Coleus Forskohlii is an Ayurvedic herb which has been studied (though not extensively) for its potential as a non-stimulant weight-loss agent and natural testosterone booster. The active component, Forskolin, has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.
A 2005 study, published in the “Journal of the International Society of Sports Nutrition”, found that 25mg Forskolin twice a day for 12 weeks was able to prevent weight gain compared to the control group in overweight women.
Another 2005 study, the subjects of which were overweight men, found that the same dose (25mg) was able to favorably influence body composition (i.e. less fat, more lean mass), which corresponded with an increase in testosterone over 12 weeks.
A more recent 2011 study noted a roughly 2.5% decrease in BMI after 2 months of supplementation. Ultimately, Forskolin may certainly result in weight-loss or at the very least, prevent weight gain. These effects may be more apparent in men, as an increase in cAMP also increases testosterone, which inherently burns fat and increases lean muscle mass.
Core Burn Ultra contains 100mg of Coleus Forskohlii, standardized to 10% Forskolin, meaning 2.5 servings daily would yield a clinical dose of 25mg.
OLEA EUROPAEA LEAF EXTRACT:
Olea europaea leaf, otherwise known as Olive leaf extract, contains a compound called Oleuropein which is responsible for the majority of the psychoactive effects.
A 2008 study from “The Journal of Nutritional Biochemistry” demonstrated increased Noradrenaline and Adrenaline levels in rats following injection of Olive leaf extract, and this effect was primarily attributed to Oleuropein.
Similar findings were noted in a 2013 study published in “The Journal of Nutritional Biochemistry” in which rats fed a diet high in Oleuropein experienced significantly increased Noradrenaline levels (measured by urine), though it’s worth mentioning that this was not accompanied by the usual decrease in weight.
The weight-loss implications of Oleuropein are not completely understood, though the preliminary evidence indicates there may be something to it.
GARCINIA CAMBOGIA EXTRACT (HYDROXYCITRIC ACID):
The primary bioactive in Garcinia Cambogia is Hydroxycitric Acid (HCA), which is alleged to reduce body weight via inhibition of ATP Citrate Lysase, an enzyme required for the synthesis of fatty acids from carbohydrates (de novo lipogenisis). Theoretically speaking, blocking this enzyme would essentially stop excess carbs from being stored as fat. While inhibition of ATP Citrate Lysase has resulted in weight-loss in rodents, the implications for humans are less promising, because de novo lipogenesis occurs less in humans than rodents. Garcinia Cambogia has produced mixed results in humans.
A 1998 placebo controlled study found that 1500mg HCA daily failed to reduce bodyweight to a significantly greater degree than the placebo group.
A 2000 study, published in “Physiology & Behavior”, found that Garcinia Cambogia (1200mg HCA daily) significantly reduced bodyweight over a 12 week period compared to the placebo group.
However, a 2011 study found that 10 weeks of supplementation with 2 grams Garcinia Cambogia Extract (60% HCA) failed to reduce weight in overweight subjects, compared to placebo group.
So out of the human studies, 2 have failed and 1 has demonstrated efficacy using the same dose as one of the failed studies. Clearly these results are difficult to interpret, and there are no valid explanations for this discrepancy at this time.
Because of the popularity Garcinia Cambogia has gained in recent years as a potential weight-loss agent, several reviews have been done which have sought to determine its efficacy based on the evidence.
Every review (and there have been at least four) has concluded that, while Garcinia Cambogia may be effective in rodents, this efficacy does not carry over to humans. While it can’t be conclusively stated that Garcinia Cambogia is worthless as a weight-loss ingredient, the research is just not too encouraging at this point, though many companies still attempt to capitalize off the buzz.
Core Burn Ultra contains 500mg of Garcinia Cambogia yielding 250mg of HCA per serving.
GREEN COFFEE EXTRACT:
Green Coffee Bean Extract is generally standardized for Chlorogenic Acid content, and in the case of Xenadrine Core, it has been standardized to 45%. Chlorogenic Acid is the bioactive compound primarily responsible for the moderate weight-loss effects of Green Coffee observed in multiple studies.
