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RSP Nutrition Incinerade Review

Incinerade is the latest weight-loss supplement from RSP Nutrition. It combines some well-known non-stimulant weight-loss supplements with a few fat-burning stimulants. Unfortunately, the dosing of certain individual ingredients may leave something to be desired…

RSP Incinerade

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CLARINOL (CLA)

Conjugated Linoleic Acid is a term which refers to a group of polyunsaturated fatty acids (loosely referred to as ‘good fats’). In recent years, CLA has gained a reputation in the supplement industry as a fat burner. The theorized mechanism of action at work here is CLA’s alleged ability to bind to the Peroxisome Proliferator activated Receptor (PPAR) which, when activated, may directly induce fat loss.

Unfortunately, the effects noted in rodents have not been replicated in humans, despite dozens of human studies being conducted. As discussed in our article, “CLA: A Waste of Time and Money?”, any weight-loss from CLA supplementation is going to be very slight, and it’s just as likely that no weight-loss at all will occur.

So, in the context of Incinerade, CLA may “encourage” fat-loss, but won’t facilitate much on its own.

L-TYROSINE

Tyrosine is a non-essential amino acid (the body can produce it from Phenylalanine) which serves a precursor to Dopamine (by first being converted into L-Dopa) and Noradrenaline.

Because of this relationship, Tyrosine is alleged to increase levels of these neurotransmitters, which would theoretically lead to performance enhancement. However, research has demonstrated that Tyrosine cannot outright raise Dopamine or Noradrenaline levels upon ingestion, though it can help maintain optimal levels when depletion might otherwise occur.

Upon ingestion, Tyrosine forms substrate pool, which can then be drawn from when an acute stressor (exercise, cold exposure, etc.) causes a temporary depletion of Dopamine/Noradrenaline. For this reason, Tyrosine can be useful for maintaining cognitive function during stressful activity.

Incinerade contains an undisclosed amount of L-Tyrosine, but given that the entire blend is 1000mg, there can’t be a particularly effective dose.

L-CARNITINE L-TARTRATE

Carnitine is an amino acid that is heavily involved with the metabolism of fat for energy. It is required for the proper transport of fatty acids in the mitochondria, where they are oxidized (burned) for energy through the process known as “beta-oxidation”.

Carnitine deficiency has been shown to hinder fat-burning capacity. Because of this integral role in the fat-burning process, Carnitine supplementation is alleged to burn-fat, and while it may certainly help normalize fat-burning capacity, human studies regarding weight loss are mixed.
A 2002 study, published in “Metabolism”, found that Carnitine supplementation (1g/day) increased fatty acid oxidation rates in humans without Carnitine deficiency.

A 2004 study from the same journal found that L-Carnitine supplementation (3g/day) increased fatty acid oxidation in overweight subjects while having no effect on protein synthesis or breakdown.

However, a 2005 study, published in the “International Journal for Vitamin and Nutrition Research”, found that Carnitine supplementation failed to influence weight-loss in rats. The results of this study were in-line with an earlier (2002) study in which L-Carnitine supplementation (4g/day) failed to influence fat mass, body mass, or resting lipid utilization in moderately obese women.

A more recent (2010) study found that Carnitine supplementation did favorably influence fatty acid utilization in rats, though this study did not measure fat mass post-supplementation.

Ultimately, Carnitine does possess the mechanisms by which it “should” burn fat (via increased utilization of fatty acids), though supplementation has failed to result in fat-loss in animals and humans.

RSP Nutrition has used Carnitine in other products, (such as Quadralean) and our view remains the same. Carnitine is not a particularly effective weight-loss agent, especially at whatever negligible dose is present in Incinerade.

CHOLINE BITARTRATE

Choline, once inside the body, is converted into the neurotransmitter Acetylcholine which is associated with many functions including (but not limited to) memory, attention, and muscle control. It is the neurotransmitter most closely associated with the “mind-muscle connection” (although this may be something of an over-simplification), and therefore of much interest to athletes and bodybuilders alike.

While certain forms of choline may be associated with increased muscular power output (namely Alpha GPC), Choline Bitartrate is generally considered the least bioavailable choline source, though oral doses of 1000-2000mg have still been shown to increase serum choline levels significantly.
Choline has no inherent fat-burning properties, but may serve as a cognitive support agent. However, the dose present in Incinerade is undoubtedly pretty negligible, considering it shares a 1000mg blend with five other ingredients, four of which are listed before it.

RASPBERRY KETONE

Despite the popularity of Raspberry Ketone, it has never actually demonstrated any efficacy for weight-loss in actual humans and, even in rat studies, has produced lackluster results using massive concentrations.

