have anti-obesity effects in mice. These effects are primarily attributed to the Higenamine, although there are other compounds which may potentiate these effects. Higenamine is a Beta(2) Adrenergic Agonist (same mechanism as Ephedra), meaning it stimulates the Beta(2) Adrenergic Receptors which initiate fat-burning.

MAN doesn’t disclose the exact dose of Higenamine (or total Nelumbo Nucifera) present in Lean Ph.D, but it generally just takes 20mg or so for noticeable effects, so there is no reason to suspect under-dosing here.


Hordenine is included in many fat-burners because of its ability to amplify the effects of Caffeine. Preliminary studies indicate that its primary mechanism of action is via Momoamine Oxidase inhibition, with oral doses being shown to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself.

So, rather than acting as a stand-alone stimulant, Hordenine can amplify/extend the effects of other stimulants by blocking the reuptake of Noradrenaline (and other Monoamines).

Like Higenamine, we don’t know the exact dose of Hordenine in Lean Ph.D, but given that only 25-50mg is needed, there are no obvious red flags pertaining to dosing.


Cocoa Extract is generally standardized for Theobromine, a chemical relative of Caffeine but that remains seriously under-researched with regards to weight-loss potential. Preliminary studies indicate that Theobromine is a cardiac stimulant, but it does not appear to have psychoactive effects like Caffeine (i.e. energy).


Sceletium tortuosum, also known as Kanna, is an herb mostly indigenous to South Africa which has a long history of use as a mood elevator/anxiolytic. Kanna contains two types of alkaloids, mesembrine tortuosamine, which are alleged to convey the psychoactive effects.

A 2011 study published in the “Journal of Ethnopharmacology” found that Sceletium tortuosum extract had limited anxiolytic effects in rats subjected to psychological stress (in the form of restraint). While no mechanism of action has been established, the results of the study indicated that the herb does not act as a serotonin reuptake inhibitor (SSRI).

MAN Sports appears to be betting big on Sceletium Toruosum, as it also can be found in NOOPump and PepTest Bulk.


Paradoxine is a standardized form of 6-Paradol, the active component of Grains of Paradise underlying its weight-loss implications.

Grains of Paradise (containing Paradoxine) has been to shown to increase metabolic rate in response to a physiological stressor (in this case cold exposure) via activation of Brown Adipose Tissue. It’s potential for weight-loss is discussed in this article.


Biobumin is a serum albumin which contains a diverse range of amino acids. MAN doesn’t exactly say how this pertains to weight-loss but we assume it is intended to enhance muscle protein synthesis during dieting when protein intake may be less than optimal.

Overall, it makes for a solid “support” ingredient in Lean Ph.D formula.


Coleus Forskohlii contains the active compound, Forskolin, which has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.

For those interested, we discuss the weight-loss implications of Coleus Forskohlii in detail here.

As far as direct fat-loss implications, Lean Ph.D may not contain enough Coleus Forskohlii on a per serving basis, but seeing as MAN has also used this ingredient in NOOPump and PepTest Bulk, it may intended to serve as a nootropic, rather than to burn fat.


Lean Ph.D contains several effect fat-burning ingredients as well as some that may function to improve cognition and focus. Assuming multiple servings daily, Lean Ph.D may help shed a few pounds, although we wouldn’t recommend it to stimulant-sensitive individuals.

1. Wutzke, Klaus D., and Henrik Lorenz. “The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects.”Metabolism 53.8 (2004): 1002-1006
2. Seim, H., W. Kiess, and T. Richter. “Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults.” Metabolism 51.11 (2002): 1389-1391
3. Melton, S. A., et al. “L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise.” International journal for vitamin and nutrition research 75.2 (2005): 156-160.
4. Villani, Rudolph G., et al. “L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.”International journal of sport nutrition and exercise metabolism 10.2 (2000): 199-207.
5. Karanth, Jyothsna, and K. Jeevaratnam. “Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity.” (2010).
6. Agharanya, Julius C., Raphael Alonso, and Richard J. Wurtman. “Changes in catecholamine excretion after short-term tyrosine ingestion in normally fed human subjects.” The American journal of clinical nutrition 34.1 (1981): 82-87.
7. Fernstrom, John D., and Madelyn H. Fernstrom. “Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain.” The Journal of nutrition137.6 (2007): 1539S-1547S.
8. Yeghiayan, Sylva K., et al. “Tyrosine improves behavioral and neurochemical deficits caused by cold exposure.” Physiology & behavior 72.3 (2001): 311-316.
9. Banderet, Louis E., and Harris R. Lieberman. “Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans.” Brain research bulletin 22.4 (1989): 759-762.
10. Shurtleff, David, et al. “Tyrosine reverses a cold-induced working memory deficit in humans.” Pharmacology Biochemistry and Behavior 47.4 (1994): 935-941.
11. Thielecke, Frank, et al. “Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study.” European journal of clinical nutrition 64.7 (2010): 704-713.
12. Lu, Hong, Xiaofeng Meng, and Chung S. Yang. “Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (−)-epigallocatechin gallate.” Drug metabolism and disposition 31.5 (2003): 572-579.
13. Keränen, Tapani, et al. “Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone.” European journal of clinical pharmacology 46.2 (1994): 151-157.
14. Brown, A. L., et al. “Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial.” British Journal of Nutrition106.12 (2011): 1880-1889.
15. Henderson, Shonteh, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr 2.2 (2005): 54-62.
16. Godard, Michael P., Brad A. Johnson, and Scott R. Richmond. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obesity Research 13.8 (2005): 1335-1343.
17. Jagtap, Madhavi, H. M. Chandola, and B. Ravishankar. “Clinical efficacy of Coleus forskohlii (Willd.) Briq.(Makandi) in hypertension of geriatric population.”Ayu 32.1 (2011): 59.
18. Smith, C. “The effects of< i> Sceletium tortuosum in an< i> in vivo model of psychological stress.” Journal of ethnopharmacology 133.1 (2011): 31-36.
19. Smith, Michael T., et al. “Psychoactive constituents of the genus< i> Sceletium NE Br. and other Mesembryanthemaceae: a review.” Journal of ethnopharmacology 50.3 (1996): 119-130
20. Ono, Yuka, et al. “Anti-obesity effect of< i> Nelumbo nucifera leaves extract in mice and rats.” Journal of Ethnopharmacology 106.2 (2006): 238-244.
21. Nojima, Hiroshi, Mari Okazaki, and Ikuko Kimura. “Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice.” Journal of Asian natural products research 2.3 (2000): 195-203.
22. Bai, Gang, et al. “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2‐adrenergic receptor agonist1.” Acta Pharmacologica Sinica 29.10 (2008): 1187-1194.
23. Ilic, Nebojsa, et al. “Toxicological evaluation of Grains of Paradise (< i> Aframomum melegueta)[Roscoe] K. Schum.” Journal of ethnopharmacology127.2 (2010): 352-356.
24. Sugita, Jun, et al. “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men.”British Journal of Nutrition 110.04 (2013): 733-738.


Click to comment
To Top