A 2007 study, published in the “Journal of International Medical Research”, found that 12 weeks of Green Coffee (450-500mg Clorogenic Acid) supplementation resulted in a reduction (6.9%) in glucose absorption in healthy volunteers. Researchers also noted average weight loss of 5.4 kg (almost 12 lbs) over the duration of the study in the group receiving the Green Coffee Extract.
A 2006 study, this time using a smaller dose of Green Coffee Extract (yielding 140mg Chlorogenic Acid), found no such weight-loss benefit over a 12 week period. The obvious difference between these two studies is that the dose of the first (positive) study was about 3 times the dose used in the second (negative) study.
A 2012 study found that adults who consumed GCE (containing about 315mg Chlorogenic Acid) daily lost an average of 8kg with the average reduction in body fat being about 4%. However, this study has since been retracted for reasons unknown.
Core Nutritionals lists the amount of Green Coffee Extract at 250mg (50% chlorogenic acid), so 2-3 servings yields an effective dose.
Multiple studies have confirmed Green Tea Extract can influence fat-loss to a statistically significant degree. Although this effect was originally thought to be related to caffeine content, more recent research has pointed to a green tea catechin known as Epigallocatechin gallate (EGCG) as the compound primarily responsible for these effects.
A 2009 study, published in “The Journal of Nutrition”, found that subjects consuming 625mg Green Tea Catechins (EGCG) alongside 40mg Caffeine paired with exercise lost an average of 2.2kg (4.8lbs) compared to the subjects in the control group (consuming just Caffeine), who lost an average of 1kg (2.2lbs).
These findings were corroborated by a 2009 meta-analysis, published in the “International Journal of Obesity”, which concluded that Green Tea extract tended to cause about 1.2kg (2.6lbs) reduction in bodyweight, and that effects could be amplified with Caffeine in non-caffeine tolerant individuals.
Further research has revealed that EGCG can effectively block Catechol-o-Methyl Transferase (COMT), the enzyme responsible for the degradation of Catcholamines such as Noradrenaline. The result is an indirect increase in Noradrenaline which induces lipolysis. So, while EGCG is not likely to induce noticeable weight-loss alone, when combined with Caffeine or other Noradrenaline-releasing stimulants, it can be quite synergistic. Most of the efficacy has been demonstrated using doses of 400-500mg EGCG daily and the less caffeine-tolerant the individual, the better.
Core Burn Ultra contains 125mg of EGCG per serving meaning 2-3 servings would yield a highly effective dose.
Despite the popularity of Raspberry Ketone, it has never actually demonstrated any efficacy for weight-loss in actual humans and, even in rat studies, has produced lackluster results using massive concentrations.
A 2010 in vitro study found that treatment with Raspberry Ketone increased fatty acid oxidation and lipolysis in adipocytes (fat cells). However, the amount/concentration of RK used in this study is beyond what could practically be consumed in oral supplement form.
A 2005 study, seeking to determine the weight loss effects of raspberry ketone on rats fed a high fat diet, noted dose dependent anti-obesity effects using doses of .5-4 grams/kg. This would roughly correspond to a 150lb person consuming 34-130 grams daily, a highly impractical dose.
In a 2012 study, similar effects were observed in rats, though this time with a focus on fat accumulation in the liver resulting from a high fat diet. The only human study that exists grouped Raspberry Ketone in with several other popular weight-loss ingredients so the effects cannot be attributed to raspberry ketones alone.
On a molecular level, Raspberry Ketone certainly demonstrates anti-obesity effects, but the doses used to achieve these effects are far more than what the average human could practically consume.
Core Nutritionals lists the amount of Raspberry Ketone in Core Burn Ultra at 100mg, an industry standard dose. However, there is no evidence to suggest that such a dose is actually effective.
Bacopa Monnieri is an herb which has traditionally been used as a nootropic and anxiolytic. However, in the context of Thermo Fire, the implied claim is that Bacopa Monnieri is able to influence Thyroid Hormones, thus positively impacting body weight.
A 2002 study from “Ethnopharmacology” found that 200mg/kg daily of Bacopa Extract was able to raise T4 (a Thryoid Hormone) by about 42% in male mice. Currently, the effects of Bacopa on Thyroid hormones have not been studied in human subjects, and it is unknown how beneficial it can be for weight loss. Logically, the most likely individuals to benefit from Bacopa supplementation would be those with Thyroid issues and abnormally low levels of T4.
