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Prime Nutrition Backdraft XP Review

Backdraft XP Is Prime Nutrition’s upcoming thermogenic fat-burner which features a few relatively under-utilized ingredients such as Paradoxine and Devil’s Horesewhip…

Prime Nutrition Backdraft XP

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N-Acetyl-L-Carnitine

Carnitine is an amino acid that is heavily involved with the metabolism of fat for energy. It is required for the proper transport of fatty acids in the mitochondria, where they are oxidized (burned) for energy through the process known as “beta-oxidation”.

Carnitine deficiency has been shown to hinder fat-burning capacity. Because of this integral role in the fat-burning process, Carnitine supplementation is alleged to burn-fat, and while it may certainly help normalize fat-burning capacity, human studies regarding weight loss are mixed.
A 2002 study, published in “Metabolism”, found that Carnitine supplementation (1g/day) increased fatty acid oxidation rates in humans without Carnitine deficiency.

A 2004 study from the same journal found that L-Carnitine supplementation (3g/day) increased fatty acid oxidation in overweight subjects while having no effect on protein synthesis or breakdown.

However, a 2005 study, published in the “International Journal for Vitamin and Nutrition Research”, found that Carnitine supplementation failed to influence weight-loss in rats. The results of this study were in-line with an earlier (2002) study in which L-Carnitine supplementation (4g/day) failed to influence fat mass, body mass, or resting lipid utilization in moderately obese women.

A more recent (2010) study found that Carnitine supplementation did favorably influence fatty acid utilization in rats, though this study did not measure fat mass post-supplementation.

Ultimately, Carnitine does possess the mechanisms by which it “should” burn fat (via increased utilization of fatty acids), but human studies are not particularly encouraging so far.

Backdraft XP contains 1g of Acetyl-L-Carnitine per serving, more than most Carnitine containing fat-burners, but not necessarily an effective dose, except in individuals who are Carnitine deficient.

Caffeine

Caffeine is by far the most common ingredient among stimulant-based fat-burners because it triggers the release of Noradrenaline, a potent activator of lipolysis.

Although Caffeine possesses pro-fat-loss properties, the effects tend to fade with prolonged use, rendering it ineffective as a long-term weight loss solution on its own. However, when paired with other fat-burning stimulants, Caffeine can kick-start the fat-burning process, so it’s a useful addition to the True GRIT Thermo formula.

With 250mg of Caffeine per serving, Backdraft XP may provide a noticeable increase in alertness and perceived energy levels but, as a fat-burner, Caffeine isn’t particularly effective in the long-term.

Achyranthes Aspera

Achyranthes aspera, also known as Devil’s Horsewhip, has been shown to exert certain anti-obesity effects in mice, and this is alleged to be the result of inhibition of pancreatic enzymes (lipase and amylase).

This effect has been replicated elsewhere, but only in mice, with absolutely no human research regarding the weight-loss potential of Achyranthes aspera.

Backdraft XP contains 225mg of Achyranthes aspera which Prime Nutrition claims is an “efficacious dose”, but since no human data exists, this claim is far from substantiated.

Theobromine

Theobromine remains under-researched, especially with regards to fat-burning potential. Preliminary research indicates that Theobromine is a cardiac stimulant, but does not appear to have any potent psychoactive properties.

In the context of Backdraft XP, Theobromine may contribute somewhat to weight-loss, but we wouldn’t consider it a key ingredient.

Capsicum

Though commonly standardized for Capsaicin content alone, Capsicum also contains other compounds, collectively referred to as Capsaicinoids, which include Dihydrocapsaicin and Nordihydrocapsaicin.

A 2007 study noted an increase in fat oxidation (relative to placebo) during low intensity exercise in healthy adult males who consumed 150mg of capsaicin one hour before exercise.

A 2001 found subjects who consumed CH-19 Sweet (containing Capsinoids) had significantly higher core body temperatures and increased oxygen consumption (indicative of energy production) compared to the placebo group.

