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MAN Sports Lean Ph.D Review

Lean Ph.D

Lean Ph.D is MAN Sports most recent thermogenic fat-burner which is essentially part weight-loss supplement and part nootropic. The nootropic component consists of a few of the same ingredients as MAN’s recent pre-workout, NOOPump…

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Lean Ph.D is MAN Sports most recent thermogenic fat-burner which is essentially part weight-loss supplement and part nootropic. The nootropic component consists of a few of the same ingredients as MAN’s recent pre-workout, NOOPump

[SKIP TO THE BOTTOM LINE]

ACETYL-L-CARNITINE (ALCAR):

Carnitine is an amino acid that is heavily involved with the metabolism of fat for energy. It is required for the proper transport of fatty acids in the mitochondria, where they are oxidized (burned) for energy through the process known as “beta-oxidation”.

Carnitine deficiency has been shown to hinder fat-burning capacity, but studies investigating whether excess Carnitine intake (i.e. supplementation) can burn-fat haven’t been very encouraging thus far.
Although Carnitine supplementation (1g/day) has been shown to increase fatty acid oxidation rates in humans without Carnitine deficiency, it has failed to induce weight-loss in rats, as well as moderately obese women.

Carnitine does have mechanisms by which it may stabilize the fat-burning process in individuals who are Carnitine deficient (unlikely if you eat enough protein), but is unlikely to actually burn excess fat. MAN Sports does not disclose the amount of Carnitine present in Lean P.hD but with the entire proprietary blend amounting to just 690mg we assume no more than 200-300mg or so.

N-ACETYL-L-TYROSINE (NALT):

Tyrosine is a non-essential amino acid (the body can produce it from Phenylalanine) which serves aprecursor to Dopamine (by first being converted into L-Dopa) and Noradrenaline.

Because of this relationship, Tyrosine is alleged to increase levels of these neurotransmitters, which would theoretically lead to performance enhancement. However, research has demonstrated thatTyrosine cannot outright raise Dopamine or Noradrenaline levels upon ingestion, though it can help maintain optimal levels when depletion might otherwise occur.

Upon ingestion, Tyrosine forms substrate pool, which can then be drawn from when an acute stressor (exercise, cold exposure, etc.) causes a temporary depletion of Dopamine/Noradrenaline. For this reason, Tyrosine can be useful for maintaining cognitive function during stressful activity.

MAN Sports does not list the exact dose of NALT in Lean Ph.D but, based on a 690mg proprietary blend, we’d estimate anywhere from 150-250mg.

GREEN TEA EXTRACT:

Green Tea has been shown to inhibit Catechol-O-Methyl Transferase (COMT), thereby extending/amplifying the effects of stimulants such as Caffeine. We discuss the fat-burning implications of Green Tea Extract more in this article.

Here’s where it gets confusing: MAN lists the amount of EGCG in Lean Ph.D at 150mg per serving and states that the Green Tea Extract is standardized to 60%, meaning there is 250mg total. However, since Green Tea Extract is the third ingredient, for there to be 250mg per serving, the entire proprietary blend would have to be at least 750mg, and that’s assuming no other ingredients.

We’re not saying Lean Ph.D doesn’t contain 150mg of EGCG per serving, just that something appears a little off here.

NELUMBO NUCIFERA (HIGENAMINE):

Nelumbo Nucifera (NN), sometimes referred to as Indian Lotus, is a flowering plant which has been shown to have anti-obesity effects in mice. These effects are primarily attributed to the Higenamine, although there are other compounds which may potentiate these effects. Higenamine is a Beta(2) Adrenergic Agonist (same mechanism as Ephedra), meaning it stimulates the Beta(2) Adrenergic Receptors which initiate fat-burning.

MAN doesn’t disclose the exact dose of Higenamine (or total Nelumbo Nucifera) present in Lean Ph.D, but it generally just takes 20mg or so for noticeable effects, so there is no reason to suspect under-dosing here.

HORDENINE:

Hordenine is included in many fat-burners because of its ability to amplify the effects of Caffeine. Preliminary studies indicate that its primary mechanism of action is via Momoamine Oxidase inhibition, with oral doses being shown to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself.

So, rather than acting as a stand-alone stimulant, Hordenine can amplify/extend the effects of other stimulants by blocking the reuptake of Noradrenaline (and other Monoamines).

Like Higenamine, we don’t know the exact dose of Hordenine in Lean Ph.D, but given that only 25-50mg is needed, there are no obvious red flags pertaining to dosing.

COCOA EXTRACT:

Cocoa Extract is generally standardized for Theobromine, a chemical relative of Caffeine but that remains seriously under-researched with regards to weight-loss potential. Preliminary studies indicate that Theobromine is a cardiac stimulant, but it does not appear to have psychoactive effects like Caffeine (i.e. energy).

SCELETIUM TORTUOSUM:

Sceletium tortuosum, also known as Kanna, is an herb mostly indigenous to South Africa which has a long history of use as a mood elevator/anxiolytic. Kanna contains two types of alkaloids, mesembrine tortuosamine, which are alleged to convey the psychoactive effects.

A 2011 study published in the “Journal of Ethnopharmacology” found that Sceletium tortuosum extract had limited anxiolytic effects in rats subjected to psychological stress (in the form of restraint). While no mechanism of action has been established, the results of the study indicated that the herb does not act as a serotonin reuptake inhibitor (SSRI).

MAN Sports appears to be betting big on Sceletium Toruosum, as it also can be found in NOOPump and PepTest Bulk.

PARADOXINE:

Paradoxine is a standardized form of 6-Paradol, the active component of Grains of Paradise underlying its weight-loss implications.

Grains of Paradise (containing Paradoxine) has been to shown to increase metabolic rate in response to a physiological stressor (in this case cold exposure) via activation of Brown Adipose Tissue. It’s potential for weight-loss is discussed in this article.

BIOBUMIN™ (BOVINE SERUM ALBUMIN):

Biobumin is a serum albumin which contains a diverse range of amino acids. MAN doesn’t exactly say how this pertains to weight-loss but we assume it is intended to enhance muscle protein synthesis during dieting when protein intake may be less than optimal.

Overall, it makes for a solid “support” ingredient in Lean Ph.D formula.

COLEUS FORSKOHLII:

Coleus Forskohlii contains the active compound, Forskolin, which has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.

For those interested, we discuss the weight-loss implications of Coleus Forskohlii in detail here.

As far as direct fat-loss implications, Lean Ph.D may not contain enough Coleus Forskohlii on a per serving basis, but seeing as MAN has also used this ingredient in NOOPump and PepTest Bulk, it may intended to serve as a nootropic, rather than to burn fat.

THE BOTTOM LINE:

Lean Ph.D contains several effect fat-burning ingredients as well as some that may function to improve cognition and focus. Assuming multiple servings daily, Lean Ph.D may help shed a few pounds, although we wouldn’t recommend it to stimulant-sensitive individuals.

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