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MuscleTech Appedex SX-7 Review

Appedex SX-7 is an appetite suppressant from MuscleTech’s recently launched SX-7 series which features Appethyl (containing Thykaloids) as a key ingredient…

Appedex SX-7

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KELP FIBER (SODIUM ALGINATE)

Sodium Alginate is generally extracted from brown seaweed (Kelp) and has a wide variety of industrial applications. It is commonly used as a good-tickening agent, because of its ability to absorb roughly 200-300 times its weight in water. As a gel-like substance, Sodium Alginate moves slowly through the intestines, and it is this property that has prompted clinical research regarding its potential as an appetite suppressant.

A 2008 study from “Appetite” found that daily Alginate ingestion decreased food intake by an average of 7% in obese humans, over the course of several weeks.

A 2010 study from “Obesity” noted no significant changes in satiety, appetite, or hormone levels in subjects who consumed Alginate daily for 10 days, indicating that the effects take time to become prevalent.

A 2014 study, published in the “Eurpoean Journal of Clinical Nutrition”, found that Sodium Alginate was able to reduce Insulin response to a glass of Chocolate Milk and decrease appetite. However, this did not translate into subjects consuming less food at a meal 2 hours later.

Ultimately, Sodium Alginate isn’t exactly the miracle weight-loss supplement it is sometimes made out to be, but over-time may be able to reduce food intake to some degree. Unfortunately, Appedex SX-7 contains just 3.37g of Kelp Fiber (with an unknown amount of Sodium Alginate), not exactly in-line with clinical doses.

APPETHYL (THYKALOIDS)

Appethyl is a patented Spinach Extract which is standardized for Thykaloids, tiny compartments found in the chloroplasts of leafy greens (such as Spinach). In recent years, the popularity of Thykaloids has exploded based on research that indicates supplementation can suppress appetite.

A 2007 study from the “Biochemistry Journal” found that Thlyakoids were able to slow fat-digestion in the intestines of mice, effective raising levels of cholecystokinin (CCK), a hormone that signals satiety (feeling of fullness), and ultimately decreasing food intake.

A 2009 study, published in the “Scandinavian Journal of Gastroenterology”, found that subjects who consumed Thylakoids (from Spinach) with a high-fat meal experienced higher levels of CCK 180 minutes after meal compared to the placebo group, as well as a reduced insulin response, both indications of slower fat-digestion.

These findings were replicated in a 2013 study from “Appetite” in moderately obese women. However, it should be noted that the design of this particular study was single-blind, and therefore should be taken lightly.

A few things to keep in mind about Thylakoids: both studies indicate that Thylakoids take approximately 2 hours to influence satiety hormone levels. So, taking Thylakoids with your meal won’t actually prevent you from eating more at that particular meal. The assumption being made is that the feeling of fullness will make you eat less at your next meal which may seem logical, but it is an assumption nonetheless.

Appedex SX-7 contains 2.5mg of Appethyl, but both of the human studies mentioned above used far more Thykaloids (anywhere from 3-25g). Whether this is enough to have any influence at all is unclear.

KUDZU

Kudzu has been shown to attenuate weight-gain associated with ovariectomy (removal or ovaries) and menopause in mice. However, a 2012 study from “Phytomedicine” noted no differences in food intake or bodyweight, also in mice.

Kudzu has not been studied in humans with regards to weight-loss and/or appetite suppression, but given the lackluster results of rodent studies, there doesn’t appear to be much reason for further research in this area.

In the context of Appedex SX-7, Kudzu can’t really be considered a “key” ingredient.

PHASEOLUS VULGARIS (WHITE KIDNEY BEAN)

Both in vitro and in vivo studies have demonstrated the ability of White Kidney Bean to block the absorption of carbohydrates, when consumed simultaneously, via inhibition of amylase (a digestive enzyme responsible for the absorption of starches). By reducing carbohydrate absorption, WKB may mimic the effects of a calorie (carb) restricted diet to some degree. While all studies have confirmed that there is some carb-blocking effect, the degree tends to vary and the total weight loss effect is likely influenced by many individual factors.

A 2004 study from “Alternative Medicine Review” found that Phase 2 (a patented White Kidney Bean extract) supplementation resulted in a trend towards weight-loss, but did not achieve statistical significance.

A 2007 study, published in the “International Journal of Medical Sciences”, found that White Kidney Bean extract (445mg) was able to reduce bodyweight in slightly overweight human subjects.

Unfortuantely, Appedex SX-7 contains 100mg of White Kidney Bean extract, a mere fraction of the doses used in a clinical setting.

PRICKLY PEAR

In a 1990 study from “Phytotherapy Research”, researchers found that 500g of Prickly Pear fruit was able to significantly reduce post-meal blood-sugar levels in diabetic subjects, but given that Appedex contains nowhere near the equivalent of 500g, these findings are probably not particularly relevant.

In the context of Appedex SX-7, Prickly Pear (like Kudzu) has no particularly important function.