A later (2010) study, published in “The American Journal of Clinical Nutrition”, found that Dihydrocapsiate supplementation (3mg/day) caused a small but noticeable increase in the resting metabolic rate of healthy human subjects.

Capsicum is one of the few ingredients in Backdraft XP that can increase thermogenesis on its own, but the effects are not going to be extremely drastic.

Paradoxine

Paradoxine is a standardized form of 6-Paradol, the active component of Grains of Paradise underlying its weight-loss implications.

Grains of Paradise (containing Paradoxine) has been to shown to increase metabolic rate in response to a physiological stressor (in this case cold exposure) via activation of Brown Adipose Tissue. It’s potential for weight-loss is discussed in this article.

Backdraft XP contains 50mg of Paradoxine.

The Bottom Line

Backdraft XP contains a few ingredients that may actually influence weight-loss, but also some that probably won’t. Prime Nutrition’s claims that “you will not find a more potent and result producing product” is off-base to say the least. We’ve come across many other fat-burners that will result in more significant weight-loss than Backdraft XP.

Still not sure which fat-burner is right for you?  Check out our Top 10 Fat-Burners List!

REFERENCES
  1. Wutzke, Klaus D., and Henrik Lorenz. “The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects.”Metabolism 53.8 (2004): 1002-1006
  2. Seim, H., W. Kiess, and T. Richter. “Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults.” Metabolism 51.11 (2002): 1389-1391
  3. Melton, S. A., et al. “L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise.” International journal for vitamin and nutrition research 75.2 (2005): 156-160.
  4. Villani, Rudolph G., et al. “L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.”International journal of sport nutrition and exercise metabolism 10.2 (2000): 199-207.
  5. Karanth, Jyothsna, and K. Jeevaratnam. “Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity.” (2010).
  6. Costill, D. L., Gl P. Dalsky, and W. J. Fink. “Effects of caffeine ingestion on metabolism and exercise performance.” Medicine and science in sports 10.3 (1977): 155-158.
  7. Arciero, PAUL J., et al. “Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men.” American Journal of Physiology-Endocrinology And Metabolism 268.6 (1995): E1192-E1198.
  8. Astrup, A., et al. “Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers.” The American journal of clinical nutrition 51.5 (1990): 759-767
  9. Graham, Terry E., Jorn W. Helge, David A. MacLean, Bente Kiens, and Erik A. Richter. “Caffeine Ingestion Does Not Alter Carbohydrate or Fat Metabolism in Human Skeletal Muscle during Exercise.” The Journal of Physiology 529.3 (2000): 837-47
  10. Rani, Neerja, Surendra Kumar Sharma, and Neeru Vasudeva. “Assessment of antiobesity potential of Achyranthes aspera Linn. seed.” Evidence-Based Complementary and Alternative Medicine 2012 (2012)
  11. Latha, B. Pushpa, et al. “Therapeutic efficacy of Achyranthes aspera saponin extract in high fat diet induced hyperlipidaemia in male wistar rats.” African Journal of Biotechnology 10.74 (2013): 17038-17042.
  12. Latha, B. Pushpa, et al. “Effect of saponin rich extract of Achyranthes aspera on high fat diet fed male wistar rats.” Journal of Pharmacy Research 4.9 (2011).
  13. Shin, Ki Ok, and Toshio Moritani. “Alterations of Autonomic Nervous Activity and Energy Metabolism by Capsaicin Ingestion during Aerobic Exercise in Healthy Men.” Journal of Nutritional Science and Vitaminology 53.2 (2007): 124-32
  14. Ohnuki, Koichiro, et al. “Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice.” Bioscience, biotechnology, and biochemistry 65.12 (2001): 2735.
  15. WATANABE, TATSUO, et al. “Adrenal sympathetic efferent nerve and catechol secretion excitation caused by capsaicin in rats.” (1988).

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