Amino HP is the most recent addition to the ANS Performance line which features a variety of performance and recovery ingredients, some well-known and some quite new to the category…FIND IT HERE
The term “Branched Chain Amino Acids” (BCAAs) refers to the amino acids Leucine, Isoleucine, and Valine which are commonly utilized together in a 2:1:1 ratio (Leucine, Isoleucine, Valine). While Leucine does appear to be the most critical in regards to muscle protein synthesis, a 2009 study published in the “Journal of the International Society of Sports Nutrition” concluded thatBCAAs (2:1:1) have a more pronounced effect on protein synthesis than the same amount of Leucine alone, indicating that all three is the best way to go.
Amino HP contains 5g of BCAAs in the classic 2:1:1 ratio, a solid dose which may certainly encourage and enhance muscle protein synthesis.
Taurine has been shown to reduce exercise-induced oxidative muscle damage in multiple studies. While these findings certainly implicate Taurine as a recovery aid, it may also enhance exercise performance.
A recent 2013 study, also from “Amino Acids” noted a 1.7% improvement in 3k-time trial of runnersafter supplementing with Taurine, and these findings were further corroborated in a later 2013 study from “Applied Physiology, Nutrition, and Metabolism” in which Taurine supplementation was able to increase strength as well as decrease oxidative muscle damage in human subjects.
Amino HP contains 2g of Taurine per serving, an effective dose on par with what has been used in a clinical setting.
Betaine (also known as Trimethylglycine) is the amino acid Glycine with the addition of three methyl groups attached. Betaine is alleged to increase power output and strength by increasing cellular swelling, a phenomenon well established with Creatine supplementation, which can drastically reduce the damaging effect of outside stimuli (such as exercise) on the working muscle. So far, Betaine has been investigated in several human studies, and has had some pretty encouraging results in most.
We discuss the strength/performance implications of Betaine in-depth in this article. Amino HP contains the industry standard dose of 1250mg per serving.
Choline is required for the synthesis of the neurotransmitter Acetylcholine, so it is commonly included in products aimed at boosting cognitive function. However, as ANS points out, it has performance implications as well. Choline can become depleted by rigorous exercise, so Choline Bitartrate serves as a way of maintaining optimal circulating Choline levels.
It has also been shown to reduce bodyweight while preserving strength in female martial arts athletes, but results like this need some replication before we can really draw conclusions there.
Amino HP contains 500mg of Choline Bitartrate.
Amentoflavone, also found in ANS’s pump pre-workout Dilate, is a relatively new entrant in the supplement industry which is alleged to a have a variety of performance implications.
Indeed, Amentoflavone has been shown, in vitro, to be a relatively potent vasodilator, with one study demonstrating that it can reduce noradrenaline-induced vasoconstriction by 35%.
Beyond that, Amentaflavone may also be able to enhance muscular contractions, as discussed in depth in this article. Ultimately, while Amentoflavone should still be considered a speculative ingredient, it helps to add a dimension of uniqueness to Amino HP.
Citrulline is an amino acid which serves as a precursor to Arginine, and therefore is directly involved in the production of Nitric Oxide. Unlike supplemental Arginine, however, Citrulline is quite reliable at increasing plasma Arginine and ultimately enhancing performance.
Citrulline has been shown to increase muscular contraction efficiency, meaning less ATP is required for a given workload. This mechanism explains why subjects who consumed Citrulline were able to perform more reps later on in the workout compared to subjects who consumed a placebo.
Additionally, Citrulline has been shown to reduce muscle soreness effectively making it both a performance enhancing ingredient as well a recovery agent.
There is also preliminary evidence to suggest Citrulline may act in a synergistic manner with Leucine by positively affecting Leucine’s stimulation of mTOR, which is why we like seeing it in BCAA-based supplements such as Amino HP.
Rosa roxburghii has an extensive and relatively well-documented use in traditional medicine as an overall vitality/longevity agent, mostly tied to its antioxidant properties.
ANS specifically mentions that Rosa roxburghii does have implications for athletes as it has been shown, in mice, to enhance glycogen recovery post-exercise. While these findings should be viewed as strictly preliminary, they do certainly warrant further (human) research and lend credibility to the notion that Rosa roxburghii can favorably impact exercise performance and/or recovery.
The Bottom Line
Amino HP is no doubt one of the more comprehensive and unique BCAA formulas out there right now. ANS has taken the performance and recovery aspect of the formula way beyond that of other “just BCAA” formulas. Amino HP is a breath of fresh air in a category (aminos) that hasn’t seen much innovation, despite being one the most saturated.
Still not sure which amino acid supplement is right for you? Check out our Best Amino Acid Supplements List!
- Anthony, Tracy G., et al. “Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats.” The Journal of nutrition 131.4 (2001): 1171-1176.
- Shimomura, Yoshiharu, et al. “Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise.” The Journal of nutrition 134.6 (2004): 1583S-1587S.
- Blomstrand, Eva. “A Role for Branched-Chain Amino Acids in Reducing Central Fatigue.”American Society for Nutrition (n.d.): n. pag.
- Tipton, Kevin D., et al. “Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein.” Applied Physiology, Nutrition, and Metabolism 34.2 (2009): 151-161.
- Tipton, Kevin D., et al. “Stimulation of net muscle protein synthesis by whey protein ingestion before and after exercise.” American Journal of Physiology-Endocrinology and Metabolism 292.1 (2007): E71-E76.
- Blomstrand, E., P. Hassm�n, B. Ekblom, and E. A. Newsholme. “Administration of Branched-chain Amino Acids during Sustained Exercise ? Effects on Performance and on Plasma Concentration of Some Amino Acids.” European Journal of Applied Physiology and Occupational Physiology 63.2 (1991): 83-88.
