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Hydroxycut Hardcore Next Gen Review

Hydroxycut Hardcore Next Gen is MuscleTech’s most recent fat-burner. It contains several ingredients which can also be found in other MuscleTech fat-burners such as Hydroxycut SX-7 and Hydroxycut SX-7 Black Onyx, but also contains some ingredients that are less common…

Hydroxycut Hardcore Next Gen

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Green Coffee Extract

Green Coffee Extract contains Chlorogenic Acid which has been shown to block carbohydrate absorption in humans, thus mimicking the effects of a reduced carb-diet.  While many supplement companies (not to mention the media) have seriously exaggerated the efficacy of Green Coffee Extract, it has been shown to induce some modest weight-loss, with over-weight individuals being the most likely to derive benefit.

We discuss Green Coffee Bean more in depth here but, to make a long story short, the effective range is 300mg or more of Chlorogenic Acid daily.  Given that the Green Coffee Bean extract in Hydroxycut Hardcore Next Gen is 45% Chlorogenic Acid, users would need at least two servings daily to achieve a clinically effective dose.

Caffeine

Caffeine is by far the most common ingredient among stimulant-based fat-burners because it triggers the release of Noradrenaline, a potent activator of lipolysis.

Although Caffeine possesses pro-fat-loss properties, the effects tend to fade with prolonged use, rendering it ineffective as a long-term weight loss solution on its own.   When paired with other fat-burning stimulants, however, Caffeine can kick-start the fat-burning process so it does make for a useful addition in Hydroxycut Hardcore Next Gen.

The 290mg of Caffeine present in Hydroxycut Hardcore Next Gen is more than enough to encourage fat-loss as well as increase alertness and focus in the average individual.

Coleus Forskohlii

Coleus Forskohlii contains the active compound, Forskolin, which has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.

We discuss the weight-loss implications of Forskolin in this article, but it may certainly contribute to the overall fat-burning capability of Hydroxycut Hardcore Next Gen.

MuscleTech doesn’t disclose the amount of Forskolin in Hydroxycut Hardcore Next Gen, just the total amount of Coleus.  If we assume a 10% standardization, 2 servings daily would yield an effective dose of Forskolin.

Blue Skullcap

Blue Skullcap has been shown to reduce anxiety and improve mood without decreasing energy of cognitive ability.  This unique quality makes it perfect for combating potential stimulant-induced anxiety brought on by other ingredients in the Hydroxycut Hardcore Next Gen formula such as Yohimbine.

Other than that, it doesn’t really have any direct weight-loss implications.  We assume MuscleTech’s goal with Blue Skullcap is to enhance the mental/cognitive aspect of the Hydroxycut Hardcore Next Gen formula.

Yohimbine

Yohimbe Bark is standardized for Yohimbine, which is an alpha(2) receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis. By blocking the action of this receptor Yohimbine allows for more lipolysis than would otherwise be possible from exercise.

We discuss the weight-loss implications of Yohimbine in-depth in this article.  To make a long story short though, it can be highly effective as a fat-burner assuming the right dose.  Unfortuantely, MuscleTech does not list the exact of Yohimbine (just Yohimbe) present in Hydroxycut Hardcore Next Gen.  Chances are there isn’t enough to make a dramatic impact, but combined with Caffeine Yohimbine may certainly encourage fat-loss.

Ophiopogon Japonicas

Ophiopogon Japonicas has a relatively well-documented history of use in Traditional Chinese Medicine where it has been used primarily for cardiovascular health.  In the context of Hydroxycut Hardcore Next Gen, MuscleTech appears primarily concerned with the weight-loss implications.

Indeed, polysaccharides from ophiopogon japonicas have demonstrated anti-diabetic properties in mice, thought to be the result of suppression of adiponectin in fat tissue.

Unfortunately, no human studies have been conducted specifically to investigate these effects further.  At this time we’d still consider Ophiopogon Japonicas a pretty speculative addition to the Hydroxycut Hardcore Next Gen formula.

Ilex Guayusa

Ilex Guayusa contains xanthines such as Caffeine and possibly Theobromine, though MuscleTech doesn’t say for sure.  Ultimately, the weight-loss implications for Ilex Guayusa is the same as Caffeine, with absolutely no evidence to suggest it is superior (or even different) in any way.

The Bottom Line

Hydroxycut Hardcore Next Gen contains a few effective fat-burning ingredients as well as some that are pretty speculative (but potentially somewhat effective).  Dosing isn’t necessarily an issue but users should shoot for two servings daily to achieve clinical doses of key ingredients.  At such a dose, Hydroxycut Hardcore Next Gen may ultimately be a moderately effective fat-burner.  We wouldn’t recommend it to stimulant-sensitive individuals though.

Still don’t know which fat-burner is right for you? Check out our Top 10 Fat-Burners List!

REFERENCES
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  2. Chen, Xiaoming, et al. “Protective effect of the polysaccharide from Ophiopogon japonicus on streptozotocin-induced diabetic rats.” Carbohydrate polymers 94.1 (2013): 378-385.
  3. Chen, Xiaoming, et al. “Extraction, purification, characterization and hypoglycemic activity of a polysaccharide isolated from the root of Ophiopogon japonicus.” Carbohydrate Polymers 83.2 (2011): 749-754.
  4. Brock, Christine, et al. “American Skullcap (Scutellaria lateriflora): A Randomised, Double‐Blind Placebo‐Controlled Crossover Study of its Effects on Mood in Healthy Volunteers.” Phytotherapy Research 28.5 (2014): 692-698.
  5. Vinson, Joe A., Bryan R. Burnham, and Mysore V. Nagendran. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.”Diabetes, metabolic syndrome and obesity: targets and therapy 5 (2012): 21.
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  7. Costill, D. L., Gl P. Dalsky, and W. J. Fink. “Effects of caffeine ingestion on metabolism and exercise performance.” Medicine and science in sports 10.3 (1977): 155-158.
  8. Arciero, PAUL J., et al. “Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men.” American Journal of Physiology-Endocrinology And Metabolism 268.6 (1995): E1192-E1198.
  9. Astrup, A., et al. “Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers.” The American journal of clinical nutrition 51.5 (1990): 759-767
  10. Graham, Terry E., Jorn W. Helge, David A. MacLean, Bente Kiens, and Erik A. Richter. “Caffeine Ingestion Does Not Alter Carbohydrate or Fat Metabolism in Human Skeletal Muscle during Exercise.” The Journal of Physiology 529.3 (2000): 837-47
  11. Henderson, Shonteh, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr 2.2 (2005): 54-62.
  12. Godard, Michael P., Brad A. Johnson, and Scott R. Richmond. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obesity Research 13.8 (2005): 1335-1343.
  13. Jagtap, Madhavi, H. M. Chandola, and B. Ravishankar. “Clinical efficacy of Coleus forskohlii (Willd.) Briq.(Makandi) in hypertension of geriatric population.”Ayu 32.1 (2011): 59.
  14. Ostojic, Sergej M. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Research in Sports Medicine 14.4 (2006): 289-299.

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