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EpiBurn Pro Review

EpiBurn Pro is USP Labs’ most recent fat-burner which is essentially the replacement for the once extremely popular OxyElite Pro which featured DMAA.

USP Labs EpiBurn Pro

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ASHWAGANDHA (WITHANIA SOMNIFERA)

Ashwagandha is an Ayurvedic herb with a well-documented history of use and a variety of implications including: cognitive enhancement, combating anxiety, enhancing vitality, and supporting bone health. However, for the purposes of EpiBurn Pro, it’s safe to assume USP Labs is primarily concerned with preliminary (in vitro) evidence indicating that Ashwagandha can have a positive impact of fat-cells.

A 2008 in vitro study from “Biofactors” noted that Withaferin A (an isolated compound found in Ashwagandha) was able to kill fat-cells. Unfortunately, the dose used in this study was so high that the same effect could not realistically be achieved with oral supplementation of Ashwagandha.

However, Ashwagandha has other implications related to performance enhancement. A 2012 study published in the “Journal of Ayurveda and Integrative Medicine” found that Ashwagandha supplementation increased VO2 max and time to fatigue in trained cyclists. So, while evidence for Ashwagandha as an effective fat-loss agent is tenuous at best, it may still be a useful addition to the EpiBurn Pro formula.

OLIVE LEAF EXTRACT (OLEA EUROPAEA)

Olive leaf extract contains two main bioactive compounds, Hydroxytyrosol and Oleuropein, which are responsible for the majority of the adrenergic effects. A 2008 study from “The Journal of Nutritional Biochemistry” demonstrated increased Noradrenaline and Adrenaline levels in rats following injection of Olive leaf extract, and this effect was primarily attributed to Oleuropein. Similar findings were noted in a 2013 study published in “The Journal of Nutritional Biochemistry” in which rats fed a diet high in Oleuropein experienced significantly increased Noradrenaline levels (measured by urine), though it’s worth mentioning that this was not accompanied by the usual decrease in weight. In fact, Oleuropein may actually down-regulate beta-adrenergic receptors, as evidenced in a 2012 study from “The American Journal of Clinical Nutrition” (although this was in Endothelial cells, not fat-cells).

While the weight-loss implications of Olea Europaea remain unclear, it may certainly induce the release of Noradrenaline which is generally accompanied by increased focus, mood, and perceived energy.

YOHIMBE EXTRACT

The primary active component of Yohimbe (Pausinystalia Yohimbe) is Yohimbine, which acts as an alpha-2 receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis. By blocking the action of this receptor Yohimbine allows for more lipolysis than would otherwise normally occur during exercise. A 2006 study showed that supplementation with 20mg Yohimbine (active component) for two weeks induced significant weight-loss, especially considering the short duration of the study.

As previously stated, Yohimbine directly acts on alpha-2 receptor, but its fat loss capabilities may also be magnified by its ability to increase the catecholamine neurotransmitters adrenaline and noradrenaline which in turn induce lipolysis. However, its ability to increase Catecholamines may degrade fairly quickly (a few weeks), so for Yohimbine to be truly effective as a weight-loss agent, it must be combined with something that activates the beta-adrenergic receptors in the first place (i.e. caffeine and other stimulants or exercise). EpiBurn Pro contains an unknown amount of Yohimbe.

FORSLEAN (COLEUS FORSKOHLII EXTRACT)

The active component in Coleus Forskohlii, Forskohlin, has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.

A 2005 study, published in the “Journal of the International Society of Sports Nutrition”, found that 50mg daily (two 25mg doses) for 12 weeks was able to prevent weight gain compared to the control group in overweight women. Another 2005 study found that the same dose (25mg twice daily) was able to favorably influence body composition (i.e. less fat, more lean mass), which corresponded with an increase in Testosterone over 12 weeks. A more recent 2011 study noted a roughly 2.5% decrease in BMI after 2 months of supplementation.

