Stryke is the most recent pre-workout by EPIQ, makers of Rush and Power SF, which features some rather unique ingredients in addition to some more commonplace ones such as Beta-Alanine and Taurine…FIND IT HERE
Beta-Alanine is a precursor to the peptide Carnosine which acts as a lactic acid buffer in muscle tissue. This means higher muscle Carnosine levels can increase muscular endurance.
Beta-Alanine is considered the rate-limiting amino acid in the synthesis of Carnosine and supplementation has been shown to significantly increase muscular Carnosine levels, leading to performance enhancement.
EPIQ Stryke contains an undisclosed amount of Beta-Alanine per serving, though given a 2630mg proprietary blend, it is potentially a clinical dose, albeit towards the lower end of the clinical range.
Taurine is an amino acid with antioxidant properties which give it a wide variety of implications pertaining to exercise. It has been shown to reduce muscular oxidative stress resulting from exercise, making it an ideal recovery-aid. Taurine has also been shown to improve performance in time-trial athletes which is thought to be related to a decrease in oxidative stress.
As with Beta-Alanine, it’s difficult to determine the exact dose of Taurine present in EPIQ Stryke because of the proprietary blend, but there could be a pretty solid dose (1g or so).
Glutathione is a versatile anti-oxidant compound, often referred to as the body’s “master antioxidant”, involved in many physiological bodily functions pertaining to detoxification. It has never been studied as a performance enhancement supplement since oral Glutathione is considered ineffective due to rapid metabolism.
Instead, the amino acid Cysteine is often supplemented to increase Glutathione because Cystine is a direct precursor involved in Glutathione synthesis. It looks like EPIQ tried to skip a step by just adding Glutathione in Stryke, but this is an example of when that rationale breaks down. Cysteine would have been a better way to go.
Ornithine is an amino acid used alongside Arginine and Citrulline in the Urea Cycle, the process by which Ammonia is metabolized into the harmless substance Urea. Prolonged exercise generally brings about increases in Ammonia, which causes fatigue in the working muscle after enough has built up.
As evidenced in a 2010 study published in the European Journal of Clinical Nutrition, supplemental Ornithine, at a dose of 100mg/kg, has failed to influence fatigue in short duration exercise.
However, a 2008 study from “Nutrition Research” noted a significant reduction in fatigue during prolonged exercise in healthy volunteers who consumed 2g Ornithine daily for 6 days and 6g prior to testing.
Stryke contains an unknown amount of Ornithine HCL, but we’d estimate the dose is pretty low and not too effective (based on the proprietary blend).
FREE ACID ARGININE
Stryke contains free-acid Arginine, a novel form that we haven’t actually seen before in any pre-workout supplements. Is it more effective than ordinary L-Arginine? We sure hope so because L-Arginine is not very effective at all as a performance enhancer, but free-acid Arginine has not be extensively researched (especially not for performance enhancement) so we really have no way of knowing.
The use of the free acid form in Stryke seems like EPIQ just trying to be different. It’s not clear if there is really anything special about it.
Ashwagandha is an adaptogenic herb with an extremely wide variety of benefits ranging from cognitive support and stress relief to performance enhancement. It has been shown to increase endurance in cyclists with some evidence for increasing power output during resistance training.
EPIQ Stryke contains an undisclosed dose of Ashwagandha.
JAPANESE RAISIN TREE (HOVENIA DULCIS):
Why EPIQ opted to include Japanese Raisin Tree in Stryke is unclear. It has been shown to exert certain anti-inflammatory effects as well as protect against alcohol to some degree, but it has virtually no known implications for performance enhancement. Seems like a reach but we’ll give EPIQ the benefit of the doubt and just think of it as a bonus.
Cordyceps is a mushroom which has a long history of use in Traditional Chinese Medicine for a variety purposes. Preliminary evidence (in mice) suggests that Cordyceps may enhance endurance, though human studies are non-existent. For that reason, we’d consider Cordyceps a speculative but potentially useful addition to the Stryke formula. Nothing to get too excited over, but it may contribute to the overall endurance-enhancing effects.
Rhodiola Rosea is yet another adaptogenic herb but has been studied much more extensively with regards to performance enhancement than the others in the Stryke formula.
It has been shown to reduce the heart response to exercise and significantly reduce perceived exertion, effectively increasing endurance in human subjects. These results have been replicated elsewhere, ultimately making Rhodiola an ingredient of interest in pre-workout supplements.
EPIQ does not list the actual amount of Rhodiola present in Stryke, but it would need to be atleast 200mg or so to be considered in the clinical range.
Caffeine is the most widely consumed psychoactive substance in the world, and for good reason: it works! Caffeine can enhance focus, increase perceived energy, cause greater muscle contractions, and encourage fat-oxidation, though individual tolerance tends to vary pretty considerably from person to person.
