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BPI Sports 24/7 Burn: An Evidence-Based Review

24/7 Burn is a non-stimulant weight-loss supplement by BPI Sports, designed to encourage weight-loss over the long-term…

BPI Sports 24/7 Burn

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24/7 Burn Ingredients

24/7 Burn contains several non-stimulant ingredients which have shown varying degrees of efficacy in studies.  Some of them may help facilitate weight-loss.  Others are completely useless…

Conjugated Linoleic Acid

Conjugated Linoleic Acid is a term which refers to a group of polyunsaturated fatty acids (loosely referred to as ‘good fats’).  BPI lists several sources of CLA on the 24/7 Burn Supplement Facts panel:  Safflower, Avocado, and Coconut Oil, as well as the isolated active compound, CLA.

The theorized mechanism of action by which CLA induces weight-loss lies in its alleged ability to bind to the Peroxisome Proliferator activated Receptor (PPAR) which, when activated, may directly induce fat loss.

Unfortunately, the effects noted in rodents have not been replicated in humans, despite dozens of human studies being conducted. As discussed in our article, “CLA: A Waste of Time and Money?”, any weight-loss from CLA supplementation is going to be very slight, and it’s just as likely that no weight-loss at all will occur.

In the context of 24/7 Burn, CLA may encourage some fat-loss, but isn’t particularly reliable or potent, even at higher doses.

Plumbago Zeylanica

Plumbago zeylanica is an Ayurvedic herb with a somewhat documented history of use as a vitality-booster and possible aphrodisiac.

A 2001 study, published in “Phytotherapy Research”, noted stimulatory properties in rats treated with an extract of Plumbago zeylanica, with the proposed mechanism of action being Dopamine related.

Unfortunately, there are no human studies from which to draw conclusions so for now we’re left with just the preliminary findings.  Plumbago Zeylanica doesn’t have any clear weight-loss implications but could function as a mood support agent in the context of 24/7 Burn.

Garcinia Cambogia

The primary bioactive in Garcinia Cambogia is Hydroxycitric Acid (HCA), which is alleged to reduce body weight via inhibition of ATP Citrate Lysase, an enzyme required for the synthesis of fatty acids from carbohydrates (de novo lipogenisis).

In theory, blocking this enzyme would essentially stop excess carbohydrates from being stored as fat. Unfortunately, while inhibition of ATP Citrate Lysase has resulted in weight-loss in rodents, the implications for humans are less promising, because de novo lipogenesis occurs less in humans than rodents.

We discuss Garcinia Cambogia in depth in this article, but the bottom line is that it isn’t particularly effective in humans.

Caralluma Fibriata

Caralluma fibriata is a cactus-like plant indigenous to India, with a history of usage as an appetite suppressant.

A 2007 study found that 1000mg of Caralluma fibriata extract was able to suppress appetite in overweight subjects, resulting in roughly 2.5% weight-loss over a 60 day period.

These findings were replicated in a 2010 study using rats, although this study also noted that appetite suppression did not begin until around 45 days of supplementation.

So, in the context of 24/7 Burn, Caralluma Fibriata may function as a long-term appetite suppressant.

Green Tea Extract

Green Tea has been shown to inhibit Catechol-O-Methyl Transferase (COMT), thereby extending/amplifying the effects of stimulants such as Caffeine. We discuss the fat-burning implications of Green Tea Extract more in this article.

BPI does not disclose the precise amount of Green Tea Extract, let alone EGCG, present in 24/7 Burn so it’s unclear how effective it is in this case.

You could also get your EGCG from Matcha, which is finely ground Green Tea leaves.

24/7 Burn Ingredient Takeaway

A couple of the ingredients in 24/7 Burn may induce some slight weight-loss over-time, but the effects are not going to be particularly potent.  Some of the ingredients, like Garcinia Cambogia, just flat out don’t work.  There is some fat-burning potential here, but nothing too powerful.

Is 24/7 Burn Safe?

24/7 Burn is entirely safe, primarily because it contains no stimulants.  Some people react poorly to Green Tea Extract, but there probably isn’t enough of it in the formula to upset your stomach, so not to worry!

The Bottom Line

24/7 Burn may encourage slight weight-loss in the long-term (a couple months), but immediately noticeable effects are not likely.  That said, the safety profile is much stronger than many stimulant-based fat-burners out there, which may be the primary concern for some users.

Still don’t know which weight-loss supplement is right for you? Check out our Top 10 Fat-Burners List!

References

  1. Bopaiah, C. P., and N. Pradhan. “Central nervous system stimulatory action from the root extract of Plumbago zeylanica in rats.” Phytotherapy Research15.2 (2001): 153-156.
  2. Malpuech‐Brugère, Corinne, et al. “Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans.” Obesity research 12.4 (2004): 591-598.
  3. Gaullier, Jean-Michel, et al. “Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans.” The Journal of nutrition 135.4 (2005): 778-784.
  4. Syvertsen, C., et al. “The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese.” International journal of obesity 31.7 (2006): 1148-1154.
  5. Steck, Susan E., et al. “Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans.” The Journal of nutrition137.5 (2007): 1188-1193.
  6. Wanders, Anne J., et al. “Effect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjects.” PLoS One 5.2 (2010): e9000.
  7. Joseph, Shama V., et al. “Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men.” The Journal of nutrition 141.7 (2011): 1286-1291.
  8. Venkatramanan, Sudha, et al. “Milk enriched with conjugated linoleic acid fails to alter blood lipids or body composition in moderately overweight, borderline hyperlipidemic individuals.” Journal of the American College of Nutrition 29.2 (2010): 152-159.
  9. Kuriyan, Rebecca, et al. “Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women.” Appetite 48.3 (2007): 338-344.
  10. Kamalakkannan, Soundararajan, et al. “Antiobesogenic and antiatherosclerotic properties of caralluma fimbriata extract.” Journal of nutrition and metabolism2010 (2010).
  11. Sano, Atsushi, et al. “Beneficial effects of grape seed extract on malondialdehyde-modified LDL.” Journal of nutritional science and vitaminology53.2 (2007): 174-182.
  12. Kamalakkannan, Soundararajan, et al. “Antiobesogenic and antiatherosclerotic properties of caralluma fimbriata extract.” Journal of nutrition and metabolism2010 (2010).

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