Forskohlin is one of the most effective non-stimulant fat-burners on its own, and can potentially amplify the effects of other fat-burning compounds. EpiBurn Pro contains an undisclosed amount of Coleus Forskohlii, so it’s tough to say how much Forskohlin is present in the formula. That being said, since only 50mg daily is needed to achieve noticeable weight-loss with Forskohlin, EpiBurn Pro may very well contain an effective dose.

NEULMBO NUCIFERA (HIGENAMINE)

Nelumbo Nucifera, sometimes referred to as Indian Lotus, is a flower which has been shown to induce lipolysis in vitro and in mice. The lipolytic effects of Nelumbo Nucifera are primarily attributed to the Higenamine content, although there are other compounds which may potentiate these effects. Higenamine is a Beta(2) Adrenergic Agonist (same mechanism as Ephedra), meaning it stimulates the Beta(2) Adrenergic Receptors which induce lipolysis (fat breakdown).

EpiBurn Pro contains an undisclosed amount of Nelumbo Nucifera, but that doesn’t really matter since an optimal dose for humans has not been established. Unfortunately, until human trials are conducted, we won’t be able to determine the true efficacy of Nelumbo Nucifera for weight-loss.

CAFFEINE ANHYDROUS

Caffeine triggers the release of Catecholamines (i.e. Noradrenaline, Adrenaline, Dopamine) which, in addition to enhancing focus and alertness, are inherently pro-lipolytic. Unfortunately, habitual Caffeine consumption tends to lead to tolerance, making it less and less effective as time goes on. That being said, Caffeine may be synergistic with other stimulants and tends to increase perceived energy, leading to more intense workouts. EpiBurn Pro contains 100mg of Caffeine per serving which is not an overwhelming amount but is certainly enough to potentiate the effects of the other stimulants in the formula.

THE BOTTOM LINE

EpiBurn Pro contains several effective fat-burning ingredients (Yohimbe, Forskohlin, Higenamine) as well as some questionable additions (Ashwagandha, Olive Leaf). Although we can’t be sure of the exact doses used, there is no obvious reason to suspect less than optimal doses of the majority of the ingredients.

While the formula isn’t particularly groundbreaking, it is on par with some of the more effective fat-burners we’ve reviewed and may be worth a shot for those looking to knock off a few pounds.

Still not sure which fat-burner is right for you?  Check out our Top 10 Fat-Burners List!

References

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  2. Siegner, Ralf, et al. “Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle.” Nutr Metab (Lond) 7 (2010): 66-76.
  3. Ohkoshi, Emika, et al. “Constituents from the Leaves of< EM EMTYPE=.”Planta medica 73.12 (2007): 1255-1259.
  4. Shenoy, Shweta, et al. “Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists.” Journal of Ayurveda and integrative medicine 3.4 (2012): 209.
  5. Castañer, Olga, et al. “Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans.” The American journal of clinical nutrition 95.5 (2012): 1238-1244.
  6. Covas, María-Isabel, et al. “The Effect of Polyphenols in Olive Oil on Heart Disease Risk FactorsA Randomized Trial.” Annals of internal medicine 145.5 (2006): 333-341.
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  8. Marrugat, Jaume, et al. “Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation.” European journal of nutrition 43.3 (2004): 140-147.
  9. Covas, María-Isabel, et al. “Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans.” Free Radical Biology and Medicine 40.4 (2006): 608-616.
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  17. Nojima, Hiroshi, Mari Okazaki, and Ikuko Kimura. “Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice.” Journal of Asian natural products research 2.3 (2000): 195-203.
  18. Bai, Gang, et al. “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2‐adrenergic receptor agonist1.” Acta Pharmacologica Sinica 29.10 (2008): 1187-1194.
  19. Costill, D. L., Gl P. Dalsky, and W. J. Fink. “Effects of caffeine ingestion on metabolism and exercise performance.” Medicine and science in sports 10.3 (1977): 155-158.
  20. Sax, L. “Yohimbine does not affect fat distribution in men.” International journal of obesity 15.9 (1991): 561-565.
  21. Gurguis, George NM, Bernard J. Vitton, and Thomas W. Uhde. “Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls.” Psychiatry research 71.1 (1997): 27-39.

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