Core Burn Ultra contains 50mg of Bacosides, not exactly a “clinical dose”, but potentially still effective.
Higenamine has been shown (in vitro) to be a beta-adrenergic receptor agonist as well as a weak alpha-adrenergic receptor antagonist, the same basic mechanisms of action by which Synephrine and Ephedrine work. By activating beta-receptors while simultaneously (albeit weakly) blocking alpha-receptors, Higenamine can potentiate the effects of Noradrenaline-releasing agents such as Caffeine and facilitate more fat-loss than could otherwise normally be achieved through exercise alone.
Higenamine is the major component underlying the fat-loss effects seen with Nelumbo Nucifera in rodent studies, but human studies are non-existent at this point in time.
For that reason, it’s tough to determine its degree of efficacy as a fat-burner, though the mechanisms certainly exist. The 25mg dose of Higenamine in Core Burn Ultra may very well poteniate (or be potentiated by) the other stimulants present in the formula.
Hordenine is included in many fat-burners because of its ability to amplify the effects of Caffeine. Preliminary studies indicate that its primary mechanism of action is via Momoamine Oxidase inhibition, with oral doses being shown to augment Noradrenaline-induced muscle contraction while not directly inducing contractions itself.
So, rather than acting as a stand-alone stimulant, Hordenine can amplify/extend the effects of other stimulants by blocking the reuptake of Noradrenaline (and other Monoamines).
Core Burn Ultra contains an industry standard dose of 50mg Hordenine, certainly an effective dose with regards to amplifying the effects of other stimulants such as Caffeine.
Theobromine remains under-researched, especially with regards to fat-burning potential. Preliminary research indicates that Theobromine is a cardiac stimulant, but does not appear to have any potent psychoactive properties.
In the context of Core Burn Ultra, it may contribute somewhat to weight-loss, but we wouldn’t consider it a key ingredient.
Caffeine certainly has pro-fat-loss mechanisms but the effects tend to fade with prolonged use, rendering caffeine ineffective as a long-term weight loss solution on its own. However, when paired with other fat-burning stimulants, Caffeine can kick-start the fat-burning process.
Core Burn Ultra contains 135mg of Caffeine per serving.
THE BOTTOM LINE:
Despite some questionable ingredients (Garcinia Cambogia and Raspberry Ketone), Core Burn Ultra is, overall, a pretty effective fat-burner. It’s definitely not for those who don’t tolerate stimulants well but, since it’s in powder form, dosing can be easily customized depending on the individual. At around 60 cents per serving, Core Burn Ultra is competitively priced making the prospect of taking 2-3 servings daily (for maximum efficacy) somewhat feasible.
- Henderson, Shonteh, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr 2.2 (2005): 54-62.
- Godard, Michael P., Brad A. Johnson, and Scott R. Richmond. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obesity Research 13.8 (2005): 1335-1343.
- Jagtap, Madhavi, H. M. Chandola, and B. Ravishankar. “Clinical efficacy of Coleus forskohlii (Willd.) Briq.(Makandi) in hypertension of geriatric population.”Ayu 32.1 (2011): 59.
- Castañer, Olga, et al. “Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans.” The American journal of clinical nutrition 95.5 (2012): 1238-1244.
- Covas, María-Isabel, et al. “The Effect of Polyphenols in Olive Oil on Heart Disease Risk FactorsA Randomized Trial.” Annals of internal medicine 145.5 (2006): 333-341.
- Gimeno, Eva, et al. “Changes in the phenolic content of low density lipoprotein after olive oil consumption in men. A randomized crossover controlled trial.”British journal of nutrition 98.06 (2007): 1243-1250.
- Marrugat, Jaume, et al. “Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation.” European journal of nutrition 43.3 (2004): 140-147.
- Covas, María-Isabel, et al. “Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans.” Free Radical Biology and Medicine 40.4 (2006): 608-616.
- Egras, Amy M., et al. “An evidence-based review of fat modifying supplemental weight loss products.” Journal of obesity 2011 (2010).