A 2010 in vitro study found that treatment with Raspberry Ketone increased fatty acid oxidation and lipolysis in adipocytes (fat cells). However, the amount/concentration of RK used in this study is beyond what could practically be consumed in oral supplement form.

A 2005 study, seeking to determine the weight loss effects of raspberry ketone on rats fed a high fat diet, noted dose dependent anti-obesity effects using doses of .5-4 grams/kg. This would roughly correspond to a 150lb person consuming 34-130 grams daily, a highly impractical dose.
In a 2012 study, similar effects were observed in rats, though this time with a focus on fat accumulation in the liver resulting from a high fat diet. The only human study that exists grouped Raspberry Ketone in with several other popular weight-loss ingredients so the effects cannot be attributed to raspberry ketones alone.

On a molecular level, Raspberry Ketone certainly demonstrates anti-obesity effects, but the doses used to achieve these effects are far more than what the average human could practically consume.

RSP Nutrition doesn’t disclose the exact amount of Raspberry Ketone in Incinerade, but it doesn’t really matter. Even if the dose was slightly higher than average it would be pretty useless.

BETA-ALANINE

Beta-Alanine is usually seen in pre-workout supplements, and while it is definitely an effective performance enhancer, it also has some implications for managing body composition.

A 2009 study, published in the “Journal of the International Society of Sports Nutrition”, found that Beta-Alanine supplementation (6g/day) increased lean mass.

These results were replicated in a 2010 study from “The Journal of Strength and Conditioning” in women, indicating no gender differences.
A 2011 study, published in “The Journal of Strength & Conditioning Research”, found that 8 weeks of Beta-Alanine supplementation (4g/day) caused a trend toward increased lean mass and decreased fat mass in collegiate athletes.

Though it doesn’t inherently burn fat, Beta-Alanine appears effective at encouraging a favorable body composition (i.e. more lean mass, less fat). So, in the context of Incinerade it actually makes sense to include it.

TAURINE

Taurine is an amino acid which has a variety of implications pertaining to exercise. Multiple studies have confirmed that Taurine can reduce exercise-induced oxidative stress potentially enhancing exercise performance. However, preliminary evidence indicates it may influence fat-burning as well.
Although the fat-burning potential of Taurine remains relatively under-researched, a 2010 study from the “International Journal of Sport Nutrition and Exercise Metabolism” found that 1660mg of Taurine was able to increase fat-oxidation during exercise in cyclists.

Taurine by itself is not likely to favorably influence body weight in a particularly significant way, but it does have certain pro-fat loss mechanisms which make it a suitable candidate for a fat-burner.

In the context of Incinerade, it functions more like a “support” ingredient, encouraging fat-loss but probably not directly facilitating it.

GUARANA

Guarana is a plant native to the Amazon, the fruit of which contains Caffeine as well as related chemical compounds such as Theobromine and Theophylline (both cardiac stimulants with less of a mental effect). Although Guarana is sometimes touted as being a sort of “slow-release” form of caffeine, a study published in the “Journal of Pharmacy and Pharmacology” found there was no difference in the absorption rates of Caffeine from Guarana as opposed to Caffeine Anhydrous (synthetic) in rats. Human studies have yet to be confirmed, but given these preliminary findings, there is certainly no reason to believe Guarana would absorb any differently in humans.

In the context of Incinerade, Guarana is just another source of Caffeine and may help to “kick-start” the fat-burning process.

COFFEA ROBUSTA

Coffea Robusta is a specific type of coffee bean commonly used to make expresso. Like all coffee beans, this particular bean contains caffeine and its inclusion in the Incinerade formula is to simply to supply caffeine in a “natural” form.

Caffeine causes an increase in catecholamines like Noradrenaline, a potent activator of lipolysis (fat-breakdown).

While the mechanisms of caffeine are certainly pro-fat-loss, the effects tend to fade with prolonged use, rendering caffeine ineffective as a long-term weight loss solution on its own. However, when paired with other fat-burning stimulants, Caffeine can kick-start the fat-burning process.

GLUCURONOLACTONE

Glucuronolactone has become a popular additive in energy drinks as well as “detox” supplements which claim cellular protective benefits. Despite being included in various energy products, it has not been studied in isolation in regards to any claims made by these companies. For now, there is absolutely no evidence that Glucuronolactone has any effective on fat-loss.

N-METHYL-TYRAMINE (NMT)

N-Methyl-Tyramine (NMT) is a Tyramine which, as mentioned above, can inhibit the reuptake of monoamines (specifically Noradrenaline), thereby amplifying and/or extending the effects of Noradrenaline releasing stimulants such as Caffeine. RSP Nutrition does not disclose the exact dose of NMT present in the Incinerade formula, but it generally takes no more than 20-30mg to deliver noticeable results.

