Drop Factor is MTS Nutrition’s fat-burner which is primarily stimulant-focused, though it does contain some effective non-stimulant ingredients as well…FIND IT HERE
Caffeine triggers the release of Catecholamines (i.e. Noradrenaline, Adrenaline, Dopamine) which, in addition to enhancing focus and alertness, are inherently pro-lipolytic. Although this mechanism can certainly burn fat in the short-term, prolonged Caffeine consumption (by itself) generally results in tolerance build-up so the effects become less potent over time. This was demonstrated in a 1992 study in which 24 weeks of Caffeine intake (200mg/day) failed to induce weight-loss in humans. For this reason, for Caffeine to be an effective fat-loss agent, it must be combined with other stimulants such as Yohimbine and/or Synephrine (both of which are also included in the Drop Factor formula).
Capsicum Annum, more commonly known as Cayenne Pepper, is generally standardized for its active component, Capsaicin, which has thermogenic properties and clear implications for weight-loss in humans.
A 1997 study, the subjects of which were rats, found that Capsaicin supplementation was able to increase adrenaline-induced fatty acid utilization, which increased exercise (swimming) endurance.
A more recent (2007) study noted an increase in fat oxidation (relative to placebo) during low intensity exercise in healthy adult males who consumed 150mg of capsaicin one hour before exercise.
MTS Nutrition has included 150mg of Capsaicin in the Drop Factor formula, consistent with the above-mentioned study.
Coleus Forskohlii is generally standardized for the active compound Forskohlin, which has been demonstrated to increase Cyclic Adenosine Monophosphate (cAMP), the result of which is an increase in the rate of fat-loss.
A 2005 study, published in the “Journal of the International Society of Sports Nutrition”, found that 50mg daily (two 25mg doses) for 12 weeks was able to prevent weight gain compared to the control group in overweight women.
Another 2005 study found that the same dose (25mg twice daily) was able to favorably influence body composition (i.e. less fat, more lean mass), which corresponded with an increase in Testosterone over 12 weeks.
A more recent (2011) study noted a roughly 2.5% decrease in BMI after 2 months of supplementation.
Forskohlin is one of the more effective non-stimulant fat-burners on its own, and can potentially amplify the effects of other fat-burning compounds. Drop Factor contains 25mg of Forskohlin per serving which means two servings daily yields an effective dose.
Theobromine belongs to the same class of chemical compounds as caffeine, known as methylxanthines. While its stimulant properties are less potent than caffeine, it is alleged to increase heart rate to a greater degree. In theory, increasing heart rate could provide more oxygen for fat oxidation (burning fat), but this is truly just a theory. Very few studies have examined the effects of Theobromine on weight loss, and those that have, have studied the effects in conjunction with other stimulants such as Caffeine and Synephrine. While it is doubtful that Theobromine by itself has much potential for weight-loss, it may contribute some when combined with the other stimulants present in the Drop Factor formula.
Synephrine and Methylsynephrine
Synephrine is a compound commonly isolated from Bitter Orange, and is similar in chemical structure (and function) to Ephedrine. It acts as a beta-receptor agonist, directly inducing lipolysis and allowing for more fat-burning than would otherwise normally occur. Methylsynephrine is very similar, though perhaps more potent than Synephrine with regards to fat-burning.
A 2011 study, published in the “International Journal of Medicinal Sciences”, found that supplementation of 50mg Synephrine increased metabolic rate in human subjects without affecting blood pressure or heart rate. Though there is some debate over how effective Synephrine is as a fat-loss agent by itself, when combined with other stimulants such as Caffeine and Yohimbine, the effects become more pronounced. Drop Factor contains 45mg of SyneLEAN, more or less consistent with the above-mentioned study.
Healthy ORAC Blend
Drop Factor contains a variety of anti-oxidant compounds including: Grape Seed Extract (Vitis Vinifera), Cranberry Powder, Broccoli Extract, Spinach Powder, Acacia Rigidula Extract, and Pomegranate extract. Rather than discuss each of these ingredients individually, we’ll just point out that antioxidants in general have a variety of health implications, two of which are reduced triglycerides and possibly attenuation of weight gain, though not to any significant degree in the short term. We wouldn’t really consider the Healthy ORAC Blend a “key” ingredient in the Drop Factor formula, but it certainly doesn’t hurt the efficacy of the product.
Vinpocetine is a synthetic derivative of Vincamine, extracted from Periwinkle, which has demonstrated the ability to increase blood flow, particularly cerebral blood flow. Vinpocetine’s potential for vasodilation has been known for quite some time, with a 1980 study from the “British Journal of Clinical Pharmacology” noting a roughly 7% increase in cerebral blood flow following infusions of Vinpocetine in healthy human subjects.
MTS Nutrition claims that, through vasodilation, Vinpocetine can increase the amount of fatty acids that are transported to the mitochondria to be burned. However, to be fair, this is just at theory and Vinpocetine has not been studied with regards to its potential for fat-loss.
However, because it is truly an effective cerebral vasodilator, Vinpocetine can reduce stimulant-induced migraines and potentially enhance cognitive ability, as evidenced in a 1985 study, published in the “European Journal of Clinical Pharmacology”, which noted decreased reaction time in subjects taking 40mg of Vinpocetine. However, Drop Factor contains just 5mg of Vinpocetine per serving, and this low of a dose has not been studied directly at this time.
BioPerine is a patented form of Black Pepper Extract which is standardized for the active component, Piperine. Several studies have found that black pepper extract, when combined with other nutrients, has increased the absorption of those nutrients (as measured by plasma levels). Piperine’s ability to increase absorption of other compounds is due to the inhibition of certain enzymes which breakdown most compounds, as well as the slowing of intestinal transit (increasing the amount of time these compounds are exposed to the possibility of uptake).
As mentioned above, Yohimbine acts as an alpha-2 receptor antagonist, meaning it inhibits the receptor responsible for blocking lipolysis. By blocking the action of this receptor Yohimbine allows for more lipolysis to occur than would normally be permitted by the alpha-adrenergic receptors.
A 2006 study, published in “Research in Sports Medicine”, found that supplementation with 20mg daily (2 10mg doses) induced significant fat-loss in athletes (Soccer players) over a two week period.
Given its role as an alpha-receptor antagonist, Yohimbine may be synergistic with other stimulants such as Synephrine and Caffeine which tend to induce lipolysis via beta-receptor agonism. Drop Factor contains 2.5mg of Yohimbine which, despite being much less than the dose used in the above-mentioned study, is actually a pretty reasonable dose when combined with other stimulants.
The Bottom Line
MTS Nutrition has done a great job with Drop Factor at creating a thorough blend of stimulant and non-stimulant fat-burning and “support” ingredients. The formula is certainly not for the stimulant-sensitive, but does not contain overwhelming doses of any individual ingredient. The formula is certainly intended for multiple servings daily (atleast 2 and at most 4), though we’d recommend sticking to MTS’s directions of working your way up to the max dose.
Still not sure which fat-burner is right for you? Check out our Top 10 Fat-Burners List!
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