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Magnum Nutraceuticals G Spring Review

Magnum Nutraceuticals G Spring

G Spring is a sleep-aid and rest/recovery formula by Magnum Nutraceuticals which is designed to enhance sleep and optimize GH production at rest…

 

G Spring is a sleep-aid and rest/recovery formula by Magnum Nutraceuticals which is designed to enhance sleep and optimize GH production at rest…

[SKIP TO THE BOTTOM LINE]

L-Arginine Pyroglutamate + L-Lysine

Arginine is commonly alleged to boost GH, though research indicates an average human would need upwards of 20g or so to experience any sort of GH boost.  This makes L-Arginine by itself a pretty ineffective GH booster.

However, a 1981 study from “Current Medical Research and Opinion” found that L-Arginine (as Pyroglutamate) combined with L-Lysine  resulted in significantly elevated GH levels with doses of 1200mg each.

This is of course a much more realistic dose.  G-Spring contains 1000mg of L-Arginine Pyroglutamate and 1000mg of L-Lysine, just under what was used in the above-mentioned study.

Mucuna Pruriens

Mucuna Pruriens is generally standardized for L-Dopa, the direct precursor to the neurotransmitter Dopamine.  Dopamine, sufficient levels of which are required for REM sleep, is generally believed to play a role in the overall sleep-wake cycle, so optimizing levels of Dopamine should theoretically lead to healthier sleep patterns.

L-Dopa has indeed been shown to increase Dopamine levels in healthy human subjects, but the effects on sleep have yet to be studied directly.

Bacopa

Bacopa is an herb (and herbal supplement) with a well-documented history of use as a cognitive enhancement agent (nootropic).

A 2011 study, published in the “Journal of Ethnopharmacology” noted a roughly 110% increase in Acetylcholine levels of rats treated with Bacopa compared to placebo. These findings were consistent with those of an earlier (2002) study from “Pharmacology, Biochemistry and Behavior” in which Bacopa was shown to inhibit Acetylcholinesterase (similar to Huperzine-A) in the brains of rats.

A 2013 study from “Phytotherapy Research” found that Bacopa was able to increase cerebral blood flow in rats without effecting blood pressure, and this effect was alleged to be the result of increased Endothelial Nitric Oxide.

Though Bacopa has not been studied directly as a sleep-aid in humans, it stands to reason that the nootropic benefits may translate into some sort of improved sleep.

G Spring contains 220mg of Bacopa.

Puerarin

Puerarin is an isoflavone found in Kudzu (Radix puerariae).  It has a variety of known health implications, though the precise reason for its inclusion in G Spring remains unclear.

L-Theanine

Theanine is a compound found in Green Tea which has been shown to reduce anxiety and induce a state of relaxation, though without causing drowsiness.

G Spring contains 100mg of Theanine per serving.

DMAE

Dimethylaminoethanol, or DMAE for short, is a cholinergic compound which is generally used for cognitive enhancement or, perhaps more reliably, to prevent cognitive decline.  It has been shown to improve certain aspects of cognitive function in older subjects with mild cognitive impairment, but has not been studied much in healthy individuals, let alone athletes.

As a sleep-aid, DMAE is under-researched but it may influence sleep quality via an Acetylcholine-related mechanism.

Melatonin

Due to its role in promoting sleep, supplemental melatonin has been used to correct and treat mild sleep disorders, as well as by people who experience mild sleeplessness. All evidence suggests that melatonin works very well when it comes to promoting sleep.

Studies have shown that Melatonin can increase REM sleep, reduce sleep-latency (time it takes to fall asleep), and improve quality of sleep.

A fair amount of research has also been conducted regarding Melatonin’s effects on Growth Hormone, which we discuss in this artcle.

G Spring contains 20mg of Melatonin, a much higher dose than what is generally found in sleep-aids.

Piperine

Piperine is the primary active component of Black Pepper Extract which has been shown to increase the absorption of other ingredients when co-ingested. Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).

So, in the context of G Spring, Piperine serves as an absorption enhancer.

The Bottom Line

G Spring is certainly an effective sleep-aid and may encourage optimal GH production during rest. Magnum fans may want to give this one a shot…

REFERENCES
  1. Isidori, A., A. Lo Monaco, and M. Cappa. “A study of growth hormone release in man after oral administration of amino acids.” Current medical research and opinion 7.7 (1981): 475-481.
  2. Kamkaew, Natakorn, et al. “Bacopa monnieri increases cerebral blood flow in rat independent of blood pressure.” Phytotherapy Research 27.1 (2013): 135-138.
  3. Kamkaew, Natakorn, et al. “< i> Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various artery types.”Journal of ethnopharmacology 137.1 (2011): 790-795.
  4. Charles, Prisila Dulcy, et al. “< i> Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: Implications in memory formation.” Journal of ethnopharmacology134.1 (2011): 55-61.
  5. Das, Amitava, et al. “A comparative study in rodents of standardized extracts of< i> Bacopa monniera and< i> Ginkgo biloba: Anticholinesterase and cognitive enhancing activities.” Pharmacology Biochemistry and Behavior 73.4 (2002): 893-900.
  6. Wang, Ji-Feng, et al. “Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats.” World journal of gastroenterology: WJG10.13 (2004): 1967-1970.
  7. Prasain, Jeevan K., et al. “The Chinese Pueraria root extract (< i> Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice.”Phytomedicine 20.1 (2012): 17-23.
  8. Haskell, Crystal F., et al. “The effects of L-theanine, caffeine and their combination on cognition and mood.” Biological psychology 77.2 (2008): 113-122.
  9. Owen, Gail N., et al. “The combined effects of L-theanine and caffeine on cognitive performance and mood.” Nutritional neuroscience 11.4 (2008): 193-19
  10. Einöther, Suzanne JL, et al. “L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness.” Appetite 54.2 (2010): 406-409.
  11. Giesbrecht, Timo, et al. “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness.” Nutritional neuroscience 13.6 (2010): 283-290.
  12. Kunz, Dieter, et al. “Melatonin in patients with reduced REM sleep duration: two randomized controlled trials.” Journal of Clinical Endocrinology & Metabolism 89.1 (2004): 128-134.
  13. Brzezinski, Amnon, et al. “Effects of exogenous melatonin on sleep: a meta-analysis.” Sleep medicine reviews 9.1 (2005): 41-50.
  14. Cajochen, Christian, et al. “Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272.4 (1997): R1189-R1196.
  15. Kamkaew, Natakorn, et al. “Bacopa monnieri increases cerebral blood flow in rat independent of blood pressure.” Phytotherapy Research 27.1 (2013): 135-138.
  16. Kamkaew, Natakorn, et al. “< i> Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various artery types.”Journal of ethnopharmacology 137.1 (2011): 790-795.
  17. Charles, Prisila Dulcy, et al. “< i> Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: Implications in memory formation.” Journal of ethnopharmacology134.1 (2011): 55-61.
  18. Das, Amitava, et al. “A comparative study in rodents of standardized extracts of< i> Bacopa monniera and< i> Ginkgo biloba: Anticholinesterase and cognitive enhancing activities.” Pharmacology Biochemistry and Behavior 73.4 (2002): 893-900.
  19. Zhou, Yan‐Xi, Hong Zhang, and Cheng Peng. “Puerarin: a review of pharmacological effects.” Phytotherapy Research 28.7 (2014): 961-975.

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