HIGENAMINE

Higenamine has been shown (in vitro) to be a beta-adrenergic receptor agonist as well as a weak alpha-adrenergic receptor antagonist, the same basic mechanisms of action by which Synephrine and Ephedrine work. By activating beta-receptors while simultaneously (albeit weakly) blocking alpha-receptors, Higenamine can potentiate the effects of Noradrenaline-releasing agents such as Caffeine and facilitate more fat-loss than could otherwise normally be achieved through exercise alone.

Higenamine is the major component underlying the fat-loss effects seen with Nelumbo Nucifera in rodent studies, but human studies are non-existent at this point in time. For that reason, it’s tough to determine its degree of efficacy as a fat-burner, though the mechanisms certainly exist. Since Incinerade contains several other stimulants with similar mechanisms of action, the dose of Higenamine, while not likely very high, may still be practical.

A-HYDROXYISOCAPROIC ACID (HICA)

A-Hydroxyisocaproic Acid (HICA) is a product of Leucine metabolism and is alleged to be an anti-catabolic agent. A 2010 study found that athletes who consumed 1500mg of HICA per day for four weeks experienced an increase in lean body mass, a decrease in delayed onset muscle soreness (DOMS) in the 4th week, but no noticeable increase in strength. Unfortunately, this is the only study directly testing the effects of HICA on muscle mass or strength so we don’t have much to go on, That being said, the preliminary evidence is promising for HICA as a potential body re-composition agent.
Unfortunately, Incinerade contains nowhere near the clinically studied dose of 1500mg, considering HICA is listed last in a 1500mg proprietary blend.

THE BOTTOM LINE

The fat-burning potential of Incinerade is limited pretty much to the stimulants present in the formula, as the other ingredients are either under-dosed or completely ineffective. At about $1 per serving, Incinerade is priced about average, but much more dramatic weight-loss could be achieved using a different product in that price range.