- Anthony Anthony, Joshua C., Tracy Gautsch Anthony, and Donald K. Layman. “Leucine supplementation enhances skeletal muscle recovery in rats following exercise.”The Journal of nutrition 129.6 (1999): 1102-1106.
- MacLean D.A..Graham,T.E. and B. Saltin. “Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise.” American Journal of Physiology-Endocrinology And Metabolism 267.6 (1994): E1010-E1022.
- Shimomura, Yoshiharu, et al. “Nutraceutical effects of branched-chain amino acids on skeletal muscle.” The Journal of nutrition 136.2 (2006): 529S-532S.
- Stoppani, Jim, et al. “Consuming branched-chain amino acid supplement during a resistance training program increases lean mass, muscle strength and fat loss.” Journal of the International Society of Sports Nutrition 6.Suppl 1 (2009): P
- Gomez-Merino, D., et al. Evidence that the branched-chain amino acid L-valine prevents exercise-induced release of 5-HT in rat hippocampus. Int J Sports Med. 2001 Jul;22(5):317-22
- Casperson, Shanon L., et al. “Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein.”Clinical Nutrition 31.4 (2012): 512-519.
- Huxtable, R. J. “Physiological actions of taurine.” Physiological reviews 72.1 (1992): 101-163.
- Balshaw, Thomas G., et al. “The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners.” Amino acids 44.2 (2013): 555-561.
- Matsuzaki, Yasushi, Teruo Miyazaki, Syunpei Miyakawa, Bernard Bouscarel, Tadashi Ikegami, and Naomi Tanaka. “Decreased Taurine Concentration in Skeletal Muscles after Exercise for Various Durations.” Medicine & Science in Sports & Exercise34.5 (2002): 793-97.
- Matsuzaki, Yasushi., et al. “Decreased taurine concentration in skeletal muscles after exercise for various durations.” Medicine and science in sports and exercise 34.5 (2002): 793-797.
- da Silva, Luciano A., et al. “Effects of taurine supplementation following eccentric exercise in young adults.” Applied Physiology, Nutrition, and Metabolism 39.1 (2013): 101-104.
- Beyranvand, Mohamad Reza, et al. “Effect of taurine supplementation on exercise capacity of patients with heart failure.” Journal of cardiology 57.3 (2011): 333-337.
- Yatabe, Yoshihisa, et al. “Effects of taurine administration on exercise.” Taurine 7. Springer New York, 2009. 245-252
- Zhang, M., et al. “Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men.” Amino acids 26.2 (2004): 203-207.
- Silva, Luciano A., et al. “Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise.” Cell biochemistry and function 29.1 (2011): 43-49.
- Hoffman, Jay R., et al. “Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise.” The Journal of Strength & Conditioning Research 25.8 (2011): 2235-2241
- i, Cheng, Masao Shinohara, John Kuhlenkamp, Christine Chan, and Neil Kaplowitz. “Mechanisms of Protection by the Betaine-homocysteine Methyltransferase/betaine System in HepG2 Cells and Primary Mouse Hepatocytes.” Hepatology 46.5 (2007): 1586-596.
- Trepanowski, John F., et al. “The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men.” The Journal of Strength & Conditioning Research 25.12 (2011): 3461-3471.
- Hoffman, Jay R., et al. “Effect of betaine supplementation on power performance and fatigue.” Journal of the International Society of Sports Nutrition 6.1 (2009): 1-10.
- Cholewa, Jason M., et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition 10.1 (2013): 39.
- Lee, Elaine C., et al. “Ergogenic effects of betaine supplementation on strength and power performance.” J Int Soc Sports Nutr 7 (2010): 27.
- Feduccia Tayebati, Seyed Khosrow, et al. “Effect of choline-containing phospholipids on brain cholinergic transporters in the rat.” Journal of the neurological sciences302.1 (2011): 49-57.
- Tomassoni, Daniele, et al. “Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats.” Current Alzheimer Research 9.1 (2012): 120-127.
- Gimenez, Rosa, Josep Raich, and Juan Aguilar. “Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP‐choline treatment of aging mice.” British journal of pharmacology 104.3 (1991): 575-578.
- Wallace, Julie MW, et al. “Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.” British Journal of Nutrition 108.07 (2012): 1264-1271.
- Penry, Jason T., and Melinda M. Manore. “Choline: an important micronutrient for maximal endurance-exercise performance?.” International journal of sport nutrition and exercise metabolism 18.2 (2008): 191.
- Elsawy, Gehan, Osama Abdelrahman, and Amr Hamza. “Effect of choline supplementation on rapid weight loss and biochemical variables among female Taekwondo and Judo athletes.” Journal of human kinetics 40.1 (2014): 77-82.
- Bendahan, D., et al. “Citrulline/malate promotes aerobic energy production in human exercising muscle.” British journal of sports medicine 36.4 (2002): 282-289.
- Giannesini, Benoît, et al. “Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle.” European journal of pharmacology 667.1 (2011): 100-104.
- Sureda, Antoni, et al. “Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise.” Free radical research 43.9 (2009): 828-835.
- Pérez-Guisado, Joaquín, and Philip M. Jakeman. “Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.” The Journal of Strength & Conditioning Research 24.5 (2010): 1215-1222.
- XIA, Xing, et al. “Study on the anti-fatigue and hypoxia tolerance effect of Rosa roxburghii Tratt. extract in mice [J].” Lishizhen Medicine and Materia Medica Research 7 (2012): 029.