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MTS Nutrition Drop Factor Review

Drop Factor is MTS Nutrition’s fat-burner which is primarily stimulant-focused, though it does contain some effective non-stimulant ingredients as well…

MTS Drop Factor

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Caffeine

Caffeine triggers the release of Catecholamines (i.e. Noradrenaline, Adrenaline, Dopamine) which, in addition to enhancing focus and alertness, are inherently pro-lipolytic. Although this mechanism can certainly burn fat in the short-term, prolonged Caffeine consumption (by itself) generally results in tolerance build-up so the effects become less potent over time. This was demonstrated in a 1992 study in which 24 weeks of Caffeine intake (200mg/day) failed to induce weight-loss in humans. For this reason, for Caffeine to be an effective fat-loss agent, it must be combined with other stimulants such as Yohimbine and/or Synephrine (both of which are also included in the Drop Factor formula).

Capsaicin

Capsicum Annum, more commonly known as Cayenne Pepper, is generally standardized for its active component, Capsaicin, which has thermogenic properties and clear implications for weight-loss in humans.

A 1997 study, the subjects of which were rats, found that Capsaicin supplementation was able to increase adrenaline-induced fatty acid utilization, which increased exercise (swimming) endurance.

A more recent (2007) study noted an increase in fat oxidation (relative to placebo) during low intensity exercise in healthy adult males who consumed 150mg of capsaicin one hour before exercise.

MTS Nutrition has included 150mg of Capsaicin in the Drop Factor formula, consistent with the above-mentioned study.

Forskolin

Coleus Forskohlii is generally standardized for the active compound Forskohlin, which has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.

A 2005 study, published in the “Journal of the International Society of Sports Nutrition”, found that 50mg daily (two 25mg doses) for 12 weeks was able to prevent weight gain compared to the control group in overweight women.

Another 2005 study found that the same dose (25mg twice daily) was able to favorably influence body composition (i.e. less fat, more lean mass), which corresponded with an increase in Testosterone over 12 weeks.

A more recent (2011) study noted a roughly 2.5% decrease in BMI after 2 months of supplementation.

Forskohlin is one of the more effective non-stimulant fat-burners on its own, and can potentially amplify the effects of other fat-burning compounds. Drop Factor contains 25mg of Forskohlin per serving which means two servings daily yields an effective dose.

Theobromine

Theobromine belongs to the same class of chemical compounds as caffeine, known as methylxanthines. While its stimulant properties are less potent than caffeine, it is alleged to increase heart rate to a greater degree. In theory, increasing heart rate could provide more oxygen for fat oxidation (burning fat), but this is truly just a theory. Very few studies have examined the effects of Theobromine on weight loss, and those that have, have studied the effects in conjunction with other stimulants such as Caffeine and Synephrine. While it is doubtful that Theobromine by itself has much potential for weight-loss, it may contribute some when combined with the other stimulants present in the Drop Factor formula.

Synephrine and Methylsynephrine

Synephrine is a compound commonly isolated from Bitter Orange, and is similar in chemical structure (and function) to Ephedrine. It acts as a beta-receptor agonist, directly inducing lipolysis and allowing for more fat-burning than would otherwise normally occur. Methylsynephrine is very similar, though perhaps more potent than Synephrine with regards to fat-burning.

A 2011 study, published in the “International Journal of Medicinal Sciences”, found that supplementation of 50mg Synephrine increased metabolic rate in human subjects without affecting blood pressure or heart rate. Though there is some debate over how effective Synephrine is as a fat-loss agent by itself, when combined with other stimulants such as Caffeine and Yohimbine, the effects become more pronounced. Drop Factor contains 45mg of SyneLEAN, more or less consistent with the above-mentioned study.

Healthy ORAC Blend

Drop Factor contains a variety of anti-oxidant compounds including: Grape Seed Extract (Vitis Vinifera), Cranberry Powder, Broccoli Extract, Spinach Powder, Acacia Rigidula Extract, and Pomegranate extract. Rather than discuss each of these ingredients individually, we’ll just point out that antioxidants in general have a variety of health implications, two of which are reduced triglycerides and possibly attenuation of weight gain, though not to any significant degree in the short term. We wouldn’t really consider the Healthy ORAC Blend a “key” ingredient in the Drop Factor formula, but it certainly doesn’t hurt the efficacy of the product.

