Reviews

Lecheek Nutrition AMPilean Black Review

AMPilean Black is Lecheek’s new stimulant-powered fat-burner. It contains several stimulant weight-loss ingredients as well as some non-stimulant “complementary” ingredients…

Ampilean Black

CAFFEINE ANHYDROUS

Caffeine releases Noradrenaline, a neurotransmitter which increases mental alertness, may enhance mood, and most importantly, triggers lipolysis.  It is the primary stimulant found in many fat-burners and, while it isn’t necessarily effective on its own, it can kick-start the fat-burning process and amplify the effects of the other stimulants found in AMPilean Black.

DICAFFEINE MALATE

Dicaffeine Malate is simply a combination of Caffeine and Malic Acid which is alleged to have longer-lasting effects and a smoother overall transition (no crash).  To be fair, these claims have not been substantiated at this time, but, at the very least, Dicaffeine Malate serves as another source of Caffeine.

DANDELION (TARAXACUM OFFICINALE)

Taraxacum Officinale, also known as Dandelion, has a long history of use in alternative medicine as a diuretic. A 1993 study published in “Pharmaceutical Biology” pointed to the high potassium content as a possible reason for the diuretic of effect, though various compounds have been isolated and alleged to contribute to this effect.

A 2009 study, published in “The Journal of Alternative and Complementary Medicine” found thatsupplementation with Dandelion Extract caused more frequent urination in subjects, but a specific mechanism of action was not identified.

As a diuretic, Dandelion extract may be pretty effective but it doesn’t target fat so any changes in body composition are more superficial if anything.  We don’t recommend diuretics alone as a weight-loss strategy, but in the context of AMPilean Black, Dandelion may help users appear leaner.

PIKATROPIN (PIKAMILON)

Pikamilon (alternatively spelled ‘Picamilon’) is formed by combining Niacin (vitamin B3) and GABA (the primary inhibitory neurotransmitter in mammals). Pikamilon is able to effectively cross the blood-brain-barrier where it is converted into GABA.

Since GABA is an inhibitory neurotransmitter (as opposed to excitatory) it may produce anxiolytic effects when levels are increased beyond normal. However, Picamilon does not produce the sedative like effects of other GABA pro-drugs and instead is commonly used as a nootropic (cognitive enhancer) because it has also been demonstrated to increase cerebral blood flow due to its Niacin component (Niacin is a vasodilator).

POMEGRANATE

Pomegranate may favorably influence cardiovascular health by lowering triglycerides, though it has not been extensively researched with regards to weight-loss.  In the context of AMPilean Black, we’d consider it more of a “support” ingredient tan a primary active ingredient.

OCTOPAMINE HCL

Octopamine is a metabolite of Synephrine that is alleged to have similar fat-burner capabilities. In vitro, Octopamine has demonstrated a distinct affinity for beta-3 receptors, as opposed to the other two types.

Unfortunately, since beta-3 receptors mediate fat-loss in human white adipose tissue to a lesser degree than the other beta-receptors, Octopamine may be less potent than Synephrine in a practical setting.

RAUWOLSCINE

Rauwolscine, also known as Alpha-yohimbine, is a close chemical relative of Yohimbine. In the context of Vexxum , its function is basically the same.
Like Yohimbine, Rauwolscine is an Alpha Receptor Antagonist, meaning it blocks the receptors responsible for blocking lipolysis. By blocking these receptors, Rauwolscine is able to potentiate the effects of other stimulant fat-burners and allow more fat-burning than would normally occur from exercise alone.

Lecheek doesn’t list the exact dose of Rauwolscine present in AMPilean Black but given that it generally only takes 1-2mg for noticeable effects, we don’t see any red flags with regards to dosing.

THE BOTTOM LINE

The fat-burning potential of AMPilean Black is more or less stimulant-dependent but for individuals who can handle heavy stims, it may be pretty effective.  Although we usuall recommend avoiding proprietary blends altogether, AMPilean Black doesn’t contain any ingredients that would require high doses to be effective so we don’t see how it could be under-dosed.

References

  1. Graham, T. E., and L. L. Spriet. “Metabolic, catecholamine, and exercise performance responses to various doses of caffeine.” Journal of Applied Physiology 78.3 (1995): 867-874
  2. Graham, Terry E. “Caffeine and exercise.” Sports medicine 31.11 (2001): 785-807.
  3. Ebashi, S., and Mi Endo. “Calcium and muscle contraction.” Progress in biophysics and molecular biology 18 (1968): 123-183
  4. Poisner, Alan M. “Caffeine–Induced Catecholamine Secretion: Similarity to Caffeine–Induced Muscle Contraction.” Experimental Biology and Medicine142.1 (1973): 103-10
  5. Râcz–Kotilla, Elisabeth, G. Racz, and Ana Solomon. “The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals.”Planta medica 26.07 (1974): 212-217.
  6. Clare, Bevin A., Richard S. Conroy, and Kevin Spelman. “The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day.”The Journal of Alternative and Complementary Medicine 15.8 (2009): 929-934.
  7. Hook, I., A. McGee, and M. Henman. “Evaluation of dandelion for diuretic activity and variation in potassium content.” Pharmaceutical biology 31.1 (1993): 29-34.
  8. Kruglikova-L’vova, R. P., et al. “Pikamilon-a new vasoactive and nootropic preparation.” Pharmaceutical Chemistry Journal 23.2 (1989): 182-186.
  9. Shephard, R. A. “Behavioral effects of GABA agonists in relation to anxiety and benzodiazepine action.” Life sciences 40.25 (1987): 2429-2436.
  10. Mirzoyan, R. S., et al. “Effect of picamilon on the cerebral cortical blood supply and microcirculation in the pial arteriolar system.” Bulletin of Experimental Biology and Medicine 107.5 (1989): 668-670.
  11. Brown, C. M., et al. “Activities of octopamine and synephrine stereoisomers on α‐adrenoceptors.” British journal of pharmacology 93.2 (1988): 417-429.
  12. Perry, Bruce D., and David C. U’Prichard. “[3 H] rauwolscine (α-yohimbine): A specific antagonist radioligand for brain α 2-adrenergic receptors.” European journal of pharmacology 76.4 (1981): 461-464.

 

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