LEMON BALM

Lemon Balm is relatively popular as an herbal relaxation/sleep supplement, but research regarding its potential as a weight-loss agent is extremely limited.

In a 2010 study from the “British Journal of Nutrition”, Lemon Balm demonstrated anti-diabetic effects in mice, but that’s where the research ends. There is certainly no reason to think that these effects would be particularly prevalent in humans at the 100mg dose present in Appedex.

MULBERRY

Mulberry has been shown to reduce food intake in obese mice which ultimately decreased bodyweight somewhat. Appetite suppression was replicated in a 2011 study from “Nutrition Research”, but no bodyweight reduction occurred in this study.

Mulberry, at high concentrations, may have some appetite suppression effect, but Appedex SX-7 contains nowhere near the doses used in those studies.

CAMU CAMU

Camu Camu contains several flavonoids that are allegedly responsible for the health claims attached to it, and the term “appetite suppression” has definitely been tied to it a few times. However, there is really no research indicating that Camu Camu is particularly effective as an appetite suppressant. It’s possibly that certain compounds found in Camu Camu may have general anti-obesity effects but, in the context of Appedex SX-7, it’s pretty much useless as an ingredient.

THE BOTTOM LINE

As far as non-stimulant appetite suppressants go, the Appedex SX-7 formula starts off strong, with a few ingredients that have actually been clinically shown to influence satiety hormones. Unfortunately, none of these ingredients are included at “clinical” doses, so any appetite suppression isn’t likely to be profound. Appedex SX-7 also contains several filler ingredients that don’t appear to serve any meaningful purpose at all.

References

  1. Köhnke, Rickard, et al. “Thylakoids promote release of the satiety hormone cholecystokinin while reducing insulin in healthy humans.” Scandinavian journal of gastroenterology 44.6 (2009): 712-719.
  2. Stenblom, Eva-Lena, et al. “Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandial hypoglycaemia in overweight women.” Appetite 68 (2013): 118-123.
  3. Albertsson, P., et al. “Chloroplast membranes retard fat digestion and induce satiety: effect of biological membranes on pancreatic lipase/co-lipase.”Biochem. J 401 (2007): 727-733.
  4. El Khoury, D., et al. “Effect of sodium alginate addition to chocolate milk on glycemia, insulin, appetite and food intake in healthy adult men.” European journal of clinical nutrition 68.5 (2014): 613-618.
  5. Paxman, J. R., et al. “Daily ingestion of alginate reduces energy intake in free-living subjects.” Appetite 51.3 (2008): 713-719.
  6. Odunsi, Suwebatu T., et al. “Effect of alginate on satiation, appetite, gastric function, and selected gut satiety hormones in overweight and obesity.” Obesity18.8 (2010): 1579-1584.
  7. Saunier, Elise F., et al. “Estrogenic plant extracts reverse weight gain and fat accumulation without causing mammary gland or uterine proliferation.” PloS one 6.12 (2011): e28333.
  8. Wang, Ji-Feng, et al. “Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats.” World journal of gastroenterology: WJG10.13 (2004): 1967-1970.
  9. Prasain, Jeevan K., et al. “The Chinese Pueraria root extract (< i> Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice.”Phytomedicine 20.1 (2012): 17-23.
  10. Layer LAYER, PETER, et al. “Effect of a purified amylase inhibitor on carbohydrate tolerance in normal subjects and patients with diabetes mellitus.” Mayo Clinic Proceedings. Vol. 61. No. 6. Elsevier, 1986.
  11. Layer Udani, Jay, Mary Hardy, and Damian C. Madsen. “Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2™ brand proprietary fractionated white bean extract.” Alternative medicine review 9.1 (2004): 63-69.
  12. Layer, P., G. L. Carlson, and E. P. DiMagno. “Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans.” Gastroenterology 88.6 (1985): 1895-902.
  13. Layer Celleno, Leonardo, et al. “A dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women.” International journal of medical sciences 4.1 (2007): 45.
  14. Frati, Alberto C., Ernesto Jiménez, and C. Raul Ariza. “Hypoglycemic effect of Opuntia ficus indica in non insulin‐dependent diabetes mellitus patients.”Phytotherapy research 4.5 (1990): 195-197.
  15. Chung, Mi Ja, et al. “Anti-diabetic effects of lemon balm (Melissa officinalis) essential oil on glucose-and lipid-regulating enzymes in type 2 diabetic mice.”British journal of nutrition 104.02 (2010): 180-188.
  16. Tanabe, Kenichi, et al. “Repeated ingestion of the leaf extract from< i> Morus alba reduces insulin resistance in KK-Ay mice.” Nutrition Research 31.11 (2011): 848-854.
  17. Oh, Kwang-Seok, et al. “Melanin-concentrating hormone-1 receptor antagonism and anti-obesity effects of ethanolic extract from< i> Morus alba leaves in diet-induced obese mice.” Journal of ethnopharmacology 122.2 (2009): 216-220.

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