Vinpocetine

Vinpocetine is a synthetic derivative of Vincamine, extracted from Periwinkle, which has demonstrated the ability to increase blood flow, particularly cerebral blood flow. Vinpocetine’s potential for vasodilation has been known for quite some time, with a 1980 study from the “British Journal of Clinical Pharmacology” noting a roughly 7% increase in cerebral blood flow following infusions of Vinpocetine in healthy human subjects.

MTS Nutrition claims that, through vasodilation, Vinpocetine can increase the amount of fatty acids that are transported to the mitochondria to be burned. However, to be fair, this is just at theory and Vinpocetine has not been studied with regards to its potential for fat-loss.

However, because it is truly an effective cerebral vasodilator, Vinpocetine can reduce stimulant-induced migraines and potentially enhance cognitive ability, as evidenced in a 1985 study, published in the “European Journal of Clinical Pharmacology”, which noted decreased reaction time in subjects taking 40mg of Vinpocetine. However, Drop Factor contains just 5mg of Vinpocetine per serving, and this low of a dose has not been studied directly at this time.

Bioperine

BioPerine is a patented form of Black Pepper Extract which is standardized for the active component, Piperine. Several studies have found that black pepper extract, when combined with other nutrients, has increased the absorption of those nutrients (as measured by plasma levels). Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).

Yohimbine

As mentioned above, Yohimbine acts as an alpha-2 receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis. By blocking the action of this receptor Yohimbine allows for more lipolysis to occur than would normally be permitted by the alpha-adrenergic receptors.

A 2006 study, published in “Research in Sports Medicine”, found that supplementation with 20mg daily (2 10mg doses) induced significant fat-loss in athletes (Soccer players) over a two week period.

Given its role as an alpha-receptor antagonist, Yohimbine may be synergistic with other stimulants such as Synephrine and Caffeine which tend to induce lipolysis via beta-receptor agonism. Drop Factor contains 2.5mg of Yohimbine which, despite being much less than the dose used in the above-mentioned study, is actually a pretty reasonable dose when combined with other stimulants.

The Bottom Line

MTS Nutrition has done a great job with Drop Factor at creating a thorough blend of stimulant and non-stimulant fat-burning and “support” ingredients. The formula is certainly not for the stimulant-sensitive, but does not contain overwhelming doses of any individual ingredient. The formula is certainly intended for multiple servings daily (atleast 2 and at most 4), though we’d recommend sticking to MTS’s directions of working your way up to the max dose.

Still not sure which fat-burner is right for you? Check out our Top 10 Fat-Burners List!