- Heymsfield, Steven B., et al. “Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial.” Jama 280.18 (1998): 1596-1600.
- Kim, Ji-Eun, et al. “Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial.” Nutrition journal 10.1 (2011): 94.
- Watson, John A., and John M. Lowenstein. “Citrate and the Conversion of Carbohydrate into Fat FATTY ACID SYNTHESIS BY A COMBINATION OF CYTOPLASM AND MITOCHONDRIA.” Journal of Biological Chemistry 245.22 (1970): 5993-6002.
- Mattes, Richard D., and Leslie Bormann. “Effects of (−)-hydroxycitric acid on appetitive variables.” Physiology & behavior 71.1 (2000): 87-94.
- Watanabe, Takuya, et al. “The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.”Clinical and experimental hypertension 28.5 (2006): 439-449.
- Vinson, Joe A., Bryan R. Burnham, and Mysore V. Nagendran. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.”Diabetes, metabolic syndrome and obesity: targets and therapy 5 (2012): 21.
- Thom, E. “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.” Journal of International Medical Research 35.6 (2007): 900-908.
- Thielecke, Frank, et al. “Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study.” European journal of clinical nutrition 64.7 (2010): 704-713.
- Lu, Hong, Xiaofeng Meng, and Chung S. Yang. “Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (−)-epigallocatechin gallate.” Drug metabolism and disposition 31.5 (2003): 572-579.
- Keränen, Tapani, et al. “Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone.” European journal of clinical pharmacology 46.2 (1994): 151-157.
- Brown, A. L., et al. “Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial.” British Journal of Nutrition106.12 (2011): 1880-1889.
- Wang, Lili, Xianjun Meng, and Fengqing Zhang. “Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.” Journal of medicinal food 15.5 (2012): 495-503.
- Egras, Amy M., et al. “An evidence-based review of fat modifying supplemental weight loss products.” Journal of obesity 2011 (2010).
- Park, Kyoung Sik. “Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes.” Planta medica 76.15 (2010): 1654
- Morimoto, Chie, et al. “Anti-obese action of raspberry ketone.” Life sciences77.2 (2005): 194-204.
- Muccioli, Giampiero, et al. “Effect of L-α-glycerylphosphorylcholine on muscarinic receptors and membrane microviscosity of aged rat brain.” Progress in Neuro-Psychopharmacology and Biological Psychiatry 20.2 (1996): 323-339.
- Kar, A., S. Panda, and S. Bharti. “Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice.”Journal of ethnopharmacology 81.2 (2002): 281-285.
- Nojima, Hiroshi, Mari Okazaki, and Ikuko Kimura. “Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice.” Journal of Asian natural products research 2.3 (2000): 195-203.
- Bai, Gang, et al. “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2‐adrenergic receptor agonist1.” Acta Pharmacologica Sinica 29.10 (2008): 1187-1194.
- Barwell, C. J., et al. “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat.” Journal of pharmacy and pharmacology41.6 (1989): 421-423.
- Arciero, PAUL J., et al. “Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men.” American Journal of Physiology-Endocrinology And Metabolism 268.6 (1995): E1192-E1198.
- Astrup, A., et al. “Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers.” The American journal of clinical nutrition 51.5 (1990): 759-767.
- Costill, D. L., Gl P. Dalsky, and W. J. Fink. “Effects of caffeine ingestion on metabolism and exercise performance.” Medicine and science in sports 10.3 (1977): 155-158.
- Graham, T. E., and L. L. Spriet. “Metabolic, catecholamine, and exercise performance responses to various doses of caffeine.” Journal of Applied Physiology 78.3 (1995): 867-874.
- Graham, Terry E. “Caffeine and exercise.” Sports medicine 31.11 (2001): 785-807
- Graham, Terry E., Jorn W. Helge, David A. MacLean, Bente Kiens, and Erik A. Richter. “Caffeine Ingestion Does Not Alter Carbohydrate or Fat Metabolism in Human Skeletal Muscle during Exercise.” The Journal of Physiology 529.3 (2000): 837-47.
- Ono, Yuka, et al. “Anti-obesity effect of< i> Nelumbo nucifera leaves extract in mice and rats.” Journal of Ethnopharmacology 106.2 (2006): 238-244.