EPIQ Stryke contains 175mg of Caffeine per serving, not a particularly high dose for most pre-workout users, but still potentially enough to increase mental alertness and perceived energy in non-habitual Caffeine users.
THE BOTTOM LINE
Stryke contains a rather unusual blend of performance enhancing ingredients and adaptogenic herbs, the cumulative effect of which should be a notable increase in muscular endurance, strength, and perceived ability to push through a workout. Unfortunately, since EPIQ has opted for a proprietary blend style label for Stryke, we don’t really know if the claims of being “clinically-dosed” are true. It seems odd to make a claim like that but not actually prove it…
Still don’t know which pre-workout is right for you? Check out our Top 10 Pre-Workout Supplements list for some recommendations.
- Hoffman J, et al. Beta-alanine and the hormonal response to exercise. Int J Sports Med. (2008)
- Stellingwerff, Trent, et al. “Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout.” Amino Acids 42.6 (2012): 2461-2472.
- Wilson, Jacob M., et al. “Beta-alanine supplementation improves aerobic and anaerobic indices of performance.” Strength & Conditioning Journal 32.1 (2010): 71-78
- Sale, Craig, Bryan Saunders, and Roger C. Harris. “Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance.” Amino acids 39.2 (2010): 321-33
- Suzuki, Yasuhiro, Osamu Ito, Naoki Mukai, Hideyuki Takahashi, and Kaoru Takamatsu. “High Level of Skeletal Muscle Carnosine Contributes to the Latter Half of Exercise Performance during 30-s Maximal Cycle Ergometer Sprinting.” The Japanese Journal of Physiology 52.2 (2002): 199-20
- Balshaw, Thomas G., et al. “The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners.” Amino acids 44.2 (2013): 555-561
- Matsuzaki, Yasushi, Teruo Miyazaki, Syunpei Miyakawa, Bernard Bouscarel, Tadashi Ikegami, and Naomi Tanaka. “Decreased Taurine Concentration in Skeletal Muscles after Exercise for Various Durations.” Medicine & Science in Sports & Exercise34.5 (2002): 793-97.
- Huxtable, R. J. “Physiological actions of taurine.” Physiological reviews 72.1 (1992): 101-163
- da Silva, Luciano A., et al. “Effects of taurine supplementation following eccentric exercise in young adults.” Applied Physiology, Nutrition, and Metabolism 39.1 (2013): 101-104
- Beyranvand, Mohamad Reza, et al. “Effect of taurine supplementation on exercise capacity of patients with heart failure.” Journal of cardiology 57.3 (2011): 333-337
- Yatabe, Yoshihisa, et al. “Effects of taurine administration on exercise.” Taurine 7. Springer New York, 2009. 245-252
- Zhang, M., et al. “Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men.” Amino acids 26.2 (2004): 203-207.
- Silva, Luciano A., et al. “Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise.” Cell biochemistry and function 29.1 (2011): 43-49.
- Demura, Shinichi, et al. “The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise.” European journal of clinical nutrition 64.10 (2010): 1166-1171.
- Sugino, Tomohiro, et al. “L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism.”Nutrition research 28.11 (2008): 738-743.
- Shenoy, Shweta, et al. “Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists.” Journal of Ayurveda and integrative medicine 3.4 (2012): 209.
- Raut, Ashwinikumar A., et al. “Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania Somnifera) in healthy volunteers.”Journal of Ayurveda and Integrative Medicine 3.3 (2012): 111.
- Koh, Jong-Ho, et al. “Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis.” Biological and Pharmaceutical Bulletin26.5 (2003): 691-694
- Noreen, Eric E., et al. “The effects of an acute dose of Rhodiola rosea on endurance exercise performance.” The Journal of Strength & Conditioning Research 27.3 (2013): 839-847.
- De Bock, Katrien, et al. “Acute Rhodiola rosea intake can improve endurance exercise performance.” International journal of sport nutrition & exercise metabolism 14.3 (2004)
- Spasov, A. A., et al. “A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of< i> Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.” Phytomedicine 7.2 (2000): 85-89.
- 吉川雅之, et al. “Absolute stereostructures of hovenidulciosides A1 and A2, bioactive novel triterpene glycosides from hoveniae semen seu fructus, the seeds and fruit of hovenia dulcis THUNB.” Chemical and pharmaceutical bulletin 43.3 (1995): 532-534.
- SAKAI, KIYOSHI, et al. “Effect of water extracts of crude drugs in decreasing blood ethanol concentrations in rats.” Chemical and pharmaceutical bulletin35.11 (1987): 4597-4604.