REFERENCES
  1. Acheson, K. J., et al. “Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals.” The American journal of clinical nutrition 33.5 (1980): 989-997.
  2. Astrup, Arne, et al. “The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial.” International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity 16.4 (1992): 269-277.
  3. Shin, Ki Ok, and Toshio Moritani. “Alterations of Autonomic Nervous Activity and Energy Metabolism by Capsaicin Ingestion during Aerobic Exercise in Healthy Men.” Journal of Nutritional Science and Vitaminology 53.2 (2007): 124-32.
  4. WATANABE, TATSUO, et al. “Adrenal sympathetic efferent nerve and catechol secretion excitation caused by capsaicin in rats.” (1988).
  5. Kim, Kyung-Mi, et al. “Increase in swimming endurance capacity of mice by capsaicin-induced adrenal catecholamine secretion.” Bioscience, biotechnology, and biochemistry 61.10 (1997): 1718.
  6. Sano, Atsushi, et al. “Beneficial effects of grape seed extract on malondialdehyde-modified LDL.” Journal of nutritional science and vitaminology53.2 (2007): 174-182.
  7. Whiting, S., E. Derbyshire, and BK Tiwari. “Capsaicinoids and Capsinoids. A Potential Role for Weight Management? A Systematic Review of the Evidence.” Manchester Food Research Centre, Manchester Metropolitan University, Hollings Faculty, Old Hall Lane, Manchester M14 6HR, UK (n.d.): n. pag.
  8. Joo, Jeong In, Dong Hyun Kim, Jung-Won Choi, and Jong Won Yun. “Proteomic Analysis for Antiobesity Potential of Capsaicin on White Adipose Tissue in Rats Fed with a High Fat Diet.” Journal of Proteome Research 9.6 (2010): 2977-987.
  9. Lejeune, Manuela P. G. M., Eva M. R. Kovacs, and Margriet S. Westerterp-Plantenga. “Effect of Capsaicin on Substrate Oxidation and Weight Maintenance after Modest Body-weight Loss in Human Subjects.” British Journal of Nutrition 90.03 (2003): 651.
  10. Kaats, Gilbert R., et al. “A 60day double-blind, placebo-controlled safety study involving< i> Citrus aurantium(bitter orange) extract.” Food and Chemical Toxicology 55 (2013): 358-362.
  11. Stohs, Sidney J., et al. “Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes.” International journal of medical sciences 8.4 (2011): 295.
  12. Haaz, S., et al. “Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update.” Obesity reviews 7.1 (2006): 79-88.
  13. Henderson, Shonteh, et al. “Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women.” J Int Soc Sports Nutr 2.2 (2005): 54-62.
  14. Godard, Michael P., Brad A. Johnson, and Scott R. Richmond. “Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.” Obesity Research 13.8 (2005): 1335-1343.
  15. Jagtap, Madhavi, H. M. Chandola, and B. Ravishankar. “Clinical efficacy of Coleus forskohlii (Willd.) Briq.(Makandi) in hypertension of geriatric population.”Ayu 32.1 (2011): 59.
  16. Szilágyi, Géza, et al. “Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients: a PET study.” Journal of the neurological sciences 229 (2005): 275-284.
  17. Lim, C. C., P. J. Cook, and I. M. James. “The effect of an acute infusion of vincamine and ethyl apovincaminate on cerebral blood flow in healthy volunteers.” British journal of clinical pharmacology 9.1 (1980): 100-101.
  18. Bönöczk, Péter, et al. “Role of sodium channel inhibition in neuroprotection: effect of vinpocetine.” Brain research bulletin 53.3 (2000): 245-254.
  19. Hagiwara, Masatoshi, Toyoshi Endo, and Hiroyoshi Hidaka. “Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle.”Biochemical pharmacology 33.3 (1984): 453-457.
  20. Charney, Dennis S., George R. Heninger, and D. Eugene Redmond Jr. “Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine.” Life sciences 33.1 (1983): 19-29
  21. Sax, L. “Yohimbine does not affect fat distribution in men.” International journal of obesity 15.9 (1991): 561-565.
  22. Gurguis, George NM, Bernard J. Vitton, and Thomas W. Uhde. “Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls.” Psychiatry research 71.1 (1997): 27-39.
  23. Drew, Geoffrey M. “Effects of α-adrenoceptor agonists and antagonists on pre-and postsynaptically located α-adrenoceptors.” European journal of pharmacology 36.2 (1976): 313-320.
  24. Wright, Elizabeth E., and Evan R. Simpson. “Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists.”Journal of lipid research 22.8 (1981): 1265-1270.
  25. Galitzky, J., et al. “Pharmacodynamic effects of chronic yohimbine treatment in healthy volunteers.” European journal of clinical pharmacology 39.5 (1990): 447-451.
  26. McCarty, Mark F. “Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis.”Medical hypotheses 58.6 (2002): 491-495.
  27. Galitzky, J., et al. “Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue.” Journal of Clinical Investigation 91.5 (1993): 1997.
  28. Ostojic, Sergej M. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Research in Sports Medicine 14.4 (2006): 289-299.
  29. Ahmadian, Maryam, Robin E. Duncan, and Hei Sook Sul. “The skinny on fat: lipolysis and fatty acid utilization in adipocytes.” Trends in Endocrinology & Metabolism 20.9 (2009): 424-428.
  30. Badmaev, Vladimir, Muhammed Majeed, and Lakshmi Prakash. “Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation.” The Journal of Nutritional Biochemistry 11.2 (2000): 109-113.
  31. Majeed, Muhammed, and Lakshmi Prakash. “Targeting Optimal Nutrient Absorption with Phytonutrients.” (2007)

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