References

  1. Vyas, Diwakar, Anil Kumar G. Kadegowda, and Richard A. Erdman. “Dietary conjugated linoleic Acid and hepatic steatosis: species-specific effects on liver and adipose lipid metabolism and gene expression.” Journal of nutrition and metabolism 2012 (2011).
  2. Moya‐Camarena, Silvia Y., and Martha A. Belury. “Species differences in the metabolism and regulation of gene expression by conjugated linoleic acid.”Nutrition reviews 57.11 (1999): 336-340.
  3. Andreoli, María F., et al. “Effects of dietary conjugated linoleic acid at high-fat levels on triacylglycerol regulation in mice.” Nutrition 25.4 (2009): 445-452.
  4. Ide, Takashi. “Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue.” Diabetes 54.2 (2005): 412-423.
  5. Zabala, Amaia, et al. “trans-10, cis-12 Conjugated linoleic acid inhibits lipoprotein lipase but increases the activity of lipogenic enzymes in adipose tissue from hamsters fed an atherogenic diet.” British journal of nutrition 95.06 (2006): 1112-1119.
  6. Blankson, Henrietta, et al. “Conjugated linoleic acid reduces body fat mass in overweight and obese humans.” The Journal of nutrition 130.12 (2000): 2943-2948
  7. Close, Rachel N., et al. “Conjugated linoleic acid supplementation alters the 6-mo change in fat oxidation during sleep.” The American journal of clinical nutrition 86.3 (2007): 797-804.
  8. Gaullier, Jean-Michel, et al. “Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans.” The American journal of clinical nutrition 79.6 (2004): 1118-1125.
  9. Thom, E., Jan Wadstein, and O. Gudmundsen. “Conjugated linoleic acid reduces body fat in healthy exercising humans.” Journal of International Medical Research 29.5 (2001): 392-396.
  10. Carvalho, Roberta F., Sofia K. Uehara, and Glorimar Rosa. “Microencapsulated conjugated linoleic acid associated with hypocaloric diet reduces body fat in sedentary women with metabolic syndrome.” Vascular health and risk management 8 (2012): 661.
  11. Wutzke, Klaus D., and Henrik Lorenz. “The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects.”Metabolism 53.8 (2004): 1002-1006
  12. Seim, H., W. Kiess, and T. Richter. “Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults.” Metabolism 51.11 (2002): 1389-1391
  13. Melton, S. A., et al. “L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise.” International journal for vitamin and nutrition research 75.2 (2005): 156-160.
  14. Villani, Rudolph G., et al. “L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.”International journal of sport nutrition and exercise metabolism 10.2 (2000): 199-207.
  15. Karanth, Jyothsna, and K. Jeevaratnam. “Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity.” (2010).
  16. Agharanya, Julius C., Raphael Alonso, and Richard J. Wurtman. “Changes in catecholamine excretion after short-term tyrosine ingestion in normally fed human subjects.” The American journal of clinical nutrition 34.1 (1981): 82-87.
  17. Fernstrom, John D., and Madelyn H. Fernstrom. “Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain.” The Journal of nutrition137.6 (2007): 1539S-1547S.
  18. Yeghiayan, Sylva K., et al. “Tyrosine improves behavioral and neurochemical deficits caused by cold exposure.” Physiology & behavior 72.3 (2001): 311-316.
  19. Banderet, Louis E., and Harris R. Lieberman. “Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans.” Brain research bulletin 22.4 (1989): 759-762.
  20. Shurtleff, David, et al. “Tyrosine reverses a cold-induced working memory deficit in humans.” Pharmacology Biochemistry and Behavior 47.4 (1994): 935-941.
  21. Wang, Lili, Xianjun Meng, and Fengqing Zhang. “Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.” Journal of medicinal food 15.5 (2012): 495-503.
  22. Egras, Amy M., et al. “An evidence-based review of fat modifying supplemental weight loss products.” Journal of obesity 2011 (2010).
  23. Park, Kyoung Sik. “Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes.” Planta medica 76.15 (2010): 1654.
  24. Morimoto, Chie, et al. “Anti-obese action of raspberry ketone.” Life sciences77.2 (2005): 194-204.
  25. Muccioli, Giampiero, et al. “Effect of L-α-glycerylphosphorylcholine on muscarinic receptors and membrane microviscosity of aged rat brain.” Progress in Neuro-Psychopharmacology and Biological Psychiatry 20.2 (1996): 323-339.
  26. Nojima, Hiroshi, Mari Okazaki, and Ikuko Kimura. “Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice.” Journal of Asian natural products research 2.3 (2000): 195-203.
  27. Bai, Gang, et al. “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2‐adrenergic receptor agonist1.” Acta Pharmacologica Sinica 29.10 (2008): 1187-1194.
  28. Walter, Ashley A., et al. “Six weeks of high-intensity interval training with and without β-alanine supplementation for improving cardiovascular fitness in women.” The Journal of Strength & Conditioning Research 24.5 (2010): 1199-1207.
  29. Kern, Ben D., and Tracey L. Robinson. “Effects of β-alanine supplementation on performance and body composition in collegiate wrestlers and football players.” The Journal of Strength & Conditioning Research 25.7 (2011): 1804-1815.
  30. Smith, Abbie E., et al. “Effects of β-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial.” Journal of the International Society of Sports Nutrition 6.1 (2009): 1-9.
  31. Huxtable, R. J. “Physiological actions of taurine.” Physiological reviews 72.1 (1992): 101-163.
  32. Matsuzaki, Yasushi, Teruo Miyazaki, Syunpei Miyakawa, Bernard Bouscarel, Tadashi Ikegami, and Naomi Tanaka. “Decreased Taurine Concentration in Skeletal Muscles after Exercise for Various Durations.” Medicine & Science in Sports & Exercise34.5 (2002): 793-97.
  33. Yatabe, Yoshihisa, et al. “Effects of taurine administration on exercise.” Taurine 7. Springer New York, 2009. 245-252
  34. da Silva, Luciano A., et al. “Effects of taurine supplementation following eccentric exercise in young adults.” Applied Physiology, Nutrition, and Metabolism 39.1 (2013): 101-104.
  35. Beyranvand, Mohamad Reza, et al. “Effect of taurine supplementation on exercise capacity of patients with heart failure.” Journal of cardiology 57.3 (2011): 333-337.
  36. Matsuzaki, Yasushi., et al. “Decreased taurine concentration in skeletal muscles after exercise for various durations.” Medicine and science in sports and exercise 34.5 (2002): 793-797.
  37. Balshaw, Thomas G., et al. “The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners.” Amino acids 44.2 (2013): 555-561.
  38. Rutherford JA, Spriet LL, Stellingwerff T. The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists. Int J Sport Nutr Exerc Metab. (2010)
  39. Zhang, M., et al. “Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men.” Amino acids 26.2 (2004): 203-207.
  40. Silva, Luciano A., et al. “Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise.” Cell biochemistry and function 29.1 (2011): 43-49
  41. Bempong, Daniel K., and Peter J. Houghton. “Dissolution and Absorption of Caffeine from Guarana.” Journal of Pharmacy and Pharmacology 44.9 (n.d.): 769-71
  42. Mero, Antti A., et al. “Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes.” Journal of the International Society of Sports Nutrition 7.1 (2010)

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